Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction. Read more about Tunable-combinatorial mechanisms of acquired resistance limit the efficacy of BRAF/MEK cotargeting but result in melanoma drug addiction.
Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease. Read more about Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.
Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity. Read more about Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity.
Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. Read more about Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells.
Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Read more about Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity.
DAISY: picking synthetic lethals from cancer genomes. Read more about DAISY: picking synthetic lethals from cancer genomes.
Drugging MYCN through an allosteric transition in Aurora kinase A. Read more about Drugging MYCN through an allosteric transition in Aurora kinase A.
When deletions gain functions: commandeering epigenetic mechanisms. Read more about When deletions gain functions: commandeering epigenetic mechanisms.
B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas. Read more about B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas.
Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Read more about Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.
