Research Summary

I am involved with the Urologic, Thoracic, Orthopedic and Gastrointestinal Oncology programs at UCSF. I spend 4 days per week providing clinical coverage for the above programs program. On average, I see 6 new patient consultations per week and 15 patients on treatment. I am responsible for patient simulations, treatment planning, supervision of external-beam radiation therapy, on-treatment visits, and follow-up visits. In addition, I am involved in the brachytherapy, intra-operative radiation therapy and stereotactic body radiotherapy programs. I attend tumor boards for GU, Thoracic, GI, orthopedic oncology programs and at the Veterans Administration Hospital. I work very closely with radiation oncology residents and medical students in all the above activities. I am the Director of the CyberKnife Radiosurgery Program at UCSF and proctor other faculty in this area. As Vice Chair of clinical services I over see clinical operations at the Mount Zion site, and over see the site directors at both the Parnassus Mission Bay and Washington Hospital.

Education

M.D., 1996 - School of Medicine, University of Chicago

Honors & Awards

  • Commitment to Patient Care Award, UCSF, 2012-2013
  • Lifetime Teaching Award, UCSF, 2012-2013
  • Educator of the Year, UCSF, 2009-2010

Selected Publications

  1. Rentsch D, Bergs A, Shao J, Elvers N, Ruse C, Seidenthal M, Aoki I, Gottschalk A. Tools and methods for cell ablation and cell inhibition in Caenorhabditis elegans. Genetics. 2025 Jan 08; 229(1):1-48.  View on PubMed
  2. Jánosi B, Liewald JF, Seidenthal M, Yu SC, Umbach S, Redzovic J, Rentsch D, Alcantara IC, Bergs ACF, Schneider MW, Shao J, Gottschalk A. RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits. J Neurosci. 2024 Jul 31; 44(31).  View on PubMed
  3. Xu D, Descovich M, Liu H, Lao Y, Gottschalk AR, Sheng K. Deep match: A zero-shot framework for improved fiducial-free respiratory motion tracking. Radiother Oncol. 2024 05; 194:110179.  View on PubMed
  4. Hanson SM, Scholüke J, Liewald J, Sharma R, Ruse C, Engel M, Schüler C, Klaus A, Arghittu S, Baumbach F, Seidenthal M, Dill H, Hummer G, Gottschalk A. Structure-function analysis suggests that the photoreceptor LITE-1 is a light-activated ion channel. Curr Biol. 2023 08 21; 33(16):3423-3435.e5.  View on PubMed
  5. Bergs ACF, Liewald JF, Rodriguez-Rozada S, Liu Q, Wirt C, Bessel A, Zeitzschel N, Durmaz H, Nozownik A, Dill H, Jospin M, Vierock J, Bargmann CI, Hegemann P, Wiegert JS, Gottschalk A. All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals. Nat Commun. 2023 04 06; 14(1):1939.  View on PubMed
  6. Vettkötter D, Schneider M, Goulden BD, Dill H, Liewald J, Zeiler S, Guldan J, Ates YA, Watanabe S, Gottschalk A. Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles. Nat Commun. 2022 12 19; 13(1):7827.  View on PubMed
  7. Seidenthal M, Vettkötter D, Gottschalk A. WormRuler: A software to track body length used to characterize a super red-shifted channelrhodopsin in Caenorhabditis elegans. MicroPubl Biol. 2022; 2022.  View on PubMed
  8. Shee K, de la Calle CM, Chang AJ, Wong AC, Feng FY, Gottschalk AR, Carroll PR, Nguyen HG. Addition of Enzalutamide to Leuprolide and Definitive Radiation Therapy Is Tolerable and Effective in High-Risk Localized or Regional Nonmetastatic Prostate Cancer: Results From a Phase 2 Trial. Adv Radiat Oncol. 2022 Sep-Oct; 7(5):100941.  View on PubMed
  9. Bergs A, Henss T, Glock C, Nagpal J, Gottschalk A. Microbial Rhodopsin Optogenetic Tools: Application for Analyses of Synaptic Transmission and of Neuronal Network Activity in Behavior. Methods Mol Biol. 2022; 2468:89-115.  View on PubMed
  10. Henss T, Schneider M, Vettkötter D, Costa WS, Liewald JF, Gottschalk A. Photoactivated Adenylyl Cyclases as Optogenetic Modulators of Neuronal Activity. Methods Mol Biol. 2022; 2483:61-76.  View on PubMed
  11. Vierock J, Rodriguez-Rozada S, Dieter A, Pieper F, Sims R, Tenedini F, Bergs ACF, Bendifallah I, Zhou F, Zeitzschel N, Ahlbeck J, Augustin S, Sauter K, Papagiakoumou E, Gottschalk A, Soba P, Emiliani V, Engel AK, Hegemann P, Wiegert JS. BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons. Nat Commun. 2021 07 26; 12(1):4527.  View on PubMed
  12. Henß T, Nagpal J, Gao S, Scheib U, Pieragnolo A, Hirschhäuser A, Schneider-Warme F, Hegemann P, Nagel G, Gottschalk A. Optogenetic tools for manipulation of cyclic nucleotides functionally coupled to cyclic nucleotide-gated channels. Br J Pharmacol. 2022 06; 179(11):2519-2537.  View on PubMed
  13. Yu SC, Liewald JF, Shao J, Steuer Costa W, Gottschalk A. Synapsin Is Required for Dense Core Vesicle Capture and cAMP-Dependent Neuropeptide Release. J Neurosci. 2021 05 12; 41(19):4187-4201.  View on PubMed
  14. Chen WC, Li Y, Lazar A, Altun A, Descovich M, Nano T, Ziemer B, Sudhyadhom A, Cunha A, Thomas H, Gottschalk A, Hsu IC, Roach M. Stereotactic Body Radiation Therapy and High-Dose-Rate Brachytherapy Boost in Combination With Intensity Modulated Radiation Therapy for Localized Prostate Cancer: A Single-Institution Propensity Score Matched Analysis. Int J Radiat Oncol Biol Phys. 2021 06 01; 110(2):429-437.  View on PubMed
  15. Wu SY, Lazar AA, Gubens MA, Blakely CM, Gottschalk AR, Jablons DM, Jahan TM, Wang VEH, Dunbar TL, Wong ML, Chan JW, Guthrie W, Belkora J, Yom SS. Evaluation of a National Comprehensive Cancer Network Guidelines-Based Decision Support Tool in Patients With Non-Small Cell Lung Cancer: A Nonrandomized Clinical Trial. JAMA Netw Open. 2020 09 01; 3(9):e209750.  View on PubMed
  16. Ikeda M, Nakano S, Giles AC, Xu L, Costa WS, Gottschalk A, Mori I. Context-dependent operation of neural circuits underlies a navigation behavior in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2020 03 17; 117(11):6178-6188.  View on PubMed
  17. Chen WC, Baal JD, Baal U, Pai J, Gottschalk A, Boreta L, Braunstein SE, Raleigh DR. Stereotactic Body Radiation Therapy of Adrenal Metastases: A Pooled Meta-Analysis and Systematic Review of 39 Studies with 1006 Patients. Int J Radiat Oncol Biol Phys. 2020 05 01; 107(1):48-61.  View on PubMed
  18. Konietzka J, Fritz M, Spiri S, McWhirter R, Leha A, Palumbos S, Costa WS, Oranth A, Gottschalk A, Miller DM, Hajnal A, Bringmann H. Epidermal Growth Factor Signaling Promotes Sleep through a Combined Series and Parallel Neural Circuit. Curr Biol. 2020 01 06; 30(1):1-16.e13.  View on PubMed
  19. Azimi Hashemi N, Bergs ACF, Schüler C, Scheiwe AR, Steuer Costa W, Bach M, Liewald JF, Gottschalk A. Rhodopsin-based voltage imaging tools for use in muscles and neurons of Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2019 08 20; 116(34):17051-17060.  View on PubMed
  20. Woldemariam S, Nagpal J, Hill T, Li J, Schneider MW, Shankar R, Futey M, Varshney A, Ali N, Mitchell J, Andersen K, Barsi-Rhyne B, Tran A, Costa WS, Krzyzanowski MC, Yu YV, Brueggemann C, Hamilton OS, Ferkey DM, VanHoven M, Sengupta P, Gottschalk A, L'Etoile N. Using a Robust and Sensitive GFP-Based cGMP Sensor for Real-Time Imaging in Intact Caenorhabditis elegans. Genetics. 2019 09; 213(1):59-77.  View on PubMed

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