Research Summary

Dr. Berger's main clinical interests are the treatment of brain tumors in adults and children and of epilepsy related to brain tumors. He has extensive expertise in intraoperative mapping of the brain to identify the sites of motor, sensory, and language function and thereby avoid their involvement or injury during surgery.

Dr. Berger is Director of the Neuro-Oncology Surgery Program. His current research interests involve identifying molecular markers in gliomas as correlates of tumor progression and prognosis. He also works in conjunction with Dr. Krys Bankiewicz to test small molecule inhibitors in brain tumors using convection enhanced delivery. Other collaborations include functional mapping localization of language pathways in the brain in conjunction with Dr. Robert Knight and the Cognitive Neuroscience Graduate Program at UC Berkeley. Dr. Berger is currently the Principal Investigator of UCSF's SPORE Brain Tumor Program. He is also the Principal Investigator of a Pediatric Brain Tumor Foundation Institute award to study the origins and treatment of pediatric brain tumors. "

Research Funding

  • September 20, 2002 - August 31, 2023 - Brain Tumor SPORE Grant, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: P50CA097257
  • July 1, 2007 - June 30, 2013 - Noninvasive Metabolic Signatures to Improve Management of Molecular Subtypes of Glioma, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: P01CA118816
  • August 5, 1999 - September 29, 2012 - Cancer Center Support Grant, Co-Investigator. Sponsor: NIH/NCI, Sponsor Award ID: P30CA082103
  • April 1, 1979 - February 28, 2007 - PROGRAMS FOR TREATMENT OF MALIGNANT BRAIN TUMORS, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: P01NS042927

Education

Harvard University, Cambridge, MA, A.B., 1975, Social Psychology
University of Miami, Miami, FL, M.D., 1979, Medicine
University of California, San Francisco, CA (UCSF), Dept. of Neurological Surgery, Brain Tumor Research Center (BTRC) Research Fellow 1983 - 1984 Neurosurgery
UCSF, BTRC, Neuro-Oncology Service, Clinical Fellow, 7/85 - 12/85, Neurosurgery
Hospital for Sick Children, Toronto, Ontario, Canada, Pediatric Neurosurgery Fellow, 1/86 - 6/86, Neurosurgery

Honors & Awards

  • 1997-Present
    Joint Section on Tumors Advisory Council, American Association of Neurological Surgeons and Congress of Neurological Surgeons
  • 1997-1999
    Vice-President, Congress of Neurological Surgeons; President, Society for Neuro-Oncology
  • 2002-Present
    America’s Top Doctors, peer-nominated referral index from Castle Connolly
  • 2006
    Tumor Section, 2006 Ronald L. Bittner Lecturer; 2006 Farber Award Winner
  • 2007–Present
    Board of Directors of the American Association of Neurological Surgeons
  • 2007–Present
    Member of the American Board of Neurological Surgeons
  • 2010
    Vice-President, American Association of Neurological Surgeons
  • 2011
    President Elect, American Association of Neurological Surgeons
  • 2012
    President, American Association of Neurological Surgeons

Selected Publications

  1. Aabedi AA, Kakaizada S, Young JS, Ahn E, Weissman DH, Berger MS, Brang D, Hervey-Jumper SL Balancing task sensitivity with reliability for multimodal language assessments.  View on PubMed
  2. Hosmann A, Millesi M, Wadiura LI, Kiesel B, Mercea PA, Mischkulnig M, Borkovec M, Furtner J, Roetzer T, Wolfsberger S, Phillips JJ, Berghoff AS, Hervey-Jumper S, Berger MS, Widhalm G 5-ALA Fluorescence Is a Powerful Prognostic Marker during Surgery of Low-Grade Gliomas (WHO Grade II)-Experience at Two Specialized Centers.  View on PubMed
  3. Ammanuel SG, Edwards CS, Chan AK, Mummaneni PV, Kidane J, Vargas E, D'Souza S, Nichols AD, Sankaran S, Abla AA, Aghi MK, Chang EF, Hervey-Jumper SL, Kunwar S, Larson PS, Lawton MT, Starr PA, Theodosopoulos PV, Berger MS, McDermott MW Are preoperative chlorhexidine gluconate showers associated with a reduction in surgical site infection following craniotomy? A retrospective cohort analysis of 3126 surgical procedures.  View on PubMed
  4. Wehle S, Adachi I, Adamczyk K, Aihara H, Asner DM, Atmacan H, Aulchenko V, Aushev T, Ayad R, Babu V, Behera P, Berger M, Bhardwaj V, Biswal J, Bozek A, Bracko M, Browder TE, Campajola M, Cao L, Chang MC, Chen A, Cheon BG, Chilikin K, Cho K, Choi Y, Choudhury S, Cinabro D, Cunliffe S, Dash N, De Nardo G, Di Capua F, Dubey S, Eidelman S, Epifanov D, Ferber T, Fulsom BG, Garg R, Gaur V, Gabyshev N, Garmash A, Giri A, Goldenzweig P, Greenwald D, Guan Y, Haba J, Hartbrich O, Hayasaka K, Hayashii H, Hedges MT, Higuchi T, Hou WS, Hsu CL, Iijima T, Inami K, Inguglia G, Ishikawa A, Itoh R, Iwasaki M, Iwasaki Y, Jacobs WW, Jia S, Jin Y, Joffe D, Kahn J, Kaliyar AB, Karyan G, Kichimi H, Kim DY, Kim KT, Kim SH, Kim YK, Kinoshita K, Komarov I, Korpar S, Kotchetkov D, Kroeger R, Krokovny P, Kuhr T, Kulasiri R, Kumar R, Kumara K, Kuzmin A, Kwon YJ, Lange JS, Lee JY, Lee SC, Li YB, Libby J, Liptak Z, Liventsev D, Luo T, MacNaughton J, Masuda M, Matsuda T, McNeil JT, Merola M, Metzner F, Miyata H, Mizuk R, Mohanty GB, Moon TJ, Mussa R, Nakao M, Natochii A, Nayak M, Niebuhr C, Niiyama M, Nisar NK, Nishida S, Ogawa K, Ogawa S, Ono H, Onuki Y, Pakhlov P, Pakhlova G, Park H, Park SH, Pedlar TK, Pestotnik R, Piilonen LE, Podobnik T, Popov V, Prencipe E, Prim MT, Resmi PK, Ritter M, Rostomyan A, Rout N, Russo G, Sahoo D, Sakai Y, Sandilya S, Sangal A, Santelj L, Savinov V, Schneider O, Schnell G, Schueler J, Schwanda C, Schwartz AJ, Seino Y, Senyo K, Sevior ME, Shapkin M, Shiu JG, Shwartz B, Solovieva E, Staric M, Strube JF, Sumiyoshi T, Sutcliffe W, Takizawa M, Tamponi U, Tanida K, Tao Y, Tenchini F, Trabelsi K, Uchida M, Uglov T, Unno Y, Uno S, Ushiroda Y, Vahsen SE, Van Tonder R, Varner G, Varvell KE, Vorobyev V, Wang CH, Wang MZ, Wang P, Wang XL, Won E, Xu X, Yang SB, Ye H, Yin JH, Yuan CZ, Zhang ZP, Zhilich V, Zhukova V, Zhulanov V, Belle Collaboration Test of Lepton-Flavor Universality in B?K^{*}l^{+}l^{-} Decays at Belle.  View on PubMed
  5. Müller DMJ, De Swart ME, Ardon H, Barkhof F, Bello L, Berger MS, Bouwknegt W, Van den Brink WA, Conti Nibali M, Eijgelaar RS, Furtner J, Han SJ, Hervey-Jumper S, Idema AJS, Kiesel B, Kloet A, Mandonnet E, Robe PAJT, Rossi M, Sciortino T, Vandertop WP, Visser M, Wagemakers M, Widhalm G, Witte MG, De Witt Hamer PC Timing of glioblastoma surgery and patient outcomes: a multicenter cohort study.  View on PubMed
  6. Yu Y, Villanueva-Meyer J, Grimmer MR, Hilz S, Solomon DA, Choi S, Wahl M, Mazor T, Hong C, Shai A, Phillips JJ, Wainer BH, McDermott M, Haas-Kogan D, Taylor JW, Butowski N, Clarke JL, Berger MS, Molinaro AM, Chang SM, Costello JF, Oberheim Bush NA Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant gliomas.  View on PubMed
  7. Karschnia P, Vogelbaum MA, van den Bent M, Cahill DP, Bello L, Narita Y, Berger MS, Weller M, Tonn JC Evidence-based recommendations on categories for extent of resection in diffuse glioma.  View on PubMed
  8. Lu J, Zhao Z, Zhang J, Wu B, Zhu Y, Chang EF, Wu J, Duffau H, Berger MS Functional maps of direct electrical stimulation-induced speech arrest and anomia: a multicentre retrospective study.  View on PubMed
  9. Aabedi AA, Kakaizada S, Young JS, Kaur J, Wiese O, Valdivia C, Krishna S, Weyer-Jamora C, Berger MS, Weissman DH, Brang D, Hervey-Jumper SL Convergence of heteromodal lexical retrieval in the lateral prefrontal cortex.  View on PubMed
  10. Winkler EA, Lee A, Yue JK, Raygor KP, Rutledge WC, Rubio RR, Josephson SA, Berger MS, Raper DMS, Abla AA Endovascular embolization versus surgical clipping in a single surgeon series of basilar artery aneurysms: a complementary approach in the endovascular era.  View on PubMed
  11. Zuckerman SL, Yengo-Kahn AM, Tang AR, Bailes JE, Beauchamp K, Berger MS, Bonfield CM, Camarata PJ, Cantu RC, Davis GA, Ellenbogen RG, Ellis MJ, Feuer H, Guazzo E, Harris OA, Heppner P, Honeybul S, Manley G, Maroon JC, Miele VJ, Nahed BV, Okonkwo DO, Oppenlander ME, Petty J, Sabin HI, Samadani U, Sherburn EW, Sheridan M, Tator CH, Theodore N, Timmons SD, Woodworth GF, Solomon GS, Sills AK Sport-Related Structural Brain Injury and Return to Play: Systematic Review and Expert Insight.  View on PubMed
  12. Mischkulnig M, Kiesel B, Lötsch D, Roetzer T, Borkovec M, Wadiura LI, Roessler K, Hervey-Jumper S, Penninger JM, Berger MS, Widhalm G, Erhart F Heme Biosynthesis mRNA Expression Signature: Towards a Novel Prognostic Biomarker in Patients with Diffusely Infiltrating Gliomas.  View on PubMed
  13. De Witt Hamer PC, De Witt Hamer PC, Klein M, Hervey-Jumper SL, Wefel JS, Berger MS Functional Outcomes and Health-Related Quality of Life Following Glioma Surgery.  View on PubMed
  14. Haddad AF, Young JS, Berger MS, Tarapore PE Preoperative Applications of Navigated Transcranial Magnetic Stimulation.  View on PubMed
  15. Gerritsen JKW, Broekman MLD, De Vleeschouwer S, Schucht P, Nahed BV, Berger MS, Vincent AJPE Letter: The European and North American Consortium and Registry for Intraoperative Stimulation Mapping: Framework for a Transatlantic Collaborative Research Initiative.  View on PubMed
  16. Young JS, Gogos AJ, Pereira MP, Morshed RA, Li J, Barkovich MJ, Hervey-Jumper SL, Berger MS Effects of ventricular entry on patient outcome during glioblastoma resection.  View on PubMed
  17. Fan JM, Gorno-Tempini ML, Dronkers NF, Miller BL, Berger MS, Chang EF Data-Driven, Visual Framework for the Characterization of Aphasias Across Stroke, Post-resective, and Neurodegenerative Disorders Over Time.  View on PubMed
  18. Morshed RA, Young JS, Kroliczek AA, Berger MS, Brang D, Hervey-Jumper SL A Neurosurgeon's Guide to Cognitive Dysfunction in Adult Glioma.  View on PubMed
  19. Morshed RA, Young JS, Lee AT, Berger MS, Hervey-Jumper SL Clinical Pearls and Methods for Intraoperative Awake Language Mapping.  View on PubMed
  20. Muster RH, Young JS, Woo PYM, Morshed RA, Warrier G, Kakaizada S, Molinaro AM, Berger MS, Hervey-Jumper SL The Relationship Between Stimulation Current and Functional Site Localization During Brain Mapping.  View on PubMed

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