Research Summary

William C. Chen, MD, is a Clinical Instructor and post-doctoral fellow in the Department of Radiation Oncology at the University of California, San Francisco. His research interests focus on development and translation of molecular biomarkers for meningioma and other central nervous system (CNS) malignancies, and on understanding the role of chromosomal instability and immune dysregulation in meningioma radiotherapy resistance.

Education

MD, 05/2018 - , University of California, San Francisco
BS, 05/2012 - Biomedical Engineering, Johns Hopkins University

Honors & Awards

  • 2023
    Society for Neuro-Oncology (SNO) Radiation Award
  • 2023
    Radiological Society of North America Roentgen Resident/Fellow Research Award
  • 2023
    Bradley Stuart Beller Endowed Special Merit Award, American Society of Clinical Oncology (ASCO)
  • 2022
    Young Investigator Award, American Society of Clinical Oncology (ASCO)
  • 2022
    Bradley Stuart Beller Endowed Special Merit Award, American Society of Clinical Oncology (ASCO)
  • 2022
    Young Oncologist Travel Grant Award, American Radium Society (ARS)
  • 2021
    Brain Tumor SPORE Developmental Research Grant, UCSF
  • 2021
    Clinical Trials Workshop Scholar, Society of Neuro-Oncology (SNO)
  • 2021
    Clinical and Translational Institute Catalyst Award, UCSF
  • 2021
    Clinical Informatics and Data Science Pathway Program, UCSF
  • 2021
    Clinical and Translational Institute Resident Research Funding Award, UCSF

Selected Publications

  1. Lucas CH, Mirchia K, Seo K, Najem H, Chen W, Zakimi N, Choudhury A, Liu SJ, Phillips J, Magill S, Horbinski C, Solomon D, Perry A, Vasudevan H, Heimberger A, Raleigh D. Spatial genomic, biochemical, and cellular mechanisms drive meningioma heterogeneity and evolution. Res Sq. 2023 May 15.  View on PubMed
  2. Choudhury A, Chen WC, Lucas CG, Bayley JC, Harmanci AS, Maas SLN, Santagata S, Klisch T, Perry A, Bi WL, Sahm F, Patel AJ, Magill ST, Raleigh DR. Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features. Neuro Oncol. 2023 03 14; 25(3):520-530.  View on PubMed
  3. Khan AB, English CW, Chen WC, Athukuri P, Bayley JC, Brandt VL, Shetty A, Hadley CC, Choudhury A, Lu HC, Harmanci AO, Harmanci AS, Magill ST, Raleigh DR, Klisch TJ, Patel AJ. Even heterozygous loss of CDKN2A/B greatly accelerates recurrence in aggressive meningioma. Acta Neuropathol. 2023 04; 145(4):501-503.  View on PubMed
  4. Chen WC, Perlow HK, Choudhury A, Nguyen MP, Mirchia K, Youngblood MW, Lucas CG, Palmer JD, Magill ST, Raleigh DR. Radiotherapy for meningiomas. J Neurooncol. 2022 Nov; 160(2):505-515.  View on PubMed
  5. Nguyen MP, Seo K, Eaton CD, Lucas CG, Chen WC, Choudhury A, Young JS, Raleigh DR. A case (report) for mechanistic validation of meningioma molecular therapies. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac162.  View on PubMed
  6. Vasudevan HN, Choudhury A, Hilz S, Villanueva-Meyer JE, Chen WC, Lucas CG, Braunstein SE, Oberheim Bush NA, Butowski N, Pekmezci M, McDermott MW, Perry A, Solomon DA, Magill ST, Raleigh DR. Intratumor and informatic heterogeneity influence meningioma molecular classification. Acta Neuropathol. 2022 09; 144(3):579-583.  View on PubMed
  7. Nguyen MP, Morshed RA, Dalle Ore CL, Cummins DD, Saggi S, Chen WC, Choudhury A, Ravi A, Raleigh DR, Magill ST, McDermott MW, Theodosopoulos PV. Supervised machine learning algorithms demonstrate proliferation index correlates with long-term recurrence after complete resection of WHO grade I meningioma. J Neurosurg. 2023 01 01; 138(1):86-94.  View on PubMed
  8. Choudhury A, Magill ST, Eaton CD, Prager BC, Chen WC, Cady MA, Seo K, Lucas CG, Casey-Clyde TJ, Vasudevan HN, Liu SJ, Villanueva-Meyer JE, Lam TC, Pu JK, Li LF, Leung GK, Swaney DL, Zhang MY, Chan JW, Qiu Z, Martin MV, Susko MS, Braunstein SE, Bush NAO, Schulte JD, Butowski N, Sneed PK, Berger MS, Krogan NJ, Perry A, Phillips JJ, Solomon DA, Costello JF, McDermott MW, Rich JN, Raleigh DR. Meningioma DNA methylation groups identify biological drivers and therapeutic vulnerabilities. Nat Genet. 2022 05; 54(5):649-659.  View on PubMed
  9. Chen WC, Lafreniere M, Phuong C, Liu SJ, Baal JD, Lometti M, Morin O, Ziemer B, Vasudevan HN, Lucas CG, Hervey-Jumper SL, Theodosopoulos PV, Magill ST, Fogh S, Nakamura JL, Boreta L, Sneed PK, McDermott MW, Raleigh DR, Braunstein SE. Resection with intraoperative cesium-131 brachytherapy as salvage therapy for recurrent brain tumors. J Neurosurg. 2022 Jan 21; 1-7.  View on PubMed
  10. Zhao CW, Gebre R, Baykara Y, Chen W, Vitkovskiy P, Li N, Johnson M, Chen EY, Kluger D, Blumenfeld H. Reliability of patient self-report of cognition, awareness, and consciousness during seizures. Ann Clin Transl Neurol. 2022 01; 9(1):16-29.  View on PubMed
  11. Kumar A, Martin R, Chen W, Bauerschmidt A, Youngblood MW, Cunningham C, Si Y, Ezeani C, Kratochvil Z, Bronen J, Thomson J, Riordan K, Yoo JY, Shirka R, Manganas L, Krestel H, Hirsch LJ, Blumenfeld H. Simulated driving in the epilepsy monitoring unit: Effects of seizure type, consciousness, and motor impairment. Epilepsia. 2022 01; 63(1):e30-e34.  View on PubMed
  12. Chen WC, Boreta L, Braunstein SE, Rabow MW, Kaplan LE, Tenenbaum JD, Morin O, Park CC, Hong JC. Association of mental health diagnosis with race and all-cause mortality after a cancer diagnosis: Large-scale analysis of electronic health record data. Cancer. 2022 01 15; 128(2):344-352.  View on PubMed
  13. Morin O, Vallières M, Braunstein S, Ginart JB, Upadhaya T, Woodruff HC, Zwanenburg A, Chatterjee A, Villanueva-Meyer JE, Valdes G, Chen W, Hong JC, Yom SS, Solberg TD, Löck S, Seuntjens J, Park C, Lambin P. An artificial intelligence framework integrating longitudinal electronic health records with real-world data enables continuous pan-cancer prognostication. Nat Cancer. 2021 07; 2(7):709-722.  View on PubMed
  14. Chen WC, Baal UH, Baal JD, Pai JS, Boreta L, Braunstein SE, Raleigh DR. Efficacy and Safety of Stereotactic Radiosurgery for Brainstem Metastases: A Systematic Review and Meta-analysis. JAMA Oncol. 2021 Jul 01; 7(7):1033-1040.  View on PubMed
  15. Susko MS, Chen WC, Vasudevan HN, Magill ST, Lucas CG, Oberheim Bush NA, Solomon DA, Theodosopoulos PV, McDermott MW, Villanueva-Meyer JE, Boreta L, Nakamura JL, Sneed PK, Braunstein SE, Raleigh DR. Letter: Patterns of Intermediate- and High-Risk Meningioma Recurrence After Treatment With Postoperative External Beam Radiotherapy. Neurosurgery. 2021 06 15; 89(1):E99-E101.  View on PubMed
  16. Baal JD, Chen WC, Baal U, Wagle S, Baal JH, Link TM, Bucknor MD. Efficacy and safety of magnetic resonance-guided focused ultrasound for the treatment of painful bone metastases: a systematic review and meta-analysis. Skeletal Radiol. 2021 Dec; 50(12):2459-2469.  View on PubMed
  17. Pan S, Baal JD, Chen WC, Baal U, Pai JS, Baal JH, Zagoria R. Image-Guided Percutaneous Ablation of Adrenal Metastases: A Meta-Analysis of Efficacy and Safety. J Vasc Interv Radiol. 2021 04; 32(4):527-535.e1.  View on PubMed
  18. Chen WC, Li Y, Lazar A, Altun A, Descovich M, Nano T, Ziemer B, Sudhyadhom A, Cunha A, Thomas H, Gottschalk A, Hsu IC, Roach M. Stereotactic Body Radiation Therapy and High-Dose-Rate Brachytherapy Boost in Combination With Intensity Modulated Radiation Therapy for Localized Prostate Cancer: A Single-Institution Propensity Score Matched Analysis. Int J Radiat Oncol Biol Phys. 2021 06 01; 110(2):429-437.  View on PubMed
  19. Chen WC, Vasudevan HN, Choudhury A, Pekmezci M, Lucas CG, Phillips J, Magill ST, Susko MS, Braunstein SE, Oberheim Bush NA, Boreta L, Nakamura JL, Villanueva-Meyer JE, Sneed PK, Perry A, McDermott MW, Solomon DA, Theodosopoulos PV, Raleigh DR. A Prognostic Gene-Expression Signature and Risk Score for Meningioma Recurrence After Resection. Neurosurgery. 2020 12 15; 88(1):202-210.  View on PubMed
  20. Lucas CG, Vasudevan HN, Chen WC, Magill ST, Braunstein SE, Jacques L, Dahiya S, Rodriguez FJ, Horvai AE, Perry A, Pekmezci M, Raleigh DR. Histopathologic findings in malignant peripheral nerve sheath tumor predict response to radiotherapy and overall survival. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa131.  View on PubMed

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