Three researchers from the UCSF Helen Diller Family Comprehensive Cancer Center have received the NCI Outstanding Investigator Award in 2015: Thea D. Tlsty, PhD, Frank McCormick, PhD, FRS, DSc (Hon), and Markus Müschen, MD, PhD.
NCI’s Outstanding Investigator Award supports accomplished leaders in cancer research, who are providing significant contributions toward understanding cancer and developing applications that may lead to a breakthrough in biomedical, behavioral, or clinical cancer research.
Title: Professor, Department of Pathology, Member, UCSF Helen Diller Family Comprehensive Cancer Center and Director of the Center for Translational Research in the Molecular Genetics of Cancer
Research: Develop strategies to control dynamic phenotypic states underlying cellular plasticity/heterogeneity in tissues responding to stress. Use these insights for early detection, disease stratification and novel approaches for prevention and treatment of cancer.
Title: Professor Emeritus, UCSF Helen Diller Family Comprehensive Cancer Center
Research: Analyze how GAPs such as the NF1 protein are regulated and how un-regulated Ras proteins cause oncogenic transformation; use engineered isogenic cells, CRISPR technology and biochemical approaches to address these questions.
Title: Professor, Department of Laboratory Medicine; Co-Leader, Hematological Malignancies Program UCSF Helen Diller Family Comprehensive Cancer Center
Research: Focus on mechanisms of drug-resistance, oncogenic B cell receptor signaling and clonal evolution in B-lymphoid malignancies. To validate B cell-specific vulnerabilities as potential therapeutic targets in B cell-lineage leukemia and lymphoma.