Rebecca E. Graff, ScD

Assistant Professor, University of California, San Francisco, Department of Epidemiology and Biostatistics, San Francisco, CA

Cancer Center Program Membership

Prostate Cancer

Research Summary

I am currently an Assistant Professor in the Department of Epidemiology and Biostatistics. Broadly speaking, my research interests reside in population-based cancer epidemiology. More specifically, my research at present focuses on: 1) discerning the shared genetic basis of seemingly distinct cancer types; 2) discerning the shared genetic basis of cancer and other chronic diseases; 3) leveraging genetic information to improve prostate-specific antigen screening; 4) determining the metabolomic basis of lethal prostate cancer; 5) examining the role of lifestyle factors in prostate cancer survivorship; and 6) examining the role of lifestyle factors in kidney cancer risk and survivorship. My work has afforded me the opportunity to gain expertise in a variety of study designs and in both established and novel analytical methods.

In addition to research, I am deeply committed to educating the next generation of scientists. As such, I co-direct Designing and Conducting Research at the School of Medicine, co-teach EPI 207 in the Department of Epidemiology and Biostatistics, and mentor students working toward their Master's Degree in Clinical Research.

Education

University of California, Berkeley, (Berkeley, CA) BA, 05/2006, Statistics
Harvard T.H. Chan School of Public Health, (Boston, MA) ScD, 05/2014, Cancer Epidemiology
University of California, San Francisco, (San Francisco, CA) Postdoctoral, 09/2018, Genetic Cancer Epidemiology

Honors & Awards

  • 2006
    Phi Beta Kappa with High Distinction in General Scholarship, University of California, Berkeley
  • 2011
    Distinction in Methods on the Written Qualifying Exam, Harvard T.H. Chan School of Public Health, Department of Epidemiology
  • 2012
    Best of Cancer Epidemiology, Biomarkers & Prevention
  • 2012
    Invited Attendee of the Society for Epidemiologic Research Student Dissertation Workshop
  • 2013
    American Association for Cancer Research Scholar-in-Training Award
  • 2015
    Invited Attendee of the American Association for Cancer Research Integrative Molecular Epidemiology Workshop
  • 2016
    Winner of the NCI's Up for a Challenge competition
  • 2017
    Selected for the NCI's Epidemiology and Genomics Research Program Research Highlights

Selected Publications

  1. Post-Diagnostic Dietary and Lifestyle Factors and Prostate Cancer Recurrence, Progression, and Mortality.  View on PubMed
  2. Graff RE, Cavazos TB, Thai KK, Kachuri L, Rashkin SR, Hoffman JD, Alexeeff SE, Blatchins M, Meyers TJ, Leong L, Tai CG, Emami NC, Corley DA, Kushi LH, Ziv E, Van Den Eeden SK, Jorgenson E, Hoffmann TJ, Habel LA, Witte JS, Sakoda LC Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts.  View on PubMed
  3. Sayaman RW, Saad M, Thorsson V, Hu D, Hendrickx W, Roelands J, Porta-Pardo E, Mokrab Y, Farshidfar F, Kirchhoff T, Sweis RF, Bathe OF, Heimann C, Campbell MJ, Stretch C, Huntsman S, Graff RE, Syed N, Radvanyi L, Shelley S, Wolf D, Marincola FM, Ceccarelli M, Galon J, Ziv E, Bedognetti D Germline genetic contribution to the immune landscape of cancer.  View on PubMed
  4. Emami NC, Cavazos TB, Rashkin SR, Graff RE, Tai CG, Mefford JA, Kachuri L, Cario CL, Wan E, Wong S, Aaronson D, Presti J, Habel LA, Shan J, Ranatunga DK, Chao CR, Ghai NR, Jorgenson E, Sakoda LC, Kvale MN, Kwok PY, Schaefer C, Risch N, Hoffmann TJ, Van Den Eeden SK, Witte JS A large-scale association study detects novel rare variants, risk genes, functional elements, and polygenic architecture of prostate cancer susceptibility.  View on PubMed
  5. Rebecca E Graff, Sarah F Ackley, Monica Ospina Romero, Scott C Zimmerman, Fanny M Elahi, Kun Ping Lu, John S Witte, M Maria Glymour Evaluation of polygenic risk scores for 17 cancer types in relation to cognitive decline in the UK Biobank.  View on PubMed
  6. Scott C Zimmerman, Sarah F Ackley, Willa D Brenowitz, Rebecca E Graff, M Maria Glymour Phenome-wide associations with an Alzheimer’s disease genetic risk score in UK Biobank: Identifying early indicators of disease.  View on PubMed
  7. Sarah F. Ackley, Pamela M. Rist, Willa D. Brenowitz, Rebecca E. Graff, M. Maria Glymour The association between migraine genetic risk and dementia: A Mendelian randomization study.  View on PubMed
  8. Kachuri L, Graff RE, Smith-Byrne K, Meyers TJ, Rashkin SR, Ziv E, Witte JS, Johansson M Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction.  View on PubMed
  9. Wang EY, Graff RE, Chan JM, Langlais CS, Broering JM, Ramsdill JW, Kessler ER, Winters-Stone KM, Van Blarigan EL, Kenfield SA Web-Based Lifestyle Interventions for Prostate Cancer Survivors: Qualitative Study.  View on PubMed
  10. Ospina-Romero M, Glymour MM, Hayes-Larson E, Mayeda ER, Graff RE, Brenowitz WD, Ackley SF, Witte JS, Kobayashi LC Association Between Alzheimer Disease and Cancer With Evaluation of Study Biases: A Systematic Review and Meta-analysis.  View on PubMed
  11. Sieh W, Rothstein JH, Klein RJ, Alexeeff SE, Sakoda LC, Jorgenson E, McBride RB, Graff RE, McGuire V, Achacoso N, Acton L, Liang RY, Lipson JA, Rubin DL, Yaffe MJ, Easton DF, Schaefer C, Risch N, Whittemore AS, Habel LA Identification of 31 loci for mammographic density phenotypes and their associations with breast cancer risk.  View on PubMed
  12. Rashkin SR, Graff RE, Kachuri L, Thai KK, Alexeeff SE, Blatchins MA, Cavazos TB, Corley DA, Emami NC, Hoffman JD, Jorgenson E, Kushi LH, Meyers TJ, Van Den Eeden SK, Ziv E, Habel LA, Hoffmann TJ, Sakoda LC, Witte JS Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.  View on PubMed
  13. Hayes-Larson E, Ackley SF, Zimmerman SC, Ospina-Romero M, Glymour MM, Graff RE, Witte JS, Kobayashi LC, Mayeda ER The competing risk of death and selective survival cannot fully explain the inverse cancer-dementia association.  View on PubMed
  14. Purdue MP, Song L, Scélo G, Houlston RS, Wu X, Sakoda LC, Thai K, Graff RE, Rothman N, Brennan P, Chanock SJ, Yu K Pathway Analysis of Renal Cell Carcinoma Genome-Wide Association Studies Identifies Novel Associations.  View on PubMed
  15. Ospina-Romero M, Brenowitz WD, Glymour MM, Mayeda ER, Graff RE, Witte JS, Ackley SF, Lu KP, Kobayashi LC The Association Between Cancer and Spousal Rate of Memory Decline: A Negative Control Study to Evaluate (Unmeasured) Social Confounding of the Cancer-memory Relationship.  View on PubMed
  16. Meyers TJ, Weiner AB, Graff RE, Desai AS, Cooley LF, Catalona WJ, Hanauer SB, Wu JD, Schaeffer EM, Abdulkadir SA, Kundu SD, Witte JS Association between inflammatory bowel disease and prostate cancer: A large-scale, prospective, population-based study.  View on PubMed
  17. Khan S, Caldwell J, Wilson KM, Gonzalez-Feliciano AG, Peisch S, Pernar CH, Graff RE, Giovannucci EL, Mucci LA, Gerke TA, Markt SC Baldness and Risk of Prostate Cancer in the Health Professionals Follow-up Study.  View on PubMed
  18. Kyle B. Zuniga, Rebecca E. Graff, David B. Feiger, Maxwell V. Meng,
    Sima P. Porten, Stacey A. Kenfield Lifestyle and Non-muscle Invasive Bladder Cancer Recurrence, Progression, and Mortality: Available Research and Future Directions  View on PubMed
  19. Kyle B. Zuniga, Rebecca E. Graff, David B. Feiger, Maxwell V. Meng, Sima P. Porten, Stacey A. Kenfield Lifestyle and Non-muscle Invasive Bladder Cancer Recurrence, Progression, and Mortality: Available Research and Future Directions.  View on PubMed
  20. Kachuri L, Johansson M, Rashkin SR, Graff RE, Bossé Y, Manem V, Caporaso NE, Landi MT, Christiani DC, Vineis P, Liu G, Scelo G, Zaridze D, Shete SS, Albanes D, Aldrich MC, Tardón A, Rennert G, Chen C, Goodman GE, Doherty JA, Bickeböller H, Field JK, Davies MP, Dawn Teare M, Kiemeney LA, Bojesen SE, Haugen A, Zienolddiny S, Lam S, Le Marchand L, Cheng I, Schabath MB, Duell EJ, Andrew AS, Manjer J, Lazarus P, Arnold S, McKay JD, Emami NC, Warkentin MT, Brhane Y, Obeidat M, Martin RM, Relton C, Davey Smith G, Haycock PC, Amos CI, Brennan P, Witte JS, Hung RJ Immune-mediated genetic pathways resulting in pulmonary function impairment increase lung cancer susceptibility.  View on PubMed

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