Research Summary

Dr. Braunstein is a radiation oncologist with a clinical interest in the treatment of pediatric, central nervous system, and soft tissue malignancies. He has expertise in modern radiation therapy techniques including stereotactic radiotherapy (Gamma Knife, Cyberknife, Linac-based SBRT), intraoperative radiotherapy, and intensity modulated radiation therapy.

Dr. Braunstein earned his M.D. at New York University School of Medicine where he also obtained a Ph.D. studying molecular pathways by which cancer cells mediate response to radiation. He currently serves as Vice Chair and Clinical Director of Radiation Oncology. His research focus includes mitigation of early and late toxicity in treatment of pediatric malignancies as well as optimizing combination of immuno- and targeted-therapies in the management of primary and metastatic central nervous system malignancies.

Education

University of California, San Francisco, 06/14, Radiation Oncology
Brighman and Women's Hospital, 06/10, Internal Medicine
New York University School of Medicine, M.D., Ph.D., 06/09

Honors & Awards

  • 2020
    UCSF Rap Award
  • 2019
    ARRO Teacher of the Year Award
  • 2018
    UCSF Rap Award
  • 2017
    UCSF Radiation Oncology-Radiology Award
  • 2016
    ARRO Teacher of the Year Award
  • 2015
    UCSF Patient Care Fund Award
  • 2014
    RSNA Roetgen Research Award
  • 2013
    UCSF Exceptional Physician Award

Selected Publications

  1. Rogers CL, Pugh SL, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Barani IJ, Braunstein S, Bovi JA, de Groot JF, Whitton AC, Lindhorst SM, Deb N, Shrieve DC, Shu HK, Bloom B, Machtay M, Mishra MV, Robinson CG, Won M, Mehta MP. Low-Risk Meningioma: Initial Outcomes from NRG Oncology/RTOG 0539. Neuro Oncol. 2022 Jun 03.  View on PubMed
  2. Sneed PK, Chan JW, Ma L, Braunstein SE, Theodosopoulos PV, Fogh SE, Nakamura JL, Boreta L, Raleigh DR, Ziemer BP, Morin O, Hervey-Jumper SL, McDermott MW. Adverse radiation effect and freedom from progression following repeat stereotactic radiosurgery for brain metastases. J Neurosurg. 2022 May 20; 1-9.  View on PubMed
  3. Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW, Qiu Z, Martin MV, Susko MS, Braunstein SE, Bush NAO, Schulte JD, Butowski N, Sneed PK, Berger MS, Krogan NJ, Perry A, Phillips JJ, Solomon DA, Costello JF, McDermott MW, Rich JN, Raleigh DR. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet. 2022 May 09.  View on PubMed
  4. Sperduto PW, De B, Li J, Carpenter D, Kirkpatrick J, Milligan M, Shih HA, Kutuk T, Kotecha R, Higaki H, Otsuka M, Aoyama H, Bourgoin M, Roberge D, Dajani S, Sachdev S, Gainey J, Buatti JM, Breen W, Brown PD, Ni L, Braunstein S, Gallitto M, Wang TJC, Shanley R, Lou E, Shiao J, Gaspar LE, Tanabe S, Nakano T, An Y, Chiang V, Zeng L, Soliman H, Elhalawani H, Cagney D, Thomas E, Boggs DH, Ahluwalia MS, Mehta MP. Graded Prognostic Assessment (GPA) for Patients With Lung Cancer and Brain Metastases: Initial Report of the Small Cell Lung Cancer GPA and Update of the Non-Small Cell Lung Cancer GPA Including the Effect of Programmed Death Ligand 1 and Other Prognostic Factors. Int J Radiat Oncol Biol Phys. 2022 Mar 21.  View on PubMed
  5. Vo KT, DuBois SG, Neuhaus J, Braunstein SE, Weil BR, Naranjo A, Irtan S, Balaguer J, Matthay KK. Pattern and predictors of sites of relapse in neuroblastoma: A report from the International Neuroblastoma Risk Group (INRG) project. Pediatr Blood Cancer. 2022 Feb 21; e29616.  View on PubMed
  6. Thomas NJ, Myall NJ, Sun F, Patil T, Mushtaq R, Yu C, Sinha S, Pollom EL, Nagpal S, Camidge DR, Rusthoven CG, Braunstein SE, Wakelee HA, McCoach CE. In Response to: "Comparing Addition of Radiotherapy in EGFR- and ALK-Positive NSCLC With Brain Metastases: Are We Evaluating the Optimal Endpoint?" J Thorac Oncol. 2022 02; 17(2):e12-e14.  View on PubMed
  7. Luks TL, Villanueva-Meyer JE, Weyer-Jamora C, Gehring K, Jakary A, Hervey-Jumper SL, Braunstein SE, Bracci PM, Brie MS, Smith EM, Chang SM, Taylor JW. T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas. Front Neurol. 2021; 12:769345.  View on PubMed
  8. Chen WC, Lafreniere M, Phuong C, Liu SJ, Baal JD, Lometti M, Morin O, Ziemer B, Vasudevan HN, Lucas CG, Hervey-Jumper SL, Theodosopoulos PV, Magill ST, Fogh S, Nakamura JL, Boreta L, Sneed PK, McDermott MW, Raleigh DR, Braunstein SE. Resection with intraoperative cesium-131 brachytherapy as salvage therapy for recurrent brain tumors. J Neurosurg. 2022 Jan 21; 1-7.  View on PubMed
  9. Cummins DD, Morshed RA, Chavez MM, Avalos LN, Sudhakar V, Chung JE, Gallagher A, Saggi S, Daras M, Braunstein S, Theodosopoulos PV, McDermott MW, Aghi MK. Salvage Surgery for Local Control of Brain Metastases After Previous Stereotactic Radiosurgery: A Single-Center Series. World Neurosurg. 2021 Nov 02.  View on PubMed
  10. Fishel Ben Kenan R, Polishchuk AL, Hawkins RA, Braunstein SE, Matthay KK, DuBois SG, Haas-Kogan DA. Anatomic patterns of relapse and progression following treatment with 131 I-MIBG in relapsed or refractory neuroblastoma. Pediatr Blood Cancer. 2022 02; 69(2):e29396.  View on PubMed
  11. Castro MRH, Magill ST, Morshed RA, Young JS, Braunstein SE, McDermott MW, Chang EF. Facial pain and sensory outcomes following resection of tumors compressing the trigeminal nerve. J Neurosurg. 2022 04 01; 136(4):1119-1127.  View on PubMed
  12. Osorio RC, Pereira MP, Joshi RS, Donohue KC, Sneed P, Braunstein S, Theodosopoulos PV, El-Sayed IH, Gurrola J, Kunwar S, Blevins LS, Aghi MK. Socioeconomic predictors of case presentations and outcomes in 225 nonfunctional pituitary adenoma resections. J Neurosurg. 2021 Oct 01; 1-12.  View on PubMed
  13. Garcia JH, Winkler EA, Morshed RA, Lu A, Ammanuel SG, Saggi S, Wang EJ, Braunstein S, Fox CK, Fullerton HJ, Kim H, Cooke DL, Hetts SW, Lawton MT, Abla AA, Gupta N. Factors associated with seizures at initial presentation in pediatric patients with cerebral arteriovenous malformations. J Neurosurg Pediatr. 2021 Sep 24; 1-6.  View on PubMed
  14. Chen WC, Boreta L, Braunstein SE, Rabow MW, Kaplan LE, Tenenbaum JD, Morin O, Park CC, Hong JC. Association of mental health diagnosis with race and all-cause mortality after a cancer diagnosis: Large-scale analysis of electronic health record data. Cancer. 2022 01 15; 128(2):344-352.  View on PubMed
  15. Sinha S, Xu MJ, Yee E, Buckmeier T, Park C, Braunstein SE. Interprofessional Education Curriculum for Medical Assistants in Radiation Oncology: A Single Institution Pilot Program. Adv Radiat Oncol. 2021 Nov-Dec; 6(6):100800.  View on PubMed
  16. Thomas NJ, Myall NJ, Sun F, Patil T, Mushtaq R, Yu C, Sinha S, Pollom EL, Nagpal S, Camidge DR, Rusthoven CG, Braunstein SE, Wakelee HA, McCoach CE. Brain Metastases in EGFR- and ALK-Positive NSCLC: Outcomes of Central Nervous System-Penetrant Tyrosine Kinase Inhibitors Alone Versus in Combination With Radiation. J Thorac Oncol. 2022 01; 17(1):116-129.  View on PubMed
  17. Morin O, Vallières M, Braunstein S, Ginart JB, Upadhaya T, Woodruff HC, Zwanenburg A, Chatterjee A, Villanueva-Meyer JE, Valdes G, Chen W, Hong JC, Yom SS, Solberg TD, Löck S, Seuntjens J, Park C, Lambin P. An artificial intelligence framework integrating longitudinal electronic health records with real-world data enables continuous pan-cancer prognostication. Nat Cancer. 2021 07; 2(7):709-722.  View on PubMed
  18. Chen WC, Baal UH, Baal JD, Pai JS, Boreta L, Braunstein SE, Raleigh DR. Efficacy and Safety of Stereotactic Radiosurgery for Brainstem Metastases: A Systematic Review and Meta-analysis. JAMA Oncol. 2021 Jul 01; 7(7):1033-1040.  View on PubMed
  19. Wu SY, Yee E, Vasudevan HN, Fogh SE, Boreta L, Braunstein SE, Hong JC. Risk Stratification for Imminent Risk of Death at the Time of Palliative Radiotherapy Consultation. JAMA Netw Open. 2021 07 01; 4(7):e2115641.  View on PubMed
  20. Ni L, Thomas HR, Raleigh DR, Boreta LC, Park CC, Braunstein SE. Residents-as-Teachers Curriculum for Radiation Oncology: A Targeted Needs Assessment. Int J Radiat Oncol Biol Phys. 2021 11 01; 111(3):638-642.  View on PubMed

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