Research Funding

  • September 27, 2021 - August 31, 2026 - Tau Metabolism in FTD: From Gene Mutations to Molecular Chaperones and Lysosomal Proteases , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54NS123985
  • June 1, 2016 - May 31, 2026 - Structure and Mechanism: Hsp90 proteostasis, cilia biogenesis and the jumbo phage ?nucleus? , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R35GM118099
  • September 30, 1988 - June 30, 2023 - Molecular Biophysics Training Grant , Principal Investigator . Sponsor: NIH, Sponsor Award ID: T32GM008284
  • September 1, 2014 - August 31, 2020 - The Yeast Centrosome - Structure Assembly & Function , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01GM105537
  • August 1, 2013 - April 30, 2018 - Characterization of a bacteriophage tubulin involved in viral replication , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM104556
  • March 1, 1983 - December 31, 2016 - Centrosome structure and mechanism of MT nucleation by gamma-tubulin complexes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM031627
  • September 30, 2012 - July 31, 2016 - Structural Basis of Protein Homeostasis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01GM098254
  • September 30, 1996 - June 30, 2016 - Comprehensive Biology: Exploiting the Yeast Genome , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR011823
  • March 1, 1982 - May 31, 2015 - Bio-Organic Biomedical Mass Spectrometry Resource , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR001614
  • July 1, 1985 - February 28, 2015 - National Biomedical NMR Resource at Madison , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR002301
  • March 1, 1980 - February 28, 2015 - A Synchroton Radiation Structural Biology Resource , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR001209
  • September 1, 1983 - June 30, 2013 - Macromolecular Diffraction Resource: MacCHESS , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR001646
  • September 30, 2002 - July 31, 2012 - National Resource for Automated Molecular Microscopy , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR017573
  • September 30, 1995 - March 31, 2012 - BioCAT - Biophysics Collaborative Access Team , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR008630
  • August 15, 2000 - July 31, 2006 - STRUCTURE AND DYNAMICS OF NUCLEAR RECEPTORS , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01DK058390
  • July 1, 2000 - June 30, 2001 - FASEB CONFERENCE: PROTEIN FOLDING AND ASSEMBLY IN CELLS , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R13GM061717
  • February 1, 2000 - January 31, 2001 - GATAN IMAGING ENERGY FILTER WITH CCD CAMERA FOR IVEM , Principal Investigator . Sponsor: NIH, Sponsor Award ID: S10RR013926

Education

Yale University, New Haven, B.S., 1975, Molec. Biol. and Biophysics
California Institute of Technology, Pasadena, Ph.D., 1980, Biological Chemistry
University of California, San Francisco, Postdoctoral, 1980
MRC Laboratory, Cambridge, England, Postdoctoral, 1981-82

Honors & Awards

  • 1975-1978
    National Science Foundation Predoctoral Fellow
  • 1976
    Dreyfus Travelling Fellowship
  • 1980-1982
    Helen Hay Whitney Postdoctoral Fellow
  • 1983-1986
    Searle Scholar
  • 1983-1991
    Presidential Young Investigator's Award (NSF)
  • 1986
    Sidhu Award for Outstanding Contributions to Crystallography
  • 1998
    Parke-Davis Paper of the Year
  • 2006
    Election to Haile T. Debas Academy of Medical Educators (excellence in teaching award)
  • 2007
    Election to Protein Society Executive Council
  • 2007
    Election to the NationalAcademy of Sciences
  • 2009
    Election to the American Academy of Arts and Sciences
  • 2011-14
    Appointment to the National Advisory General Medical Sciences Council

Selected Publications

  1. Herreros D, Mata CP, Noddings C, Irene D, Krieger J, Agard DA, Tsai MD, Sorzano COS, Carazo JM. Real-space heterogeneous reconstruction, refinement, and disentanglement of CryoEM conformational states with HetSIREN. bioRxiv. 2024 Sep 19.  View on PubMed
  2. Li S, Fernandez JJ, Ruehle MD, Howard-Till RA, Fabritius A, Pearson CG, Agard DA, Winey ME. The Structure of Cilium Inner Junctions Revealed by Electron Cryo-tomography. bioRxiv. 2024 Sep 09.  View on PubMed
  3. Mozumdar D, Fossati A, Stevenson E, Guan J, Nieweglowska E, Rao S, Agard D, Swaney DL, Bondy-Denomy J. Characterization of a lipid-based jumbo phage compartment as a hub for early phage infection. Cell Host Microbe. 2024 Jul 10; 32(7):1050-1058.e7.  View on PubMed
  4. Ruehle MD, Li S, Agard DA, Pearson CG. Poc1 bridges basal body inner junctions to promote triplet microtubule integrity and connections. J Cell Biol. 2024 Aug 05; 223(8).  View on PubMed
  5. Chio US, Palovcak E, Smith AAA, Autzen H, Muñoz EN, Yu Z, Wang F, Agard DA, Armache JP, Narlikar GJ, Cheng Y. Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun. 2024 Mar 12; 15(1):2225.  View on PubMed
  6. Ruehle MD, Li S, Agard DA, Pearson CG. Poc1 is a basal body inner junction protein that promotes triplet microtubule integrity and interconnections. bioRxiv. 2023 Nov 28.  View on PubMed
  7. Noddings CM, Johnson JL, Agard DA. Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor. Nat Struct Mol Biol. 2023 Dec; 30(12):1867-1877.  View on PubMed
  8. Walsh MA, Nannenga BL, Gonen T, Sexton PM, Wootten D, Chiu W, Sun F, Carragher B, Potter CS, Agard D, Burley SK. The next decade in structural biology. Structure. 2023 11 02; 31(11):1284-1288.  View on PubMed
  9. Chen Z, Shiozaki M, Haas KM, Skinner WM, Zhao S, Guo C, Polacco BJ, Yu Z, Krogan NJ, Lishko PV, Kaake RM, Vale RD, Agard DA. De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Cell. 2023 11 09; 186(23):5041-5053.e19.  View on PubMed
  10. Fossati A, Mozumdar D, Kokontis C, Mèndez-Moran M, Nieweglowska E, Pelin A, Li Y, Guo B, Krogan NJ, Agard DA, Bondy-Denomy J, Swaney DL. Next-generation proteomics for quantitative Jumbophage-bacteria interaction mapping. Nat Commun. 2023 08 24; 14(1):5156.  View on PubMed
  11. Chio US, Palovcak E, Autzen AAA, Autzen HE, Muñoz EN, Yu Z, Wang F, Agard DA, Armache JP, Narlikar GJ, Cheng Y. Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. bioRxiv. 2023 Jun 20.  View on PubMed
  12. Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA. Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun. 2023 04 17; 14(1):2197.  View on PubMed
  13. Fossati A, Mozumdar D, Kokontis C, Mèndez-Moran M, Nieweglowska E, Pelin A, Li Y, Guo B, Krogan NJ, Agard DA, Bondy-Denomy J, Swaney DL. Next-generation interaction proteomics for quantitative Jumbophage-bacteria interaction mapping. bioRxiv. 2023 Feb 23.  View on PubMed
  14. Nieweglowska ES, Brilot AF, Méndez-Moran M, Kokontis C, Baek M, Li J, Cheng Y, Baker D, Bondy-Denomy J, Agard DA. The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice. Nat Commun. 2023 02 18; 14(1):927.  View on PubMed
  15. Noddings CM, Johnson JL, Agard DA. Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor. bioRxiv. 2023 Jan 16.  View on PubMed
  16. Hoopmann MR, Shteynberg DD, Zelter A, Riffle M, Lyon AS, Agard DA, Luan Q, Nolen BJ, MacCoss MJ, Davis TN, Moritz RL. Improved Analysis of Cross-Linking Mass Spectrometry Data with Kojak 2.0, Advanced by Integration into the Trans-Proteomic Pipeline. J Proteome Res. 2023 02 03; 22(2):647-655.  View on PubMed
  17. Chen Z, Greenan GA, Shiozaki M, Liu Y, Skinner WM, Zhao X, Zhao S, Yan R, Yu Z, Lishko PV, Agard DA, Vale RD. In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes. Nat Struct Mol Biol. 2023 03; 30(3):360-369.  View on PubMed
  18. Agard DA, Bowman GR, DeGrado W, Dokholyan NV, Zhou HX. Solution of the protein structure prediction problem at last: crucial innovations and next frontiers. Fac Rev. 2022; 11:38.  View on PubMed
  19. Yu Z, Chen J, Takagi E, Wang F, Saha B, Liu X, Joubert LM, Gleason CE, Jin M, Li C, Nowotny C, Agard D, Cheng Y, Pearce D. Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. J Biol Chem. 2022 09; 298(9):102288.  View on PubMed
  20. Zheng S, Wolff G, Greenan G, Chen Z, Faas FGA, Bárcena M, Koster AJ, Cheng Y, Agard DA. AreTomo: An integrated software package for automated marker-free, motion-corrected cryo-electron tomographic alignment and reconstruction. J Struct Biol X. 2022; 6:100068.  View on PubMed

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