Research Summary

Soonmee Cha, MD, is a Professor In Residence of Radiology and Neurological Surgery at the University of California, San Francisco. She is the Diagnostic Radiology Residency Program Director, and she is Radiology's Vice-Chair of Education. Dr. Cha has focused on the importance of validating the usefulness of MRI as a tool for brain tumor diagnosis, monitoring and identifying therapy endpoints. She obtained her medical degree from Georgetown University, School of Medicine, Washington in 1991. She completed her Diagnostic Radiology residency from North Shore University Hospital, Cornell University Medical College in New York, followed by a fellowship in Neuroradiology from New York University Medical Center in 1998.

Dr. Cha is committed to a career dedicated to patient-oriented research in the field of brain tumor imaging. She believes that non-invasive imaging technology will make important contributions to the health of patients through improving the specificity and precision of diagnosis and treatment monitoring, which will have significant impact on therapeutic decisions.

The main focus of Dr. Cha’s research is to identify reliable surrogate markers of prognosis and therapeutic efficacy by quantitative MR imaging methods in patients with brain tumors. She believes that by using MR imaging techniques such perfusion MR imaging, diffusion-weighted imaging, and 3-dimensional proton magnetic resonance spectroscopic imaging, detection of changes in tumor angiogenesis, cellularity, invasion, tumor hypoxia, and metabolic burden can be accurately measured and will provide more specific information about patient’s early response to therapy in the context of tumor growth.

Dr. Cha has been awarded several NIH grants, serving as Principal Investigator and Co-Principal Investigator on many NIH projects. She has published 87 articles, and she has written 77 peer-reviewed articles and 4 book chapters.

Expertise:
Neuroradiology

Specialty:
Brain tumor imaging

Professional Interests:
Brain tumor, brain cancer, glioblastoma multiforme, gliomas, primary cerebral lymphoma, angiogenesis, hypoxia, invasion, perfusion MR imaging, diffusion-weighted imaging, molecular imaging, biomarkers, microarray, genomics, neural stem cell

Education and Training:
• Medical School: Georgetown University, College of Arts and Sciences, Washington, District of Columbia
• Internship: Georgetown University Fairfax Hospital, Falls Church
• Residency: North Shore University Hospital, Cornell University Medical College, Manhasset, New York - Diagnostic Radiology
• Fellowship: New York University Medical Center, New York - Neuroradiology

Research Funding

  • August 1, 2003 - April 30, 2009 - Brain Tumor Imaging: Quantitative MRI and 1H MRS, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: K23NS045013
  • August 1, 2003 - April 30, 2009 - Brain Tumor Imaging: Quantitative MRI and 1H MRS, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: K23NS045013
  • August 1, 2003 - April 30, 2009 - Brain Tumor Imaging: Quantitative MRI and 1H MRS, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: K23NS045013
  • August 1, 2003 - April 30, 2009 - Brain Tumor Imaging: Quantitative MRI and 1H MRS, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: K23NS045013

Education

Georgetown University, Washington, DC, B.S., 1983-1987, Chemistry
Georgetown University, Washington, DC, M.D., 1987-1991, Medicine
Georgetown University Hospital, Washington, DC, Internship, 1991-1992, Transitional Internship
North Shore University Hospital, Manhasset, NY, Residency, 1992-1996, Diagnostic Radiology
New York University Medical Center, New York, NY, Fellowship, 1996-1998, Neuroradiology

Honors & Awards

  • April 2000
    ASNR Outstanding Presentation Award in General Neuroradiology at the 38th Annual Meeting in Atlanta, GA.
  • 1995
    Certificate of Merit Award, Scientific exhibit at RSNA
  • 1994
    Certificate of Merit Award, Scientific exhibit at RSNA

Selected Publications

  1. Cluceru J, Nelson SJ, Wen Q, Phillips JJ, Shai A, Molinaro AM, Alcaide-Leon P, Olson MP, Nair D, LaFontaine M, Chunduru P, Villanueva-Meyer JE, Cha S, Chang SM, Berger MS, Lupo JM. Recurrent tumor and treatment-induced effects have different MR signatures in contrast enhancing and non-enhancing lesions of high-grade gliomas. Neuro Oncol. 2020 10 14; 22(10):1516-1526.  View on PubMed
  2. Choi ES, Cha SM, Shin HD. Autogenous Bone Graft With Kirschner Wire Fixation Could Be a Reliable Treatment Option for Scaphoid Nonunion in Adolescents. J Pediatr Orthop. 2020 Sep; 40(8):e708-e711.  View on PubMed
  3. Calabrese E, Villanueva-Meyer JE, Cha S. A fully automated artificial intelligence method for non-invasive, imaging-based identification of genetic alterations in glioblastomas. Sci Rep. 2020 07 16; 10(1):11852.  View on PubMed
  4. Cha SM, Shin HD. Features of the Ulnar Nerve Predicting Postoperative Prognosis in Idiopathic Cubital Tunnel Syndrome: Three Distinct Features of the Ulnar Nerve. Ann Plast Surg. 2020 07; 85(1):50-55.  View on PubMed
  5. Cha SM, Shin HD, Choi ES. Long-term outcomes of distal humeral epiphyseal separations treated via closed reduction and pinning under arthrogram. Injury. 2020 Feb; 51(2):207-211.  View on PubMed
  6. Young JS, Morshed RA, Mansoori Z, Cha S, Berger MS. Disruption of Frontal Aslant Tract Is Not Associated with Long-Term Postoperative Language Deficits. World Neurosurg. 2020 Jan; 133:192-195.  View on PubMed
  7. Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, McDermott M, Berger M, Raffel C, Gupta N, Sun PP, Li Y, Shah V, Cha S, Braunstein S, Raleigh DR, Samuel D, Scharnhorst D, Fata C, Guo H, Moes G, Kim JYH, Koschmann C, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Phillips JJ, Tihan T, Bollen AW, Perry A, Solomon DA. Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas. Acta Neuropathol. 2019 11; 138(5):877-881.  View on PubMed
  8. Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA. High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis. Brain Pathol. 2020 01; 30(1):46-62.  View on PubMed
  9. Cha SM, Shin HD, Kim KH, Kim JH. Histological Evidence of Intrinsic Muscle Degeneration in Compression Ulnar Neuropathy. Ann Plast Surg. 2019 05; 82(5):541-545.  View on PubMed
  10. Cha SM, Shin HD, Song SH. Cross-sectional Area Just Proximal to the Carpal Tunnel According to the Ulnar Variances: Positive Ulnar Variance and Carpal Tunnel Syndrome. Ann Plast Surg. 2019 01; 82(1):76-81.  View on PubMed
  11. Behr SC, Villanueva-Meyer JE, Li Y, Wang YH, Wei J, Moroz A, Lee JK, Hsiao JC, Gao KT, Ma W, Cha S, Wilson DM, Seo Y, Nelson SJ, Chang SM, Evans MJ. Targeting iron metabolism in high-grade glioma with 68Ga-citrate PET/MR. JCI Insight. 2018 11 02; 3(21).  View on PubMed
  12. Aoki Y, Ochiai K, Lim S, Aoki D, Kamiura S, Lin H, Katsumata N, Cha SD, Kim JH, Kim BG, Hirashima Y, Fujiwara K, Kim YT, Kim SM, Chung HH, Chang TC, Kamura T, Takizawa K, Takeuchi M, Kang SB. Phase III study of cisplatin with or without S-1 in patients with stage IVB, recurrent, or persistent cervical cancer. Br J Cancer. 2018 08; 119(5):530-537.  View on PubMed
  13. Merritt BA, Henry TS, Cha S, Ordovas KG, Kallianos KG, Elicker BM, Hope MD, Naeger DM. Tailoring Radiology Resident Education Using Aggregated Missed-Cases Data. J Am Coll Radiol. 2018 Jul; 15(7):1013-1015.  View on PubMed
  14. Aboian MS, Kline CN, Li Y, Solomon DA, Felton E, Banerjee A, Braunstein SE, Mueller S, Dillon WP, Cha S. Early detection of recurrent medulloblastoma: the critical role of diffusion-weighted imaging. Neurooncol Pract. 2018 Nov; 5(4):234-240.  View on PubMed
  15. Villanueva-Meyer JE, Wood MD, Choi BS, Mabray MC, Butowski NA, Tihan T, Cha S. MRI Features and IDH Mutational Status of Grade II Diffuse Gliomas: Impact on Diagnosis and Prognosis. AJR Am J Roentgenol. 2018 Mar; 210(3):621-628.  View on PubMed
  16. Autry A, Phillips JJ, Maleschlijski S, Roy R, Molinaro AM, Chang SM, Cha S, Lupo JM, Nelson SJ. Characterization of Metabolic, Diffusion, and Perfusion Properties in GBM: Contrast-Enhancing versus Non-Enhancing Tumor. Transl Oncol. 2017 Dec; 10(6):895-903.  View on PubMed
  17. Villanueva-Meyer JE, Mabray MC, Cha S. Current Clinical Brain Tumor Imaging. Neurosurgery. 2017 Sep 01; 81(3):397-415.  View on PubMed
  18. Kline CN, Packer RJ, Hwang EI, Raleigh DR, Braunstein S, Raffel C, Bandopadhayay P, Solomon DA, Aboian M, Cha S, Mueller S. Case-based review: pediatric medulloblastoma. Neurooncol Pract. 2017 Sep; 4(3):138-150.  View on PubMed
  19. Tremblay MA, Villanueva-Meyer JE, Cha S, Tihan T, Gelfand JM. Clinical and imaging correlation in patients with pathologically confirmed tumefactive demyelinating lesions. J Neurol Sci. 2017 Oct 15; 381:83-87.  View on PubMed
  20. Cha SM, Choi BS, Shin HD. Radiological degenerative changes in the distal radioulnar joint after ulnar shortening osteotomy in patients with idiopathic ulnar impaction syndrome: Analysis of factors affecting degenerative lesions. J Orthop Sci. 2017 Nov; 22(6):1042-1048.  View on PubMed

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