Research Summary

My research focus is on the development of novel therapies for patients, as well as the assessment of novel imaging markers of prognosis and response to therapy. As program leader for the Neuro-Oncology Program at the Helen Diller Family Comprehensive Cancer Center, my role is to provide the overall direction of the program and facilitate the interaction of the basic science and translational research programs with the clinical team to bring novel findings from the lab to the patient. I am the lead and contact PI for a P01 focused on integrating advances in physiologic and metabolic imaging with tissue biomarkers in order to optimize the management of patients with molecular subtypes of glioma. I am the overall Clinical Leader for the UCSF Brain SPORE grant as well as the Clinical Core Director and Co-PI of a SPORE project that addresses the evaluation of steady and dynamic metabolic imaging in glioblastoma.

Research Funding

  • July 1, 2021 - June 30, 2026 - Glioblastoma Therapeutics Network , Administrative and Clinical Core Co Investigator . Sponsor: NIH/NCI, Sponsor Award ID: UCA264338A
  • December 1, 2005 - July 31, 2024 - Noninvasive Metabolic Signatures to Improve Management of Molecular Subtypes of Glioma , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P01CA118816
  • September 20, 2002 - August 31, 2023 - Brain Tumor SPORE Grant , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50CA097257
  • August 5, 1999 - July 31, 2023 - NCI Comprehensive Cancer Center Grant , Program Co-leader . Sponsor: NIH/NCI, Sponsor Award ID: P30 CA082103-17

Education

University of British Columbia, 1981
University of British Columbia, MD, 1985, Medicine
Pasqua Hospital, University of Saskatchewan, Regina, Internship, 1985-1986
Plains Health Centre, Regina, Saskatchewan, Residency, 1986-1987
Toronto General Hospital, U of Toronto, Ontario, Residency, 1987-1989
Princess Margaret Hospital, U of Toronto, Ontario, Residency, 1989-1991
Royal College of Physicians & Surgeons, Canada, FRCPS, 1990, Internal Medicine
Royal College of Physicians & Surgeons, Canada, FRCPS, 1991, Medical Oncology

Honors & Awards

  • 2014
    UCSF Voice of the Patient Pinnacle Award x 7 years, Press Ganey award for excellence in patient care per division, Hall of Fame
  • 2014
    John J. Mealey Jr. Neuro-Oncology Lectureship

Selected Publications

  1. Chang SM Celebrating 30 years of the Society for NeuroOncology and its tremendous impact on the Journal.  View on PubMed
  2. Bettegowda C, Noushmehr H, Affinito A, Ahluwalia MS, Ansorge O, Ayasoufi K, Bagley S, Barnholtz-Sloan J, Best M, Brandsma D, Brodie C, Brüning-Richardson A, Castro AV, Chang SM, Condorelli G, Daher A, Datta V, de Groot J, French P, Galanis E, Golebiewska A, Hamerlik P, Hanemann CO, Holdhoff M, Huse J, Khasraw M, LeBlang S, Melin B, Mouliere F, O'Leary C, Rak J, Ray A, Robinson S, Rominiyi O, Roncaroli F, Rudà R, Seoane J, Sol N, van den Bent MJ, Vogelbaum MA, Walbert T, Watts C, Weiss T, Weller M, Wen PY, Wykes V, Yip S, Short SC, Soffietti R Preanalytical variables and analytes in liquid biopsy approach for brain tumors: A comprehensive review and recommendations from the RANO Group and the Brain Liquid Biopsy Consortium.  View on PubMed
  3. Wen PY, Weller M, Lee EQ, Touat M, Khasraw M, Rahman R, Platten M, Lim M, Winkler F, Horbinski C, Verhaak RGW, Huang RY, Ahluwalia MS, Albert NL, Tonn JC, Schiff D, Barnholtz-Sloan JS, Ostrom Q, Aldape KD, Batchelor TT, Bindra RS, Chiocca EA, Cloughesy TF, DeGroot JF, French P, Galanis E, Galldiks N, Gilbert MR, Hegi ME, Lassman AB, Le Rhun E, Mehta MP, Mellinghoff IK, Minniti G, Roth P, Sanson M, Taphoorn MJB, von Deimling A, Weiss T, Wick W, Zadeh G, Reardon DA, Chang SM, Short SC, van den Bent MJ, Preusser M Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions.  View on PubMed
  4. Tran N, Luks TL, Li Y, Jakary A, Ellison J, Liu B, Adegbite O, Nair D, Kakhandiki P, Molinaro AM, Villanueva-Meyer JE, Butowski N, Clarke JL, Chang SM, Braunstein SE, Morin O, Lin H, Lupo JM Novel radiotherapy target definition using AI-driven predictions of glioblastoma recurrence from metabolic and diffusion MRI.  View on PubMed
  5. Albert NL, Galldiks N, Ellingson BM, van den Bent MJ, Chang SM, Cicone F, Koh ES, Law I, Le Rhun E, Mair MJ, Werner JM, Berghoff AS, Furtner J, Minniti G, Scott AM, Short SC, Ivanidze J, Johnson DR, Suchorska B, Tolboom N, Tonn JC, Verger A, Galanis E, Brastianos PK, Wen PY, Weller M, Lin NU, Preusser M Author Correction: RANO criteria for response assessment of brain metastases based on amino acid PET imaging.  View on PubMed
  6. Galldiks N, Lohmann P, Aboian M, Barajas RF, Breen WG, Ivanidze J, Johnson DR, Kaufmann TJ, Kim MM, Mair MJ, Minniti G, Müther M, Nabavizadeh A, Palmer JD, Rudà R, Smits M, Tolboom N, Veldhuijzen van Zanten SEM, Veronesi MC, Werner JM, van den Bent M, Chang SM, Langen KJ, Law I, McConathy J, Mehta M, Preusser M, Short SC, Soffietti R, Vogelbaum M, Weller M, Wen PY, Tonn JC, Albert NL Update to the RANO working group and EANO recommendations for the clinical use of PET imaging in gliomas.  View on PubMed
  7. van den Bent MJ, Cloughesy TF, Ellingson BM, Allen JE, Blackman SC, Kieran MW, Tonn JC, Karschnia P, Wijnenga M, Pallud J, Young RJ, Huang RY, Mellinghoff IK, de Groot J, van der Hoorn A, Youssef G, Hervey-Jumper SL, Vogelbaum MA, Chang SM, Wen PY The Use of Minor Response, Volumetric Assessment and Growth Rate Kinetics as Endpoints in Grade 1-3 Glioma Clinical Trials: a RANO perspective.  View on PubMed
  8. Albert NL, Galldiks N, Ellingson BM, van den Bent MJ, Chang SM, Cicone F, Koh ES, Law I, Le Rhun E, Mair MJ, Werner JM, Berghoff AS, Furtner J, Minniti G, Scott AM, Short SC, Ivanidze J, Johnson DR, Suchorska B, Tolboom N, Tonn JC, Verger A, Galanis E, Brastianos PK, Wen PY, Weller M, Lin NU, Preusser M RANO criteria for response assessment of brain metastases based on amino acid PET imaging.  View on PubMed
  9. van den Bent MJ, Vogelbaum MA, Cloughesy T, Galldiks N, Albert NL, Tonn JC, Avila E, Fangusaro J, Mirsky D, Sahgal A, Soffietti R, Karschnia P, Mehta M, Kim MM, Boele F, Huse JT, Nayak L, Lim-Fat MJ, le Rhun E, Desjardins A, Lee EQ, Chukwueke U, Koekkoek JAF, Mendoza T, Loughan AR, Budhu JA, Bakas S, Huang RY, Villanueva-Meyer JE, Leone JP, Okada H, Reardon DA, Bi WL, Wen PY, Chang SM. Response Assessment in Neuro-Oncology (RANO) 2009-2025: Broad Scope and Implementation - A Progress Report. Neuro Oncol. 2025 May 03.  View on PubMed
  10. Asogwa OA, Dirven L, Walbert T, Armstrong TS, Arons D, van den Bent MJ, Blakeley J, Coomans MB, Brown PD, Bulbeck H, Chang SM, Coens C, Gilbert MR, Grant R, Jalali R, Koekkoek JAF, Panda PK, Leach D, Leeper H, Mendoza T, Nayak L, Oliver K, Reijneveld JC, Le Rhun E, Rubinstein L, Taylor JW, Weller M, Wen PY, Taphoorn MJB. Establishing the content validity of Patient-Reported Outcome measures used in neuro-oncology based on the WHO ICF framework: part of the RANO-PRO initiative. Neuro Oncol. 2025 Apr 28.  View on PubMed
  11. Wang Q, Wang J, Mathur R, Youngblood MW, Jin Q, Hou Y, Stasiak LA, Luan Y, Zhao H, Hilz S, Hong C, Chang SM, Lupo JM, Phillips JJ, Costello JF, Yue F Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples.  View on PubMed
  12. Autry AW, Kim Y, Dang D, Chen HY, Slater JB, Bok RA, Xu D, Lupo JM, Gordon JW, Larson PEZ, Vigneron DB, Li Y, Chang SM. Clinical Translation of Hyperpolarized 13C Metabolic Probes for Glioma Imaging. AJNR Am J Neuroradiol. 2025 Mar 05.  View on PubMed
  13. Kwok DW, Stevers NO, Etxeberria I, Nejo T, Colton Cove M, Chen LH, Jung J, Okada K, Lakshmanachetty S, Gallus M, Barpanda A, Hong C, Chan GKL, Liu J, Wu SH, Ramos E, Yamamichi A, Watchmaker PB, Ogino H, Saijo A, Du A, Grishanina NR, Woo J, Diaz A, Hervey-Jumper SL, Chang SM, Phillips JJ, Wiita AP, Klebanoff CA, Costello JF, Okada H. Tumour-wide RNA splicing aberrations generate actionable public neoantigens. Nature. 2025 Mar; 639(8054):463-473.  View on PubMed
  14. Rodriguez Almaraz E, Guerra GA, Al-Adli NN, Young JS, Dada A, Quintana D, Taylor JW, Oberheim Bush NA, Clarke JL, Butowski NA, de Groot J, Pekmezci M, Perry A, Bollen AW, Scheffler AW, Glidden DV, Phillips JJ, Costello JF, Chang EF, Hervey-Jumper S, Berger MS, Francis SS, Chang SM, Solomon DA. Longitudinal profiling of IDH-mutant astrocytomas reveals acquired RAS-MAPK pathway mutations associated with inferior survival. Neurooncol Adv. 2025 Jan-Dec; 7(1):vdaf024.  View on PubMed
  15. Lim-Fat MJ, Bennett J, Ostrom Q, Touat M, Franceschi E, Schulte J, Bindra RS, Fangusaro J, Dhall G, Nicholson J, Jackson S, Davidson TB, Calaminus G, Robinson G, Whittle JR, Hau P, Ramaswamy V, Pajtler KW, Rudà R, Foreman NK, Hervey-Jumper SL, Das S, Dirks P, Bi WL, Huang A, Merchant TE, Fouladi M, Aldape K, Van den Bent MJ, Packer RJ, Miller JJ, Reardon DA, Chang SM, Haas-Kogan D, Tabori U, Hawkins C, Monje M, Wen PY, Bouffet E, Yeo KK. Central nervous system tumors in adolescents and young adults: A Society for Neuro-Oncology Consensus Review on diagnosis, management, and future directions. Neuro Oncol. 2025 Jan 12; 27(1):13-32.  View on PubMed
  16. Chang SM. Investment in the team approach to enhance the Journal's impact. Neuro Oncol. 2025 Jan 12; 27(1):1-2.  View on PubMed
  17. Lucas CG, Al-Adli NN, Young JS, Gupta R, Morshed RA, Wu J, Ravindranathan A, Shai A, Oberheim Bush NA, Taylor JW, de Groot J, Villanueva-Meyer JE, Pekmezci M, Perry A, Bollen AW, Theodosopoulos PV, Aghi MK, Chang EF, Hervey-Jumper SL, Raleigh DR, Molinaro AM, Costello JF, Diaz AA, Clarke JL, Butowski NA, Phillips JJ, Chang SM, Berger MS, Solomon DA. Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responses. Neuro Oncol. 2025 Jan 12; 27(1):89-105.  View on PubMed
  18. Ellingson BM, Sanvito F, Pope WB, Cloughesy TF, Huang RY, Villanueva-Meyer JE, Barboriak DP, Shankar LK, Smits M, Kaufmann TJ, Boxerman JL, Weller M, Galanis E, Groot J, Chang SM, Gilbert MR, Lassman AB, Shiroishi MS, Nabavizadeh A, Mehta M, Stupp R, Wick W, Reardon DA, Wen PY, Vogelbaum MA, van den Bent M. Reply. AJNR Am J Neuroradiol. 2025 Jan 08; 46(1):221-222.  View on PubMed
  19. Verger A, Tolboom N, Cicone F, Chang SM, Furtner J, Galldiks N, Gempt J, Guedj E, Huang RY, Johnson DR, Law I, Le Rhun E, Short SC, Bent MJVD, Weehaeghe DV, Vogelbaum MA, Wen PY, Albert NL, Preusser M Joint EANM/EANO/RANO/SNMMI practice guideline/procedure standard for PET imaging of brain metastases: version 1.0.  View on PubMed
  20. de la Fuente MI, Touat M, van den Bent MJ, Preusser M, Peters KB, Young RJ, Huang RY, Ellingson BM, Capper D, Phillips JJ, Halasz LM, Shih HA, Rudà R, Lim-Fat MJ, Blumenthal DT, Weller M, Arakawa Y, Whittle JR, Ducray F, Reardon DA, Bi WL, Minniti G, Rahman R, Hervey-Jumper S, Chang SM, Wen PY. The role of vorasidenib in the treatment of isocitrate dehydrogenase-mutant glioma. Neuro Oncol. 2024 Dec 25.  View on PubMed

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