• Universidad de Talca (Chile), Bachelor of Science, 2005, Medical Technology
  • Universidad Andres Bello (Chile), PhD, 2013, Molecular Biology
  • University of California San Francisco (USA), Postdoc, 2022, Cancer Metastasis

Selected Publications

  1. You R, Artichoker J, Ray A, Gonzalez Velozo H, Rock DA, Conner KP, Krummel MF. Visualizing Spatial and Stoichiometric Barriers to Bispecific T-Cell Engager Efficacy. Cancer Immunol Res. 2022 Jun 3;10(6):698-712. doi: 10.1158/2326-6066.CIR-21-0594. View on PubMed
  2. Gonzalez H, Mei W, Robles I, Hagerling C, Allen BM, Hauge Okholm TL, Nanjaraj A, Verbeek T, Kalavacherla S, van Gogh M, Georgiou S, Daras M, Phillips JJ, Spitzer MH, Roose JP, Werb Z. Cellular architecture of human brain metastases. Cell. 2022 Feb 17;185(4):729-745.e20. doi: 10.1016/j.cell.2021.12.043. Epub 2022 Jan 20. View on PubMed
  3. Marsh T, Kenific CM, Suresh D, Gonzalez H, Shamir ER, Mei W, Tankka A, Leidal AM, Kalavacherla S, Woo K, Werb Z, Debnath J. Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression. Dev Cell. 2020 Mar 9;52(5):591-604.e6. doi: 10.1016/j.devcel.2020.01.025. Epub 2020 Feb 20. View on PubMed
  4. Hagerling C, Gonzalez H, Salari K, Wang CY, Lin C, Robles I, van Gogh M, Dejmek A, Jirström K, Werb Z. Immune effector monocyte-neutrophil cooperation induced by the primary tumor prevents metastatic progression of breast cancer. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21704-21714. doi: 10.1073/pnas.1907660116. Epub 2019 Oct 7. View on PubMed
  5. Prado C, Ugalde V, González H, Figueroa A, López E, Lladser A, Pacheco R. STAT3 Activation in Combination with NF-KappaB Inhibition Induces Tolerogenic Dendritic Cells with High Therapeutic Potential to Attenuate Collagen-Induced Arthritis. J Immunol Res. 2019;2019:1982570. doi: 10.1155/2019/1982570. eCollection 2019. View on PubMed
  6. Gonzalez H, Hagerling C, Werb Z. Roles of the immune system in cancer: from tumor initiation to metastatic progression. Genes Dev. 2018 Oct 1;32(19-20):1267-1284. doi: 10.1101/gad.314617.118. Review. View on PubMed
  7. Prado C, Gaiazzi M, González H, Ugalde V, Figueroa A, Osorio-Barrios FJ, López E, Lladser A, Rasini E, Marino F, Zaffaroni M, Cosentino M, Pacheco R. Dopaminergic Stimulation of Myeloid Antigen-Presenting Cells Attenuates Signal Transducer and Activator of Transcription 3-Activation Favouring the Development of Experimental Autoimmune Encephalomyelitis. Front Immunol. 2018;9:571. doi: 10.3389/fimmu.2018.00571. eCollection 2018. View on PubMed
  8. Sun Z, Wang CY, Lawson DA, Kwek S, Velozo HG, Owyong M, Lai MD, Fong L, Wilson M, Su H, Werb Z, Cooke DL. Single-cell RNA sequencing reveals gene expression signatures of breast cancer-associated endothelial cells. Oncotarget. 2018 Feb 16;9(13):10945-10961. doi: 10.18632/oncotarget.23760. eCollection 2018 Feb 16. View on PubMed
  9. Gonzalez H, Robles I, Werb Z. Innate and acquired immune surveillance in the postdissemination phase of metastasis. FEBS J. 2018 Feb;285(4):654-664. doi: 10.1111/febs.14325. Epub 2017 Nov 24. Review. View on PubMed
  10. Shahi P, Wang CY, Lawson DA, Slorach EM, Lu A, Yu Y, Lai MD, Gonzalez Velozo H, Werb Z. ZNF503/Zpo2 drives aggressive breast cancer progression by down-regulation of GATA3 expression. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3169-3174. doi: 10.1073/pnas.1701690114. Epub 2017 Mar 3. View on PubMed
  11. Elgueta D, Aymerich MS, Contreras F, Montoya A, Celorrio M, Rojo-Bustamante E, Riquelme E, González H, Vásquez M, Franco R, Pacheco R. Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease. Neuropharmacology. 2017 Feb;113(Pt A):110-123. doi: 10.1016/j.neuropharm.2016.09.028. Epub 2016 Sep 28. View on PubMed
  12. Contreras F, Prado C, González H, Franz D, Osorio-Barrios F, Osorio F, Ugalde V, Lopez E, Elgueta D, Figueroa A, Lladser A, Pacheco R. Dopamine Receptor D3 Signaling on CD4+ T Cells Favors Th1- and Th17-Mediated Immunity. J Immunol. 2016 May 15;196(10):4143-9. doi: 10.4049/jimmunol.1502420. Epub 2016 Apr 18. View on PubMed
  13. Moraga-Amaro R, González H, Ugalde V, Donoso-Ramos JP, Quintana-Donoso D, Lara M, Morales B, Rojas P, Pacheco R, Stehberg J. Dopamine receptor D5 deficiency results in a ive reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory. Neuropharmacology. 2016 Apr;103:222-35. doi: 10.1016/j.neuropharm.2015.12.018. Epub 2015 Dec 20. View on PubMed
  14. González H, Contreras F, Pacheco R. Regulation of the Neurodegenerative Process Associated to Parkinson's Disease by CD4+ T-cells. J Neuroimmune Pharmacol. 2015 Dec;10(4):561-75. doi: 10.1007/s11481-015-9618-9. Epub 2015 May 28. Review. View on PubMed
  15. Franz D, Contreras F, González H, Prado C, Elgueta D, Figueroa C, Pacheco R. Dopamine receptors D3 and D5 regulate CD4(+)T-cell activation and differentiation by modulating ERK activation and cAMP production. J Neuroimmunol. 2015 Jul 15;284:18-29. doi: 10.1016/j.jneuroim.2015.05.003. Epub 2015 May 1. View on PubMed
  16. González H, Pacheco R. T-cell-mediated regulation of neuroinflammation involved in neurodegenerative diseases. J Neuroinflammation. 2014 Dec 2;11:201. doi: 10.1186/s12974-014-0201-8. Review. View on PubMed
  17. Moraga-Amaro R, Gonzalez H, Pacheco R, Stehberg J. Dopamine receptor D3 deficiency results in chronic depression and anxiety. Behav Brain Res. 2014 Nov 1;274:186-93. doi: 10.1016/j.bbr.2014.07.055. Epub 2014 Aug 8. View on PubMed
  18. Fernández-Suárez D, Celorrio M, Riezu-Boj JI, Ugarte A, Pacheco R, González H, Oyarzabal J, Hillard CJ, Franco R, Aymerich MS. Monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. Neurobiol Aging. 2014 Nov;35(11):2603-2616. doi: 10.1016/j.neurobiolaging.2014.05.021. Epub 2014 May 28. View on PubMed
  19. González H, Elgueta D, Montoya A, Pacheco R. Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases. J Neuroimmunol. 2014 Sep 15;274(1-2):1-13. doi: 10.1016/j.jneuroim.2014.07.012. Epub 2014 Jul 23. Review. View on PubMed
  20. González H, Contreras F, Prado C, Elgueta D, Franz D, Bernales S, Pacheco R. Dopamine receptor D3 expressed on CD4+ T cells favors neurodegeneration of dopaminergic neurons during Parkinson's disease. J Immunol. 2013 May 15;190(10):5048-56. doi: 10.4049/jimmunol.1203121. Epub 2013 Apr 15. View on PubMed

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