Research Funding

  • May 1, 2020 - April 30, 2025 - Structure and function of a novel population of regenerating ependymal cells, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R01NS113910
  • December 2, 2014 - September 29, 2020 - Interneuron Precursors and the induction of cortical plasticity, Principal Investigator. Sponsor: NIH/NEI, Sponsor Award ID: R01EY025174
  • July 1, 2014 - June 30, 2019 - Regulation of Cellular Pathwaysin Human Brain Development, Co-Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: P01NS083513
  • April 1, 1990 - June 30, 2019 - Characterization of Neural Stem Cells in Adult Brain, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R01NS028478

Education

Physics, 1977-1978, Queens University, Kingston, Canada
UNAM, Mexico City, Licenciado, 1983, Bio-Medicine
Rockefeller University, Ph.D., 1988, Neurobiology
Rockefeller University, Postdoc, 1988-1989, Neurobiology

Honors & Awards

  • 1983
    Medal Gavino Barreda -- Universidad Nacional Autonoma de Mexico
  • 1990
    First Award, The origin of new neurons in the adult avian brain
  • 1992
    Sinsheimer Award
  • 1994
    NIH-RO1 HD32116-01
  • 2000
    Jacob Javits Award, 2000/NIH Grant RO1 NS28478
  • 2001
    Brain Tumor Society. Are neural stem cells a source of brain tumors?
  • 2003
    NIH R01 HD032116-09. Origins of new neurons and glia in the postnatal brain
  • 2004
    Goldhirsh Foundation. Brain Tumor Research Grant 7/1/04 - 6/30/08.
  • 2006
    Catedra Santiago Grisolía, Spain. Lecture and Award
  • 2006
    "Académico Correspondiente Extranjero”. Real Academia de Ciencias Exactas, Físicas y Naturales. Spain
  • 2007
    Catedra Ramón y Cajal, Sociedad Española de Neurología, Spain
  • 2011
    Prince of Asturias Award for Technical and Scientific Research, Fundacíon Príncipe de Asturias, Spain. (Shared with Dr. Joseph Altman and Giacomo Rizzolatti)
  • 2012
    NICH; NIH Merit award
  • 2013
    American Academy of Arts and Sciences
  • 2013
    Catedra de Excelencia Banco de Santander, Pompeu Fabra University, Barcelona,
  • 2014
    New York University, Honors Lecture, New York
  • 2014
    Honorary Segerfalk Lecture Award/ Annual Neuroscience Day, Lund University, Sweden,
  • 2016
    Scientific Council of P.K. Anokhin Research Institute of Normal Physiology, Pentennial Medal
  • 2017
    60th annual Faculty Research Lectureship (FRL) in Basic Science
  • 2021
    Elected to the National Academy of Sciences

Selected Publications

  1. Sorrells SF, Paredes MF, Zhang Z, Kang G, Pastor-Alonso O, Biagiotti S, Page CE, Sandoval K, Knox A, Connolly A, Huang EJ, Garcia-Verdugo JM, Oldham MC, Yang Z, Alvarez-Buylla A Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus.  View on PubMed
  2. Huang W, Bhaduri A, Velmeshev D, Wang S, Wang L, Rottkamp CA, Alvarez-Buylla A, Rowitch DH, Kriegstein AR Origins and Proliferative States of Human Oligodendrocyte Precursor Cells.  View on PubMed
  3. Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V, Maniatis T, Hasenstaub AR, Stryker MP, Alvarez-Buylla A Clustered gamma-protocadherins regulate cortical interneuron programmed cell death.  View on PubMed
  4. Delgado RN, Mansky B, Ahanger SH, Lu C, Andersen RE, Dou Y, Alvarez-Buylla A, Lim DA Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1.  View on PubMed
  5. Hoseini MS, Rakela B, Flores-Ramirez Q, Hasenstaub AR, Alvarez-Buylla A, Stryker MP Transplanted Cells Are Essential for the Induction But Not the Expression of Cortical Plasticity.  View on PubMed
  6. Sorrells SF, Paredes MF, Velmeshev D, Herranz-Pérez V, Sandoval K, Mayer S, Chang EF, Insausti R, Kriegstein AR, Rubenstein JL, Manuel Garcia-Verdugo J, Huang EJ, Alvarez-Buylla A Immature excitatory neurons develop during adolescence in the human amygdala.  View on PubMed
  7. Redmond SA, Figueres-Oñate M, Obernier K, Nascimento MA, Parraguez JI, López-Mascaraque L, Fuentealba LC, Alvarez-Buylla A Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor.  View on PubMed
  8. Obernier K, Alvarez-Buylla A Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain.  View on PubMed
  9. Mayer S, Chen J, Velmeshev D, Mayer A, Eze UC, Bhaduri A, Cunha CE, Jung D, Arjun A, Li E, Alvarado B, Wang S, Lovegren N, Gonzales ML, Szpankowski L, Leyrat A, West JAA, Panagiotakos G, Alvarez-Buylla A, Paredes MF, Nowakowski TJ, Pollen AA, Kriegstein AR Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex.  View on PubMed
  10. Priya R, Rakela B, Kaneko M, Spatazza J, Larimer P, Hoseini MS, Hasenstaub AR, Alvarez-Buylla A, Stryker MP Vesicular GABA Transporter Is Necessary for Transplant-Induced Critical Period Plasticity in Mouse Visual Cortex.  View on PubMed
  11. Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A Does Adult Neurogenesis Persist in the Human Hippocampus?  View on PubMed
  12. Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma.  View on PubMed
  13. Li J, Wang C, Zhang Z, Wen Y, An L, Liang Q, Xu Z, Wei S, Li W, Guo T, Liu G, Tao G, You Y, Du H, Fu Z, He M, Chen B, Campbell K, Alvarez-Buylla A, Rubenstein JL, Yang Z Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development.  View on PubMed
  14. Raju CS, Spatazza J, Stanco A, Larimer P, Sorrells SF, Kelley KW, Nicholas CR, Paredes MF, Lui JH, Hasenstaub AR, Kriegstein AR, Alvarez-Buylla A, Rubenstein JL, Oldham MC Secretagogin is Expressed by Developing Neocortical GABAergic Neurons in Humans but not Mice and Increases Neurite Arbor Size and Complexity.  View on PubMed
  15. Griveau A, Seano G, Shelton SJ, Kupp R, Jahangiri A, Obernier K, Krishnan S, Lindberg OR, Yuen TJ, Tien AC, Sabo JK, Wang N, Chen I, Kloepper J, Larrouquere L, Ghosh M, Tirosh I, Huillard E, Alvarez-Buylla A, Oldham MC, Persson AI, Weiss WA, Batchelor TT, Stemmer-Rachamimov A, Suvà ML, Phillips JJ, Aghi MK, Mehta S, Jain RK, Rowitch DH A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.  View on PubMed
  16. Sorrells SF, Paredes MF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults.  View on PubMed
  17. Priya R, Paredes MF, Karayannis T, Yusuf N, Liu X, Jaglin X, Graef I, Alvarez-Buylla A, Fishell G Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism.  View on PubMed
  18. Obernier K, Cebrian-Silla A, Thomson M, Parraguez JI, Anderson R, Guinto C, Rodas Rodriguez J, Garcia-Verdugo JM, Alvarez-Buylla A Adult Neurogenesis Is Sustained by Symmetric Self-Renewal and Differentiation.  View on PubMed
  19. Cebrián-Silla A, Alfaro-Cervelló C, Herranz-Pérez V, Kaneko N, Park DH, Sawamoto K, Alvarez-Buylla A, Lim DA, García-Verdugo JM Unique Organization of the Nuclear Envelope in the Post-natal Quiescent Neural Stem Cells.  View on PubMed
  20. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier.  View on PubMed

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