Jeffrey Bluestone, PhD

Research Summary

Jeffrey Bluestone, PhD, is the A.W. and Mary Margaret Clausen Distinguished Professor of Metabolism and Endocrinology and is the Director of the Hormone Research Institute in the Diabetes Center. His research over the past 25 years has focused on understanding the basic processes that control T cell activation and immune tolerance in autoimmunity and organ transplantation. He and members of his lab have developed soluble receptor antagonists; monoclonal antibodies and animals deficient in individual members of TCR and co-stimulatory pathways to define their individual roles in transplant rejection and autoimmunity including a special emphasis on a specialized subset of T cells termed “regulatory T cells” (Treg). Tregs control fundamental aspect of immune homeostasis. During the last several years, his research has adapted the animal studies using biologics and cell based therapies to develop therapeutics that can be used in humans with autoimmunity and under conditions of allotransplant rejection. Moreover, a strong role for antigen-specific Tregs have been found in these model systems and further evidence in humanized mice and transplant patients that alloantigen-specific Tregs are more effective. Thus, the major goal of this work is to identify the antigen-specificity of thymic- and peripherally-derived Tregs with the expectation that these TCRs can be adapted for immunotherapy. Finally, his lab initiated several projects to determine mechanisms that control Treg stability. The goal is to develop approaches using pharmacogenomics to either stabilize or destabilize Tregs in autoimmunity and cancer.

In March 2010 Dr. Bluestone was appointed executive vice chancellor and provost at the University of California San Francisco (UCSF) serving as chief academic officer guiding the research and academic enterprise advancing the campus priorities in close collaboration with the chancellor and the campus leadership teams, and to oversee the campus ethics and compliance enterprise. Previously he served in a number of posts including Director of theUCSF Diabetes Center, as Director of the Immune Tolerance Network.

In June 2008 Dr. Bluestone served as interim vice chancellor of research, directing the advancement of cross-campus research initiatives, such as enhancing core research facilities. In this capacity, he played a leading role in coordinating and integrating current research cores. He worked also to strengthen external research partnerships, particularly with industry, and focused on facilitating the translation of UCSF discoveries into public benefit.

In 2009, Dr. Bluestone led the UCSF committee to strategize and secure funds available through the American Recovery and Reinvestment Act, making the campus one of the top institutional recipients in the nation of science-based stimulus funds.

Dr. Bluestone joined the UCSF faculty in 2000. He is an international leader in the field of immunotherapy, with a stellar record of scholarly achievement and a decade of significant contributions to the research enterprise at UCSF, including the creation and directorship of an integrated UCSF Diabetes Center to focus on translating basic research in both type 1 and type 2 diabetes into improved therapies for patients. He also founded and directed the Immune Tolerance Network, a consortium of more than 1,000 of the world’s leading scientific researchers and clinical specialists from nearly 50 institutions, with the mission of testing new therapies to promote immune tolerance in transplantation, autoimmune diseases, asthma and allergic diseases.

As a research scientist, Dr. Bluestone has helped clarify the body’s immune response on a molecular level. His systematic investigation has catalyzed recent progress in stem cell research, islet cell transplantation and immune tolerance therapies – experimentation that has formidably translated into drugs to treat human disease.

Through his 30-year scientific career, he has authored more than 300 peer-reviewed publications that include prominent papers in Nature, Nature Immunology, and the Journal of Immunology and Diabetes. He has received numerous accolades for his work, including his 2006 election to the American Academy of Arts and Sciences, the Mary Tyler Moore & Robert Levine Excellence in Clinical Research Award from the Juvenile Diabetes Research Foundation, and the distinguished alumni award from the Cornell Graduate School of Medical Science.

Prior to joining UCSF, Bluestone was at the University of Chicago, where he was a member of the Ben May Institute for Cancer Research, rising over 13 years from an associate professor to the director of the institute. He had previously worked for seven years in various roles at the National Cancer Institute of the National Institutes of Health, ultimately becoming a senior investigator in the Immunology Branch of the National Cancer Institute.

Dr. Bluestone earned both his BS in biology and his MS in microbiology from Rutgers State University, and his PhD in immunology from the Cornell Graduate School of Medical Science (Sloan-Kettering Division)."

Research Funding

• July 1, 1979 - June 30, 2024 - Interdisciplinary Training Program in Immunology , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: T32AI007090
• September 20, 2017 - August 31, 2021 - Designer Tregs for restoring tolerance in patients with type 1 diabetes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: UC4DK116264
• June 8, 2016 - May 31, 2021 - Disruption of T cell tolerance in type 1 diabetes , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI118688
• June 1, 2014 - May 31, 2021 - Donor-Alloantigen-Reactive Regulatory T Cell Therapy in Liver Transplantation , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01AI110658
• September 1, 2002 - March 31, 2021 - Diabetes Research Center , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: P30DK063720
• July 1, 2016 - December 31, 2020 - Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01DK107383
• July 1, 2016 - June 30, 2020 - Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance , Co-Principal Investigator . Sponsor: NIH/NIDDK, Sponsor Award ID: R01DK107383
• May 1, 2014 - April 30, 2020 - Autoimmunity Center of Excellence Clinical Research Program , Co-Investigator . Sponsor: NIH, Sponsor Award ID: UM1AI110498
• February 1, 1977 - March 31, 2018 - Cancer Center Support Grant , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P30CA014599
• March 1, 2000 - November 30, 2016 - Immunomodulation of transplant rejection by Anti-CD3 mAb , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI046643
• December 1, 2013 - November 30, 2015 - Role of Innate Lymphoid Cells in Autoimmunity , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI107328
• September 15, 2010 - June 30, 2015 - Expanding beta-cell mass , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01DK089541
• September 30, 2003 - April 30, 2015 - Autoimmunity Center of Excellence , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U19AI056388
• September 30, 2001 - April 30, 2014 - Immune tolerance network: Multiple sclerosis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-20-0-5
• September 30, 2001 - April 30, 2014 - Immune Tolerance Network: Systemic lupus rythematosus (SLE) , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-20-0-12
• September 30, 2001 - April 30, 2014 - Immune tolerance network: liver transplantation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-23-0-11
• September 30, 2001 - April 30, 2014 - Immune tolerance network: kidney transplantation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-23-0-13
• September 30, 2001 - April 30, 2014 - Immune Tolerance Network: Systemic lupus rythematosus (SLE) , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-23-0-12
• September 30, 2001 - April 30, 2014 - Immune tolerance network: Multiple sclerosis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-23-0-5
• September 30, 2001 - April 30, 2014 - Immune Tolerance Network: Kidney, Liver and Bone Marrow Transplantation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-20-0-2
• September 30, 2001 - April 30, 2014 - IImmune Tolerance Network: Airborne Allergens and Allergic Rhintitis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-23-0-14
• September 30, 2001 - April 30, 2014 - Immune tolerance network: heart tranplantation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-20-0-9
• September 30, 2001 - April 30, 2014 - Immune tolerance network: Autoimmune diseases: Vasculitis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-20-0-7
• September 30, 2001 - April 30, 2014 - Immune Tolerance Network: Food Allergy , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-20-0-3
• September 30, 2001 - April 30, 2014 - Immune Tolerance Network: Type 1 diabetes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-20-0-4
• September 30, 2001 - April 30, 2014 - Immune tolerance network: Rheumatoid arthritis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-20-0-6
• September 30, 2001 - April 30, 2014 - Immune tolerance network: lung transplantation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-20-0-10
• September 30, 2001 - April 30, 2014 - Immune Tolerance Network: Type 1 diabetes , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-23-0-4
• September 30, 2001 - April 30, 2014 - Immune Tolerance Network: Food Allergy , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-23-0-3
• September 30, 2001 - April 30, 2014 - Immune tolerance network: liver transplantation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-20-0-11
• September 30, 2001 - April 30, 2014 - Immune tolerance network: Islet cell transplantation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01AI15416-20-0-8
• April 1, 2012 - March 31, 2014 - Donor-Specific Regulatory T Cell Therapy in Liver Transplantation , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R34AI095135
• December 15, 2001 - November 30, 2012 - Spontaneous Autoimmune Model of Peripheral Neuropathy , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI050834
• January 1, 1900 - July 31, 2012 - Immune Tolerance and Autoimmunity , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01AI035297
• March 1, 2000 - February 28, 2011 - IMMUNOMODULATION OF TRANSPLANT REJECTION BY ANTI-CD3 MAB , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R37AI046643
• April 1, 2004 - March 31, 2007 - Role of Notch 1 in Immune Tolerance , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI059979
• September 30, 1999 - September 29, 2006 - COLLABORATIVE NETWORK FOR CLINICAL RES ON IMMUNE TOLERAN , Principal Investigator . Sponsor: NIH/NIAID, Sponsor Award ID: N01AI095380
• September 30, 1996 - August 31, 2006 - SCOR in Cellular and Molecular Mechanisms of Asthma , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: P50HL056399
• June 15, 1999 - May 31, 2003 - TOLERANCE OF ISLET CELL GRAFT , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01DK055351
• April 1, 2002 - March 31, 2003 - Conf on Mechanism and Applications of Immune Tolerance , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R13AI051294
• September 1, 1993 - August 31, 2001 - COSTIMULATION IN PERIPHERAL T CELL TOLERANCE AND ANERGY , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P01AI035294
• June 1, 2000 - May 31, 2001 - FASEB SUMMER CONFERENCE--LYMPHOCYTES AND ANTIBODIES , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R13AI047114
• March 1, 2000 - February 28, 2001 - MOFLO MULTILASER FLOW CYTOMETER , Principal Investigator . Sponsor: NIH, Sponsor Award ID: S10RR014884
• June 1, 1990 - August 31, 2000 - IMMUNOMODULATION OF TRANSPLANT REJECTION , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P01AI029531
• June 15, 1995 - May 31, 2000 - IMMUNOREGULATION OF IDDM , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01DK049799
• September 1, 1988 - August 31, 1999 - IMMUNOBIOLOGY OF TCR GAMMA/DELTA T-CELLS , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI026847
• June 1, 1976 - March 31, 1996 - IMMUNITY AND CANCER , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01CA019266
• August 5, 1988 - July 31, 1995 - IN VIVO POTENTIATION OF IMMUNE RESPONSES , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA049260
• March 22, 1998 - January 1, 1900 - CTLA 4 ANTAGONISM DURING T CELL ACTIVATION , Principal Investigator . Sponsor: NIH, Sponsor Award ID: F33AI009895
• January 1, 1900 - January 1, 1900 - Immune Tolerance Network: Autoimmune Diseases , Co-Principal Investigator . Sponsor: NIH/NIAID, Sponsor Award ID: N01AI15416