Research Summary

I am involved with the Urologic, Thoracic, Orthopedic and Gastrointestinal Oncology programs at UCSF. I spend 4 days per week providing clinical coverage for the above programs program. On average, I see 6 new patient consultations per week and 15 patients on treatment. I am responsible for patient simulations, treatment planning, supervision of external-beam radiation therapy, on-treatment visits, and follow-up visits. In addition, I am involved in the brachytherapy, intra-operative radiation therapy and stereotactic body radiotherapy programs. I attend tumor boards for GU, Thoracic, GI, orthopedic oncology programs and at the Veterans Administration Hospital. I work very closely with radiation oncology residents and medical students in all the above activities. I am the Director of the CyberKnife Radiosurgery Program at UCSF and proctor other faculty in this area. As Vice Chair of clinical services I over see clinical operations at the Mount Zion site, and over see the site directors at both the Parnassus Mission Bay and Washington Hospital.

Education

M.D., 1996 - School of Medicine, University of Chicago

Honors & Awards

  • Commitment to Patient Care Award, UCSF, 2012-2013
  • Lifetime Teaching Award, UCSF, 2012-2013
  • Educator of the Year, UCSF, 2009-2010

Selected Publications

  1. Dunkel E, Aoki I, Bergs A, Gottschalk A Neurons and molecules involved in noxious light sensation in Caenorhabditis elegans.  View on PubMed
  2. Seidenthal M, Redzovic J, Liewald JF, Rentsch D, Shapiguzov S, Schuh N, Rosenkranz N, Eimer S, Gottschalk A Flower/FLWR-1 regulates neuronal activity via the plasma membrane Ca2+ ATPase to promote recycling of synaptic vesicles.  View on PubMed
  3. Descovich M, Lau E, Hasse K, Gottschalk A A Quality Control Procedure for Single Fiducial Tracking of Lung Lesions.  View on PubMed
  4. Shao J, Liewald JF, Steuer Costa W, Ruse C, Gruber J, Djamshedzad MS, Gebhardt W, Gottschalk A Loss of neuropeptidergic regulation of cholinergic transmission induces homeostatic compensation in muscle cells to preserve synaptic strength.  View on PubMed
  5. Ruse C, Liewald J, Seidenthal M, Tillert L, Vierock J, Gottschalk A Potassium-selective channelrhodopsins can exert hyper- or depolarizing effects in excitable cells of Caenorhabditis elegans, depending on experimental conditions.  View on PubMed
  6. Rentsch D, Bergs A, Shao J, Elvers N, Ruse C, Seidenthal M, Aoki I, Gottschalk A. Tools and methods for cell ablation and cell inhibition in Caenorhabditis elegans. Genetics. 2025 Jan 08; 229(1):1-48.  View on PubMed
  7. Aoki I, Golinelli L, Dunkel E, Bhat S, Bassam E, Beets I, Gottschalk A Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair.  View on PubMed
  8. Dill H, Liewald JF, Becker M, Seidenthal M, Gottschalk A Neuropeptidergic regulation of neuromuscular signaling in larval zebrafish alters swimming behavior and synaptic transmission.  View on PubMed
  9. Jánosi B, Liewald JF, Seidenthal M, Yu SC, Umbach S, Redzovic J, Rentsch D, Alcantara IC, Bergs ACF, Schneider MW, Shao J, Gottschalk A. RIM and RIM-Binding Protein Localize Synaptic CaV2 Channels to Differentially Regulate Transmission in Neuronal Circuits. J Neurosci. 2024 Jul 31; 44(31).  View on PubMed
  10. Xu D, Descovich M, Liu H, Lao Y, Gottschalk AR, Sheng K. Deep match: A zero-shot framework for improved fiducial-free respiratory motion tracking. Radiother Oncol. 2024 05; 194:110179.  View on PubMed
  11. Hanson SM, Scholüke J, Liewald J, Sharma R, Ruse C, Engel M, Schüler C, Klaus A, Arghittu S, Baumbach F, Seidenthal M, Dill H, Hummer G, Gottschalk A. Structure-function analysis suggests that the photoreceptor LITE-1 is a light-activated ion channel. Curr Biol. 2023 08 21; 33(16):3423-3435.e5.  View on PubMed
  12. Bergs ACF, Liewald JF, Rodriguez-Rozada S, Liu Q, Wirt C, Bessel A, Zeitzschel N, Durmaz H, Nozownik A, Dill H, Jospin M, Vierock J, Bargmann CI, Hegemann P, Wiegert JS, Gottschalk A. All-optical closed-loop voltage clamp for precise control of muscles and neurons in live animals. Nat Commun. 2023 04 06; 14(1):1939.  View on PubMed
  13. Seidenthal M, Jánosi B, Rosenkranz N, Schuh N, Elvers N, Willoughby M, Zhao X, Gottschalk A pOpsicle: An all-optical reporter system for synaptic vesicle recycling combining pH-sensitive fluorescent proteins with optogenetic manipulation of neuronal activity.  View on PubMed
  14. Vettkötter D, Schneider M, Goulden BD, Dill H, Liewald J, Zeiler S, Guldan J, Ates YA, Watanabe S, Gottschalk A. Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles. Nat Commun. 2022 12 19; 13(1):7827.  View on PubMed
  15. Seidenthal M, Vettkötter D, Gottschalk A. WormRuler: A software to track body length used to characterize a super red-shifted channelrhodopsin in Caenorhabditis elegans. MicroPubl Biol. 2022; 2022.  View on PubMed
  16. Shee K, de la Calle CM, Chang AJ, Wong AC, Feng FY, Gottschalk AR, Carroll PR, Nguyen HG. Addition of Enzalutamide to Leuprolide and Definitive Radiation Therapy Is Tolerable and Effective in High-Risk Localized or Regional Nonmetastatic Prostate Cancer: Results From a Phase 2 Trial. Adv Radiat Oncol. 2022 Sep-Oct; 7(5):100941.  View on PubMed
  17. Bergs A, Henss T, Glock C, Nagpal J, Gottschalk A. Microbial Rhodopsin Optogenetic Tools: Application for Analyses of Synaptic Transmission and of Neuronal Network Activity in Behavior. Methods Mol Biol. 2022; 2468:89-115.  View on PubMed
  18. Henss T, Schneider M, Vettkötter D, Costa WS, Liewald JF, Gottschalk A. Photoactivated Adenylyl Cyclases as Optogenetic Modulators of Neuronal Activity. Methods Mol Biol. 2022; 2483:61-76.  View on PubMed
  19. Vierock J, Rodriguez-Rozada S, Dieter A, Pieper F, Sims R, Tenedini F, Bergs ACF, Bendifallah I, Zhou F, Zeitzschel N, Ahlbeck J, Augustin S, Sauter K, Papagiakoumou E, Gottschalk A, Soba P, Emiliani V, Engel AK, Hegemann P, Wiegert JS. BiPOLES is an optogenetic tool developed for bidirectional dual-color control of neurons. Nat Commun. 2021 07 26; 12(1):4527.  View on PubMed
  20. Henß T, Nagpal J, Gao S, Scheib U, Pieragnolo A, Hirschhäuser A, Schneider-Warme F, Hegemann P, Nagel G, Gottschalk A. Optogenetic tools for manipulation of cyclic nucleotides functionally coupled to cyclic nucleotide-gated channels. Br J Pharmacol. 2022 06; 179(11):2519-2537.  View on PubMed

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