Research Summary

I am a neurosurgeon-scientist, and I have been running a neurosurgical practice caring for brain tumor patients and a basic science lab in the UCSF Brain Tumor Research Center (BTRC) since my initial faculty appointment at UCSF in 2008. Throughout that time, my lab has been well funded by the NIH and numerous private foundations, with the central focus of the lab being mechanisms of angiogenesis, invasion, and therapeutic resistance in brain tumors like glioblastoma, metastases, and pituitary tumors. My clinical practice has developed in parallel with my laboratory, with my glioblastoma and pituitary tumor surgical cases often providing valuable tissue for lab research as part of my clinical and translational research programs. The expertise from my scientific and clinical research has been supplemented by numerous successful collaborations with academic and industry investigators in the past eight years. As a neurosurgeon-scientist, I have mentored numerous medical and graduate students, postdoctoral fellows, and neurosurgery residents on scientific and clinical projects, as well as assisting them developing their careers integrating dual roles combining neurosurgical practices with scientific investigation. My position as a neurosurgeon and scientist specializing in the care of patients with aggressive brain tumors and the role of the tumor microenvironment in driving this aggressive biology and therapeutic resistance uniquely positions me to serve as PI for a variety of grants.

Research Funding

  • September 17, 2018 - August 31, 2023 - Modeling and druggable-genome screening of glioblastoma invasion using regional biopsy-guided biomaterials systems, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA227136
  • September 30, 2013 - May 31, 2018 - Tumor cell and microenvironment changes causing antiangiogenic therapy resistance, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R01NS079697
  • July 1, 2009 - June 30, 2014 - Characterizing and Targeting Tumoral Factors Recruiting Perivascular Progenitors, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: K02NS064167
  • September 17, 2018 - August 31, 2023 - Modeling and druggable-genome screening of glioblastoma invasion using regional biopsy-guided biomaterials systems, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA227136

Education

Stanford University (Stanford, CA), BS, 1993, Biological Sciences
Stanford University (Stanford, CA), MS, 1993, Biological Sciences
Harvard Medical School (Boston, MA), MD, 2000, Medicine
Harvard Medical School (Boston, MA), PhD, 2000, Neuroscience

Honors & Awards

  • 2004
    Preuss Award, best basic science brain tumor research, American Association of Neurologic Surgeons (AANS) meeting, "Generation of Brain Tumor Neovasculature from Transplanted Bone Marrow."
  • 2005
    Ronald L. Bittner Award, best brain tumor research, American Association of Neurologic Surgeons (AANS) meeting
  • 2005
    William Scoville Resident Research Award, New England Neurosurgery meeting, "Generation of Glioma Neovasculature from Transplanted Bone Marrow."
  • 2005
    Congress of Neurologic Surgeons (CNS) Resident Research Award, "Enhanced Replication of Oncolytic HSV in Glioma Cells that Evade Temozolomide Chemotherapy Through DNA Repair."
  • 2005
    American Academy of Neurologic Surgeons Resident Research Award, "Stromal Derived Factor-1 Interacts with Environmental Cues to Induce Bone Marrow-Derived Cells to Differentiate into Tumor Endothelium and Pericytes."
  • 2006
    Mahaley Award, best clinical study in neuro-oncology, presented at American Association of Neurologic Surgeons (AANS) meeting
  • 2006
    Integra Foundation Award, best benign brain and peripheral nerve tumor research, presented at Congress of Neurologic Surgeons (CNS) meeting
  • 2007
    Synthes Skull Base Award, Congress of Neurologic Surgeons (CNS) meeting
  • 2009
    American Brian Tumor Association (ABTA) Young Investigator Award, Congress of Neurological Surgeons (CNS) meeting

Selected Publications

  1. Haddad AF, Young JS, Aghi MK Using viral vectors to deliver local immunotherapy to glioblastoma.  View on PubMed
  2. Magill ST, Nguyen MP, Aghi MK, Theodosopoulos PV, Villanueva-Meyer JE, McDermott MW Postoperative diffusion-weighted imaging and neurological outcome after convexity meningioma resection.  View on PubMed
  3. Haddad AF, Young JS, Mummaneni NV, Kasahara N, Aghi MK Immunologic aspects of viral therapy for glioblastoma and implications for interactions with immunotherapies.  View on PubMed
  4. Vogelbaum MA, Krivosheya D, Borghei-Razavi H, Sanai N, Weller M, Wick W, Soffietti R, Reardon DA, Aghi MK, Galanis E, Wen PY, van den Bent M, Chang S Phase 0 and window of opportunity clinical trial design in neuro-oncology: a RANO review.  View on PubMed
  5. Chandra A, Lopez-Rivera V, Dono A, Brandel MG, Lewis C, O'Connor KP, Sheth SA, Ballester LY, Aghi MK, Esquenazi Y Comparative Analysis of Survival Outcomes and Prognostic Factors of Supratentorial versus Cerebellar Glioblastoma in the Elderly: Does Location Really Matter?  View on PubMed
  6. Akins EA, Aghi MK, Kumar S Incorporating Tumor-Associated Macrophages into Engineered Models of Glioma.  View on PubMed
  7. Chandra A, Brandel MG, Aghi MK In Reply to the Letter to the Editor "Regarding the Path to U.S. Neurosurgical Residency for Foreign Medical Graduates: Trends from a Decade 2007-2017".  View on PubMed
  8. Schulte JD, Buerki RA, Lapointe S, Molinaro AM, Zhang Y, Villanueva-Meyer JE, Perry A, Phillips JJ, Tihan T, Bollen AW, Pekmezci M, Butowski N, Oberheim Bush NA, Taylor JW, Chang SM, Theodosopoulos P, Aghi MK, Hervey-Jumper SL, Berger MS, Solomon DA, Clarke JL Clinical, radiologic, and genetic characteristics of histone H3 K27M-mutant diffuse midline gliomas in adults.  View on PubMed
  9. Haddad AF, Chen JS, Oh T, Pereira MP, Joshi RS, Aghi MK Higher cytolytic score correlates with an immunosuppressive tumor microenvironment and reduced survival in glioblastoma.  View on PubMed
  10. Pereira MP, Oh T, Joshi RS, Haddad AF, Pereira KM, Osorio RC, Donohue KC, Peeran Z, Sudhir S, Jain S, Beniwal A, Gurrola J, El-Sayed IH, Blevins LS, Theodosopoulos PV, Kunwar S, Aghi MK Clinical characteristics and outcomes in elderly patients undergoing transsphenoidal surgery for nonfunctioning pituitary adenoma.  View on PubMed
  11. Magill ST, Vasudevan HN, Seo K, Villanueva-Meyer JE, Choudhury A, John Liu S, Pekmezci M, Findakly S, Hilz S, Lastella S, Demaree B, Braunstein SE, Bush NAO, Aghi MK, Theodosopoulos PV, Sneed PK, Abate AR, Berger MS, McDermott MW, Lim DA, Ullian EM, Costello JF, Raleigh DR Multiplatform genomic profiling and magnetic resonance imaging identify mechanisms underlying intratumor heterogeneity in meningioma.  View on PubMed
  12. Lucas CG, Gupta R, Doo P, Lee JC, Cadwell CR, Ramani B, Hofmann JW, Sloan EA, Kleinschmidt-DeMasters BK, Lee HS, Wood MD, Grafe M, Born D, Vogel H, Salamat S, Puccetti D, Scharnhorst D, Samuel D, Cooney T, Cham E, Jin LW, Khatib Z, Maher O, Chamyan G, Brathwaite C, Bannykh S, Mueller S, Kline CN, Banerjee A, Reddy A, Taylor JW, Clarke JL, Oberheim Bush NA, Butowski N, Gupta N, Auguste KI, Sun PP, Roland JL, Raffel C, Aghi MK, Theodosopoulos P, Chang E, Hervey-Jumper S, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Chang S, Berger MS, Perry A, Solomon DA Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor.  View on PubMed
  13. Haddad AF, Young JS, Kanungo I, Sudhir S, Chen JS, Raleigh DR, Magill ST, McDermott MW, Aghi MK WHO Grade I Meningioma Recurrence: Identifying High Risk Patients Using Histopathological Features and the MIB-1 Index.  View on PubMed
  14. Chandra A, Haddad YW, Lewis CT, Spatz J, Carrera D, Aghi MK Letter to the Editor Regarding "Global Diversity and Academic Success of Foreign-Trained Academic Neurosurgeons in the United States".  View on PubMed
  15. Haddad AF, Young JS, Oh T, Pereira MP, Joshi RS, Pereira KM, Osorio RC, Donohue KC, Peeran Z, Sudhir S, Jain S, Beniwal A, Chopra AS, Sandhu NS, Theodosopoulos PV, Kunwar S, El-Sayed IH, Gurrola J, Blevins LS, Aghi MK Clinical characteristics and outcomes of null-cell versus silent gonadotroph adenomas in a series of 1166 pituitary adenomas from a single institution.  View on PubMed
  16. Chandra A, Pereira MP, Aghi MK In Reply to the Letter to the Editor Regarding "The Path to U.S. Neurosurgical Residency for Foreign Medical Graduates: Trends from a Decade 2007-2017".  View on PubMed
  17. Chandra A, Aghi MK Letter to the Editor Regarding "Geographic Distribution of International Medical Graduate Residents in U.S. Neurosurgery Training Programs".  View on PubMed
  18. Chandra A, Aghi MK Strategies to Address Projected Challenges Facing Foreign Applicants in the U.S. Neurosurgery Match.  View on PubMed
  19. Lee YM, Ordaz A, Durcanova B, Viner JA, Theodosopoulos PV, Aghi MK, McDermott MW Cerebrospinal Fluid Leaks and Pseudomeningocele after Posterior Fossa Surgery: Effect of an Autospray Dural Sealant.  View on PubMed
  20. David AP, Jiam NT, Reither JM, Gurrola JG, Aghi MK, El-Sayed IH Endoscopic skull base and transoral surgery during COVID-19 pandemic: Minimizing droplet spread with negative-pressure otolaryngology viral isolation drape.  View on PubMed

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