Research Summary

My research focus is on the development of novel therapies for patients, as well as the assessment of novel imaging markers of prognosis and response to therapy. As program leader for the Neuro-Oncology Program at the Helen Diller Family Comprehensive Cancer Center, my role is to provide the overall direction of the program and facilitate the interaction of the basic science and translational research programs with the clinical team to bring novel findings from the lab to the patient. I am the lead and contact PI for a P01 focused on integrating advances in physiologic and metabolic imaging with tissue biomarkers in order to optimize the management of patients with molecular subtypes of glioma. I am the overall Clinical Leader for the UCSF Brain SPORE grant as well as the Clinical Core Director and Co-PI of a SPORE project that addresses the evaluation of steady and dynamic metabolic imaging in glioblastoma.

Research Funding

  • July 1, 2021 - June 30, 2026 - Glioblastoma Therapeutics Network , Administrative and Clinical Core Co Investigator . Sponsor: NIH/NCI, Sponsor Award ID: UCA264338A
  • December 1, 2005 - July 31, 2024 - Noninvasive Metabolic Signatures to Improve Management of Molecular Subtypes of Glioma , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P01CA118816
  • September 20, 2002 - August 31, 2023 - Brain Tumor SPORE Grant , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50CA097257
  • August 5, 1999 - July 31, 2023 - NCI Comprehensive Cancer Center Grant , Program Co-leader . Sponsor: NIH/NCI, Sponsor Award ID: P30 CA082103-17

Education

University of British Columbia, 1981
University of British Columbia, MD, 1985, Medicine
Pasqua Hospital, University of Saskatchewan, Regina, Internship, 1985-1986
Plains Health Centre, Regina, Saskatchewan, Residency, 1986-1987
Toronto General Hospital, U of Toronto, Ontario, Residency, 1987-1989
Princess Margaret Hospital, U of Toronto, Ontario, Residency, 1989-1991
Royal College of Physicians & Surgeons, Canada, FRCPS, 1990, Internal Medicine
Royal College of Physicians & Surgeons, Canada, FRCPS, 1991, Medical Oncology

Honors & Awards

  • 2014
    UCSF Voice of the Patient Pinnacle Award x 7 years, Press Ganey award for excellence in patient care per division, Hall of Fame
  • 2014
    John J. Mealey Jr. Neuro-Oncology Lectureship

Selected Publications

  1. Nabavizadeh A, Narsinh K, Kaufmann TJ, Liu H, Pouliopoulos AN, Prada F, Agarwal V, Ellingson BM, Sanvito F, Everson RG, Meng Y, Gandhi D, Chang SM, Wen PY, Ahluwalia MS, Sul N, Hadley L, Leblang S, Shah BR, Arvanitis CD, Burns TC, Moosa S, Woodworth GF. Focused Ultrasound in Brain Tumors: Mechanisms, Imaging Guidance, and Emerging Clinical Applications. AJNR Am J Neuroradiol. 2026 May 05. View on PubMed
  2. Chen J, Oberheim Bush NA, Grabowsky JA, Kline C, Kroetz DL, Taylor JW, Villanueva-Meyer J, Molinaro AM, de Groot JF, Butowski NA, Tedesco M, Rabbitt J, Phillips JJ, Hervey-Jumper S, Aghi MK, Berger MS, Chang EF, Chang SM, Solomon DA, Clarke JL. A Genomically Tailored Multiagent Precision Medicine Clinical Trial for Adults with Recurrent Glioblastoma. Clin Cancer Res. 2026 May 01; 32(9):1652-1665. View on PubMed
  3. Kim Y, Dang D, Slater J, Riselli A, Hong D, Gordon JW, Chang SM, Li Y, Villanueva-Meyer JE, Autry AW, Escobar E, Andosca S, Chen HY, Tan CT, Suszczynski C, Maddali S, Bok RA, Vigneron DB. Development and First-in-Human Translation of Hyperpolarized [1-13C]Alpha-Ketoglutarate MR Spectroscopy in the Brain. Sensors (Basel). 2026 Apr 29; 26(9). View on PubMed
  4. Teske N, Dono A, Young JS, Jünger ST, Youssef G, Häni L, Sciortino T, Bruno F, Dietrich J, Mau CY, Weller M, Beck J, Hervey-Jumper S, Molinaro AM, Chang SM, van den Bent M, Vogelbaum MA, Ruge MI, Cahill DP, Rudà R, Bello L, Grau SJ, Schnell O, Huang RY, Wen PY, Tandon N, Berger MS, Tonn JC, Esquenazi Y, Karschnia P. Associations of supramaximal resection with outcome in glioblastoma across age groups: A report of the RANO resect group. Neuro Oncol. 2026 Feb 01; 28(2):470-484. View on PubMed
  5. Gerritsen JKW, Karschnia P, Bello L, Hervey-Jumper S, Young JS, Seidel K, Satoer DD, Schnell O, Parsons M, Nahed BV, Menna G, Teske N, External Rater Panel, Smith TR, Sanai N, Krieg SM, Schucht P, Broekman MLD, De Vleeschouwer S, Jakola AS, van den Bent MJ, Chang SM, Vogelbaum MA, Vincent AJPE, Tonn JC, Berger MS. A comprehensive framework for glioma surgery by the PIONEER Consortium and RANO resect group, part 1: intraoperative recommendations for mapping, monitoring, and decision making. Lancet Oncol. 2026 Jan; 27(1):e11-e23. View on PubMed
  6. Gerritsen JKW, Karschnia P, Bello L, Hervey-Jumper S, Young JS, Seidel K, Satoer DD, Schnell O, Parsons M, Nahed BV, Menna G, Teske N, External Rater Panel, Smith TR, Sanai N, Krieg SM, Schucht P, Broekman MLD, De Vleeschouwer S, Jakola AS, van den Bent MJ, Chang SM, Vogelbaum MA, Vincent AJPE, Tonn JC, Berger MS. A comprehensive framework for glioma surgery by the PIONEER Consortium and RANO resect group, part 2: perioperative recommendations for neurological, language, functional, and quality-of-life assessment. Lancet Oncol. 2026 Jan; 27(1):e24-e32. View on PubMed
  7. Chang SM. Letter from the Editor. Neuro Oncol. 2026 Jan 01; 28(1):1-2. View on PubMed
  8. de la Fuente MI, Brastianos PK, Gampel B, Nassiri F, Raleigh DR, Ida CM, Abdelbaki MS, Pekmezci M, Bagley S, Young JS, Lukas RV, Hirbe AC, Ellingson BM, Villanueva-Meyer J, Lasorella A, Sarkaria JN, Gutmann DH, Haas-Kogan D, Galanis E, Chang SM. Reflecting on scientific growth and innovation as the Society for Neuro-Oncology turns 30. Neuro Oncol. 2026 Jan 01; 28(1):7-18. View on PubMed
  9. Karschnia P, Young JS, Wijnenga MMJ, Sciortino T, Teske N, Corell A, Wagner A, Youssef G, Park YW, Häni L, Jünger ST, Dono A, Ehret F, Mireles EEM, Neidert N, Bruno F, Tuchek CA, van der Vaart T, Rossi M, Nibali MC, Gay L, Gramelt A, Tandon N, Ahn SS, Chang JH, Weller M, Vincent AJPE, Goldbrunner R, Cahill DP, Huang RY, Raabe A, Meyer B, Beck J, Molinaro AM, Chang SM, Vogelbaum MA, Rudà R, Vik-Mo EO, Dietrich J, Esquenazi Y, Grau SJ, Wen PY, Jakola AS, Schnell O, Bello L, van den Bent MJ, Hervey-Jumper S, Berger MS, Tonn JC. A prognostic classification system for extent of resection in IDH-mutant grade 2 glioma: an international, multicentre, retrospective cohort study with external validation by the RANO resect group. Lancet Oncol. 2025 Dec; 26(12):1638-1650. View on PubMed
  10. Kann BH, Vossough A, Brüningk SC, Familiar AM, Aboian M, Linguraru MG, Yeom KW, Chang SM, Hargrave D, Mirsky D, Storm PB, Huang RY, Resnick AC, Weller M, Mueller S, Prados M, Peet AC, Villanueva-Meyer JE, Bakas S, Fangusaro J, Nabavizadeh A, Kazerooni AF, Response Assessment in Pediatric Neuro-Oncology (RAPNO) group. Artificial Intelligence for Response Assessment in Pediatric Neuro-Oncology (AI-RAPNO), part 1: review of the current state of the art. Lancet Oncol. 2025 Nov; 26(11):e597-e606. View on PubMed
  11. Kazerooni AF, Familiar AM, Aboian M, Brüningk SC, Vossough A, Linguraru MG, Huang RY, Hargrave D, Peet AC, Resnick AC, Storm PB, Mirsky D, Yeom KW, Weller M, Prados M, Chang SM, Mueller S, Villanueva-Meyer JE, Bakas S, Fangusaro J, Kann BH, Nabavizadeh A, Response Assessment in Pediatric Neuro-Oncology (RAPNO) group. Artificial Intelligence for Response Assessment in Pediatric Neuro-Oncology (AI-RAPNO), part 2: challenges, opportunities, and recommendations for clinical translation. Lancet Oncol. 2025 Nov; 26(11):e607-e618. View on PubMed
  12. Wen PY, Weller M, Lee EQ, Touat M, Khasraw M, Rahman R, Platten M, Lim M, Winkler F, Horbinski C, Verhaak RGW, Huang RY, Ahluwalia MS, Albert NL, Tonn JC, Schiff D, Barnholtz-Sloan JS, Ostrom Q, Aldape KD, Batchelor TT, Bindra RS, Chiocca EA, Cloughesy TF, DeGroot JF, French P, Galanis E, Galldiks N, Gilbert MR, Hegi ME, Lassman AB, Le Rhun E, Mehta MP, Mellinghoff IK, Minniti G, Roth P, Sanson M, Taphoorn Andreas MJB, Weiss VDT, Wick W, Zadeh G, Reardon DA, Chang SM, Short SC, van den Bent MJ, Preusser M. Glioblastoma in adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro Oncol. 2025 Nov 01; 27(11):2751-2788. View on PubMed
  13. Asogwa OA, Dirven L, Walbert T, Armstrong TS, Arons D, van den Bent MJ, Blakeley J, Coomans MB, Brown PD, Bulbeck H, Chang SM, Coens C, Gilbert MR, Grant R, Jalali R, Koekkoek JAF, Panda PK, Leach D, Leeper H, Mendoza T, Nayak L, Oliver K, Reijneveld JC, Le Rhun E, Rubinstein L, Taylor JW, Weller M, Wen PY, Taphoorn MJB. Establishing the content validity of patient-reported outcome measures used in neuro-oncology based on the WHO ICF framework: Part of the RANO-PRO initiative. Neuro Oncol. 2025 Oct 14; 27(9):2399-2414. View on PubMed
  14. van den Bent MJ, Vogelbaum MA, Cloughesy T, Galldiks N, Albert NL, Tonn JC, Avila E, Fangusaro J, Mirsky D, Sahgal A, Soffietti R, Karschnia P, Mehta M, Kim MM, Boele F, Huse JT, Nayak L, Lim-Fat MJ, le Rhun E, Desjardins A, Lee EQ, Chukwueke U, Koekkoek JAF, Mendoza T, Loughan AR, Budhu JA, Bakas S, Huang RY, Villanueva-Meyer JE, Leone JP, Okada H, Reardon DA, Bi WL, Wen PY, Chang SM. Response Assessment in Neuro-Oncology (RANO) 2009-2025: Broad scope and implementation-A progress report. Neuro Oncol. 2025 Oct 14; 27(9):2209-2224. View on PubMed
  15. Young JS, Berger MS, Lasocki A, Suwala AK, Niyazi M, Chang SM, Schnell O, Karschnia P. Point/counterpoint: The role of re-resection in recurrent glioblastoma. Neuro Oncol. 2025 Oct 01; 27(10):2524-2529. View on PubMed
  16. Bettegowda C, Noushmehr H, Affinito A, Ahluwalia MS, Ansorge O, Ayasoufi K, Bagley S, Barnholtz-Sloan J, Best M, Brandsma D, Brodie C, Brüning-Richardson A, Castro AV, Chang SM, Condorelli G, Daher A, Datta V, de Groot J, French P, Galanis E, Golebiewska A, Hamerlik P, Hanemann CO, Holdhoff M, Huse J, Khasraw M, LeBlang S, Melin B, Mouliere F, O'Leary C, Rak J, Ray A, Robinson S, Rominiyi O, Roncaroli F, Rudà R, Seoane J, Sol N, van den Bent MJ, Vogelbaum MA, Walbert T, Watts C, Weiss T, Weller M, Wen PY, Wykes V, Yip S, Short SC, Soffietti R. Preanalytical variables and analytes in liquid biopsy approach for brain tumors: A comprehensive review and recommendations from the RANO Group and the Brain Liquid Biopsy Consortium. Neuro Oncol. 2025 Oct 01; 27(10):2496-2513. View on PubMed
  17. van den Bent MJ, Cloughesy TF, Ellingson BM, Allen JE, Blackman SC, Kieran MW, Tonn JC, Karschnia P, Wijnenga M, Pallud J, Young RJ, Huang RY, Mellinghoff IK, de Groot J, van der Hoorn A, Youssef G, Hervey-Jumper SL, Vogelbaum MA, Chang SM, Wen PY. The use of minor response, volumetric assessment, and growth rate kinetics as endpoints in grade 1-3 glioma clinical trials: a RANO perspective. Neuro Oncol. 2025 Oct 01; 27(10):2514-2523. View on PubMed
  18. Pan S, Mirchia K, Payne E, Liu SJ, Al-Adli N, Peeran Z, Shukla P, Young JS, Gupta R, Wu J, Pak J, Ozawa T, Na B, Reddy AT, Braunstein SE, Phillips JJ, Chang S, Solomon DA, Perry A, Raleigh DR, Berger MS, Abate AR, Vasudevan HN. Tumor heterogeneity underlies clinical outcome and MEK inhibitor response in somatic NF1-mutant glioblastoma. JCI Insight. 2025 Sep 23; 10(18). View on PubMed
  19. Chang SM. Celebrating 30 years of the Society for NeuroOncology and its tremendous impact on the Journal. Neuro Oncol. 2025 Sep 08; 27(7):1667-1669. View on PubMed
  20. Autry AW, Kim Y, Dang D, Chen HY, Slater JB, Bok RA, Xu D, Lupo JM, Gordon JW, Larson PEZ, Vigneron DB, Li Y, Chang SM. Clinical Translation of Hyperpolarized 13C Metabolic Probes for Glioma Imaging. AJNR Am J Neuroradiol. 2025 Sep 02; 46(9):1754-1764. View on PubMed

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