Research Funding

  • July 1, 1985 - May 31, 2023 - UCSF Liver Center , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P30DK026743
  • October 1, 1974 - November 30, 2007 - General Clinical Research Center , Co-Investigator . Sponsor: NIH, Sponsor Award ID: M01RR000083
  • July 1, 1982 - June 30, 2004 - CELLULAR PATHOPHYSIOLOGY OF HEPATIC FIBROSIS , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R37DK031198
  • September 1, 1996 - August 31, 2000 - REGULATION OF THE FIBRONECTIN GENE IN LIVER CELLS , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R03TW000717


Harvard College, Cambridge, MA, A.B., 1962, English
Harvard Medical School, Boston, MA, M.D., 1967, Medicine
Harvard Medical Service, Boston City Hospital, Residency training, 1967-70, Int. Medicine
University of California, San Francisco, Research training, 1970-73, Liver Biology

Honors & Awards

  • 1992
    Election to the American Society for Clinical Investigation
  • 1982
    Election to the Intl. Assn. for the Study of Liver Diseases
  • 1982
    Election to the Association of American Physicians
  • 1992
    Council, American Association for the Study of Liver Diseases
  • 1992
    President, American Association for the Study of Liver Diseases
  • 1998-2002
    NIDDK Advisory Council
  • 1997-2002
    Editor, HEPATOLOGY
  • 1995-2002
    Principal investigator, Merit award R37DK31192
  • 2002
    Distinguished achievement award, American Association for the Study of Liver Diseases

Selected Publications

  • (selected from over 100)
  • Pitas RE, Boyles J, Mahley RW, Bissell DM. Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells. J Cell Biol 100~103-117, 1985.
  • Friedman SL, Roll FJ, Boyles J, Bissell DM. Hepatic lipocytes: The principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci USA 82:8681-8685, 1985.
  • Bissell DM. Stamatoglou SC, Nermut MV, Hughes RC. Interactions of rat hepatocytes with type IV collagen, fibronectin and laminin matrices. Distinct matrix-controlled modes of attachment and spreading. Eur J Cell Biol 40,72-78, 1986.
  • Bissell DM, Arenson DM, Maher JJ, Roll FJ. Support of cultured hepatocytes by a laminin-rich gel. Evidence for a functionally significant subendothelial matrix in normal rat liver. J Clin Invest 79: 801-812, 1987.
  • Maher JJ, Friedman SL, Roll FJ, Bissell DM. Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. Gastroenterology 94: 1053-1062, 1988.
  • Maher JJ, Bissell DM, Friedman SL. Roll FJ. Collagen measured in primary cultures of normal rat hepatocytes derived from lipocytes within the monolayer. J Clin Invest 82:450-59, 1988.
  • Friedman SL, Roll FJ, Boyles J, Arenson DM, Bissell DM. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem 264:10756-B2, 1989.
  • Arthur MJP, Friedman SL. Roll FJ, Bissell DM. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J Clin Invest 84: 1076-85, 1989.
  • Bissell DM, Caron JM, Babiss, LE, Friedman JM. Transcriptional regulation of the albumin gene in cultured rat hepatocytes: role of basement membrane matrix. Mol Biol Med 7:187-197, 1990.
  • Hultcrantz RH, Bissell DM, Roll, FJ. Iron mediates production of a neutrophil chemoattractant by rat hepatocytes metabolizing ethanol. J Clin Invest 87:45-49, 1992
  • McGuire RF, Bissell DM, Boyles J, Roll FJ. Role of extracellular matrix in regulating fenestrations of sinusoidal endothelial cells isolated from normal rat liver. Hepatology 15:989-997, 1992.
  • Jarnagin WR, Debs RJ, Wang S-S, Bissell DM. Cationic lipid-mediated transfection of liver cells in primary culture. Nucl Acid Res 20;4205-4211, 1992.
  • Maher JJ, Bissell DM. Cell-matrix interactions in liver. Seminars in Cell Biology 4:189-201, 1993.
  • Housset C, Rockey DC, Bissell DM. Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin-1. Proc Natl Acad Sci USA, 90:9266-9270, 1993.
  • Jarnagin WR, Rockey DC, Koteliansky VE, Bissell DM. Expression of variant fibronectin in wound-healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J Cell Biol 127:2037-2048, 1994.
  • Bissell DM, Wang SS, Jarnagin WR, Roll FJ. Cell-specific expression of TGF in rat liver regeneration, autocrine regulation of hepatocyte proliferation by TGF-2. J Clin Invest 96:447-455, 1995.
  • Racine-Samson L, Rockey DC, Bissell DM. The role of 11 integrin in wound contraction. A quantitative analysis of liver myofibroblasts in vivo and in primary culture. J Biol Chem 1997;272:30911-17.
  • Wang Y-J, Wang S-S, Bickel M, Guenzler V, Gerl M, Bissell DM. Two novel antifibrotics, HOE 077 and Safironil, modulate stellate cell activation in rat liver injury. Differential effects in males and females. Amer J Pathol 1998;152:279-287.
  • McDonagh AF, Bissell DM. Porphyria and porphyrinology - the past fifteen years. Semin Liver Dis 1998;18:3-15.
  • George J, Roulot D, Koteliansky VE, Bissell DM. In vivo inhibition of rat stellate cell activation by soluble TGF type II receptor: a potential new therapy for hepatic fibrosis. Proc Natl Acad Sci USA 1999;96:12719-24.
  • Bissell DM, Roulot D, George J. Transforming growth factor and the liver. Hepatology 2001;34:859-867.
  • Alonso CR, George J, Pesce CG, Bissell DM, Kornblihtt AR. Fibronectin transcription in liver cells: promoter occupation and function in sinusoidal endothelial cells and hepatocytes. Biochem Biophys Res Commun 2002;295:1077-84.
  • Bissell, DM. Assessing fibrosis without a liver biopsy: are we there yet? Gastroenterology 2004; in press.
  • Chang ML, Chen JC, Alonso CR, Kornblihtt AR, Bissell DM. Regulation of fibronectin splicing in sinusoidal endothelial cells from normal or injured liver. Proc Natl Acad Sci USA 2004; in press.
  • Kikuchi S, Griffin CT, Wang SS, Bissell DM. Role of cd44 in epithelial wound repair: migration of rat hepatic stellate cells utilizes hyaluronic acid and cd44v6. J Biol Chem 2005;280:15398-404.
  • Jakubowski A, Ambrose C, Parr M, Lincecum JM, Wang MZ, Zheng TS, Browning B, Michaelson JS, Baestcher M, Wang B, Bissell DM, Burkly LC. Tweak induces liver progenitor cell proliferation. J Clin Invest 2005;115:2330-40.

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