Arturo Alvarez-Buylla, PhD

Education

Physics, 1977-1978, Queens University, Kingston, Canada
UNAM, Mexico City, Licenciado, 1983, Bio-Medicine
Rockefeller University, Ph.D., 1988, Neurobiology
Rockefeller University, Postdoc, 1988-1989, Neurobiology

Honors & Awards

• 1983
  Medal Gavino Barreda -- Universidad Nacional Autonoma de Mexico
• 1990
  First Award, The origin of new neurons in the adult avian brain
• 1992
  Sinsheimer Award
• 1994
  NIH-RO1 HD32116-01
• 2000
  Jacob Javits Award, 2000/NIH Grant RO1 NS28478
• 2001
  Brain Tumor Society. Are neural stem cells a source of brain tumors?
• 2003
  NIH R01 HD032116-09. Origins of new neurons and glia in the postnatal brain
• 2004
  Goldhirsh Foundation. Brain Tumor Research Grant 7/1/04 - 6/30/08.
• 2006
  Catedra Santiago Grisolía, Spain. Lecture and Award
• 2006
  "Académico Correspondiente Extranjero”. Real Academia de Ciencias Exactas, Físicas y Naturales. Spain
• 2007
  Catedra Ramón y Cajal, Sociedad Española de Neurología, Spain
• 2011
  Prince of Asturias Award for Technical and Scientific Research, Fundacíon Príncipe de Asturias, Spain. (Shared with Dr. Joseph Altman and Giacomo Rizzolatti)
• 2012
  NICH; NIH Merit award
• 2013
  American Academy of Arts and Sciences
• 2013
  Catedra de Excelencia Banco de Santander, Pompeu Fabra University, Barcelona,
• 2014
  New York University, Honors Lecture, New York
• 2014
  Honorary Segerfalk Lecture Award/ Annual Neuroscience Day, Lund University, Sweden,
• 2016
  Scientific Council of P.K. Anokhin Research Institute of Normal Physiology, Pentennial Medal
• 2017
  60th annual Faculty Research Lectureship (FRL) in Basic Science
• 2021
  Elected to the National Academy of Sciences

Selected Publications

1. Wang L, Pang K, Zhou L, Cebrián-Silla A, González-Granero S, Wang S, Bi Q, White ML, Ho B, Li J, Li T, Perez Y, Huang EJ, Winkler EA, Paredes MF, Kovner R, Sestan N, Pollen AA, Liu P, Li J, Piao X, García-Verdugo JM, Alvarez-Buylla A, Liu Z, Kriegstein AR. A cross-species proteomic map reveals neoteny of human synapse development. Nature. 2023 Sep 13.  View on PubMed
2. Li J, Godoy MI, Zhang AJ, Diamante G, Ahn IS, Cebrian-Silla A, Alvarez-Buylla A, Yang X, Novitch BG, Zhang Y. Prdm16 and Vcam1 regulate the postnatal disappearance of embryonic radial glia and the ending of cortical neurogenesis. bioRxiv. 2023 Feb 14.  View on PubMed
3. Mancia Leon WR, Steffen DM, Dale-Huang F, Rakela B, Breevoort A, Romero-Rodriguez R, Hasenstaub AR, Stryker MP, Weiner JA, Alvarez-Buylla A. The Clustered Gamma Protocadherin Pcdhγc4 Isoform Regulates Cortical Interneuron Programmed Cell Death in the Mouse Cortex. bioRxiv. 2023 Feb 06.  View on PubMed
4. Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-Granero S, Lozano JF, Vento M, Haeussler M, Paredes MF, Nakamura K, Garcia-Verdugo JM, Alvarez-Buylla A, Kriegstein AR, Huang EJ. Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain. Cell. 2022 09 29; 185(20):3753-3769.e18.  View on PubMed
5. Alvarez-Buylla A, Cebrian-Silla A, Sorrells SF, Nascimento MA, Paredes MF, Garcia-Verdugo JM, Yang Z, Huang EJ. Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis". Science. 2022 04 15; 376(6590):eabn8861.  View on PubMed
6. Paredes MF, Mora C, Flores-Ramirez Q, Cebrian-Silla A, Del Dosso A, Larimer P, Chen J, Kang G, Gonzalez Granero S, Garcia E, Chu J, Delgado R, Cotter JA, Tang V, Spatazza J, Obernier K, Ferrer Lozano J, Vento M, Scott J, Studholme C, Nowakowski TJ, Kriegstein AR, Oldham MC, Hasenstaub A, Garcia-Verdugo JM, Alvarez-Buylla A, Huang EJ. Nests of dividing neuroblasts sustain interneuron production for the developing human brain. Science. 2022 01 28; 375(6579):eabk2346.  View on PubMed
7. Delgado RN, Allen DE, Keefe MG, Mancia Leon WR, Ziffra RS, Crouch EE, Alvarez-Buylla A, Nowakowski TJ. Individual human cortical progenitors can produce excitatory and inhibitory neurons. Nature. 2022 01; 601(7893):397-403.  View on PubMed
8. Sorrells SF, Paredes MF, Zhang Z, Kang G, Pastor-Alonso O, Biagiotti S, Page CE, Sandoval K, Knox A, Connolly A, Huang EJ, Garcia-Verdugo JM, Oldham MC, Yang Z, Alvarez-Buylla A. Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus. J Neurosci. 2021 03 24; 41(12):2554-2565.  View on PubMed
9. Huang W, Bhaduri A, Velmeshev D, Wang S, Wang L, Rottkamp CA, Alvarez-Buylla A, Rowitch DH, Kriegstein AR. Origins and Proliferative States of Human Oligodendrocyte Precursor Cells. Cell. 2020 08 06; 182(3):594-608.e11.  View on PubMed
10. Mancia Leon WR, Spatazza J, Rakela B, Chatterjee A, Pande V, Maniatis T, Hasenstaub AR, Stryker MP, Alvarez-Buylla A. Clustered gamma-protocadherins regulate cortical interneuron programmed cell death. Elife. 2020 07 07; 9.  View on PubMed
11. Delgado RN, Mansky B, Ahanger SH, Lu C, Andersen RE, Dou Y, Alvarez-Buylla A, Lim DA. Maintenance of neural stem cell positional identity by mixed-lineage leukemia 1. Science. 2020 04 03; 368(6486):48-53.  View on PubMed
12. Hoseini MS, Rakela B, Flores-Ramirez Q, Hasenstaub AR, Alvarez-Buylla A, Stryker MP. Transplanted Cells Are Essential for the Induction But Not the Expression of Cortical Plasticity. J Neurosci. 2019 09 18; 39(38):7529-7538.  View on PubMed
13. Sorrells SF, Paredes MF, Velmeshev D, Herranz-Pérez V, Sandoval K, Mayer S, Chang EF, Insausti R, Kriegstein AR, Rubenstein JL, Manuel Garcia-Verdugo J, Huang EJ, Alvarez-Buylla A. Immature excitatory neurons develop during adolescence in the human amygdala. Nat Commun. 2019 06 21; 10(1):2748.  View on PubMed
14. Redmond SA, Figueres-Oñate M, Obernier K, Nascimento MA, Parraguez JI, López-Mascaraque L, Fuentealba LC, Alvarez-Buylla A. Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor. Cell Rep. 2019 04 09; 27(2):429-441.e3.  View on PubMed
15. Obernier K, Alvarez-Buylla A. Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain. Development. 2019 02 18; 146(4).  View on PubMed
16. Mayer S, Chen J, Velmeshev D, Mayer A, Eze UC, Bhaduri A, Cunha CE, Jung D, Arjun A, Li E, Alvarado B, Wang S, Lovegren N, Gonzales ML, Szpankowski L, Leyrat A, West JAA, Panagiotakos G, Alvarez-Buylla A, Paredes MF, Nowakowski TJ, Pollen AA, Kriegstein AR. Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex. Neuron. 2019 04 03; 102(1):143-158.e7.  View on PubMed
17. Priya R, Rakela B, Kaneko M, Spatazza J, Larimer P, Hoseini MS, Hasenstaub AR, Alvarez-Buylla A, Stryker MP. Vesicular GABA Transporter Is Necessary for Transplant-Induced Critical Period Plasticity in Mouse Visual Cortex. J Neurosci. 2019 04 03; 39(14):2635-2648.  View on PubMed
18. Paredes MF, Sorrells SF, Cebrian-Silla A, Sandoval K, Qi D, Kelley KW, James D, Mayer S, Chang J, Auguste KI, Chang EF, Gutierrez Martin AJ, Kriegstein AR, Mathern GW, Oldham MC, Huang EJ, Garcia-Verdugo JM, Yang Z, Alvarez-Buylla A. Does Adult Neurogenesis Persist in the Human Hippocampus? Cell Stem Cell. 2018 12 06; 23(6):780-781.  View on PubMed
19. Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, Obernier K, Alvarez-Buylla A, Bergers G, Phillips JJ, Nam DH, Bertozzi CR, Weaver VM. A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma. Nat Cell Biol. 2018 10; 20(10):1203-1214.  View on PubMed
20. Li J, Wang C, Zhang Z, Wen Y, An L, Liang Q, Xu Z, Wei S, Li W, Guo T, Liu G, Tao G, You Y, Du H, Fu Z, He M, Chen B, Campbell K, Alvarez-Buylla A, Rubenstein JL, Yang Z. Transcription Factors Sp8 and Sp9 Coordinately Regulate Olfactory Bulb Interneuron Development. Cereb Cortex. 2018 09 01; 28(9):3278-3294.  View on PubMed

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