Research Summary

My work focuses on the prevention and treatment of HIV infection.

I have been involved in studies of HIV prevention (specifically, truvada for PrEP) for over 12 years. I was the statistician for the iPrEx trial -- the first trial to report the efficacy of oral PrEP and worked on the drugs approval by the FDA. My current work involves studies of the global scale-up of PrEP, innovative designs/statistical analyses of new PrEP agents, and pharmacologic markers of PrEP exposure.

I also collaborate on studies on the outcomes of HIV treatment in resource limited settings. In these settings many patients are absent from clinics. This data requires handling several statistical issues including clustering, competing risk/multiple outcomes, time-dependent covariates and informative censoring. My colleagues and I have pioneered sampling based approaches to losses to follow-up which have given rigorous information about treatment outcomes.

I also collaborate for groups in neurology, pediatrics, LGBT health and nephrology and teach in my department's MCR and Ph.D. program.

Research Funding

  • September 24, 2018 - August 31, 2022 - Statistical methods for clinical trials of novel PrEP agents , Principal Investigator . Sponsor: NIH/NIAIDS, Sponsor Award ID: R01AI143357
  • January 10, 2016 - December 31, 2017 - Comparison of Pharmacologic Markers of Exposure to HIV Pre-Exposure Prophylaxis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R03AI122908
  • June 19, 2015 - May 31, 2017 - Chemoprophylaxis for HIV Prevention: Analysis of Bone and Metabolic Effects , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R03AI120819
  • April 1, 2001 - March 31, 2006 - FAILURE TIME METHODS FOR FAMILY DISEASE STUDIES , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL065411

Education

University of California, Berkeley, CA, BA, 1988, Statistics
University of Washington, Seattle, WA, PhD, 1993, Biostatistics
Harvard University, Boston, MA, Fellowship, 1995, Biostatistics

Honors & Awards

  • 1988
    W.W. Stout Fellowship, Graduate School, University of Washington
  • 1988 - 1990
    Graduate Fellowship Award, Graduate School, University of Washington
  • 1990 - 1993
    National Research Service Award, National Heart, Lung and Blood Institute
  • 1993
    School of Public Health Outstanding Student Citation for Biostatistics, Univ. of Washington
  • 2007
    TICR Award for Excellence in Teaching

Selected Publications

  1. Spinelli MA, Heise MJ, Gistand N, Cox C, Grochowski J, Oskarsson J, Glidden DV, Gandhi M. HIV Viral Suppression With Use of Long-Acting Antiretroviral Therapy in People With and Without Initial Viremia. JAMA. 2025 Mar 06.  View on PubMed
  2. Crook S, Rosenbluth G, Glidden DV, Fernandez A, Lee CM, Avina L, Magana L, Washington K, Bardach NS. Variations in digital health literacy for pediatric caregivers of hospitalized children: implications for digital health equity. J Am Med Inform Assoc. 2025 Mar 01; 32(3):572-578.  View on PubMed
  3. Rodriguez Almaraz E, Guerra GA, Al-Adli NN, Young JS, Dada A, Quintana D, Taylor JW, Oberheim Bush NA, Clarke JL, Butowski NA, de Groot J, Pekmezci M, Perry A, Bollen AW, Scheffler AW, Glidden DV, Phillips JJ, Costello JF, Chang EF, Hervey-Jumper S, Berger MS, Francis SS, Chang SM, Solomon DA. Longitudinal profiling of IDH-mutant astrocytomas reveals acquired RAS-MAPK pathway mutations associated with inferior survival. Neurooncol Adv. 2025 Jan-Dec; 7(1):vdaf024.  View on PubMed
  4. Sankaran M, Glidden DV, Kohn RP, Nguyen TQ, Bacon O, Buchbinder SP, Gandhi M, Havlir DV, Liebi C, Luetkemeyer AF, Nguyen JQ, Roman J, Scott H, Torres TS, Cohen SE. Doxycycline Postexposure Prophylaxis and Sexually Transmitted Infection Trends. JAMA Intern Med. 2025 Jan 06.  View on PubMed
  5. Bhimraj A, Falck-Ytter Y, Kim AY, Li JZ, Baden LR, Johnson S, Shafer RW, Shoham S, Tebas P, Bedimo R, Cheng VC, Chew KW, Chiotos K, Daar ES, Dzierba AL, Glidden DV, Hardy EJ, Martin GS, MacBrayne C, Nadig N, Nakamura MM, Shumaker AH, Tien P, Loveless J, Morgan RL, Gandhi RT. 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on the Management of COVID-19: Anti-SARS-CoV-2 Neutralizing Antibody Pemivibart for Pre-exposure Prophylaxis. Clin Infect Dis. 2024 Oct 29.  View on PubMed
  6. Schaefer R, Donaldson L, Leus M, Osakwe CE, Chimukangara B, Dalal S, Duerr A, Gao F, Glidden DV, Grinsztejn B, Justman J, Kumwenda G, Laeyendecker O, Lee HY, Maldarelli F, Mayer KH, Murray J, Parekh BS, Rice B, Robertson MN, Saito S, Vannappagari V, Warren M, Zeballos D, Zinserling J, Miller V. Promising results of HIV prevention trials highlight the benefits of collaboration in global health: The perspective of the Forum HIV Recency Assay Working Group. PLOS Glob Public Health. 2024; 4(10):e0003878.  View on PubMed
  7. Gulick RM, Pau AK, Daar E, Evans L, Gandhi RT, Tebas P, Ridzon R, Masur H, Lane HC, NIH COVID-19 Treatment Guidelines Panel, Adimora AA, Baker J, Kreuziger LB, Bedimo R, Belperio P, Bhalla A, Burgess T, Campbell D, Cantrill S, Chew K, Chiotos K, Coopersmith C, Davey R, Dzierba A, Eisnor D, Eschenauer G, Francis J, Gallagher J, Glidden D, Goldenberg N, Grund B, Han A, Hardy E, Harrison C, Henderson L, Higgs E, Hinkson C, Hughes B, Johnson S, Keller M, Kim A, Knight R, Kuriakose S, Lennox J, Lerner A, Levy M, Li J, MacBrayne C, Martin G, Nadig N, Nason M, Patel P, Pavia A, Proschan M, Schulert G, Seam N, Sheikh V, Simpson S, Singh K, Swindells S, Tien P, Uyeki T, Waghmare A, Wolfe C, Yazdany J, Aberg J. National Institutes of Health COVID-19 Treatment Guidelines Panel: Perspectives and Lessons Learned. Ann Intern Med. 2024 Nov; 177(11):1547-1557.  View on PubMed
  8. Spinelli MA, Johnson MO, Lisha NE, Jain JP, Moreira CV, Glidden DV, Burkholder GA, Crane HM, Jacobson JM, Cachay ER, Mayer KH, Napravnik S, Moore RD, Gandhi M, Christopoulos KA. Prevalence and Correlates of SARS-CoV-2 Vaccine Uptake and Hesitancy Among People With HIV Across the United States. J Acquir Immune Defic Syndr. 2024 Sep 01; 97(1):13-18.  View on PubMed
  9. Lu S, Peluso MJ, Glidden DV, Davidson MC, Lugtu K, Pineda-Ramirez J, Tassetto M, Garcia-Knight M, Zhang A, Goldberg SA, Chen JY, Fortes-Cobby M, Park S, Martinez A, So M, Donovan A, Viswanathan B, Hoh R, Donohue K, McIlwain DR, Gaudiliere B, Anglin K, Yee BC, Chenna A, Winslow JW, Petropoulos CJ, Deeks SG, Briggs-Hagen M, Andino R, Midgley CM, Martin JN, Saydah S, Kelly JD. Early biological markers of post-acute sequelae of SARS-CoV-2 infection. Nat Commun. 2024 Aug 29; 15(1):7466.  View on PubMed
  10. Byakwaga H, Semeere A, Laker-Oketta M, Busakhala N, Freeman E, Rotich E, Wenger M, Kadama-Makanga P, Kisuya J, Semakadde M, Mwine B, Kasozi C, Mwebesa B, Maurer T, Glidden DV, Wools-Kaloustian K, Kambugu A, Martin J. Survival Following Diagnosis of HIV-Associated Kaposi Sarcoma Among Adults in East Africa in the "Treat-All" Era. medRxiv. 2024 Aug 28.  View on PubMed
  11. Koss CA, Gandhi M, Halvas EK, Okochi H, Chu C, Glidden DV, Georgetti Gomez L, Heaps AL, Conroy AA, Tran M, Shetler C, Hoeth D, Kuncze K, Louie A, Rivera Garza H, Wafula Mugoma E, Penrose KJ, Chohan BH, Ayieko JO, Mills A, Patel RR, Mellors JW, Parikh UM. First Case of HIV Seroconversion With Integrase Resistance Mutations on Long-Acting Cabotegravir for Prevention in Routine Care. Open Forum Infect Dis. 2024 Sep; 11(9):ofae468.  View on PubMed
  12. Jain JP, Heise MJ, Lisha NE, Moreira CH, Glidden DV, Burkholder GA, Crane HM, Jacobson JM, Cachay ER, Mayer KH, Napravnik S, Moore RD, Dawson-Rose C, Johnson MO, Christopoulos KA, Gandhi M, Spinelli MA. Impact of the Coronavirus Disease 2019 Pandemic on Substance Use Disorder Risk Among People Living With Human Immunodeficiency Virus (HIV) Enrolled in HIV Care in the United States: An Interrupted Time Series Analysis. Open Forum Infect Dis. 2024 Sep; 11(9):ofae491.  View on PubMed
  13. Chaphekar AV, Sevelius J, Glidden D, Vance SR. School Absenteeism Among Racially and Ethnically Minoritized Transgender High School Students and Their Peers: A Cross-Sectional Study. J Adolesc Health. 2024 Nov; 75(5):785-791.  View on PubMed
  14. Tymofiyeva O, Sipes BS, Luks T, Hamlat EJ, Samson TE, Hoffmann TJ, Glidden DV, Jakary A, Li Y, Ngan T, Henje E, Yang TT. Interoceptive brain network mechanisms of mindfulness-based training in healthy adolescents. Front Psychol. 2024; 15:1410319.  View on PubMed
  15. Raney JH, Weinstein S, Testa A, Ganson KT, Memon Z, Glidden DV, Baker FC, Brindis CD, Nagata JM. Sexual Identity Is Associated With Adverse Childhood Experiences in US Early Adolescents. Acad Pediatr. 2025 Jan-Feb; 25(1):102555.  View on PubMed
  16. Gandhi M, Glidden DV, Chakravarty D, Wang G, Biwott C, Mogere P, Maina G, Njeru I, Kiptinness C, Okello P, Spinelli MA, Chatterjee P, Velloza J, Ogello V, Medina-Marino A, Okochi H, Mugo NR, Ngure K. Impact of a point-of-care urine tenofovir assay on adherence to HIV pre-exposure prophylaxis among women in Kenya: a randomised pilot trial. Lancet HIV. 2024 Aug; 11(8):e522-e530.  View on PubMed
  17. Martinson T, Montoya R, Moreira C, Kuncze K, Sassaman K, Heise MJ, Glidden DV, Amico KR, Arnold EA, Buchbinder SP, Ewart LD, Carrico A, Wang G, Okochi H, Scott HM, Gandhi M, Spinelli MA. Point-of-care urine tenofovir test predicts future HIV preexposure prophylaxis discontinuation among young users. AIDS. 2024 Sep 01; 38(11):1671-1676.  View on PubMed
  18. Wu L, Saina M, Brown C, Chege D, Donnell D, Glidden DV, Ngure K, Mugo NR, Akelo N, Schaafsma T, Anderson PL, Mugwanya KK. Establishing adherence-concentration-efficacy thresholds of TDF-FTC pre-exposure prophylaxis for HIV prevention in African women: a protocol for the Women TDF-FTC Benchmark Study. Front Reprod Health. 2024; 6:1325257.  View on PubMed
  19. Al-Shoaibi AAA, Lavender JM, Kim SJ, Shao IY, Ganson KT, Testa A, He J, Glidden DV, Baker FC, Nagata JM. Association of body mass index with progression from binge-eating behavior into binge-eating disorder among adolescents in the United States: A prospective analysis of pooled data. Appetite. 2024 09 01; 200:107419.  View on PubMed
  20. Nagata JM, Balasubramanian P, Iyra P, Ganson KT, Testa A, He J, Glidden DV, Baker FC. Screen use in transgender and gender-questioning adolescents: Findings from the Adolescent Brain Cognitive Development (ABCD) Study. Ann Epidemiol. 2024 Jul; 95:6-11.  View on PubMed

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