My main research interests include identifying clinical and pathologic determinants of prostate cancer recurrence, progression, and mortality; discovering novel biomarkers for prostate cancer diagnostics and prognostics; developing evidence-based guidelines for improved management of prostate cancer patients; and examining the impact of lifestyle on health-related quality of life and survivorship among men with prostate cancer. Since 1995, I have been PI of CaPSURE™, a national disease registry study of over 14,000 men with prostate cancer treated at 40+ sites. At UCSF, we have developed a novel program in clinical management of and research on active surveillance for men with low-burden prostate cancer. We are committed to reducing the burden of prostate cancer treatment (physical, psychological and monetary). In 2007, I and colleagues initiated the Prostate Cancer Active Surveillance Study (PASS), a large multi-institutional cohort of men on active surveillance, designed to examine quantitative metabolic, molecular, and physiologic imaging biomarkers and lifestyle factors as novel predictors of prostate cancer progression. We aim to better determine which patients may safely avoid radical treatment, while concurrently identifying men who may benefit from early treatment instead of active surveillance.
September 30, 2008 - July 31, 2018 - UCSF KURe Career Development Program, Co-Principal Investigator. Sponsor: NIH/NIDDK, Sponsor Award ID: K12DK083021
August 5, 1999 - September 29, 2012 - Cancer Center Support Grant, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: P30CA082103
September 30, 2009 - August 31, 2012 - Effectiveness of Early Stage Prostate Cancer Treatment, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: RC1CA146596
September 30, 2006 - September 29, 2011 - Male Reproductive Health Research Career Development Program, Principal Investigator. Sponsor: NIH/NICHD, Sponsor Award ID: K12HD053943
University of California, Berkeley, BA, 1974, Zoology
Georgetown University School of Medicine, Washington, D.C., MD, 1979, Medicine
University of California, Berkeley, MPH, 2008