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Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release.

Author List
Zarifi N, Asthana P, Doustmohammadi H, Klaus C, Sanchez J, Hunt SE, Rakotoharisoa RV, Osuna S, Fraser JS, Chica RA
Publication
Nature communications
Publication ID (Profile URL)
https://researcherprofiles.org/profile/757527893
Publication Year
2025
PubMed ID
41027962
Publication Title
Zarifi N, Asthana P, Doustmohammadi H, Klaus C, Sanchez J, Hunt SE, Rakotoharisoa RV, Osuna S, Fraser JS, Chica RA. Distal mutations enhance catalysis in designed enzymes by facilitating substrate binding and product release. Nat Commun. 2025 Sep 30; 16(1):8662.
Publication Medline TA
Nat Commun
Date
2025-09-30