Research Funding

  • July 1, 2018 - June 30, 2021 - Role of DNA damage in Pulmonary Artery Hypertension, Principle Investigator. Sponsor: TRDRP, Sponsor Award ID: 587294
  • June 1, 2016 - March 31, 2020 - Identification of a novel modulator of Pulmonary Artery Hypertension, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL132058
  • July 1, 2017 - June 30, 2018 - FASEB SRC on TGF-beta Superfamily: Signaling in Development and Disease, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R13CA217045
  • August 15, 2013 - May 31, 2017 - Role of the PDGF signaling pathway in pulmonary artery hypertension, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL116191

Education

Tokyo University of Science, Tokyo, Japan, B.A., 03/1988, Pharmacy
University of Tokyo, Tokyo, Japan, M.S., 03/1990, Biochemistry
Rockefeller University, NY, Ph.D., 06/1995, Cell Biology

Selected Publications

  1. Jiang X, Prabhakar A, Van der Voorn SM, Ghatpande P, Celona B, Venkataramanan S, Calviello L, Lin C, Wang W, Black BL, Floor SN, Lagna G, Hata A Control of ribosomal protein synthesis by the Microprocessor complex.  View on PubMed
  2. Oda Y, Nguyen T, Hata A, Meyer MB, Pike JW, Bikle DD Deletion of Mediator 1 suppresses TGFß signaling leading to changes in epidermal lineages and regeneration.  View on PubMed
  3. Hata A, Lagna G Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.  View on PubMed
  4. Vattulainen-Collanus S, Southwood M, Yang XD, Moore S, Ghatpande P, Morrell NW, Lagna G, Hata A Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.  View on PubMed
  5. Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease.  View on PubMed
  6. Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.  View on PubMed
  7. Kashima R, Hata A The role of TGF-ß superfamily signaling in neurological disorders.  View on PubMed
  8. Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.  View on PubMed
  9. Jiang X, Hawkins JS, Lee J, Lizama CO, Bos FL, Zape JP, Ghatpande P, Peng Y, Louie J, Lagna G, Zovein AC, Hata A Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice.  View on PubMed
  10. Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.  View on PubMed
  11. Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.  View on PubMed
  12. Hata A, Chen YG TGF-ß Signaling from Receptors to Smads.  View on PubMed
  13. Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.  View on PubMed
  14. Kang H, Hata A Quantitative Real-Time PCR Analysis of MicroRNAs and Their Precursors Regulated by TGF-ß Signaling.  View on PubMed
  15. Hata A, Kashima R Dysregulation of microRNA biogenesis machinery in cancer.  View on PubMed
  16. Morrell NW, Bloch DB, ten Dijke P, Goumans MJ, Hata A, Smith J, Yu PB, Bloch KD Targeting BMP signalling in cardiovascular disease and anaemia.  View on PubMed
  17. Nazer B, Ghahghaie F, Kashima R, Khokhlova T, Perez C, Crum L, Matula T, Hata A Therapeutic Ultrasound Promotes Reperfusion and Angiogenesis in a Rat Model of Peripheral Arterial Disease.  View on PubMed
  18. Kang H, Hata A The role of microRNAs in cell fate determination of mesenchymal stem cells: balancing adipogenesis and osteogenesis.  View on PubMed
  19. Cushing L, Costinean S, Xu W, Jiang Z, Madden L, Kuang P, Huang J, Weisman A, Hata A, Croce CM, Lü J Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature.  View on PubMed
  20. Hata A, Lieberman J Dysregulation of microRNA biogenesis and gene silencing in cancer.  View on PubMed

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