Jody Lynn Baron, MD, PhD

Education

Swarthmore College, Swarthmore, PA, 1984-85 Rice University, Houston, Texas, BA, 1986, Biology & Philosophy
Yale University, MD 1993, Medicine
Yale University, PhD, 1994, Immunobiology
Stanford University, Residency, 1993-95 Internal Medicine
University of California, San Francisco, Clinical Fellow, 1995-96, Infectious Diseases
University of California, San Francisco, Fellowship, 1996-2000, Microbiol & Immunology

Honors & Awards

• 1982
  Westinghouse Science Talent Search honors group
• 1992
  NIH Resident research award
• 1986-1992
  NIH Fellowship -Medical Scientist Training Program Yale University
• 1992
  Molecular Medicine Fellowship, University of California at San Francisco
• 1997-2002
  Howard Hughes Postdoctoral Research Fellowship for Physicians
• 1992
  UCSF Liver center pilot research grant
• 2000-2002
  Pfizer Postdoctoral Fellowship in Infectious Diseases
• 2003-2002
  Burroughs Wellcome Career Award in the Biomedical Sciences
• 2002
  HHMI/BWF Leadership Coaching Award
• 2002
  American Gastroenterological Association Fiterman Basic Science Award
• 2004-2002
  American Liver Foundation Liver Scholar Award
• 2005-2002
  Cancer Research Institute Investigator award
• 2006-2011
  Burroughs Wellcome Fund Investigator in Pathogenesis of Infectious Disease
• 2011-2013
  UCSF Program in Breakthrough Biomedical Research Award

Selected Publications

1. Jin M, Seed RI, Cai G, Shing T, Wang L, Ito S, Cormier A, Wankowicz SA, Jespersen JM, Baron JL, Carey ND, Campbell MG, Yu Z, Tang PK, Cossio P, Wen W, Lou J, Marks J, Nishimura SL, Cheng Y. Dynamic allostery drives autocrine and paracrine TGF-β signaling. Cell. 2024 Oct 31; 187(22):6200-6219.e23.  View on PubMed
2. Meyers NL, Ashuach T, Lyons DE, Khalid MM, Simoneau CR, Erickson AL, Bouhaddou M, Nguyen TT, Kumar GR, Taha TY, Natarajan V, Baron JL, Neff N, Zanini F, Mahmoudi T, Quake SR, Krogan NJ, Cooper S, McDevitt TC, Yosef N, Ott M. Hepatitis C virus infects and perturbs liver stem cells. mBio. 2023 Dec 19; 14(6):e0131823.  View on PubMed
3. Patel RK, Jaszczak RG, Im K, Carey ND, Courau T, Bunis DG, Samad B, Avanesyan L, Chew NW, Stenske S, Jespersen JM, Publicover J, Edwards AW, Naser M, Rao AA, Lupin-Jimenez L, Krummel MF, Cooper S, Baron JL, Combes AJ, Fragiadakis GK. Cyclone: an accessible pipeline to analyze, evaluate, and optimize multiparametric cytometry data. Front Immunol. 2023; 14:1167241.  View on PubMed
4. Natarajan V, Simoneau CR, Erickson AL, Meyers NL, Baron JL, Cooper S, McDevitt TC, Ott M. Modelling T-cell immunity against hepatitis C virus with liver organoids in a microfluidic coculture system. Open Biol. 2022 03; 12(3):210320.  View on PubMed
5. Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL. A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8. Sci Immunol. 2021 03 26; 6(57).  View on PubMed
6. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL. Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β. Cell. 2020 02 06; 180(3):490-501.e16.  View on PubMed
7. Melody G. Campbell, Anthony Cormier, Saburo Ito, Shenping Wu, Jianlong Lou, James Marks, Jody L. Baron, Stephen L. Nishimura, Yifan Cheng. Structural Studies avß8 Integrin by Single Particle Cryo-EM. Microscopy and Microanalysis. 2019 Aug 1; 25(S2):1312-1313.  View on PubMed
8. Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL. Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells. JCI Insight. 2018 10 18; 3(20).  View on PubMed
9. Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y. Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension. Nat Struct Mol Biol. 2018 08; 25(8):698-704.  View on PubMed
10. Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL. An OX40/OX40L interaction directs successful immunity to hepatitis B virus. Sci Transl Med. 2018 03 21; 10(433).  View on PubMed
11. Pierce AA, Duwaerts CC, Siao K, Mattis AN, Goodsell A, Baron JL, Maher JJ. CD18 deficiency improves liver injury in the MCD model of steatohepatitis. PLoS One. 2017; 12(9):e0183912.  View on PubMed
12. Duwaerts CC, Amin AM, Siao K, Her C, Fitch M, Beysen C, Turner SM, Goodsell A, Baron JL, Grenert JP, Cho SJ, Maher JJ. Specific Macronutrients Exert Unique Influences on the Adipose-Liver Axis to Promote Hepatic Steatosis in Mice. Cell Mol Gastroenterol Hepatol. 2017 Sep; 4(2):223-236.  View on PubMed
13. Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, Ito S, Araya J, Budelsky A, Goodsell A, Baron JL, Nishimura SL. Role of IL-17A in murine models of COPD airway disease. Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L122-L130.  View on PubMed
14. Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL. Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man. Hepatology. 2016 Jan; 63(1):260.  View on PubMed
15. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL. TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease. J Immunol. 2015 Aug 01; 195(3):1182-90.  View on PubMed
16. Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL. Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter. J Biol Chem. 2015 Jun 05; 290(23):14717-28.  View on PubMed
17. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL. A critical role for dendritic cells in the evolution of IL-1β-mediated murine airway disease. J Immunol. 2015 Apr 15; 194(8):3962-9.  View on PubMed
18. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. Selective targeting of TGF-β activation to treat fibroinflammatory airway disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79.  View on PubMed
19. Fomin ME, Zhou Y, Beyer AI, Publicover J, Baron JL, Muench MO. Production of factor VIII by human liver sinusoidal endothelial cells transplanted in immunodeficient uPA mice. PLoS One. 2013; 8(10):e77255.  View on PubMed
20. Jean Publicover, Anuj Gaggar, Stephen Nishimura, Christine M. Van Horn, Amanda Goodsell, Marcus O. Muench, R. Lee Reinhardt, Nico van Rooijen, Adil E. Wakil Marion Peters, Jason G. Cyster, David J. Erle, Philip Rosenthal, Lia Avanesyan, Rosanne Spolski, Warren J. Leonard, Stewart Cooper, Jody L. Baron. S-3 Age-dependent hepatic lymphoid organization directs immune priming, cytokine production, and successful immunity to Hepatitis B virus. Cytokine. 2013 Sep 1; 63(3):241.  View on PubMed

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