Jody Lynn Baron, MD, PhD

Education

Swarthmore College, Swarthmore, PA, 1984-85 Rice University, Houston, Texas, BA, 1986, Biology & Philosophy
Yale University, MD 1993, Medicine
Yale University, PhD, 1994, Immunobiology
Stanford University, Residency, 1993-95 Internal Medicine
University of California, San Francisco, Clinical Fellow, 1995-96, Infectious Diseases
University of California, San Francisco, Fellowship, 1996-2000, Microbiol & Immunology

Honors & Awards

• 1982
  Westinghouse Science Talent Search honors group
• 1992
  NIH Resident research award
• 1986-1992
  NIH Fellowship -Medical Scientist Training Program Yale University
• 1992
  Molecular Medicine Fellowship, University of California at San Francisco
• 1997-2002
  Howard Hughes Postdoctoral Research Fellowship for Physicians
• 1992
  UCSF Liver center pilot research grant
• 2000-2002
  Pfizer Postdoctoral Fellowship in Infectious Diseases
• 2003-2002
  Burroughs Wellcome Career Award in the Biomedical Sciences
• 2002
  HHMI/BWF Leadership Coaching Award
• 2002
  American Gastroenterological Association Fiterman Basic Science Award
• 2004-2002
  American Liver Foundation Liver Scholar Award
• 2005-2002
  Cancer Research Institute Investigator award
• 2006-2011
  Burroughs Wellcome Fund Investigator in Pathogenesis of Infectious Disease
• 2011-2013
  UCSF Program in Breakthrough Biomedical Research Award

Selected Publications

1. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL Cryo-EM Reveals Integrin-Mediated TGF-ß Activation without Release from Latent TGF-ß.  View on PubMed
2. Melody G. Campbell, Anthony Cormier, Saburo Ito, Shenping Wu, Jianlong Lou, James Marks, Jody L. Baron, Stephen L. Nishimura, Yifan Cheng Structural Studies avß8 Integrin by Single Particle Cryo-EM.  View on PubMed
3. Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL Integrin avß8-expressing tumor cells evade host immunity by regulating TGF-ß activation in immune cells.  View on PubMed
4. Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y Cryo-EM structure of the avß8 integrin reveals a mechanism for stabilizing integrin extension.  View on PubMed
5. Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL An OX40/OX40L interaction directs successful immunity to hepatitis B virus.  View on PubMed
6. Pierce AA, Duwaerts CC, Siao K, Mattis AN, Goodsell A, Baron JL, Maher JJ CD18 deficiency improves liver injury in the MCD model of steatohepatitis.  View on PubMed
7. Duwaerts CC, Amin AM, Siao K, Her C, Fitch M, Beysen C, Turner SM, Goodsell A, Baron JL, Grenert JP, Cho SJ, Maher JJ Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice.  View on PubMed
8. Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, Ito S, Araya J, Budelsky A, Goodsell A, Baron JL, Nishimura SL Role of IL-17A in murine models of COPD airway disease.  View on PubMed
9. Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man.  View on PubMed
10. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL TGF-ß-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.  View on PubMed
11. Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL Transforming Growth Factor-ß and Interleukin-1ß Signaling Pathways Converge on the Chemokine CCL20 Promoter.  View on PubMed
12. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL A critical role for dendritic cells in the evolution of IL-1ß-mediated murine airway disease.  View on PubMed
13. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL Selective targeting of TGF-ß activation to treat fibroinflammatory airway disease.  View on PubMed
14. Fomin ME, Zhou Y, Beyer AI, Publicover J, Baron JL, Muench MO Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice.  View on PubMed
15. Jean Publicover, Anuj Gaggar, Stephen Nishimura, Christine M. Van Horn, Amanda Goodsell, Marcus O. Muench, R. Lee Reinhardt, Nico van Rooijen, Adil E. Wakil Marion Peters, Jason G. Cyster, David J. Erle, Philip Rosenthal, Lia Avanesyan, Rosanne Spolski, Warren J. Leonard, Stewart Cooper, Jody L. Baron S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus.  View on PubMed
16. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B.  View on PubMed
17. Zeissig S, Murata K, Sweet L, Publicover J, Hu Z, Kaser A, Bosse E, Iqbal J, Hussain MM, Balschun K, Röcken C, Arlt A, Günther R, Hampe J, Schreiber S, Baron JL, Moody DB, Liang TJ, Blumberg RS Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity.  View on PubMed
18. Sebastian Zeissig, Kazumoto Murata, Lindsay Sweet, Jean Publicover, Zongyi Hu, Arthur Kaser, Alexander Arlt, Rainer Günther, Jochen Hampe, Stefan Schreiber, Jody Baron, D. Branch Moody, T Jake Liang, Richard S. Blumberg 742 Hepatitis B Virus Infection Leads to Alterations in the Repertoire of Self Lipid Antigens Presented by Hepatocytes and is Associated With Direct and Indirect Activation of Natural Killer T Cells.  View on PubMed
19. Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin avß8-mediated activation of TGF-ß.  View on PubMed
20. Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang ZE, Avanesyan L, Spolski R, Leonard WJ, Cooper S, Baron JL IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B.  View on PubMed

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