July 1, 2018 - June 30, 2021 - Role of DNA damage in Pulmonary Artery Hypertension, Principle Investigator. Sponsor: TRDRP, Sponsor Award ID: 587294
June 1, 2016 - March 31, 2020 - Identification of a novel modulator of Pulmonary Artery Hypertension, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL132058
July 1, 2017 - June 30, 2018 - FASEB SRC on TGF-beta Superfamily: Signaling in Development and Disease, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R13CA217045
August 15, 2013 - May 31, 2017 - Role of the PDGF signaling pathway in pulmonary artery hypertension, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL116191
Education
Tokyo University of Science, Tokyo, Japan, B.A., 03/1988, Pharmacy University of Tokyo, Tokyo, Japan, M.S., 03/1990, Biochemistry Rockefeller University, NY, Ph.D., 06/1995, Cell Biology
Selected Publications
Oda Y, Nguyen T, Hata A, Meyer MB, Pike JW, Bikle DD
Deletion of Mediator 1 suppresses TGFß signaling leading to changes in epidermal lineages and regeneration.
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Hata A, Lagna G
Deregulation of Drosha in the pathogenesis of hereditary hemorrhagic telangiectasia.
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Vattulainen-Collanus S, Southwood M, Yang XD, Moore S, Ghatpande P, Morrell NW, Lagna G, Hata A
Bone morphogenetic protein signaling is required for RAD51-mediated maintenance of genome integrity in vascular endothelial cells.
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Kameny RJ, He Y, Zhu T, Gong W, Raff GW, Chapin CJ, Datar SA, Boehme JT, Hata A, Fineman JR
Analysis of the microRNA signature driving adaptive right ventricular hypertrophy in an ovine model of congenital heart disease.
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Jiang X, Wooderchak-Donahue WL, McDonald J, Ghatpande P, Baalbaki M, Sandoval M, Hart D, Clay H, Coughlin S, Lagna G, Bayrak-Toydemir P, Hata A
Inactivating mutations in Drosha mediate vascular abnormalities similar to hereditary hemorrhagic telangiectasia.
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Kashima R, Hata A
The role of TGF-ß superfamily signaling in neurological disorders.
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Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton AR, Frid MG, Upton PD, D'Alessandro A, Hadinnapola C, Kiskin FN, Taha M, Hurst LA, Ormiston ML, Hata A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW
Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.
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Jiang X, Hawkins JS, Lee J, Lizama CO, Bos FL, Zape JP, Ghatpande P, Peng Y, Louie J, Lagna G, Zovein AC, Hata A
Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice.
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Kashima R, Redmond PL, Ghatpande P, Roy S, Kornberg TB, Hanke T, Knapp S, Lagna G, Hata A
Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome.
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Celona B, Dollen JV, Vatsavayai SC, Kashima R, Johnson JR, Tang AA, Hata A, Miller BL, Huang EJ, Krogan NJ, Seeley WW, Black BL
Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.
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Hata A, Chen YG
TGF-ß Signaling from Receptors to Smads.
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Kashima R, Roy S, Ascano M, Martinez-Cerdeno V, Ariza-Torres J, Kim S, Louie J, Lu Y, Leyton P, Bloch KD, Kornberg TB, Hagerman PJ, Hagerman R, Lagna G, Hata A
Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.
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Kang H, Hata A
Quantitative Real-Time PCR Analysis of MicroRNAs and Their Precursors Regulated by TGF-ß Signaling.
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Hata A, Kashima R
Dysregulation of microRNA biogenesis machinery in cancer.
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Morrell NW, Bloch DB, ten Dijke P, Goumans MJ, Hata A, Smith J, Yu PB, Bloch KD
Targeting BMP signalling in cardiovascular disease and anaemia.
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Nazer B, Ghahghaie F, Kashima R, Khokhlova T, Perez C, Crum L, Matula T, Hata A
Therapeutic Ultrasound Promotes Reperfusion and Angiogenesis in a Rat Model of Peripheral Arterial Disease.
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Kang H, Hata A
The role of microRNAs in cell fate determination of mesenchymal stem cells: balancing adipogenesis and osteogenesis.
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Cushing L, Costinean S, Xu W, Jiang Z, Madden L, Kuang P, Huang J, Weisman A, Hata A, Croce CM, Lü J
Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature.
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Hata A, Lieberman J
Dysregulation of microRNA biogenesis and gene silencing in cancer.
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Hata A, Kang H
Functions of the bone morphogenetic protein signaling pathway through microRNAs (review).
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