Research Summary

Dr. Braunstein is a radiation oncologist with a clinical interest in the treatment of pediatric, central nervous system, and soft tissue malignancies. He has expertise in modern radiation therapy techniques including stereotactic radiotherapy (Gamma Knife, Cyberknife, Linac-based SBRT), intraoperative radiotherapy, and intensity modulated radiation therapy.

Dr. Braunstein earned his M.D. at New York University School of Medicine where he also obtained a Ph.D. studying molecular pathways by which cancer cells mediate response to radiation. He currently serves as Vice Chair and Clinical Director of Radiation Oncology. His research focus includes mitigation of early and late toxicity in treatment of pediatric malignancies as well as optimizing combination of immuno- and targeted-therapies in the management of primary and metastatic central nervous system malignancies.


University of California, San Francisco, 06/14, Radiation Oncology
Brighman and Women's Hospital, 06/10, Internal Medicine
New York University School of Medicine, M.D., Ph.D., 06/09

Honors & Awards

  • 2020
    UCSF Rap Award
  • 2019
    ARRO Teacher of the Year Award
  • 2018
    UCSF Rap Award
  • 2017
    UCSF Radiation Oncology-Radiology Award
  • 2016
    ARRO Teacher of the Year Award
  • 2015
    UCSF Patient Care Fund Award
  • 2014
    RSNA Roetgen Research Award
  • 2013
    UCSF Exceptional Physician Award

Selected Publications

  1. Morshed RA, Saggi S, Cummins DD, Molinaro AM, Young JS, Viner JA, Villanueva-Meyer JE, Goldschmidt E, Boreta L, Braunstein SE, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Aghi MK, Daras M. Identification of risk factors associated with leptomeningeal disease after resection of brain metastases. J Neurosurg. 2023 Jan 13; 1-12.  View on PubMed
  2. Singh R, Valluri A, Didwania P, Lehrer EJ, Baliga S, Hiniker S, Braunstein SE, Murphy ES, Lazarev S, Tinkle C, Terezakis S, Palmer JD. Efficacy and Safety of Stereotactic Body Radiation Therapy for Pediatric Malignancies: The LITE-SABR Systematic Review and Meta-Analysis. Adv Radiat Oncol. 2023 Mar-Apr; 8(2):101123.  View on PubMed
  3. Rogers CL, Pugh SL, Vogelbaum MA, Perry A, Ashby LS, Modi JM, Alleman AM, Barani IJ, Braunstein S, Bovi JA, de Groot JF, Whitton AC, Lindhorst SM, Deb N, Shrieve DC, Shu HK, Bloom B, Machtay M, Mishra MV, Robinson CG, Won M, Mehta MP. Low-risk meningioma: Initial outcomes from NRG Oncology/RTOG 0539. Neuro Oncol. 2023 01 05; 25(1):137-145.  View on PubMed
  4. Thomas HR, Braunstein SE, Golden DW, Du KL, Weiner AA, Bridges K, Vijayakumar S, McLean S, Edgar L, Fields EC. Milestones 2.0: Refining the Competency-Based Assessment of Radiation Oncology Medical Residents. Int J Radiat Oncol Biol Phys. 2023 Jan 01; 115(1):12-18.  View on PubMed
  5. Liu EK, Chen JJ, Braunstein S. Management of Adverse Radiation Effect Associated with Stereotactic Radiosurgery of Brain Metastasis in Multiple Sclerosis. Adv Radiat Oncol. 2023 Mar-Apr; 8(2):101150.  View on PubMed
  6. Kowalchuk RO, Niranjan A, Hess J, Antonios JP, Zhang MY, Braunstein S, Ross RB, Pikis S, Deibert CP, Lee CC, Yang HC, Langlois AM, Mathieu D, Peker S, Samanci Y, Rusthoven CG, Chiang V, Wei Z, Lunsford LD, Trifiletti DM, Sheehan JP. Stereotactic radiosurgery and local control of brain metastases from triple-negative breast cancer. J Neurosurg. 2022 Nov 25; 1-7.  View on PubMed
  7. Coleman C, Chen K, Lu A, Seashore E, Stoller S, Davis T, Braunstein S, Gupta N, Mueller S. Interdisciplinary care of children with diffuse midline glioma. Neoplasia. 2023 01; 35:100851.  View on PubMed
  8. Vasudevan HN, Susko MS, Ma L, Nakamura JL, Raleigh DR, Boreta L, Fogh S, Theodosopoulos PV, McDermott MW, Tsai KK, Sneed PK, Braunstein SE. Mutational status and clinical outcomes following systemic therapy with or without focal radiation for resected melanoma brain metastases. World Neurosurg. 2022 Nov 15.  View on PubMed
  9. Vargas E, Mummaneni PV, Rivera J, Huang J, Berven SH, Braunstein SE, Chou D. Wound complications in metastatic spine tumor patients with and without preoperative radiation. J Neurosurg Spine. 2023 Feb 01; 38(2):265-270.  View on PubMed
  10. Morrison MA, Walter S, Mueller S, Felton E, Jakary A, Stoller S, Molinaro AM, Braunstein SE, Hess CP, Lupo JM. Functional network alterations in young brain tumor patients with radiotherapy-induced memory impairments and vascular injury. Front Neurol. 2022; 13:921984.  View on PubMed
  11. Prasad RN, Perlow HK, Bovi J, Braunstein SE, Ivanidze J, Kalapurakal JA, Kleefisch C, Knisely JPS, Mehta MP, Prevedello DM, Raleigh DR, Mishra MV, Roberge D, Rogers CL, Palmer JD. 68Ga-DOTATATE PET: The Future of Meningioma Treatment. Int J Radiat Oncol Biol Phys. 2022 07 15; 113(4):868-871.  View on PubMed
  12. Keek SA, Beuque M, Primakov S, Woodruff HC, Chatterjee A, van Timmeren JE, Valli?res M, Hendriks LEL, Kraft J, Andratschke N, Braunstein SE, Morin O, Lambin P. Predicting Adverse Radiation Effects in Brain Tumors After Stereotactic Radiotherapy With Deep Learning and Handcrafted Radiomics. Front Oncol. 2022; 12:920393.  View on PubMed
  13. Vasudevan HN, Choudhury A, Hilz S, Villanueva-Meyer JE, Chen WC, Lucas CG, Braunstein SE, Oberheim Bush NA, Butowski N, Pekmezci M, McDermott MW, Perry A, Solomon DA, Magill ST, Raleigh DR. Intratumor and informatic heterogeneity influence meningioma molecular classification. Acta Neuropathol. 2022 09; 144(3):579-583.  View on PubMed
  14. Waqar M, Roncaroli F, Lehrer EJ, Palmer JD, Villanueva-Meyer J, Braunstein S, Hall E, Aznar M, De Witt Hamer PC, D'Urso PI, Trifiletti D, Quiñones-Hinojosa A, Wesseling P, Borst GR. Rapid early progression (REP) of glioblastoma is an independent negative prognostic factor: Results from a systematic review and meta-analysis. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac075.  View on PubMed
  15. Sneed PK, Chan JW, Ma L, Braunstein SE, Theodosopoulos PV, Fogh SE, Nakamura JL, Boreta L, Raleigh DR, Ziemer BP, Morin O, Hervey-Jumper SL, McDermott MW. Adverse radiation effect and freedom from progression following repeat stereotactic radiosurgery for brain metastases. J Neurosurg. 2023 01 01; 138(1):104-112.  View on PubMed
  16. Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW, Qiu Z, Martin MV, Susko MS, Braunstein SE, Bush NAO, Schulte JD, Butowski N, Sneed PK, Berger MS, Krogan NJ, Perry A, Phillips JJ, Solomon DA, Costello JF, McDermott MW, Rich JN, Raleigh DR. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet. 2022 05; 54(5):649-659.  View on PubMed
  17. Sperduto PW, De B, Li J, Carpenter D, Kirkpatrick J, Milligan M, Shih HA, Kutuk T, Kotecha R, Higaki H, Otsuka M, Aoyama H, Bourgoin M, Roberge D, Dajani S, Sachdev S, Gainey J, Buatti JM, Breen W, Brown PD, Ni L, Braunstein S, Gallitto M, Wang TJC, Shanley R, Lou E, Shiao J, Gaspar LE, Tanabe S, Nakano T, An Y, Chiang V, Zeng L, Soliman H, Elhalawani H, Cagney D, Thomas E, Boggs DH, Ahluwalia MS, Mehta MP. Graded Prognostic Assessment (GPA) for Patients With Lung Cancer and Brain Metastases: Initial Report of the Small Cell Lung Cancer GPA and Update of the Non-Small Cell Lung Cancer GPA Including the Effect of Programmed Death Ligand 1 and Other Prognostic Factors. Int J Radiat Oncol Biol Phys. 2022 09 01; 114(1):60-74.  View on PubMed
  18. Vo KT, DuBois SG, Neuhaus J, Braunstein SE, Weil BR, Naranjo A, Irtan S, Balaguer J, Matthay KK. Pattern and predictors of sites of relapse in neuroblastoma: A report from the International Neuroblastoma Risk Group (INRG) project. Pediatr Blood Cancer. 2022 09; 69(9):e29616.  View on PubMed
  19. Thomas NJ, Myall NJ, Sun F, Patil T, Mushtaq R, Yu C, Sinha S, Pollom EL, Nagpal S, Camidge DR, Rusthoven CG, Braunstein SE, Wakelee HA, McCoach CE. In Response to: "Comparing Addition of Radiotherapy in EGFR- and ALK-Positive NSCLC With Brain Metastases: Are We Evaluating the Optimal Endpoint?" J Thorac Oncol. 2022 02; 17(2):e12-e14.  View on PubMed
  20. Luks TL, Villanueva-Meyer JE, Weyer-Jamora C, Gehring K, Jakary A, Hervey-Jumper SL, Braunstein SE, Bracci PM, Brie MS, Smith EM, Chang SM, Taylor JW. T2 FLAIR Hyperintensity Volume Is Associated With Cognitive Function and Quality of Life in Clinically Stable Patients With Lower Grade Gliomas. Front Neurol. 2021; 12:769345.  View on PubMed

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