Research Funding

  • September 27, 2021 - August 31, 2026 - Tau Metabolism in FTD: From Gene Mutations to Molecular Chaperones and Lysosomal Proteases , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U54NS123985
  • June 1, 2016 - May 31, 2026 - Structure and Mechanism: Hsp90 proteostasis, cilia biogenesis and the jumbo phage ?nucleus? , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R35GM118099
  • September 30, 1988 - June 30, 2023 - Molecular Biophysics Training Grant , Principal Investigator . Sponsor: NIH, Sponsor Award ID: T32GM008284
  • September 1, 2014 - August 31, 2020 - The Yeast Centrosome - Structure Assembly & Function , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01GM105537

Education

Yale University, New Haven, B.S., 1975, Molec. Biol. and Biophysics
California Institute of Technology, Pasadena, Ph.D., 1980, Biological Chemistry
University of California, San Francisco, Postdoctoral, 1980
MRC Laboratory, Cambridge, England, Postdoctoral, 1981-82

Honors & Awards

  • 1975-1978
    National Science Foundation Predoctoral Fellow
  • 1976
    Dreyfus Travelling Fellowship
  • 1980-1982
    Helen Hay Whitney Postdoctoral Fellow
  • 1983-1986
    Searle Scholar
  • 1983-1991
    Presidential Young Investigator's Award (NSF)
  • 1986
    Sidhu Award for Outstanding Contributions to Crystallography
  • 1998
    Parke-Davis Paper of the Year
  • 2006
    Election to Haile T. Debas Academy of Medical Educators (excellence in teaching award)
  • 2007
    Election to Protein Society Executive Council
  • 2007
    Election to the NationalAcademy of Sciences
  • 2009
    Election to the American Academy of Arts and Sciences
  • 2011-14
    Appointment to the National Advisory General Medical Sciences Council

Selected Publications

  1. Jaime-Garza M, Nowotny CA, Coutandin D, Wang F, Tabios M, Agard DA. Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun. 2023 04 17; 14(1):2197.  View on PubMed
  2. Fossati A, Mozumdar D, Kokontis C, Mèndez-Moran M, Nieweglowska E, Pelin A, Li Y, Guo B, Krogan NJ, Agard DA, Bondy-Denomy J, Swaney DL. Next-generation interaction proteomics for quantitative Jumbophage-bacteria interaction mapping. bioRxiv. 2023 Feb 23.  View on PubMed
  3. Nieweglowska ES, Brilot AF, Méndez-Moran M, Kokontis C, Baek M, Li J, Cheng Y, Baker D, Bondy-Denomy J, Agard DA. The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice. Nat Commun. 2023 02 18; 14(1):927.  View on PubMed
  4. Noddings CM, Johnson JL, Agard DA. Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the Glucocorticoid Receptor. bioRxiv. 2023 Jan 16.  View on PubMed
  5. Hoopmann MR, Shteynberg DD, Zelter A, Riffle M, Lyon AS, Agard DA, Luan Q, Nolen BJ, MacCoss MJ, Davis TN, Moritz RL. Improved Analysis of Cross-Linking Mass Spectrometry Data with Kojak 2.0, Advanced by Integration into the Trans-Proteomic Pipeline. J Proteome Res. 2023 02 03; 22(2):647-655.  View on PubMed
  6. Chen Z, Greenan GA, Shiozaki M, Liu Y, Skinner WM, Zhao X, Zhao S, Yan R, Yu Z, Lishko PV, Agard DA, Vale RD. In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes. Nat Struct Mol Biol. 2023 03; 30(3):360-369.  View on PubMed
  7. Agard DA, Bowman GR, DeGrado W, Dokholyan NV, Zhou HX. Solution of the protein structure prediction problem at last: crucial innovations and next frontiers. Fac Rev. 2022; 11:38.  View on PubMed
  8. Yu Z, Chen J, Takagi E, Wang F, Saha B, Liu X, Joubert LM, Gleason CE, Jin M, Li C, Nowotny C, Agard D, Cheng Y, Pearce D. Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt. J Biol Chem. 2022 09; 298(9):102288.  View on PubMed
  9. Zheng S, Wolff G, Greenan G, Chen Z, Faas FGA, Bárcena M, Koster AJ, Cheng Y, Agard DA. AreTomo: An integrated software package for automated marker-free, motion-corrected cryo-electron tomographic alignment and reconstruction. J Struct Biol X. 2022; 6:100068.  View on PubMed
  10. Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N. Author Correction: Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface. Nature. 2022 Feb; 602(7898):E26.  View on PubMed
  11. Li S, Fernandez JJ, Fabritius AS, Agard DA, Winey M. Electron cryo-tomography structure of axonemal doublet microtubule from Tetrahymena thermophila. Life Sci Alliance. 2022 03; 5(3).  View on PubMed
  12. Wang RY, Noddings CM, Kirschke E, Myasnikov AG, Johnson JL, Agard DA. Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism. Nature. 2022 01; 601(7893):460-464.  View on PubMed
  13. Noddings CM, Wang RY, Johnson JL, Agard DA. Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism. Nature. 2022 01; 601(7893):465-469.  View on PubMed
  14. Croxford M, Elbaum M, Arigovindan M, Kam Z, Agard D, Villa E, Sedat J. Entropy-regularized deconvolution of cellular cryotransmission electron tomograms. Proc Natl Acad Sci U S A. 2021 12 14; 118(50).  View on PubMed
  15. Diwanji D, Trenker R, Thaker TM, Wang F, Agard DA, Verba KA, Jura N. Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface. Nature. 2021 12; 600(7888):339-343.  View on PubMed
  16. Fabritius AS, Bayless BA, Li S, Stoddard D, Heydeck W, Ebmeier CC, Anderson L, Gunnels T, Nachiappan C, Whittall JB, Old W, Agard DA, Nicastro D, Winey M. Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs. Mol Biol Cell. 2021 11 01; 32(21):br8.  View on PubMed
  17. Verba K, Gupta M, Azumaya C, Moritz M, Pourmal S, Diallo A, Merz G, Jang G, Bouhaddou M, Fossati A, Brilot A, Diwanji D, Hernandez E, Herrera N, Kratochvil H, Lam V, Li F, Li Y, Nguyen H, Nowotny C, Owens T, Peters J, Rizo A, Schulze-Gahmen U, Smith A, Young I, Yu Z, Asarnow D, Billesbølle C, Campbell M, Chen J, Chen KH, Chio US, Dickinson M, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez K, Mancino A, Iii FM, Paul M, Pawar K, Pelin A, Pospiech T, Puchades C, Remesh S, Safari M, Schaefer K, Sun M, Tabios M, Thwin A, Titus E, Trenker R, Tse E, Tsui TKM, Feng F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, Agard D, Cheng Y, Fraser J, Jura N, Kortemme T, Manglik A, Southworth D, Stroud R, Swaney D, Krogan N, Frost A, Rosenberg O. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Res Sq. 2021 May 19.  View on PubMed
  18. Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, Li F, Li Y, Nguyen HC, Nowotny C, Owens TW, Peters JK, Rizo AN, Schulze-Gahmen U, Smith AM, Young ID, Yu Z, Asarnow D, Billesbølle C, Campbell MG, Chen J, Chen KH, Chio US, Dickinson MS, Doan L, Jin M, Kim K, Li J, Li YL, Linossi E, Liu Y, Lo M, Lopez J, Lopez KE, Mancino A, Moss FR, Paul MD, Pawar KI, Pelin A, Pospiech TH, Puchades C, Remesh SG, Safari M, Schaefer K, Sun M, Tabios MC, Thwin AC, Titus EW, Trenker R, Tse E, Tsui TKM, Wang F, Zhang K, Zhang Y, Zhao J, Zhou F, Zhou Y, Zuliani-Alvarez L, QCRG Structural Biology Consortium, Agard DA, Cheng Y, Fraser JS, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Swaney DL, Krogan NJ, Frost A, Rosenberg OS, Verba KA. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. 2021 May 11.  View on PubMed
  19. Sun M, Azumaya CM, Tse E, Bulkley DP, Harrington MB, Gilbert G, Frost A, Southworth D, Verba KA, Cheng Y, Agard DA. Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM. J Struct Biol. 2021 09; 213(3):107745.  View on PubMed
  20. Brilot AF, Lyon AS, Zelter A, Viswanath S, Maxwell A, MacCoss MJ, Muller EG, Sali A, Davis TN, Agard DA. CM1-driven assembly and activation of yeast γ-tubulin small complex underlies microtubule nucleation. Elife. 2021 05 05; 10.  View on PubMed

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