Sophie Dumont, PhD

Education

Princeton University, Princeton, NJ, USA, B.A., 08/95-06/99, Physics
University of Oxford, UK, D.Phil. candidate, 09/99-08/00, Theoretical Physics
University of California, Berkeley, CA, USA, Ph.D., 08/00-12/05, Molecular Biophysics
University of California, Berkeley, CA, USA, Postdoc, 01/06-03/06, Molecular Biophysics
Harvard Society of Fellows, Junior Fellow, 07/06-06/09, Cellular Biophysics
Harvard Medical School, Boston, MA, USA, Postdoc, 07/06-05/12, Cellular Biophysics

Honors & Awards

• 2006
  Weintraub Graduate Student Award
• 2006-2009
  Junior Fellow, Harvard Society of Fellows
• 2013-2015
  Kimmel Cancer Foundation Scholar
• 2013-2016
  Searle Scholar
• 2013-2018
  Rita Allen Foundation and Milton E. Cassel Scholar
• 2015-2020
  NIH New Innovator Award
• 2016-2021
  NSF CAREER Award
• 2018
  UCSF Outstanding Faculty Mentorship Award
• 2020
  Chan Zuckerberg Biohub Investigator
• 2021
  UCSF Byers Award in Basic Science

Selected Publications

1. Suresh P, Galstyan V, Phillips R, Dumont S. Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle. Elife. 2022 11 08; 11.  View on PubMed
2. Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R, Weaver VM. ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells. EMBO J. 2022 09 01; 41(17):e109205.  View on PubMed
3. Rosas-Salvans M, Sutanto R, Suresh P, Dumont S. The Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface. Curr Biol. 2022 06 20; 32(12):2621-2631.e3.  View on PubMed
4. Pooja Suresh, Vahe Galstyan, Rob Phillips, Sophie Dumont. Connections distributed within 3 µm of chromosomes are necessary and sufficient for the kinetochore-fiber’s robust anchorage in the mammalian spindle. Biophysical Journal. 2022 Feb 1; 121(3):448a-449a.  View on PubMed
5. Miquel R. Salvans, Renaldo Sutanto, Sophie Dumont. The Astrin-SKAP complex lubricates the kinetochore-microtubule interface. Biophysical Journal. 2022 Feb 1; 121(3):522a.  View on PubMed
6. Neahring L, Cho NH, Dumont S. Opposing motors provide mechanical and functional robustness in the human spindle. Dev Cell. 2021 11 08; 56(21):3006-3018.e5.  View on PubMed
7. Lila Neahring, Sophie Dumont. Opposing Motors Provide Mechanical and Functional Robustness in the Mammalian Spindle. Biophysical Journal. 2021 Feb 1; 120(3):347a.  View on PubMed
8. Vahe Galstyan, Pooja Suresh, Sophie Dumont, Rob Phillips. Understanding the Mechanisms that Give Rise to the Mammalian Spindle's Response to Force using Theory and Microneedle Manipulation. Biophysical Journal. 2021 Feb 1; 120(3):347a.  View on PubMed
9. Serra-Marques A, Houtekamer R, Hintzen D, Canty JT, Yildiz A, Dumont S. The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics. J Cell Biol. 2020 12 07; 219(12).  View on PubMed
10. Long AF, Suresh P, Dumont S. Individual kinetochore-fibers locally dissipate force to maintain robust mammalian spindle structure. J Cell Biol. 2020 08 03; 219(8).  View on PubMed
11. Suresh P, Long AF, Dumont S. Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes. Elife. 2020 03 19; 9.  View on PubMed
12. Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A. MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities. Cell Rep. 2020 03 10; 30(10):3368-3382.e7.  View on PubMed
13. Kuhn J, Dumont S. Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner. J Cell Biol. 2019 11 04; 218(11):3583-3596.  View on PubMed
14. FuiBoon Kai, Guanqing Ou, Alexandra Long, Wei Guo, Richard Tourdot, Ravi Radhakrishnan, Christopher Chen, Sophie Dumont, Valerie M. Weaver. Abstract 1028: Extracellular matrix dimensionality reduces cellular cortical tension to stimulate pro-survival signaling in mammary epithelial cells. Cancer Research. 2019 Jul 1; 79(13_Supplement):1028-1028.  View on PubMed
15. Long AF, Kuhn J, Dumont S. The mammalian kinetochore-microtubule interface: robust mechanics and computation with many microtubules. Curr Opin Cell Biol. 2019 10; 60:60-67.  View on PubMed
16. Hueschen CL, Galstyan V, Amouzgar M, Phillips R, Dumont S. Microtubule End-Clustering Maintains a Steady-State Spindle Shape. Curr Biol. 2019 02 18; 29(4):700-708.e5.  View on PubMed
17. Neahring L, Dumont S. Chromosome Segregation Fidelity Integrates Information across Scales. Dev Cell. 2018 12 03; 47(5):525-526.  View on PubMed
18. Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S. Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nat Med. 2019 01; 25(1):111-118.  View on PubMed
19. Elting MW, Suresh P, Dumont S. The Spindle: Integrating Architecture and Mechanics across Scales. Trends Cell Biol. 2018 11; 28(11):896-910.  View on PubMed
20. Serra-Marques A, Dumont S. Shining light on spindle positioning. Elife. 2018 07 09; 7.  View on PubMed

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