Research Funding

  • September 10, 2021 - June 30, 2025 - Editing CG and non-CG DNA methylation to identify genomic elements that regulate gene expression , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HG012227
  • September 30, 2018 - May 31, 2023 - A GENETIC INTERACTION MAP OF THE HUMAN NUCLEUS , Principal Investigator . Sponsor: NIH, Sponsor Award ID: DP2CA239597
  • May 1, 2020 - April 30, 2021 - Drug target identification using CRISPRi/a screening , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R41GM137625
  • April 1, 2017 - March 31, 2020 - A functional genomics approach to determine the mechanism of cellular response to new anti-cancer , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R00CA204602

Education

University of California, Los Angeles, BS, 06/2006, Microbiology, Immunology, and Molecular Genetics
Massachusetts Institute of Technology, PhD, 05/2012, Biology
University of California, San Francisco, Postdoctoral, 4/2017, Cell Biology, Synthetic Biology

Honors & Awards

  • 2010
    Virginia and Daniel K. Ludwig Graduate Research Fellow
  • 2013
    Leukemia and Lymphoma Society Postdoctoral Fellow
  • 2016
    NIH/NCI Pathway to Independence Award
  • 2018
    Gabrielle's Angel Foundation Medical Research Fellow
  • 2018
    NIH Director's New Innovator Award
  • 2019-2023
    Pew-Stewart Scholar for Cancer Research
  • 2020
    AAAS / Martin and Rose Wachtel Cancer Research Award
  • 2022-2023
    Prostate Cancer Foundation Challenge Award
  • 2022-2027
    CRUK/NCI Cancer Grand Challenge Award
  • 2022-2027
    NIH NHGRI UM1 HG012660

Selected Publications

  1. Wang S, Böhnert V, Joseph AJ, Sudaryo V, Swinderman J, B Yu F, Lyu X, Skariah G, Subramanyam V, Gilbert LA, Goodarzi H, Li L. ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway. bioRxiv. 2023 Jun 05.  View on PubMed
  2. Woo BJ, Moussavi-Baygi R, Karner H, Karimzadeh M, Garcia K, Joshi T, Yin K, Navickas A, Gilbert LA, Wang B, Asgharian H, Feng FY, Goodarzi H. Integrative identification of non-coding regulatory regions driving metastatic prostate cancer. bioRxiv. 2023 Jun 02.  View on PubMed
  3. Replogle JM, Bonnar JL, Pogson AN, Liem CR, Maier NK, Ding Y, Russell BJ, Wang X, Leng K, Guna A, Norman TM, Pak RA, Ramos DM, Ward ME, Gilbert LA, Kampmann M, Weissman JS, Jost M. Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors. Elife. 2022 Dec 28; 11.  View on PubMed
  4. Lou K, Wassarman DR, Yang T, Paung Y, Zhang Z, O'Loughlin TA, Moore MK, Egan RK, Greninger P, Benes CH, Seeliger MA, Taunton J, Gilbert LA, Shokat KM. IFITM proteins assist cellular uptake of diverse linked chemotypes. Science. 2022 12 09; 378(6624):1097-1104.  View on PubMed
  5. Sjöström M, Zhao SG, Levy S, Zhang M, Ning Y, Shrestha R, Lundberg A, Herberts C, Foye A, Aggarwal R, Hua JT, Li H, Bergamaschi A, Maurice-Dror C, Maheshwari A, Chen S, Ng SWS, Ye W, Petricca J, Fraser M, Chesner L, Perry MD, Moreno-Rodriguez T, Chen WS, Alumkal JJ, Chou J, Morgans AK, Beer TM, Thomas GV, Gleave M, Lloyd P, Phillips T, McCarthy E, Haffner MC, Zoubeidi A, Annala M, Reiter RE, Rettig MB, Witte ON, Fong L, Bose R, Huang FW, Luo J, Bjartell A, Lang JM, Mahajan NP, Lara PN, Evans CP, Tran PT, Posadas EM, He C, Cui XL, Huang J, Zwart W, Gilbert LA, Maher CA, Boutros PC, Chi KN, Ashworth A, Small EJ, He HH, Wyatt AW, Quigley DA, Feng FY. The 5-Hydroxymethylcytosine Landscape of Prostate Cancer. Cancer Res. 2022 11 02; 82(21):3888-3902.  View on PubMed
  6. Marcela C. Briones Martin del Campo, Alex Lee, Max Horlbeck, Truc Dinh, Marta Roman-Moreno, Leanne Sayles, Bokyung Seong, Kimberly Stegmaier, Luke Gilbert, E. Alejandro Sweet-Cordero. Abstract B021: Long non-coding RNAs that are required for robust cell growth in ewing Sarcoma. Clinical Cancer Research. 2022 Sep 15; 28(18_Supplement):b021-b021.  View on PubMed
  7. Li H, Busquets O, Verma Y, Syed KM, Kutnowski N, Pangilinan GR, Gilbert LA, Bateup HS, Rio DC, Hockemeyer D, Soldner F. Highly efficient generation of isogenic pluripotent stem cell models using prime editing. Elife. 2022 09 07; 11.  View on PubMed
  8. Shao H, Taguwa S, Gilbert L, Shkedi A, Sannino S, Guerriero CJ, Gale-Day ZJ, Young ZT, Brodsky JL, Weissman J, Gestwicki JE, Frydman J. A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities. Cell Chem Biol. 2022 08 18; 29(8):1303-1316.e3.  View on PubMed
  9. Luke A. Gilbert. Applications of CRISPRi and CRISPRa in Drug Discovery. . 2022 Mar 17; 139-150.  View on PubMed
  10. Zhao B, Rao Y, Leighow S, O'Brien EP, Gilbert L, Pritchard JR. A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments. Nat Commun. 2022 02 02; 13(1):625.  View on PubMed
  11. Timothy T. Ferng, Theodore C. Tarver, Shaheen Kabir, Benjamin Braun, Aaron C. Logan, Luke A. Gilbert, Catherine C. Smith. RNA Polymerase II Is a Therapeutic Target to Overcome FLT3 Inhibitor Resistance Mediated By the Bone Marrow Microenvironment. Blood. 2021 Nov 5; 138(Supplement 1):2236-2236.  View on PubMed
  12. Yogodzinski C, Arab A, Pritchard JR, Goodarzi H, Gilbert LA. A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy. Genome Med. 2021 10 18; 13(1):167.  View on PubMed
  13. Przybyla L, Gilbert LA. A new era in functional genomics screens. Nat Rev Genet. 2022 02; 23(2):89-103.  View on PubMed
  14. Das R, Sjöström M, Shrestha R, Yogodzinski C, Egusa EA, Chesner LN, Chen WS, Chou J, Dang DK, Swinderman JT, Ge A, Hua JT, Kabir S, Quigley DA, Small EJ, Ashworth A, Feng FY, Gilbert LA. An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer. Nat Commun. 2021 07 29; 12(1):4601.  View on PubMed
  15. Kuzuoglu-Ozturk D, Hu Z, Rama M, Devericks E, Weiss J, Chiang GG, Worland ST, Brenner SE, Goodarzi H, Gilbert LA, Ruggero D. Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome. Cell Rep. 2021 06 29; 35(13):109321.  View on PubMed
  16. Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS. Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing. Cell. 2021 04 29; 184(9):2503-2519.e17.  View on PubMed
  17. Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2021 Feb 04; 184(3):844.  View on PubMed
  18. Gilbert LA. Mapping cancer genetics at single-cell resolution. Sci Transl Med. 2020 08 26; 12(558).  View on PubMed
  19. Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Laura Chang S, Houlahan KE, Shiah YJ, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Yvonne Kim M, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY. The DNA methylation landscape of advanced prostate cancer. Nat Genet. 2020 08; 52(8):778-789.  View on PubMed
  20. Jost M, Chen Y, Gilbert LA, Horlbeck MA, Krenning L, Menchon G, Rai A, Cho MY, Stern JJ, Prota AE, Kampmann M, Akhmanova A, Steinmetz MO, Tanenbaum ME, Weissman JS. Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent. Mol Cell. 2020 07 02; 79(1):191-198.e3.  View on PubMed

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