Research Summary

I am involved with the Urologic, Thoracic, Orthopedic and Gastrointestinal Oncology programs at UCSF. I spend 4 days per week providing clinical coverage for the above programs program. On average, I see 6 new patient consultations per week and 15 patients on treatment. I am responsible for patient simulations, treatment planning, supervision of external-beam radiation therapy, on-treatment visits, and follow-up visits. In addition, I am involved in the brachytherapy, intra-operative radiation therapy and stereotactic body radiotherapy programs. I attend tumor boards for GU, Thoracic, GI, orthopedic oncology programs and at the Veterans Administration Hospital. I work very closely with radiation oncology residents and medical students in all the above activities. I am the Director of the CyberKnife Radiosurgery Program at UCSF and proctor other faculty in this area. As Vice Chair of clinical services I over see clinical operations at the Mount Zion site, and over see the site directors at both the Parnassus Mission Bay and Washington Hospital.

Education

M.D., 1996 - School of Medicine, University of Chicago

Honors & Awards

  • Commitment to Patient Care Award, UCSF, 2012-2013
  • Lifetime Teaching Award, UCSF, 2012-2013
  • Educator of the Year, UCSF, 2009-2010

Selected Publications

  1. Tovilla-Loza FI, Téllez-Arreola JL, Martínez-García I, Pimentel-Domínguez R, Avila R, Seidenthal M, Gottschalk A, Martínez-Torres A. Endoplasmic reticulum proteins MCTP-1 and ESYT-2 support presynaptic function during sustained activity in Caenorhabditis elegans. Neuroscience. 2026 Sep 11; 611:145-154. View on PubMed
  2. Duan X, Zhang C, Ott S, Zhang Z, Ruse C, Dannhäuser S, Jacobi R, Ehmann N, Sachidanandan D, Nagel G, Heckmann M, Kittel RJ, Gottschalk A, Claridge-Chang A, Gao S. Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins. Adv Sci (Weinh). 2026 Jan; 13(6):e09180. View on PubMed
  3. Rosenkranz N, Birtasu AN, Wieland K, Rehm L, Sharma R, Vats A, Manger S, Srivastava A, Bhattacharya A, Hummer G, Frangakis AS, Gottschalk A. In situ structure of a gap junction-stomatin complex. Sci Adv. 2025 Nov 07; 11(45):eaea8596. View on PubMed
  4. Ruse C, Liewald JF, Seidenthal M, Tillert L, Vierock J, Gottschalk A. Potassium-selective channelrhodopsins can exert hyper- or depolarizing effects in excitable cells of Caenorhabditis elegans, depending on experimental conditions. Genetics. 2025 07 09; 230(3). View on PubMed
  5. Dunkel E, Aoki I, Bergs A, Gottschalk A. Neurons and molecules involved in noxious light sensation in Caenorhabditis elegans. G3 (Bethesda). 2025 06 04; 15(6). View on PubMed
  6. Seidenthal M, Redzovic J, Liewald JF, Rentsch D, Shapiguzov S, Schuh N, Rosenkranz N, Eimer S, Gottschalk A. Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca2+ ATPase to promote recycling of synaptic vesicles. Elife. 2025 May 20; 13. View on PubMed
  7. Descovich M, Lau E, Hasse K, Gottschalk A. A Quality Control Procedure for Single Fiducial Tracking of Lung Lesions. Cureus. 2025 May; 17(5):e83935. View on PubMed
  8. Shao J, Liewald JF, Steuer Costa W, Ruse C, Gruber J, Djamshedzad MS, Gebhardt W, Gottschalk A. Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength. PLoS Biol. 2025 May; 23(5):e3003171. View on PubMed
  9. Rentsch D, Bergs A, Shao J, Elvers N, Ruse C, Seidenthal M, Aoki I, Gottschalk A. Tools and methods for cell ablation and cell inhibition in Caenorhabditis elegans. Genetics. 2025 01 08; 229(1):1-48. View on PubMed
  10. Aoki I, Golinelli L, Dunkel E, Bhat S, Bassam E, Beets I, Gottschalk A. Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair. Nat Commun. 2024 11 03; 15(1):9504. View on PubMed
  11. Dill H, Liewald JF, Becker M, Seidenthal M, Gottschalk A. Neuropeptidergic regulation of neuromuscular signaling in larval zebrafish alters swimming behavior and synaptic transmission. iScience. 2024 Sep 20; 27(9):110687. View on PubMed
  12. Jánosi B, Liewald JF, Seidenthal M, Yu SC, Umbach S, Redzovic J, Rentsch D, Alcantara IC, Bergs ACF, Schneider MW, Shao J, Gottschalk A. RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits. J Neurosci. 2024 07 31; 44(31). View on PubMed
  13. Xu D, Descovich M, Liu H, Lao Y, Gottschalk AR, Sheng K. Deep match: A zero-shot framework for improved fiducial-free respiratory motion tracking. Radiother Oncol. 2024 05; 194:110179. View on PubMed
  14. Hanson SM, Scholüke J, Liewald J, Sharma R, Ruse C, Engel M, Schüler C, Klaus A, Arghittu S, Baumbach F, Seidenthal M, Dill H, Hummer G, Gottschalk A. Structure-function analysis suggests that the photoreceptor LITE-1 is a light-activated ion channel. Curr Biol. 2023 08 21; 33(16):3423-3435.e5. View on PubMed
  15. Bergs ACF, Liewald JF, Rodriguez-Rozada S, Liu Q, Wirt C, Bessel A, Zeitzschel N, Durmaz H, Nozownik A, Dill H, Jospin M, Vierock J, Bargmann CI, Hegemann P, Wiegert JS, Gottschalk A. All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals. Nat Commun. 2023 04 06; 14(1):1939. View on PubMed
  16. Seidenthal M, Jánosi B, Rosenkranz N, Schuh N, Elvers N, Willoughby M, Zhao X, Gottschalk A. pOpsicle: An all-optical reporter system for synaptic vesicle recycling combining pH-sensitive fluorescent proteins with optogenetic manipulation of neuronal activity. Front Cell Neurosci. 2023; 17:1120651. View on PubMed
  17. Vettkötter D, Schneider M, Goulden BD, Dill H, Liewald J, Zeiler S, Guldan J, Ates YA, Watanabe S, Gottschalk A. Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles. Nat Commun. 2022 12 19; 13(1):7827. View on PubMed
  18. Seidenthal M, Vettkötter D, Gottschalk A. WormRuler: A software to track body length used to characterize a super red-shifted channelrhodopsin in Caenorhabditis elegans. MicroPubl Biol. 2022; 2022. View on PubMed
  19. Shee K, de la Calle CM, Chang AJ, Wong AC, Feng FY, Gottschalk AR, Carroll PR, Nguyen HG. Addition of Enzalutamide to Leuprolide and Definitive Radiation Therapy Is Tolerable and Effective in High-Risk Localized or Regional Nonmetastatic Prostate Cancer: Results From a Phase 2 Trial. Adv Radiat Oncol. 2022 Sep-Oct; 7(5):100941. View on PubMed
  20. Bergs A, Henss T, Glock C, Nagpal J, Gottschalk A. Microbial Rhodopsin Optogenetic Tools: Application for Analyses of Synaptic Transmission and of Neuronal Network Activity in Behavior. Methods Mol Biol. 2022; 2468:89-115. View on PubMed

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