DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade. Read more about DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade.
CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2. Read more about CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2.
Differential impact of RB status on E2F1 reprogramming in human cancer. Read more about Differential impact of RB status on E2F1 reprogramming in human cancer.
Hedgehog signaling drives medulloblastoma growth via CDK6. Read more about Hedgehog signaling drives medulloblastoma growth via CDK6.
Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis. Read more about Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis.
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. Read more about Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells.
Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I. Read more about Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I.
Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas. Read more about Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas.
Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency. Read more about Mutations in sphingosine-1-phosphate lyase cause nephrosis with ichthyosis and adrenal insufficiency.
Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma. Read more about Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma.
