UCSF Radiation Oncologist Honored for Prostate Cancer Care and Research

American Society of Radiation Oncology celebrates Mack Roach, III, MD, for profound impact on patient treatment and leadership in cancer disparities treatment outcomes.

By Melinda Krigel | UCSF.edu | September 09, 2024

Radiation oncologist Mack Roach, III MD with an insert of original art published in the May 2023 issue of the International Journal of Radiation Oncology, Biology, Physics

Radiation oncologist Mack Roach, III MD with an insert of original art published in the May 2023 issue of the International Journal of Radiation Oncology, Biology, Physics

Mack Roach, III, MD, FASTRO, has been chosen by the American Society for Radiation Oncology (ASTRO) to receive its 2024 Gold Medal Award. Roach is being recognized with ASTRO’s highest honor for his outstanding contributions to the field of radiation oncology.

Dr. Mack Roach is a world-renowned expert in the treatment of prostate cancer, a highly respected trialist and clinician, and former UCSF Chair who has impacted our field over many years, if not decades. We are all very proud of him being awarded the prestigious ASTRO Gold Medal this year, one of our society's highest honors.

Cathy Park, MD
Chair of UCSF Radiation Oncology

Roach is a radiation oncologist, UCSF professor of a Radiation Oncology, and Urology, and an internationally renowned expert on treating and managing prostate cancer. Roach’s major research interest involves new techniques for treating prostate cancer, such as three-dimensional (3D) conformal radiation therapy and intensity modulated radiation therapy (IMRT). His achievements in devising predictive equations and leading significant phase III trials in prostate cancer have positioned him as a key figure in the field with a profound impact on patient treatment protocols. Roach is also considered a foremost authority on disparities in outcomes from cancer treatment in underserved populations.

“Dr. Roach embodies the very essence of the ASTRO Gold Medal through his outstanding contributions to advancing radiation oncology through research, clinical care, teaching, advocacy and service,” wrote Iris C. Gibbs, MD, FASTRO, ASTRO’s Health Equity, Diversity and Inclusion Council Chair and member of ASTRO’s Board of Directors. “His distinguished career, marked by groundbreaking advancements in the treatment of prostate and other genitourinary cancers, as well as his unwavering commitment to research, service, integrity and mentorship, makes him an exemplary recipient of the Gold Medal, ASTRO’s highest honor.”

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Q & A: Dr. Roach discusses his work and the value of art in everyday life.

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"The Tree" by Mack Roach, III, MD, in the International Journal of Radiation Oncology, Biology, Physics on May 1, 2023 — Vol 116, No 1.
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Mack Roach, III MD original art featured on the cover of the Journal of Clinical Oncology Practice

Original art from Dr. Roach, left to right: "The Tree" by Mack Roach, III, MD, in the International Journal of Radiation Oncology, Biology, Physics on May 1, 2023 — Vol 116, No 1; original art featured on the cover of the Journal of Clinical Oncology Practice in May 2021.

There is much to discuss in terms of your illustrious career and contributions to medicine and cancer treatment, but first let’s begin with your background. You were born in Texas and grew up in California?

I grew up in San Francisco. My father asked the doctor how old I had to be before we moved to Calif. He said, “one month,” so we left for California when I was 30 days old. I asked my father, now 94, why we left. He told me about Jim Crow racism in

Who or what inspired your interest in science, physics in particular, and ultimately medicine/cancer/radiation oncology?

I always enjoyed visualizing things and understanding why things were.

An article from 2012 suggested that at one point you considered a career as an artist. Are you still making art and what kind? Also, please talk about the nexus between physics and art for you.

I have published art on several covers of cancer journals, the most recent in a special issue of the JCO Oncology Practice in 2021.

Your scientific and medical contributions prompted former President Obama to nominate you to the National Cancer Advisory Board in 2006. What was that experience like? Do you have any anecdotes about Obama that you can share?

I never met him. I was very honored that he found and appointed me.

With degrees from Morehouse (physics) and Stanford (MD), you could have practiced medicine in many places. Why did you choose to spend your career at UCSF?

I love San Francisco and grew up here as a 49ers, SF Giants, and Warriors fan. I love a place where 85% of people voted against Trump! I could not imagine living in a “Red State.”

How has the focus of your work evolved, and what are you working on these days?

Alternative forms of radiation, such a charged carbon ion radiation, as well as research related to the use of biomarkers. Perhaps most important would be to teach people to really read and not to trust poorly done studies.

In terms of cancer research and treatment, where do you find inspiration? And what excites you the most about where things are headed?

I am writing a book entitled: Art, Prostate Cancer, Wine, Quotes, Truth, and A.I. The point of the book is that art is the single thing that distinguishes humans from other animals and is a source of strength and inspiration when science comes up short. As a society, we need to value art more.

 

Outside of work, what are your favorite pursuits? Where do you find contentment?

I am a runner, wine collector, jazz lover, traveler and I do as much art as I can (not much).

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Roach has made significant, practice-changing contributions to prostate cancer treatment, pioneering the “Roach Formula,” which is the initial equation to estimate the risk of lymph node and seminal vesicle involvement in prostate cancer. He spearheaded the inaugural large-scale phase III trial that utilized prostate-specific antigen (PSA) levels as a measure for outcomes such as progression-free survival and proactively incorporated PSA nadir as a secondary endpoint. Roach has also been instrumental in developing the first model to predict disease-specific and overall survival based on data from prostate cancer patients treated in phase III trials.

He has gained recognition as an authority on treatment planning for prostate cancer and served as senior author for the guidelines for treatment planning by the American College of Radiology. He has begun to pioneer intensity modulated radiotherapy (IMRT), in combination with online portal imaging, and improved dose calculation algorithms that should allow UCSF Radiation Oncology to provide leadership in the field of radiotherapy for many years to come. 

“This award is an incredible honor and I thank ASTRO for recognizing the work I have been involved with in treatment, research and heath equity,” said Roach. “I also want to thank my colleagues and my inspiring patients who provide the strongest motivation for advancing our field.”

Roach’s commitment to community service has been demonstrated by over two decades of volunteer work in cancer control efforts and his contributions to reducing health care disparities. His leadership and service have been recognized with numerous awards and honors. In 2012, he was appointed by President Barack Obama to serve a six-year term as the only radiation oncologist on the National Cancer Advisory Board (NCAB), where he was particularly active in the sub-committee on global health. Roach was also awarded an honorary doctorate and a “Candle in the Dark” award from Morehouse College, his alma mater.

Roach has been a member of the UCSF faculty since 1990, rising through the academic ranks to become chair of the Department of Radiation Oncology from 2006 to 2015. He earned his medical degree at Stanford University School of Medicine and did his internship and residency at Martin Luther King Jr. General Hospital in Los Angeles. He completed a fellowship in Hematology-Oncology at UCSF as well as a residency in radiation oncology at Stanford. He also served as chief resident in medicine at Highland Hospital in Oakland.

He is a member of numerous professional organizations, including the American Society of Clinical Oncology, American Society for Therapeutic Radiology and Oncology, Radiation Therapy Oncology Group, National Cancer Institute’s IMRT Working Group, American Joint Commission for Cancer Staging, the American Cancer Society (ACS) Task Force for Cancer Screening Guidelines (prostate cancer) and the NCI Concept Evaluation Panel (prostate cancer phase III trials).

Roach and two other Gold Medal recipients will be celebrated Oct.1 during the awards ceremony at ASTRO’s 66th Annual Meeting in Washington, DC.

ASTRO’s Gold Medal is bestowed on revered members who have made outstanding contributions to the field of radiation oncology. This includes research, clinical care, teaching and service. Recipients are drawn from any of the scientific disciplines represented by the members of the Society.

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