Research Funding

  • September 30, 2018 - June 30, 2023 - A GENETIC INTERACTION MAP OF THE HUMAN NUCLEUS, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: DP2CA239597
  • May 1, 2020 - April 30, 2021 - Drug target identification using CRISPRi/a screening, Co-Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: R41GM137625
  • April 1, 2016 - March 31, 2021 - A functional genomics approach to determine the mechanism of cellular response to new anti-cancer drugs, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: K99CA204602
  • April 1, 2017 - March 31, 2020 - A functional genomics approach to determine the mechanism of cellular response to new anti-cancer, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R00CA204602

Education

University of California, Los Angeles, BS, 06/2006, Microbiology, Immunology, and Molecular Genetics
Massachusetts Institute of Technology, PhD, 05/2012, Biology
University of California, San Francisco, Postdoctoral, 4/2017, Cell Biology, Synthetic Biology

Honors & Awards

  • 2010
    Virginia and Daniel K. Ludwig Graduate Research Fellow
  • 2013
    Leukemia and Lymphoma Society Postdoctoral Fellow
  • 2016
    NIH/NCI Pathway to Independence Award
  • 2018
    Gabrielle's Angel Foundation Medical Research Fellow
  • 2018
    NIH Director's New Innovator Award
  • 2019
    Pew-Stewart Scholar for Cancer Research
  • 2020
    AAAS / Martin and Rose Wachtel Cancer Research Award

Selected Publications

  1. Kuzuoglu-Ozturk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA, Ruggero D. Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Cell Rep. 2021 Jun 29; 35(13):109321.  View on PubMed
  2. Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS. Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Cell. 2021 Apr 29; 184(9):2503-2519.e17.  View on PubMed
  3. Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2021 Feb 04; 184(3):844.  View on PubMed
  4. Gilbert LA. Mapping cancer genetics at single-cell resolution. Sci Transl Med. 2020 08 26; 12(558).  View on PubMed
  5. Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Laura Chang S, Houlahan KE, Shiah YJ, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Yvonne Kim M, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY. The DNA methylation landscape of advanced prostate cancer. Nat Genet. 2020 08; 52(8):778-789.  View on PubMed
  6. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2020 07 02; 79(1):191-198.e3.  View on PubMed
  7. Luke A. Gilbert. Keap1ing an eye on Slc33A1. Nature Cancer. 2020 Jun 1; 1(6):575-576.  View on PubMed
  8. Chandra A, Jahangiri A, Chen W, Nguyen AT, Yagnik G, Pereira MP, Jain S, Garcia JH, Shah SS, Wadhwa H, Joshi RS, Weiss J, Wolf KJ, Lin JG, Müller S, Rick JW, Diaz AA, Gilbert LA, Kumar S, Aghi MK. Clonal ZEB1-Driven Mesenchymal Transition Promotes Targetable Oncologic Antiangiogenic Therapy Resistance. Cancer Res. 2020 04 01; 80(7):1498-1511.  View on PubMed
  9. Norman TM, Horlbeck MA, Replogle JM, Ge AY, Xu A, Jost M, Gilbert LA, Weissman JS. Exploring genetic interaction manifolds constructed from rich single-cell phenotypes. Science. 2019 08 23; 365(6455):786-793.  View on PubMed
  10. Lou K, Gilbert LA, Shokat KM. A Bounty of New Challenging Targets in Oncology for Chemical Discovery. Biochemistry. 2019 08 06; 58(31):3328-3330.  View on PubMed
  11. Kothari V, Goodwin JF, Zhao SG, Drake JM, Yin Y, Chang SL, Evans JR, Wilder-Romans K, Gabbara K, Dylgjeri E, Chou J, Sun G, Tomlins SA, Mehra R, Hege K, Filvaroff EH, Schaeffer EM, Karnes RJ, Quigley DA, Rathkopf DE, He HH, Speers C, Spratt DE, Gilbert LA, Ashworth A, Chinnaiyan AM, Raj GV, Knudsen KE, Feng FY. DNA-Dependent Protein Kinase Drives Prostate Cancer Progression through Transcriptional Regulation of the Wnt Signaling Pathway. Clin Cancer Res. 2019 09 15; 25(18):5608-5622.  View on PubMed
  12. Lou K, Steri V, Ge AY, Hwang YC, Yogodzinski CH, Shkedi AR, Choi ALM, Mitchell DC, Swaney DL, Hann B, Gordan JD, Shokat KM, Gilbert LA. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 05 28; 12(583).  View on PubMed
  13. Feng FY, Gilbert LA. Lethal clues to cancer-cell vulnerability. Nature. 2019 04; 568(7753):463-464.  View on PubMed
  14. Liaud N, Horlbeck MA, Gilbert LA, Gjoni K, Weissman JS, Cate JHD. Cellular response to small molecules that selectively stall protein synthesis by the ribosome. PLoS Genet. 2019 03; 15(3):e1008057.  View on PubMed
  15. Thomas A. O'Loughlin, Luke A. Gilbert. Functional Genomics for Cancer Research: Applications In Vivo and In Vitro. Annual Review of Cancer Biology. 2019 Mar 4; 3(1):1-19.  View on PubMed
  16. Jonathan Weissman, Thomas Norman, Max Horlbeck, Luke Gilbert. Finding and Interpreting Genetic Interactions using Perturb-Seq Single Cell RNA-Seq CRISPR Screens. Biophysical Journal. 2019 Feb 1; 116(3):318a.  View on PubMed
  17. Ankush Chandra, Arman Jahangiri, William Chen, Garima Yagnik, Joseph Garcia, Alan Nguyen, Jacob Weiss, Kayla Wolf, Jung-Ming Lin, Soeren Mueller, Jonathan Rick, Aaron Diaz, Luke Gilbert, Sanjay Kumar, Manish Aghi. DRES-01. ZEB1-MEDIATED INVASIVE MESENCHYMAL TRANSITION AT THE SINGLE CELL LEVEL PROMOTES ANTI-ANGIOGENIC THERAPY RESISTANCE IN GLIOBLASTOMA. Neuro-Oncology. 2018 Nov 5; 20(suppl_6):vi75-vi75.  View on PubMed
  18. Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. 2018 10 18; 175(3):889.  View on PubMed
  19. Mendelsohn BA, Bennett NK, Darch MA, Yu K, Nguyen MK, Pucciarelli D, Nelson M, Horlbeck MA, Gilbert LA, Hyun W, Kampmann M, Nakamura JL, Nakamura K. A high-throughput screen of real-time ATP levels in individual cells reveals mechanisms of energy failure. PLoS Biol. 2018 08; 16(8):e2004624.  View on PubMed
  20. Quigley DA, Dang HX, Zhao SG, Lloyd P, Aggarwal R, Alumkal JJ, Foye A, Kothari V, Perry MD, Bailey AM, Playdle D, Barnard TJ, Zhang L, Zhang J, Youngren JF, Cieslik MP, Parolia A, Beer TM, Thomas G, Chi KN, Gleave M, Lack NA, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Ryan CJ, Fong L, Kim W, Friedlander T, Chou J, Li H, Das R, Li H, Moussavi-Baygi R, Goodarzi H, Gilbert LA, Lara PN, Evans CP, Goldstein TC, Stuart JM, Tomlins SA, Spratt DE, Cheetham RK, Cheng DT, Farh K, Gehring JS, Hakenberg J, Liao A, Febbo PG, Shon J, Sickler B, Batzoglou S, Knudsen KE, He HH, Huang J, Wyatt AW, Dehm SM, Ashworth A, Chinnaiyan AM, Maher CA, Small EJ, Feng FY. Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer. Cell. 2018 07 26; 174(3):758-769.e9.  View on PubMed

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