My main research interests are in understanding how diet, exercise, other lifestyle factors, and genetics contribute to cancer progression and death. Our program aims to identify modifiable lifestyle risk factors for cancer progression, use this information to better understand cancer biology, and inform public health guidelines. I have worked in this area, with a specific focus on prostate cancer, for ~20 years. Our work is highly collaborative - our clinical and translational studies work to identify risk-reduction strategies for men with or at high risk for prostate cancer, evaluate novel molecular markers of prostate cancer aggressiveness that may improve screening, diagnosis, or prognosis of clinically relevant disease, and improve cancer survivorship for the millions of men living with prostate cancer worldwide.
I lead the Diet and Lifestyle Study within the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE); am PI of a randomized clinical trial examining an exercise intervention among men pursuing active surveillance for prostate cancer; co-PI on a large Dept. of Defense Translational Impact Award focused on improving risk stratification and decision support for men considering active surveillance for low risk prostate cancer; serve on the steering committee for a global clinical trial of exercise among men with metastatic prostate cancer; and am co-investigator on a trial examining a 2 year remotely monitored blended diet and exercise intervention for men undergoing surgery for prostate cancer. I also collaborate with team members on lifestyle interventions and observational research in bladder and colorectal cancer survivors.
April 14, 2014 - February 28, 2021 - Effect of Aerobic Exercise on Genomic Signatures of Prostate Cancer Prognosis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA181802
September 1, 2006 - August 31, 2011 - Prostate Microenvironmental &Prostate Cancer Progression , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA106947
Harvard College, Cambridge, MA , B.A., 1994, Applied Math in Biology
Harvard School of Public Health, Boston, MA, ScD, 11/98, Epidemiology (Cancer)
Harvard School of Public Health, Boston, MA, 11/98-11/00, Postdoctoral Fellow-Epidemiology