Research Summary

Dr. Caroline H. Shiboski cares for adult and pediatric patients with oral mucosal diseases and other oral disorders. These include inflammatory conditions (lichen planus, pemphigus, pemphigoid), infectious diseases (such as candidiasis and herpes virus infections), the oral manifestations of Sjögren's disease, certain oral pain conditions (such as burning mouth syndrome) and the oral complications of graft-versus-host disease, which may develop following a stem cell transplant. She is also involved with the initial diagnosis of oral cancer and precancerous conditions, and works closely with the head and neck surgery team for timely referral and treatment.

Shiboski earned her doctor of dental surgery degree from Paris Descartes University in France. She completed a residency in oral medicine at UCSF. She earned a master of public health degree in epidemiology and a doctorate in epidemiology at the University of California, Berkeley.

Shiboski's research focuses on the possible oral manifestations of immune system dysfunction, in particular Sjögren's disease (SjD), and she has been funded through NIH grants and contracts consistently since 1994. Dr Shiboski was part of the team that established the NIDCR-funded Sjögren’s International Collaborative Clinical Alliance (SICCA) in 2003, and has served as its Principal Investigator (PI) since 2010 as SICCA continues to yield important research aimed at identifying therapeutic targets for SjD. She also led a team of international experts in the development and validation of the current classification criteria for SjD approved by the American College of Rheumatology and the European Alliance of Associations for Rheumatology in 2016. Dr Shiboski is the current contact PI for the Sjögren’s Team for Accelerating Medicines Partnership that is one of four disease teams participating in the Accelerating Medicines Partnership® Autoimmune and Immune-Mediated Diseases (AMP®AIM) Program.

Shiboski is a member of the American Association for Dental Research, International Association for Dental Research, American Academy of Oral Medicine, and American College of Rheumatology.

Research Funding

  • September 1, 2019 - April 30, 2028 - Sjögren?s International Collaborative Clinical Alliance Next Generation Studies (SICCA-NextGen) , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R56DE028891
  • March 7, 2022 - December 31, 2026 - Sj?gren?s Team for Accelerating Medicines Partnership (STAMP) , Principal Investigator . Sponsor: NIH, Sponsor Award ID: UC2DE032254
  • March 7, 2022 - December 31, 2026 - Sjögren's Team for Accelerated Medicines Partnership (STAMP) , Contact PI . Sponsor: NIH/NIDCR, Sponsor Award ID: UC2AR081028
  • August 1, 2015 - July 31, 2025 - Pediatric HIV/AIDS Cohort Study (PHACS) , PI UCFS site . Sponsor: NIH/NICHD, Sponsor Award ID: P01HD103133
  • June 1, 2020 - May 31, 2025 - Sj?gren's International Collaborative Clinical Alliance Next Generation Studies (SICCA-NextGen) , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01DE028891
  • September 9, 2020 - August 31, 2022 - Epigenetic and transcriptomic determinants of Sjogren's Syndrome subtypes utilizing data from the Sjogren's International Collaborative Clinical Alliance (SICCA) cohort , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R03DE029800
  • August 1, 1993 - December 31, 2019 - The Connie Wofsy Women's HIV Study , Co-Investigator . Sponsor: NIH, Sponsor Award ID: U01AI034989
  • September 30, 2013 - September 29, 2018 - IGF::OT::IGF Sjogren's International Collaborative Clinical Alliance (SICCA) Bior , Principal Investigator . Sponsor: NIH, Sponsor Award ID: 268201300057C-0-0-1
  • September 30, 2003 - May 18, 2012 - International Research Registry Network for Sjogren's Syndrome , Principal Investigator . Sponsor: NIH, Sponsor Award ID: N01DE32636-23-0-1
  • August 1, 2003 - May 31, 2007 - Oral Health Outcomes in Pediatric Transplant Recipients , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R03DE014939
  • May 1, 2001 - April 30, 2007 - ORAL DISEASE AMONG RENAL TRANSPLANT RECIPIENTS , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K23DE000443
  • September 30, 1994 - September 29, 2000 - ORAL HEALTH ASSESSMENT OF HIV POSITIVE WOMEN , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K15DE000359

Education

Lycee Rabelais, Versailles Academy, France, BS, 1978, Biology, Math, Physics
Universite R. Descartes, Paris V, France, DDS, 1984, General Dentistry
University of California San Francisco, Certificate, 1991, Advanced General Dentistry
University of California, Berkeley, MPH, 1992, Epidemiology
University of California San Francisco, Certificate, 1993, Dental Public Health
University of California San Francisco, Certificate, 1994, Dental Clinical Epidemiology
University of California, Berkeley, PhD, 1997, Epidemiology
University of California San Francisco, Certificate, 1998, Oral Medicine

Honors & Awards

  • 1984
    Received High Honor for doctoral thesis titled "La prevention bucco-dentaire au Danemark"
  • 1987
    "Michele Bardet-Viatte Award" for best publication on Dental Health Promotion in Departement des Yvelines, France
  • 1994
    Dentist Scientist Award, Department of Stomatology, University of California San Francisco, CA
  • 2001
    K23 award, Department of Stomatology, University of California San Francisco, CA
  • 2001
    Diplomate of the American Academy of Oral Medicine
  • 2001
    Dean's Creativity fund Award
  • 2003
    Academic Senate New Investigator Award
  • 2004
    Teacher of the Year Award, Department of Stomatology, UCSF

Selected Publications

  1. Al-Amad SH, Bankvall M, Okoh M, Smith DK, Kerr AR, Sollecito TP, Peterson DE, Elad S, Warnakulasuriya S, Greenberg MS, Farag AM, Gueiros LA, Shiboski CH. World Workshop on Oral Medicine VIII: barriers to Research in Oral Medicine: results from a global survey. Oral Surg Oral Med Oral Pathol Oral Radiol. 2023 Jul 14. View on PubMed
  2. Chi C, Solomon O, Shiboski C, Taylor KE, Quach H, Quach D, Barcellos LF, Criswell LA. Identification of Sjögren's syndrome patient subgroups by clustering of labial salivary gland DNA methylation profiles. PLoS One. 2023; 18(3):e0281891. View on PubMed
  3. Avenetti DM, Martin MA, Gansky SA, Ramos-Gomez FJ, Hyde S, Van Horn R, Jue B, Rosales GF, Cheng NF, Shiboski CH. Calibration and reliability testing of a novel asynchronous photographic plaque scoring system in young children. J Public Health Dent. 2023 03; 83(1):108-115. View on PubMed
  4. Khatri B, Tessneer KL, Rasmussen A, Aghakhanian F, Reksten TR, Adler A, Alevizos I, Anaya JM, Aqrawi LA, Baecklund E, Brun JG, Bucher SM, Eloranta ML, Engelke F, Forsblad-d'Elia H, Glenn SB, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kvarnström M, Kelly JA, Li H, Mandl T, Martín J, Nocturne G, Norheim KB, Palm Ø, Skarstein K, Stolarczyk AM, Taylor KE, Teruel M, Theander E, Venuturupalli S, Wallace DJ, Grundahl KM, Hefner KS, Radfar L, Lewis DM, Stone DU, Kaufman CE, Brennan MT, Guthridge JM, James JA, Scofield RH, Gaffney PM, Criswell LA, Jonsson R, Eriksson P, Bowman SJ, Omdal R, Rönnblom L, Warner B, Rischmueller M, Witte T, Farris AD, Mariette X, Alarcon-Riquelme ME, PRECISESADS Clinical Consortium, Shiboski CH, Sjögren’s International Collaborative Clinical Alliance (SICCA), Wahren-Herlenius M, Ng WF, UK Primary Sjögren’s Syndrome Registry, Sivils KL, Adrianto I, Nordmark G, Lessard CJ. Author Correction: Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells. Nat Commun. 2023 Feb 03; 14(1):598. View on PubMed
  5. Alsafwani Z, Aljishi M, Shiboski C, Jordan R, Villa A. Oral manifestations of delusional infestation: a case series. BMC Oral Health. 2022 12 29; 22(1):652. View on PubMed
  6. Shiboski CH. Deborah Greenspan: A pioneer in the field of oral HIV disease. Oral Dis. 2023 Mar; 29 Suppl 1:886-889. View on PubMed
  7. Khatri B, Tessneer KL, Rasmussen A, Aghakhanian F, Reksten TR, Adler A, Alevizos I, Anaya JM, Aqrawi LA, Baecklund E, Brun JG, Bucher SM, Eloranta ML, Engelke F, Forsblad-d'Elia H, Glenn SB, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kvarnström M, Kelly JA, Li H, Mandl T, Martín J, Nocturne G, Norheim KB, Palm Ø, Skarstein K, Stolarczyk AM, Taylor KE, Teruel M, Theander E, Venuturupalli S, Wallace DJ, Grundahl KM, Hefner KS, Radfar L, Lewis DM, Stone DU, Kaufman CE, Brennan MT, Guthridge JM, James JA, Scofield RH, Gaffney PM, Criswell LA, Jonsson R, Eriksson P, Bowman SJ, Omdal R, Rönnblom L, Warner B, Rischmueller M, Witte T, Farris AD, Mariette X, Alarcon-Riquelme ME, PRECISESADS Clinical Consortium, Shiboski CH, Sjögren’s International Collaborative Clinical Alliance (SICCA), Wahren-Herlenius M, Ng WF, UK Primary Sjögren’s Syndrome Registry, Sivils KL, Adrianto I, Nordmark G, Lessard CJ. Author Correction: Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells. Nat Commun. 2022 Oct 31; 13(1):6519. View on PubMed
  8. Nortey J, Shiboski C, Rose-Nussbaumer J, Bunya VY, Lietman T, Gonzales JA. How Are Sicca Signs and Symptoms Associated With Depression Among Men Classified With and Without Sjögren Disease? Am J Ophthalmol. 2023 03; 247:96-102. View on PubMed
  9. Khatri B, Tessneer KL, Rasmussen A, Aghakhanian F, Reksten TR, Adler A, Alevizos I, Anaya JM, Aqrawi LA, Baecklund E, Brun JG, Bucher SM, Eloranta ML, Engelke F, Forsblad-d'Elia H, Glenn SB, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kvarnström M, Kelly JA, Li H, Mandl T, Martín J, Nocturne G, Norheim KB, Palm Ø, Skarstein K, Stolarczyk AM, Taylor KE, Teruel M, Theander E, Venuturupalli S, Wallace DJ, Grundahl KM, Hefner KS, Radfar L, Lewis DM, Stone DU, Kaufman CE, Brennan MT, Guthridge JM, James JA, Scofield RH, Gaffney PM, Criswell LA, Jonsson R, Eriksson P, Bowman SJ, Omdal R, Rönnblom L, Warner B, Rischmueller M, Witte T, Farris AD, Mariette X, Alarcon-Riquelme ME, PRECISESADS Clinical Consortium, Shiboski CH, Sjögren’s International Collaborative Clinical Alliance (SICCA), Wahren-Herlenius M, Ng WF, UK Primary Sjögren’s Syndrome Registry, Sivils KL, Adrianto I, Nordmark G, Lessard CJ. Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells. Nat Commun. 2022 07 27; 13(1):4287. View on PubMed
  10. Vistoso Monreal A, Polonsky G, Shiboski C, Sankar V, Villa A. Salivary Gland Dysfunction Secondary to Cancer Treatment. Front Oral Health. 2022; 3:907778. View on PubMed
  11. Zahra Ali Alsafwani, Caroline Shiboski, Alessandro Villa. TELEMEDICINE FOR SYMPTOMS MANAGEMENT IN ORAL MEDICINE. Oral Surgery Oral Medicine Oral Pathology and Oral Radiology. 2022 Apr 14; 133(5):e120. View on PubMed
  12. Alsafwani Z, Shiboski C, Villa A. The role of telemedicine for symptoms management in oral medicine: a retrospective observational study. BMC Oral Health. 2022 03 27; 22(1):92. View on PubMed
  13. Gebreegziabher EA, Oldenburg CE, Shiboski SC, Baer AN, Jordan RC, Rose-Nussbaumer JR, Bunya VY, Akpek EK, Criswell LA, Shiboski CH, Lietman TM, Gonzales JA. Associations Between Smoking and Primary Sjögren Syndrome Classification Using the Sjögren's International Collaborative Clinical Alliance Cohort. ACR Open Rheumatol. 2022 Mar; 4(3):231-237. View on PubMed
  14. Caroline H. Shiboski, Troy E. Daniels. Historical background, classification, and diagnostic criteria. . 2021 Apr 1; 5-12. View on PubMed
  15. Abrar Bakhsh, Caroline H. Shiboski. Racial Disparity Among Adults With Oral Cancer Persists in the U.S. from 2000 to 2017. Journal of the California Dental Association. 2021 Apr 1; 49(4):207-214. View on PubMed
  16. Gebreegziabher EA, Bunya VY, Baer AN, Jordan RC, Akpek EK, Rose-Nussbaumer J, Criswell LA, Shiboski CH, Lietman TM, Gonzales JA. Neuropathic Pain in the Eyes, Body, and Mouth: Insights from the Sjögren's International Collaborative Clinical Alliance. Pain Pract. 2021 07; 21(6):630-637. View on PubMed
  17. Villa A, Sankar V, Shazib MA, Ramos D, Veluppillai P, Wu A, Shiboski C. Patient and providers' satisfaction with tele(oral)medicine during the COVID-19 pandemic. Oral Dis. 2022 04; 28 Suppl 1:929-932. View on PubMed
  18. Schulte F, King OD, Paster BJ, Moscicki AB, Yao TJ, Van Dyke RB, Shiboski C, Ryder M, Seage G, Hardt M, Pediatric HIV/AIDS Cohort Study. Salivary metabolite levels in perinatally HIV-infected youth with periodontal disease. Metabolomics. 2020 09 11; 16(9):98. View on PubMed
  19. Gonzales JA, Shiboski SC, Bunya VY, Akpek EK, Rose-Nussbaumer J, Seitzman GD, Criswell LA, Shiboski CH, Lietman TM. Ocular Clinical Signs and Diagnostic Tests Most Compatible With Keratoconjunctivitis Sicca: A Latent Class Approach. Cornea. 2020 Aug; 39(8):1013-1016. View on PubMed
  20. Villa A, Sankar V, Shiboski C. Tele(oral)medicine: A new approach during the COVID-19 crisis. Oral Dis. 2021 04; 27 Suppl 3:744-745. View on PubMed

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