Research Funding

  • June 1, 2020 - May 31, 2025 - Emergent mechanics of mammalian chromosome segregation, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R35GM136420
  • May 15, 2020 - May 14, 2025 - , Principal Investigator. Sponsor: CZ Biohub Investigator, Sponsor Award ID: CZ Biohub
  • September 1, 2019 - June 30, 2023 - Mechanics of the dynamic mammalian kinetochore-microtubule interface, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R01GM134132
  • January 15, 2021 - January 14, 2023 - , Principal Investigator. Sponsor: UCSF Program in Breakthrough Biomedical Research, Sponsor Award ID: PBBR

Education

Princeton University, Princeton, NJ, USA, B.A., 08/95-06/99, Physics
University of Oxford, UK, D.Phil. candidate, 09/99-08/00, Theoretical Physics
University of California, Berkeley, CA, USA, Ph.D., 08/00-12/05, Molecular Biophysics
University of California, Berkeley, CA, USA, Postdoc, 01/06-03/06, Molecular Biophysics
Harvard Society of Fellows, Junior Fellow, 07/06-06/09, Cellular Biophysics
Harvard Medical School, Boston, MA, USA, Postdoc, 07/06-05/12, Cellular Biophysics

Honors & Awards

  • 2006
    Weintraub Graduate Student Award
  • 2006-2009
    Junior Fellow, Harvard Society of Fellows
  • 2013-2015
    Kimmel Cancer Foundation Scholar
  • 2013-2016
    Searle Scholar
  • 2013-2018
    Rita Allen Foundation and Milton E. Cassel Scholar
  • 2015-2020
    NIH New Innovator Award
  • 2016-2021
    NSF CAREER Award
  • 2018
    UCSF Outstanding Faculty Mentorship Award
  • 2020
    Chan Zuckerberg Biohub Investigator
  • 2021
    UCSF Byers Award in Basic Science

Selected Publications

  1. Lila Neahring, Sophie Dumont. Opposing Motors Provide Mechanical and Functional Robustness in the Mammalian Spindle. Biophysical Journal. 2021 Feb 1; 120(3):347a.  View on PubMed
  2. Vahe Galstyan, Pooja Suresh, Sophie Dumont, Rob Phillips. Understanding the Mechanisms that Give Rise to the Mammalian Spindle's Response to Force using Theory and Microneedle Manipulation. Biophysical Journal. 2021 Feb 1; 120(3):347a.  View on PubMed
  3. Serra-Marques A, Houtekamer R, Hintzen D, Canty JT, Yildiz A, Dumont S. The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics. J Cell Biol. 2020 12 07; 219(12).  View on PubMed
  4. Long AF, Suresh P, Dumont S. Individual kinetochore-fibers locally dissipate force to maintain robust mammalian spindle structure. J Cell Biol. 2020 08 03; 219(8).  View on PubMed
  5. Suresh P, Long AF, Dumont S. Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes. Elife. 2020 03 19; 9.  View on PubMed
  6. Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A. MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities. Cell Rep. 2020 03 10; 30(10):3368-3382.e7.  View on PubMed
  7. Kuhn J, Dumont S. Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner. J Cell Biol. 2019 11 04; 218(11):3583-3596.  View on PubMed
  8. Long AF, Kuhn J, Dumont S. The mammalian kinetochore-microtubule interface: robust mechanics and computation with many microtubules. Curr Opin Cell Biol. 2019 10; 60:60-67.  View on PubMed
  9. Hueschen CL, Galstyan V, Amouzgar M, Phillips R, Dumont S. Microtubule End-Clustering Maintains a Steady-State Spindle Shape. Curr Biol. 2019 02 18; 29(4):700-708.e5.  View on PubMed
  10. Neahring L, Dumont S. Chromosome Segregation Fidelity Integrates Information across Scales. Dev Cell. 2018 12 03; 47(5):525-526.  View on PubMed
  11. Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S. Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nat Med. 2019 01; 25(1):111-118.  View on PubMed
  12. Elting MW, Suresh P, Dumont S. The Spindle: Integrating Architecture and Mechanics across Scales. Trends Cell Biol. 2018 11; 28(11):896-910.  View on PubMed
  13. Serra-Marques A, Dumont S. Shining light on spindle positioning. Elife. 2018 07 09; 7.  View on PubMed
  14. Hueschen CL, Kenny SJ, Xu K, Dumont S. NuMA recruits dynein activity to microtubule minus-ends at mitosis. Elife. 2017 11 29; 6.  View on PubMed
  15. Elting MW, Prakash M, Udy DB, Dumont S. Mapping Load-Bearing in the Mammalian Spindle Reveals Local Kinetochore Fiber Anchorage that Provides Mechanical Isolation and Redundancy. Curr Biol. 2017 Jul 24; 27(14):2112-2122.e5.  View on PubMed
  16. Long AF, Udy DB, Dumont S. Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules. Curr Biol. 2017 Jun 05; 27(11):1692-1699.e3.  View on PubMed
  17. Kuhn J, Dumont S. Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension. J Cell Biol. 2017 06 05; 216(6):1533-1542.  View on PubMed
  18. Karg T, Elting MW, Vicars H, Dumont S, Sullivan W. The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation. J Cell Biol. 2017 06 05; 216(6):1597-1608.  View on PubMed
  19. Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S. Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Mol Biol Cell. 2017 Jul 07; 28(14):1975-1983.  View on PubMed
  20. Guild J, Haque A, Gheibi P, Gao Y, Son KJ, Foster E, Dumont S, Revzin A. Embryonic Stem Cells Cultured in Microfluidic Chambers Take Control of Their Fate by Producing Endogenous Signals Including LIF. Stem Cells. 2016 06; 34(6):1501-12.  View on PubMed

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