Targeted Therapy for ‘Undruggable’ Lung Cancer Stems from Decades of UCSF Research

Over the past two decades, targeted cancer therapies have changed the prognosis for thousands of patients. By targeting the specific genetic mutation behind a patient’s cancer, these therapies have enabled increasing numbers of patients to experience fewer toxic side effects and, often, live free of

Next-Generation T-Cell Therapeutics Set Sights on Cancers, Autoimmune Disorders and More

T cells – immune cells that patrol our bodies in search of trouble – have become a central focus for UC San Francisco scientists working on living cell therapies, an approach that views cells themselves as a form of medicine. “From my perspective there’s no more important system in the body than the

Examining Leukemia Risks Among Children with Down Syndrome

Down syndrome is one of the most common genetic conditions in the U.S. and Canada. According to the Centers for Disease Control and Prevention (CDC), about 6,000 babies with Down syndrome are born in the U.S. each year. When compared with the general population, children born with Down syndrome have

UCSF Benioff Children’s Hospitals Rank Among the Nation’s Best in 2021-2022 US News & World Report

UCSF Benioff Children’s Hospitals have been recognized among the nation’s best pediatric medical centers in all 10 specialties assessed in U.S. News & World Report’s annual survey of Best Children’s Hospitals for 2021-2022, reflecting the quality of specialty care the hospitals provide for children

Space Travel Weakens Our Immune Systems – Now Scientists May Know Why

Microgravity in space perturbs human physiology and is detrimental for astronaut health, a fact first realized during early Apollo missions when astronauts experienced inner ear disturbances, heart arrhythmia, low blood pressure, dehydration, and loss of calcium from their bones after their missions

Sophie Dumont Delivers 2021 Byers Award Lecture: ‘Who Conducts the Symphony of Cell Division?’

Sophie Dumont, PhD, was on track to become a physicist when she stumbled upon a mind-blowing description of cell division at a Berkeley auto shop while waiting for her clunker to be fixed. “My old car was being worked on so I picked up a book left by a previous customer titled “Landmark Papers in

Full-Genome CRISPR Screen Reveals Surprising Ways Neurons Survive Oxidative Stress

When a single gene in a cell is turned on or off, its resulting presence or absence can affect the function and survival of the cell. In a new study appearing May 24 in Nature Neuroscience, UCSF researchers have successfully catalogued this effect in the human neuron by separately toggling each of