Research Summary

Dr. Shawn Hervey-Jumper is a neurosurgeon with subspecialty focus on neuro-oncology. His clinical practice is focused on the surgical management of patients with brain cancer within functional areas using physiological mapping. Dr. Hervey-Jumper's research focuses on the mechanisms by which intrinsic brain tumors, such as low- and high-grade gliomas, interface with neural networks and how repair of these networks impacts cognition. Though the survival of some may be short, it is increasingly understood that many glioma patients will survive for years with extensive language, motor, and cognitive disabilities that impact the quality of their lives. Despite the prevailing assumption that gliomas represent an ablative process, we now know that interactions between glioma cells and the neuronal microenvironment influence tumor growth, invasiveness, and potentially cognition. In his research laboratory he uses neurophysiology in order to address questions in human cognition as well as tumor-network dynamics.

Research Funding

  • February 3, 2026 - January 31, 2031 - EXPanding Access to Neurosurgery reSearch Education (EXPANSE) , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R25NS143071
  • July 9, 2024 - June 30, 2029 - Cortical information loss in diffuse low-grade glioma infiltrated cortex , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01NS137950
  • May 1, 2019 - April 30, 2024 - Intratumoral functional connectivity with implications on synaptogenesis and aphasia recovery in adult astrocytic WHO II-III glioma , Principal Investigator . Sponsor: NINDS, Sponsor Award ID: 1K08NS110919-01
  • February 1, 2018 - February 28, 2023 - IDH1 Mutant Glioma Model: Tumor Progression and Impact on Therapeutics , Co-Investigator . Sponsor: NINDS, Sponsor Award ID: P0523121
  • July 1, 2017 - July 1, 2021 - The consequences of brain irradiation on white matter repair and language pathways reorganization in adult glioma , Principal Investigator . Sponsor: Robert Wood Johnson Foundation, Sponsor Award ID: 74259
  • July 1, 2017 - June 30, 2020 - Neurogenesis mediated Aphasia Recovery in Adult High Grade Glioma , Principal Investigator . Sponsor: University of California San Francisco, Sponsor Award ID: Dean's Diversity Fund
  • October 10, 2017 - October 1, 2019 - NIH NCI SPORE Career Enhancement Award Language network repair and white matter recovery in WHO IV glioma , Co-Investigator . Sponsor: NCI, Sponsor Award ID: 5P50CA097257-15

Education

Oakwood College, Huntsville, AL, B.S., 05/2001, Biology
The Ohio State University, Columbus, OH, M.D., 06/2006,Medicine
University of Michigan, Ann Arbor, MI, Internship, 06/2007, Transitional
University of Michigan, Ann Arbor, MI, Research Fellowship, 01/2012, Neuro-Oncology
University of Michigan, Ann Arbor, MI, Resident, 06/2012, Neurosurgery
University of Michigan, Ann Arbor, MI, Chief Resident, 06/2013, Neurosurgery
University of California San Francisco, SF, CA, Clinical Fellowship, 06/2014, Neuro-Oncology

Honors & Awards

  • 2005
    Alpha Omega Alpha Medical Honors Society, Ohio State University
  • 2005
    Gold Humanism Honor Society, The Ohio State University
  • 2006
    Landacre Research Honors Society, Ohio State University
  • 2006
    Watchman Achievement Award, Alpha Omega Alpha Medical Honors Society
  • 2007
    National Scholars Honor Society, The Ohio State University
  • 2007
    Arnold G. Coran Teaching Award, University of Michigan
  • 2010
    Health Policy Scholar, Ruben J Williams (RJW) Foundation
  • 2011
    Wilder Penfield Award, Congress of Neurological Surgeons
  • 2011
    NREF/AAcNS Research Award
  • 2013
    Chandler-McGillicuddy leadership award, University of Michigan
  • 2013
    Max Peet Teaching Award, University of Michigan
  • 2014
    Ronald L. Bittner Award in Brain Tumor Research, AANS/CNS Section on Tumors
  • 2016
    Alfred Taubman Medical Research Institute Emerging Scholar
  • 2017
    Robert Wood Johnson Foundation Harold Amos Fellow
  • 2017
    John A. Watson Faculty Scholar
  • 2022
    Weill Award for Clinician-Scientists in the Neurosciences

Selected Publications

  1. Pittarello M, Hervey-Jumper S. Targeting neurotumoral signaling networks in cancer. Sci Transl Med. 2026 Jul 29; 18(860):eaei7803. View on PubMed
  2. Hashemi E, Akshaya RL, Wang L, Bergland S, Piyadasa H, Ranek JS, Voong V, Kshirsagar A, Shai A, Oberlton B, Kumar A, Berger MS, Chang EF, Oldham MC, Prins RM, Bendall SC, Angelo M, Hervey-Jumper SL, Okada H, Diaz A, Phillips JJ. MAPK-driven glioma progression and reprogramming of the tumor-associated immune response. Neuro Oncol. 2026 Jun 30. View on PubMed
  3. Ellison J, Tran N, Luks TL, Singh P, Jakary A, Ngan T, Cluceru J, Phillips JJ, Li Y, Molinaro AM, Pedoia V, Shai A, Nair D, Villanueva-Meyer JE, Berger MS, Hervey-Jumper SL, Aghi M, Chang SM, Lupo JM. Spatially identifying regions of tumor recurrence in patients with suspected recurrent glioma using physiologic MRI and machine learning. NPJ Digit Med. 2026 Jun 25. View on PubMed
  4. Chen JS, Bergsneider B, Haddad AF, Morshed RA, Hervey-Jumper SL, Young JS, Berger MS. Intraoperative functional brain mapping for glioma surgery: a comprehensive review of the University of California San Francisco mapping protocol. J Neurooncol. 2026 Jun 13; 178(2). View on PubMed
  5. Dunn GP, Yu KKH, Krucoff MO, Bojanowski-Hoang K, Goldschmidt E, Erol-Demirturk M, Adesina D, Quintana D, Winkler F, Hervey-Jumper S, Deneen B, Giles DA, Ko CH, Leuthardt EC, Kim AH, Stegh AH, Christopher Davidson Forum Investigators
    . Recent progress and future directions to advance glioblastoma research: A consensus perspective from the 2024 Christopher Davidson Forum. Neuro Oncol. 2026 Jun 01; 28(6):1366-1382. View on PubMed
  6. Goff NK, Markert JE, Reinecke D, Springer A, Chen AM, Park M, Malte G, Scotford-Broemmer K, Hoonsbeen S, Eddy K, Chowdury A, Jiang C, Kondepudi A, Meissner AK, Fürtjes G, Müller N, Neuschmelting V, Pekmezci M, Young J, Freudinger C, Snuderl M, Berger M, Hervey-Jumper S, Golfinos JG, Hollon T, Orringer DA. SIGNAL: A Scalable, Real-World Model for Rapid Intraoperative Molecular Classification of Gliomas Using Stimulated Raman Histology. medRxiv. 2026 May 13. View on PubMed
  7. Young JS, Al-Adli NN, Quintana D, Menna G, Gerritsen JKW, Li J, Morshed RA, Hervey-Jumper SL, Berger MS. Maximum safe resection of insular gliomas: update on surgical outcomes from 500 cases. J Neurosurg. 2026 May 08; 1-17. View on PubMed
  8. Chen J, Oberheim Bush NA, Grabowsky JA, Kline C, Kroetz DL, Taylor JW, Villanueva-Meyer J, Molinaro AM, de Groot JF, Butowski NA, Tedesco M, Rabbitt J, Phillips JJ, Hervey-Jumper S, Aghi MK, Berger MS, Chang EF, Chang SM, Solomon DA, Clarke JL. A Genomically Tailored Multiagent Precision Medicine Clinical Trial for Adults with Recurrent Glioblastoma. Clin Cancer Res. 2026 May 01; 32(9):1652-1665. View on PubMed
  9. Regalia C, Young T, Asfaw ZK, Carrasquilla A, Ivan ME, Hervey-Jumper SL, Sivakumar W, D'amico RS, Germano IM. Nutrition optimization in enhanced recovery after brain tumor surgery: scoping review of evidence, gaps, and a proposed perioperative nutrition score. Neurooncol Adv. 2026 Jan-Dec; 8(1):vdag056. View on PubMed
  10. Aggarwal A, Youngblood MW, Picart T, Najem H, Oten S, Cady MA, Magill ST, Horbinski CM, Chandler JP, Heimberger AB, Mirchia K, Hervey-Jumper SL, Raleigh DR. Meningioma cell reprogramming and microenvironment interactions underlie brain invasion. Neuro Oncol. 2026 Apr 01; 28(4):926-938. View on PubMed
  11. Herr S, Oten S, Bernstock JD, Rolston JD, Hervey-Jumper SL. Leveraging neuroscience imaging and electrophysiological assessments to decode neuron-glioma interactions. Neurooncol Adv. 2026 May; 8(Suppl 3):iii4-iii12. View on PubMed
  12. Hou X, Kondepudi AV, Jiang C, Lyu Y, Harake ES, Chowdury A, Meißner AK, Neuschmelting V, Reinecke D, Fürtjes G, Widhalm G, Körner LI, Straehle J, Neidert N, Scheffler P, Beck J, Ivan ME, Shah AH, Pandey AS, Camelo-Piragua S, Heiland DH, Schnell O, Freudiger C, Young J, Pekmezci M, Scotford K, Hervey-Jumper S, Orringer D, Berger M, Hollon T. Intelligent histology for tumor neurosurgery. Neurooncol Adv. 2026 Jan-Dec; 8(1):vdag065. View on PubMed
  13. Bouget D, Faanes MG, Jakola AS, Barkhof F, Ardon H, Bello L, Berger MS, Hervey-Jumper SL, Furtner J, Idema AJS, Kiesel B, Widhalm G, Tewarie RN, Mandonnet E, Robe PA, Wagemakers M, Smith TR, De Witt Hamer PC, Solheim O, Reinertsen I. Automatic and standardized reporting of perioperative MRIs in patients with central nervous system tumors. Front Neurol. 2025; 16:1707481. View on PubMed
  14. Teske N, Dono A, Young JS, Jünger ST, Youssef G, Häni L, Sciortino T, Bruno F, Dietrich J, Mau CY, Weller M, Beck J, Hervey-Jumper S, Molinaro AM, Chang SM, van den Bent M, Vogelbaum MA, Ruge MI, Cahill DP, Rudà R, Bello L, Grau SJ, Schnell O, Huang RY, Wen PY, Tandon N, Berger MS, Tonn JC, Esquenazi Y, Karschnia P. Associations of supramaximal resection with outcome in glioblastoma across age groups: A report of the RANO resect group. Neuro Oncol. 2026 Feb 01; 28(2):470-484. View on PubMed
  15. Gerritsen JKW, Karschnia P, Bello L, Hervey-Jumper S, Young JS, Seidel K, Satoer DD, Schnell O, Parsons M, Nahed BV, Menna G, Teske N, External Rater Panel, Smith TR, Sanai N, Krieg SM, Schucht P, Broekman MLD, De Vleeschouwer S, Jakola AS, van den Bent MJ, Chang SM, Vogelbaum MA, Vincent AJPE, Tonn JC, Berger MS. A comprehensive framework for glioma surgery by the PIONEER Consortium and RANO resect group, part 1: intraoperative recommendations for mapping, monitoring, and decision making. Lancet Oncol. 2026 Jan; 27(1):e11-e23. View on PubMed
  16. Gerritsen JKW, Karschnia P, Bello L, Hervey-Jumper S, Young JS, Seidel K, Satoer DD, Schnell O, Parsons M, Nahed BV, Menna G, Teske N, External Rater Panel, Smith TR, Sanai N, Krieg SM, Schucht P, Broekman MLD, De Vleeschouwer S, Jakola AS, van den Bent MJ, Chang SM, Vogelbaum MA, Vincent AJPE, Tonn JC, Berger MS. A comprehensive framework for glioma surgery by the PIONEER Consortium and RANO resect group, part 2: perioperative recommendations for neurological, language, functional, and quality-of-life assessment. Lancet Oncol. 2026 Jan; 27(1):e24-e32. View on PubMed
  17. Nguyen MP, Al-Adli NN, Theodosopoulos PV, Hervey-Jumper SL, Braunstein SE, Vasudevan HN, Morshed RA, Aghi MK. Association of cystic features with more rapid recovery of neurological deficits following resection of brain metastases. J Neurosurg. 2026 Apr 01; 144(4):868-877. View on PubMed
  18. Chen JS, Oh JY, Hollon TC, Hervey-Jumper SL, Young JS, Berger MS. The Intraoperative Utility of Raman Spectroscopy for Neurosurgical Oncology. Cancers (Basel). 2025 Dec 08; 17(24). View on PubMed
  19. Karschnia P, Young JS, Wijnenga MMJ, Sciortino T, Teske N, Corell A, Wagner A, Youssef G, Park YW, Häni L, Jünger ST, Dono A, Ehret F, Mireles EEM, Neidert N, Bruno F, Tuchek CA, van der Vaart T, Rossi M, Nibali MC, Gay L, Gramelt A, Tandon N, Ahn SS, Chang JH, Weller M, Vincent AJPE, Goldbrunner R, Cahill DP, Huang RY, Raabe A, Meyer B, Beck J, Molinaro AM, Chang SM, Vogelbaum MA, Rudà R, Vik-Mo EO, Dietrich J, Esquenazi Y, Grau SJ, Wen PY, Jakola AS, Schnell O, Bello L, van den Bent MJ, Hervey-Jumper S, Berger MS, Tonn JC. A prognostic classification system for extent of resection in IDH-mutant grade 2 glioma: an international, multicentre, retrospective cohort study with external validation by the RANO resect group. Lancet Oncol. 2025 Dec; 26(12):1638-1650. View on PubMed
  20. Voong V, Beccari S, Hashemi E, Kriener B, Mathur R, Lafontaine M, Shai A, Lupo JM, Chang EF, Hervey-Jumper SL, Berger MS, Waszak SM, Costello JF, Phillips JJ. 3D spatial sampling to quantify morphologic heterogeneity in isocitrate dehydrogenase-wildtype glioblastoma. J Neuropathol Exp Neurol. 2025 Nov 01; 84(11):1053-1058. View on PubMed

Go to UCSF Profiles, powered by CTSI