Research Summary

My lab aims to define the rules used by cells to self-organize into structurally ordered tissues, and to reveal how tissue structure guides the flow of chemical, mechanical, and electrical information between cells to coordinate collective decisions and behaviors. A better understanding of these processes will guide the development of new therapies for regenerative medicine and new strategies to block the progression of cancer. My lab’s multidisciplinary approach is uniquely suited to tackling these problems. We apply concepts and methods from chemistry, biology, and engineering, and develop new and enabling technologies when existing methods are insufficient for our experimental needs.

Research Funding

  • May 1, 2020 - April 30, 2025 - Understanding breast cancer progression as a defect in the mechanics of tissue self-organization, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA244109
  • September 20, 2019 - June 30, 2023 - MULTIseq: multiplexing massively parallel single cell transcriptional analysis across time, space, and conditions, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R01GM135462
  • September 30, 2013 - July 31, 2018 - Total synthesis of the human mammary gland, Principal Investigator. Sponsor: NIH/NICHD, Sponsor Award ID: DP2HD080351
  • September 18, 2014 - August 31, 2016 - Identifying the intercellular networks regulating estrogen receptor expression with a high definition single cell printer, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R21CA195709

Education

University of California, Berkeley B.S. 1994-1999 Chemistry
Harvard University M.S. Ph.D. 1999-2004 Chemical Biology
University of California, Berkeley Postdoctoral 2005-2008 Chemical Biology

Honors & Awards

  • 2000
    National Science Foundation Graduate Research Fellowship
  • 2003
    Bristol-Myers Squibb Fellowship
  • 2003
    Harvard Merit Fellowship
  • 2005
    IUPAC Prize for Young Chemists
  • 2006
    Jane Coffin Childs Postdoctoral Fellow
  • 2008
    Sandler Opportunity Award
  • 2010
    Kimmel Scholar Award
  • 2010
    Era of Hope Scholar Award
  • 2013
    NIH New Innovator Award
  • 2017
    Named to first cohort of Chan Zuckerberg Biohub Investigators

Selected Publications

  1. Kindberg AA, Srivastava V, Muncie JM, Weaver VM, Gartner ZJ, Bush JO EPH/EPHRIN regulates cellular organization by actomyosin contractility effects on cell contacts.  View on PubMed
  2. Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.  View on PubMed
  3. Hernandez-Lopez RA, Yu W, Cabral KA, Creasey OA, Lopez Pazmino MDP, Tonai Y, De Guzman A, Mäkelä A, Saksela K, Gartner ZJ, Lim WA T cell circuits that sense antigen density with an ultrasensitive threshold.  View on PubMed
  4. Cabral KA, Patterson DM, Scheideler OJ, Cole R, Abate AR, Schaffer DV, Sohn LL, Gartner ZJ Simple, Affordable, and Modular Patterning of Cells using DNA.  View on PubMed
  5. Zhang JQ, Siltanen CA, Dolatmoradi A, Sun C, Chang KC, Cole RH, Gartner ZJ, Abate AR High diversity droplet microfluidic libraries generated with a commercial liquid spotter.  View on PubMed
  6. Gartner ZJ, Martyn I Expanding the boundaries of synthetic development.  View on PubMed
  7. Vasudha Srivastava, Jennifer L. Hu, James C. Garbe, Martha R. Stampfer, Mark A. LaBarge, Matthew Thomson, Zev J. Gartner Identifying Enthalpic Barriers to Entropically-Driven Structural Disruption in Breast Cancers.  View on PubMed
  8. McGinnis CS, Siegel DA, Xie G, Hartoularos G, Stone M, Ye CJ, Gartner ZJ, Roan NR, Lee SA No detectable alloreactive transcriptional responses under standard sample preparation conditions during donor-multiplexed single-cell RNA sequencing of peripheral blood mononuclear cells.  View on PubMed
  9. Gartner ZJ, Hu JL Guiding tissue-scale self-organization.  View on PubMed
  10. Lenne PF, Munro E, Heemskerk I, Warmflash A, Bocanegra-Moreno L, Kishi K, Kicheva A, Long Y, Fruleux A, Boudaoud A, Saunders TE, Caldarelli P, Michaut A, Gros J, Maroudas-Sacks Y, Keren K, Hannezo E, Gartner ZJ, Stormo BS, Gladfelter AG, Rodrigues A, Shyer A, Minc N, Maître JL, Di Talia S, Khamaisi B, Sprinzak D, Tlili S Roadmap on multiscale coupling of biochemical and mechanical signals during development.  View on PubMed
  11. Hu KH, Eichorst JP, McGinnis CS, Patterson DM, Chow ED, Kersten K, Jameson SC, Gartner ZJ, Rao AA, Krummel MF ZipSeq: barcoding for real-time mapping of single cell transcriptomes.  View on PubMed
  12. Srivastava V, Huycke TR, Phong KT, Gartner ZJ Organoid models for mammary gland dynamics and breast cancer.  View on PubMed
  13. OLIVIA A. CREASEY, JULIE B. SNEDDON, ZEV J. GARTNER 2063-P: Quantitative Analysis of Human and Mouse Islet Tissue Structure.  View on PubMed
  14. Zhang JQ, Chang KC, Liu L, Gartner ZJ, Abate AR High Throughput Yeast Strain Phenotyping with Droplet-Based RNA Sequencing.  View on PubMed
  15. Zhang JQ, Siltanen CA, Liu L, Chang KC, Gartner ZJ, Abate AR Linked optical and gene expression profiling of single cells at high-throughput.  View on PubMed
  16. Murrow LM, Gartner ZJ Balancing Act: Cell Polarity and Shape Compete to Ensure Robust Development.  View on PubMed
  17. Harel ET, Drake PM, Barfield RM, Lui I, Farr-Jones S, Van't Veer L, Gartner ZJ, Green EM, Lourenço AL, Cheng Y, Hann BC, Rabuka D, Craik CS Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer.  View on PubMed
  18. Gartner Z, Hughes A Getting the measure of living biomaterials.  View on PubMed
  19. McGinnis CS, Patterson DM, Winkler J, Conrad DN, Hein MY, Srivastava V, Hu JL, Murrow LM, Weissman JS, Werb Z, Chow ED, Gartner ZJ MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices.  View on PubMed
  20. OLIVIA A. CREASEY, DANIEL ELNATAN, JULIE B. SNEDDON, ZEV J. GARTNER 2151-P: Quantification of Tissue Structure in Human and Mouse Islets.  View on PubMed

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