Research Summary

Persistent low-grade inflammation during aging underlies many chronic diseases, including insulin resistance, cardiovascular diseases, Alzheimer’s disease, and immunesenescence. Development of effective strategies to dampen age-related inflammation have been limited by our lack of understanding of the basic mechanisms that lead to its accumulation. We use integrative approaches to understand how immune-metabolic interactions regulate inflammation and can be harnessed to improve immunity and health during aging.

Research Funding

  • January 1, 2019 - May 31, 2023 - Impact of ketone bodies on age-related inflammation and healthspan extension , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R00AG058801
  • January 1, 2019 - December 31, 2020 - Impact of ketone bodies on age-related inflammation and healthspan extension , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K99AG058801

Education

  • University of Arizona, B.S., 2008, Biochemistry, Molecular Biology
  • University of Arizona, Ph.D., 2014, Nutritional Science, Immunology
  • Yale University, Postdoc, 2020, Immunometabolism

Honors & Awards

  • 2020
    Chan Zuckerberg Investigator Award
  • 2018
    Society for Leukocyte Biology Trainee Award
  • 2016
    American Heart Association Postdoctoral Fellowship
  • 2015
    American Federation for Aging Research Postdoctoral Fellowship

Selected Publications

  1. Zhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, Fernández-Hernando C. Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis. Proc Natl Acad Sci U S A. 2021 11 23; 118(47).  View on PubMed
  2. Goldberg EL, Shchukina I, Youm YH, Ryu S, Tsusaka T, Young KC, Camell CD, Dlugos T, Artyomov MN, Dixit VD. IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2. Cell Metab. 2021 11 02; 33(11):2277-2287.e5.  View on PubMed
  3. Goldberg EL. Integration of immune-metabolic signals to preserve healthy aging. Transl Med Aging. 2020; 4:93-95.  View on PubMed
  4. Stubbs BJ, Koutnik AP, Goldberg EL, Upadhyay V, Turnbaugh PJ, Verdin E, Newman JC. Investigating Ketone Bodies as Immunometabolic Countermeasures against Respiratory Viral Infections. Med (N Y). 2020 12 18; 1(1):43-65.  View on PubMed
  5. Goldberg EL, Shaw AC, Montgomery RR. How Inflammation Blunts Innate Immunity in Aging. Interdiscip Top Gerontol Geriatr. 2020; 43:1-17.  View on PubMed
  6. Goldberg EL, Shchukina I, Asher JL, Sidorov S, Artyomov MN, Dixit VD. Ketogenesis activates metabolically protective γδ T cells in visceral adipose tissue. Nat Metab. 2020 01; 2(1):50-61.  View on PubMed
  7. Goldberg EL, Molony RD, Kudo E, Sidorov S, Kong Y, Dixit VD, Iwasaki A. Ketogenic diet activates protective γδ T cell responses against influenza virus infection. Sci Immunol. 2019 11 15; 4(41).  View on PubMed
  8. Camell CD, Günther P, Lee A, Goldberg EL, Spadaro O, Youm YH, Bartke A, Hubbard GB, Ikeno Y, Ruddle NH, Schultze J, Dixit VD. Aging Induces an Nlrp3 Inflammasome-Dependent Expansion of Adipose B Cells That Impairs Metabolic Homeostasis. Cell Metab. 2019 12 03; 30(6):1024-1039.e6.  View on PubMed
  9. Goldberg EL, Dixit VD. Bone Marrow: An Immunometabolic Refuge during Energy Depletion. Cell Metab. 2019 10 01; 30(4):621-623.  View on PubMed
  10. Camporez JP, Lyu K, Goldberg EL, Zhang D, Cline GW, Jurczak MJ, Dixit VD, Petersen KF, Shulman GI. Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance. J Physiol. 2019 08; 597(15):3885-3903.  View on PubMed
  11. Camell CD, Sander J, Spadaro O, Lee A, Nguyen KY, Wing A, Goldberg EL, Youm YH, Brown CW, Elsworth J, Rodeheffer MS, Schultze JL, Dixit VD. Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing. Nature. 2017 10 05; 550(7674):119-123.  View on PubMed
  12. Goldberg EL, Asher JL, Molony RD, Shaw AC, Zeiss CJ, Wang C, Morozova-Roche LA, Herzog RI, Iwasaki A, Dixit VD. β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares. Cell Rep. 2017 02 28; 18(9):2077-2087.  View on PubMed
  13. Goldberg EL, Dixit VD. Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation. Mol Metab. 2017 02; 6(2):219-225.  View on PubMed
  14. Spadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD. Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence. Cell Rep. 2016 Feb 23; 14(7):1571-1580.  View on PubMed
  15. Goldberg EL, Dixit VD. Editorial: "Crowning" eosinophils in adipose tissue: does location matter? J Leukoc Biol. 2015 Oct; 98(4):451-2.  View on PubMed
  16. Camell C, Goldberg E, Dixit VD. Regulation of Nlrp3 inflammasome by dietary metabolites. Semin Immunol. 2015 Sep; 27(5):334-42.  View on PubMed
  17. Goldberg EL, Dixit VD. Drivers of age-related inflammation and strategies for healthspan extension. Immunol Rev. 2015 May; 265(1):63-74.  View on PubMed
  18. Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, Alnemri E, Dixit VD. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015 Mar; 21(3):263-9.  View on PubMed
  19. Goldberg EL, Romero-Aleshire MJ, Renkema KR, Ventevogel MS, Chew WM, Uhrlaub JL, Smithey MJ, Limesand KH, Sempowski GD, Brooks HL, Nikolich-Žugich J. Lifespan-extending caloric restriction or mTOR inhibition impair adaptive immunity of old mice by distinct mechanisms. Aging Cell. 2015 Feb; 14(1):130-8.  View on PubMed
  20. Goldberg EL, Smithey MJ, Lutes LK, Uhrlaub JL, Nikolich-Žugich J. Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infections. J Immunol. 2014 Jul 15; 193(2):757-63.  View on PubMed

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