Research Funding

  • April 1, 1997 - March 31, 2020 - Degenerative and Dementing Diseases of Aging, Co-Investigator. Sponsor: NIH/NIA, Sponsor Award ID: P01AG002132
  • April 1, 1997 - March 31, 2020 - Degenerative and Dementing Diseases of Aging, Co-Investigator. Sponsor: NIH/NIA, Sponsor Award ID: P01AG002132
  • April 1, 1997 - March 31, 2020 - Degenerative and Dementing Diseases of Aging, Co-Investigator. Sponsor: NIH/NIA, Sponsor Award ID: P01AG002132
  • January 1, 1981 - December 31, 2008 - Degenerative and Dementing Diseases of Aging, Co-Investigator. Sponsor: NIH, Sponsor Award ID: P01AG002132

Selected Publications

  1. Krejciova Z, Carlson GA, Giles K, Prusiner SB Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human a-synuclein.  View on PubMed
  2. Woerman AL, Watts JC, Aoyagi A, Giles K, Middleton LT, Prusiner SB a-Synuclein: Multiple System Atrophy Prions.  View on PubMed
  3. Zuzana Krejciova, George Carlson, Kurt Giles, Stanley B. Prusiner Modeling Multiple System Atrophy Prion Propagation in Astrocytes From Transgenic Mice.  View on PubMed
  4. Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, Giles K, DeGrado WF, Prusiner SB Structural heterogeneity and intersubject variability of Aß in familial and sporadic Alzheimer's disease.  View on PubMed
  5. Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice.  View on PubMed
  6. Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB A novel vector for transgenesis in the rat CNS.  View on PubMed
  7. Giles K, Woerman AL, Berry DB, Prusiner SB Bioassays and Inactivation of Prions.  View on PubMed
  8. Giles K, Olson SH, Prusiner SB Developing Therapeutics for PrP Prion Diseases.  View on PubMed
  9. Watts JC, Giles K, Saltzberg DJ, Dugger BN, Patel S, Oehler A, Bhardwaj S, Sali A, Prusiner SB Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions.  View on PubMed
  10. Watts JC, Giles K, Bourkas ME, Patel S, Oehler A, Gavidia M, Bhardwaj S, Lee J, Prusiner SB Towards authentic transgenic mouse models of heritable PrP prion diseases.  View on PubMed
  11. Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB Optimization of Aryl Amides that Extend Survival in Prion-Infected Mice.  View on PubMed
  12. Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K Evidence for a-synuclein prions causing multiple system atrophy in humans with parkinsonism.  View on PubMed
  13. Watts JC, Giles K, Serban A, Patel S, Oehler A, Bhardwaj S, Guan S, Greicius MD, Miller BL, DeArmond SJ, Geschwind MD, Prusiner SB Modulation of Creutzfeldt-Jakob disease prion propagation by the A224V mutation.  View on PubMed
  14. Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB Propagation of prions causing synucleinopathies in cultured cells.  View on PubMed
  15. Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.  View on PubMed
  16. Berry D, Giles K, Oehler A, Bhardwaj S, DeArmond SJ, Prusiner SB Use of a 2-aminothiazole to Treat Chronic Wasting Disease in Transgenic Mice.  View on PubMed
  17. Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB Distinct synthetic Aß prion strains producing different amyloid deposits in bigenic mice.  View on PubMed
  18. Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB Serial propagation of distinct strains of Aß prions from Alzheimer's disease patients.  View on PubMed
  19. Watts JC, Giles K, Patel S, Oehler A, DeArmond SJ, Prusiner SB Evidence that bank vole PrP is a universal acceptor for prions.  View on PubMed
  20. Silber BM, Gever JR, Rao S, Li Z, Renslo AR, Widjaja K, Wong C, Giles K, Freyman Y, Elepano M, Irwin JJ, Jacobson MP, Prusiner SB Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells.  View on PubMed

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