Research Funding

  • June 1, 2020 - May 31, 2025 - Emergent mechanics of mammalian chromosome segregation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R35GM136420
  • May 15, 2020 - May 14, 2025 - , Principal Investigator . Sponsor: CZ Biohub Investigator, Sponsor Award ID: CZ Biohub
  • January 15, 2021 - January 14, 2023 - , Principal Investigator . Sponsor: UCSF Program in Breakthrough Biomedical Research, Sponsor Award ID: PBBR
  • September 1, 2016 - September 30, 2022 - Center for Cellular Construction , Sophie Dumont, Investigator . Sponsor: NSF, Sponsor Award ID: 1548297
  • September 1, 2019 - June 30, 2021 - Mechanics of the dynamic mammalian kinetochore-microtubule interface , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM134132
  • March 1, 2016 - February 28, 2021 - CAREER: Slip-Clutch of Biological Machines: The Kinetochore-Microtubule Interface , Principal Investigator . Sponsor: NSF, Sponsor Award ID: 1554139
  • December 1, 2013 - November 30, 2020 - , Principal Investigator . Sponsor: Rita Allen Foundation Scholars Program, Sponsor Award ID: Rita Allen
  • September 30, 2015 - May 31, 2020 - Rewiring cellular architecture to probe mechanical signal processing at kinetochores , Principal Investigator . Sponsor: NIH, Sponsor Award ID: DP2GM119177
  • September 15, 2013 - September 14, 2017 - , Principal Investigator . Sponsor: Sloan Research Fellowships, Sponsor Award ID: BR2013-125
  • July 1, 2013 - June 30, 2017 - , Principal Investigator . Sponsor: Searle Scholars Program, Sponsor Award ID: 13-SSP-213
  • September 1, 2010 - July 31, 2016 - Spindle forces for chromosome movement , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R00GM094335
  • July 1, 2013 - June 30, 2016 - , Principal Investigator . Sponsor: Sidney Kimmel Foundation for Cancer Research, Sponsor Award ID: SKF-13-053
  • September 1, 2012 - August 31, 2014 - , Principal Investigator . Sponsor: UCSF Program for Breakthrough Biomedical Research, Sponsor Award ID: PBBR
  • July 1, 2012 - July 31, 2014 - Dynamics in the tissue state: from normal to tumor and back , Sophie Dumont, Investigator . Sponsor: NIH/NCI, Sponsor Award ID: U54CA143836
  • September 1, 2010 - May 31, 2012 - Force generation and detection in the spindle: the case of the kinetochore , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K99GM094335

Education

Princeton University, Princeton, NJ, USA, B.A., 08/95-06/99, Physics
University of Oxford, UK, D.Phil. candidate, 09/99-08/00, Theoretical Physics
University of California, Berkeley, CA, USA, Ph.D., 08/00-12/05, Molecular Biophysics
University of California, Berkeley, CA, USA, Postdoc, 01/06-03/06, Molecular Biophysics
Harvard Society of Fellows, Junior Fellow, 07/06-06/09, Cellular Biophysics
Harvard Medical School, Boston, MA, USA, Postdoc, 07/06-05/12, Cellular Biophysics

Honors & Awards

  • 2006
    Weintraub Graduate Student Award
  • 2006-2009
    Junior Fellow, Harvard Society of Fellows
  • 2013-2015
    Kimmel Cancer Foundation Scholar
  • 2013-2016
    Searle Scholar
  • 2013-2018
    Rita Allen Foundation and Milton E. Cassel Scholar
  • 2015-2020
    NIH New Innovator Award
  • 2016-2021
    NSF CAREER Award
  • 2018
    UCSF Outstanding Faculty Mentorship Award
  • 2020
    Chan Zuckerberg Biohub Investigator
  • 2021
    UCSF Byers Award in Basic Science

Selected Publications

  1. Nathan Cho, Sophie Dumont. BPS2025 - NuMA mechanically reinforces spindle poles independently of dynein through self-interactions. Biophysical Journal. 2025 Feb 1; 124(3):376a.  View on PubMed
  2. Nathan Cho, Sophie Dumont. BPS2025 - NuMA mechanically reinforces spindle poles independently of dynein through self-interactions. Biophysical Journal. 2025 Feb 1; 124(3):476a-477a.  View on PubMed
  3. Aslan M, d'Amico EA, Cho NH, Taheri A, Zhao Y, Zhong X, Blaauw M, Carter AP, Dumont S, Yildiz A. Structural and functional insights into activation and regulation of the dynein-dynactin-NuMA complex. bioRxiv. 2024 Dec 03.  View on PubMed
  4. Rosas-Salvans M, Rux C, Das M, Dumont S. SKAP binding to microtubules reduces friction at the kinetochore-microtubule interface and increases attachment stability under force. bioRxiv. 2024 Aug 08.  View on PubMed
  5. Neahring L, Cho NH, He Y, Liu G, Fernandes J, Rux CJ, Nakos K, Subramanian R, Upadhyayula S, Yildiz A, Dumont S. Torques within and outside the human spindle balance twist at anaphase. J Cell Biol. 2024 Sep 02; 223(9).  View on PubMed
  6. Chong MK, Rosas-Salvans M, Tran V, Dumont S. Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction. J Cell Biol. 2024 Aug 05; 223(8).  View on PubMed
  7. Sutanto R, Neahring L, Serra Marques A, Jacobo Jacobo M, Kilinc S, Goga A, Dumont S. The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force. PLoS One. 2024; 19(3):e0296779.  View on PubMed
  8. Nathan Cho, Sophie Dumont. NuMA mechanically reinforces mammalian spindle poles independent of its partner dynein. Biophysical Journal. 2024 Feb 1; 123(3):539a.  View on PubMed
  9. Miquel Salvans, Sophie Dumont. Probing how the Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface. Biophysical Journal. 2024 Feb 1; 123(3):1a-2a.  View on PubMed
  10. Neahring L, He Y, Cho NH, Liu G, Fernandes J, Rux CJ, Nakos K, Subramanian R, Upadhyayula S, Yildiz A, Dumont S. Torques within and outside the human spindle balance twist at anaphase. bioRxiv. 2023 Dec 10.  View on PubMed
  11. Chong MK, Rosas-Salvans M, Tran V, Dumont S. Chromosome size-dependent polar ejection force impairs mammalian mitotic error correction. bioRxiv. 2023 Oct 18.  View on PubMed
  12. Bakshi A, Iturra FE, Alamban A, Rosas-Salvans M, Dumont S, Aydogan MG. Cytoplasmic division cycles without the nucleus and mitotic CDK/cyclin complexes. Cell. 2023 10 12; 186(21):4694-4709.e16.  View on PubMed
  13. Richter M, Neahring L, Tao J, Sutanto R, Cho NH, Dumont S. Kinetochore-fiber lengths are maintained locally but coordinated globally by poles in the mammalian spindle. Elife. 2023 Jul 03; 12.  View on PubMed
  14. Sutanto R, Neahring L, Marques AS, Kilinc S, Goga A, Dumont S. The oncogene cyclin D1 promotes bipolar spindle integrity under compressive force. bioRxiv. 2023 May 31.  View on PubMed
  15. Valdez VA, Neahring L, Petry S, Dumont S. Mechanisms underlying spindle assembly and robustness. Nat Rev Mol Cell Biol. 2023 08; 24(8):523-542.  View on PubMed
  16. Suresh P, Galstyan V, Phillips R, Dumont S. Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle. Elife. 2022 11 08; 11.  View on PubMed
  17. Kai F, Ou G, Tourdot RW, Stashko C, Gaietta G, Swift MF, Volkmann N, Long AF, Han Y, Huang HH, Northey JJ, Leidal AM, Viasnoff V, Bryant DM, Guo W, Wiita AP, Guo M, Dumont S, Hanein D, Radhakrishnan R, Weaver VM. ECM dimensionality tunes actin tension to modulate endoplasmic reticulum function and spheroid phenotypes of mammary epithelial cells. EMBO J. 2022 09 01; 41(17):e109205.  View on PubMed
  18. Rosas-Salvans M, Sutanto R, Suresh P, Dumont S. The Astrin-SKAP complex reduces friction at the kinetochore-microtubule interface. Curr Biol. 2022 06 20; 32(12):2621-2631.e3.  View on PubMed
  19. Pooja Suresh, Vahe Galstyan, Rob Phillips, Sophie Dumont. Connections distributed within 3 µm of chromosomes are necessary and sufficient for the kinetochore-fiber’s robust anchorage in the mammalian spindle. Biophysical Journal. 2022 Feb 1; 121(3):448a-449a.  View on PubMed
  20. Miquel R. Salvans, Renaldo Sutanto, Sophie Dumont. The Astrin-SKAP complex lubricates the kinetochore-microtubule interface. Biophysical Journal. 2022 Feb 1; 121(3):522a.  View on PubMed

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