Research Funding

  • June 1, 2019 - May 31, 2024 - Kinome-guided Targeting of Cooperative Dependencies in BRAF and KRAS Mutated Colorectal Cancer , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA229447

Education

  • University of Lyon, France, and University of Montreal, Canada (Summa cum laude), B.Sc., 2001, Molecular and Cell Biology
  • Ecole Normale Superieure, France, and University of Lyon, France (Magna cum laude), M.Sc.,2002, Genetics and Immunology
  • University of California, Berkeley, Ph.D., 2007, Molecular and Cell Biology
  • Lawrence Berkeley National Laboratory, and Buck Institute for Age Research, Post-doctoral Fellowship, 2008, Molecular Biology of Aging and Cancer

Honors & Awards

  • 2018
    AACR 2018 Annual Meeting invited speaker; Symposium session: Novel Therapeutic Agents and Combinations; Talk title: “Systematic identification of the actionable kinase dependencies of chemotherapy-resistant triple-negative breast cancer”
  • 2012
    AACR 2012 Annual Meeting Award for top rated, highly meritorious scientific research: 'Mapping the oncogenic kinome using a kinase activity screening array'
  • 2012
    Best Early Detection and Prevention Research, Breast Oncology Program, Helen Diller Family Comprehensive Cancer Center, UCSF
  • 2008
    Keystone Symposia (Inflammation and Cancer): travel scholarship.

Selected Publications

  1. Malaquin N, Olivier MA, Martinez A, Nadeau S, Sawchyn C, Coppé JP, Cardin G, Mallette FA, Campisi J, Rodier F. Non-canonical ATM/MRN activities temporally define the senescence secretory program. EMBO Rep. 2020 10 05; 21(10):e50718.  View on PubMed
  2. Xu Q, Long Q, Zhu D, Fu D, Zhang B, Han L, Qian M, Guo J, Xu J, Cao L, Chin YE, Coppé JP, Lam EW, Campisi J, Sun Y. Targeting amphiregulin (AREG) derived from senescent stromal cells diminishes cancer resistance and averts programmed cell death 1 ligand (PD-L1)-mediated immunosuppression. Aging Cell. 2019 12; 18(6):e13027.  View on PubMed
  3. Muñoz DP, Yannone SM, Daemen A, Sun Y, Vakar-Lopez F, Kawahara M, Freund AM, Rodier F, Wu JD, Desprez PY, Raulet DH, Nelson PS, van 't Veer LJ, Campisi J, Coppé JP. Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging. JCI Insight. 2019 06 11; 5.  View on PubMed
  4. Coppé JP, Mori M, Pan B, Yau C, Wolf DM, Ruiz-Saenz A, Brunen D, Prahallad A, Cornelissen-Steijger P, Kemper K, Posch C, Wang C, Dreyer CA, Krijgsman O, Lee PRE, Chen Z, Peeper DS, Moasser MM, Bernards R, van 't Veer LJ. Mapping phospho-catalytic dependencies of therapy-resistant tumours reveals actionable vulnerabilities. Nat Cell Biol. 2019 06; 21(6):778-790.  View on PubMed
  5. Chen F, Long Q, Fu D, Zhu D, Ji Y, Han L, Zhang B, Xu Q, Liu B, Li Y, Wu S, Yang C, Qian M, Xu J, Liu S, Cao L, Chin YE, Lam EW, Coppé JP, Sun Y. Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance. Nat Commun. 2018 10 17; 9(1):4315.  View on PubMed
  6. Sun Y, Coppé JP, Lam EW. Cellular Senescence: The Sought or the Unwanted? Trends Mol Med. 2018 10; 24(10):871-885.  View on PubMed
  7. Bartelink IH, Prideaux B, Krings G, Wilmes L, Lee PRE, Bo P, Hann B, Coppé JP, Heditsian D, Swigart-Brown L, Jones EF, Magnitsky S, Keizer RJ, de Vries N, Rosing H, Pawlowska N, Thomas S, Dhawan M, Aggarwal R, Munster PN, Esserman LJ, Ruan W, Wu AHB, Yee D, Dartois V, Savic RM, Wolf DM, van 't Veer L. Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors. Breast Cancer Res. 2017 Sep 11; 19(1):107.  View on PubMed
  8. Olow A, Chen Z, Niedner RH, Wolf DM, Yau C, Pankov A, Lee EP, Brown-Swigart L, van 't Veer LJ, Coppé JP. An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer. Cancer Res. 2016 04 01; 76(7):1733-45.  View on PubMed
  9. Muñoz DP, Lee EL, Takayama S, Coppé JP, Heo SJ, Boffelli D, Di Noia JM, Martin DI. Activation-induced cytidine deaminase (AID) is necessary for the epithelial-mesenchymal transition in mammary epithelial cells. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):E2977-86.  View on PubMed
  10. Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J. p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol. 2013 May 13; 201(4):613-29.  View on PubMed
  11. Coppé JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J. Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem. 2011 Oct 21; 286(42):36396-403.  View on PubMed
  12. Coppé JP, Xu Z, Chen Y, Liu GL. Metallic nanocone array photonic substrate for high-uniformity surface deposition and optical detection of small molecules. Nanotechnology. 2011 Jun 17; 22(24):245710.  View on PubMed
  13. Krtolica A, Larocque N, Genbacev O, Ilic D, Coppe JP, Patil CK, Zdravkovic T, McMaster M, Campisi J, Fisher SJ. GROα regulates human embryonic stem cell self-renewal or adoption of a neuronal fate. Differentiation. 2011 Apr; 81(4):222-32.  View on PubMed
  14. Rodier F, Muñoz DP, Teachenor R, Chu V, Le O, Bhaumik D, Coppé JP, Campeau E, Beauséjour CM, Kim SH, Davalos AR, Campisi J. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci. 2011 Jan 01; 124(Pt 1):68-81.  View on PubMed
  15. Davalos AR, Coppe JP, Campisi J, Desprez PY. Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev. 2010 Jun; 29(2):273-83.  View on PubMed
  16. Zielinski AJ, Fong S, Allison J, Kawahara M, Coppe JP, Feiler H, Lee NM, Desprez PY. The helix-loop-helix Id-1 inhibits PSA expression in prostate cancer cells. Int J Cancer. 2010 May 15; 126(10):2490-6.  View on PubMed
  17. Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdière C, Kokta V, Haddad E, Beauséjour CM. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell. 2010 Jun; 9(3):398-409.  View on PubMed
  18. Coppé JP, Patil CK, Rodier F, Krtolica A, Beauséjour CM, Parrinello S, Hodgson JG, Chin K, Desprez PY, Campisi J. A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One. 2010 Feb 12; 5(2):e9188.  View on PubMed
  19. Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010; 5:99-118.  View on PubMed
  20. Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol. 2009 Aug; 11(8):973-9.  View on PubMed

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