Research Summary

Dr. Shawn Hervey-Jumper is a neurosurgeon with subspecialty focus on neuro-oncology. His clinical practice is focused on the surgical management of patients with brain cancer within functional areas using physiological mapping. Dr. Hervey-Jumper's research focuses on the mechanisms by which intrinsic brain tumors, such as low- and high-grade gliomas, interface with neural networks and how repair of these networks impacts cognition. Though the survival of some may be short, it is increasingly understood that many glioma patients will survive for years with extensive language, motor, and cognitive disabilities that impact the quality of their lives. Despite the prevailing assumption that gliomas represent an ablative process, we now know that interactions between glioma cells and the neuronal microenvironment influence tumor growth, invasiveness, and potentially cognition. In his research laboratory he uses neurophysiology in order to address questions in human cognition as well as tumor-network dynamics.

Research Funding

  • May 1, 2019 - April 30, 2024 - Intratumoral functional connectivity with implications on synaptogenesis and aphasia recovery in adult astrocytic WHO II-III glioma , Principal Investigator . Sponsor: NINDS, Sponsor Award ID: 1K08NS110919-01
  • February 1, 2018 - February 28, 2023 - IDH1 Mutant Glioma Model: Tumor Progression and Impact on Therapeutics , Co-Investigator . Sponsor: NINDS, Sponsor Award ID: P0523121
  • July 1, 2017 - July 1, 2021 - The consequences of brain irradiation on white matter repair and language pathways reorganization in adult glioma , Principal Investigator . Sponsor: Robert Wood Johnson Foundation, Sponsor Award ID: 74259
  • July 1, 2017 - June 30, 2020 - Neurogenesis mediated Aphasia Recovery in Adult High Grade Glioma , Principal Investigator . Sponsor: University of California San Francisco, Sponsor Award ID: Dean's Diversity Fund

Education

Oakwood College, Huntsville, AL, B.S., 05/2001, Biology
The Ohio State University, Columbus, OH, M.D., 06/2006,Medicine
University of Michigan, Ann Arbor, MI, Internship, 06/2007, Transitional
University of Michigan, Ann Arbor, MI, Research Fellowship, 01/2012, Neuro-Oncology
University of Michigan, Ann Arbor, MI, Resident, 06/2012, Neurosurgery
University of Michigan, Ann Arbor, MI, Chief Resident, 06/2013, Neurosurgery
University of California San Francisco, SF, CA, Clinical Fellowship, 06/2014, Neuro-Oncology

Honors & Awards

  • 2005
    Alpha Omega Alpha Medical Honors Society, Ohio State University
  • 2005
    Gold Humanism Honor Society, The Ohio State University
  • 2006
    Landacre Research Honors Society, Ohio State University
  • 2006
    Watchman Achievement Award, Alpha Omega Alpha Medical Honors Society
  • 2007
    National Scholars Honor Society, The Ohio State University
  • 2007
    Arnold G. Coran Teaching Award, University of Michigan
  • 2010
    Health Policy Scholar, Ruben J Williams (RJW) Foundation
  • 2011
    Wilder Penfield Award, Congress of Neurological Surgeons
  • 2011
    NREF/AAcNS Research Award
  • 2013
    Chandler-McGillicuddy leadership award, University of Michigan
  • 2013
    Max Peet Teaching Award, University of Michigan
  • 2014
    Ronald L. Bittner Award in Brain Tumor Research, AANS/CNS Section on Tumors
  • 2016
    Alfred Taubman Medical Research Institute Emerging Scholar
  • 2017
    Robert Wood Johnson Foundation Harold Amos Fellow
  • 2017
    John A. Watson Faculty Scholar
  • 2022
    Weill Award for Clinician-Scientists in the Neurosciences

Selected Publications

  1. Scott AJ, Correa LO, Edwards D, Sun Y, Ravikumar V, Andren AC, Zhang L, Srinivasan S, Jairath N, Verbal K, Muraszko K, Sagher O, Carty SA, Hervey-Jumper S, Orringer D, Kim MM, Junck L, Umemura Y, Leung D, Venneti S, Camelo-Piragua S, Lawrence TS, Ippolito JE, Al-Holou WN, Chinnaiyan P, Heth J, Rao A, Lyssiotis CA, Wahl DR. Metabolomic profiles of human glioma inform patient survival. Antioxid Redox Signal. 2023 Feb 27.  View on PubMed
  2. Morshed RA, Saggi S, Cummins DD, Molinaro AM, Young JS, Viner JA, Villanueva-Meyer JE, Goldschmidt E, Boreta L, Braunstein SE, Chang EF, McDermott MW, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Aghi MK, Daras M. Identification of risk factors associated with leptomeningeal disease after resection of brain metastases. J Neurosurg. 2023 Jan 13; 1-12.  View on PubMed
  3. Hervey-Jumper SL, Zhang Y, Phillips JJ, Morshed RA, Young JS, McCoy L, Lafontaine M, Luks T, Ammanuel S, Kakaizada S, Egladyous A, Gogos A, Villanueva-Meyer J, Shai A, Warrier G, Rice T, Crane J, Wrensch M, Wiencke JK, Daras M, Oberheim Bush NA, Taylor JW, Butowski N, Clarke J, Chang S, Chang E, Aghi M, Theodosopoulos P, McDermott M, Jakola AS, Kavouridis VK, Nawabi N, Solheim O, Smith T, Berger MS, Molinaro AM. Interactive Effects of Molecular, Therapeutic, and Patient Factors on Outcome of Diffuse Low-Grade Glioma. J Clin Oncol. 2023 Jan 04; JCO2102929.  View on PubMed
  4. Forster MT, De Witt Hamer P, Hervey-Jumper SL, Renovanz M. Corrigendum: Editorial: Quality of care of glioma patients. Front Neurol. 2022; 13:1084412.  View on PubMed
  5. Zhang JJY, Lee KS, Wang DD, Hervey-Jumper SL, Berger MS. Seizure outcome after resection of insular glioma: a systematic review, meta-analysis, and institutional experience. J Neurosurg. 2022 Oct 14; 1-12.  View on PubMed
  6. Forster MT, De Witt Hamer P, Hervey-Jumper SL, Renovanz M. Editorial: Quality of care of glioma patients. Front Neurol. 2022; 13:1041388.  View on PubMed
  7. Taylor JW, Weyer-Jamora C, Hervey-Jumper S. Molecularly determining cognition in glioma: New insights as the plot thickens. Neuro Oncol. 2022 10 03; 24(10):1671-1672.  View on PubMed
  8. Zhang Y, Lucas CG, Young JS, Morshed RA, McCoy L, Oberheim Bush NA, Taylor JW, Daras M, Butowski NA, Villanueva-Meyer JE, Cha S, Wrensch M, Wiencke JK, Lee JC, Pekmezci M, Phillips JJ, Perry A, Bollen AW, Aghi MK, Theodosopoulos P, Chang EF, Hervey-Jumper SL, Berger MS, Clarke JL, Chang SM, Molinaro AM, Solomon DA. Prospective genomically guided identification of "early/evolving" and "undersampled" IDH-wildtype glioblastoma leads to improved clinical outcomes. Neuro Oncol. 2022 10 03; 24(10):1749-1762.  View on PubMed
  9. Karschnia P, Young JS, Dono A, H?ni L, Juenger ST, Sciortino T, Bruno F, Teske N, Morshed RA, Haddad AF, Zhang Y, Stoecklein S, Vogelbaum MA, Beck J, Tandon N, Hervey-Jumper S, Molinaro AM, Rud? R, Bello L, Schnell O, Esquenazi Y, Ruge MI, Grau SJ, van den Bent M, Weller M, Berger MS, Chang SM, Tonn JC. TERT promotor status does not add prognostic information in IDH-wildtype glioblastomas fulfilling other diagnostic WHO criteria: A report of the RANO resect group. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac158.  View on PubMed
  10. Hosmann A, Jaber M, Roetzer-Pejrimovsky T, Timelthaler G, Borkovec M, Kiesel B, Wadiura LI, Millesi M, Mercea PA, Phillips J, Hervey-Jumper S, Berghoff AS, Hainfellner JA, Berger MS, Stummer W, Widhalm G. CD34 microvascularity in low-grade glioma: correlation with 5-aminolevulinic acid fluorescence and patient prognosis in a multicenter study at three specialized centers. J Neurosurg. 2022 Sep 16; 1-10.  View on PubMed
  11. Mischkulnig M, Kiesel B, R?tzer-Pejrimovsky T, Borkovec M, Lang A, Millesi M, Wadiura LI, Hervey-Jumper S, Penninger JM, Berger MS, Widhalm G, Erhart F. The impact of heme biosynthesis regulation on glioma aggressiveness: Correlations with diagnostic molecular markers. Front Mol Neurosci. 2022; 15:928355.  View on PubMed
  12. Karschnia P, Young JS, Dono A, H?ni L, Sciortino T, Bruno F, Juenger ST, Teske N, Morshed RA, Haddad AF, Zhang Y, Stoecklein S, Weller M, Vogelbaum MA, Beck J, Tandon N, Hervey-Jumper S, Molinaro AM, Rud? R, Bello L, Schnell O, Esquenazi Y, Ruge MI, Grau SJ, Berger MS, Chang SM, van den Bent M, Tonn JC. Prognostic validation of a new classification system for extent of resection in glioblastoma: a report of the RANO resect group. Neuro Oncol. 2022 Aug 12.  View on PubMed
  13. Lucas CG, Sloan EA, Gupta R, Wu J, Pratt D, Vasudevan HN, Ravindranathan A, Barreto J, Williams EA, Shai A, Whipple NS, Bruggers CS, Maher O, Nabors B, Rodriguez M, Samuel D, Brown M, Carmichael J, Lu R, Mirchia K, Sullivan DV, Pekmezci M, Tihan T, Bollen AW, Perry A, Banerjee A, Mueller S, Gupta N, Hervey-Jumper SL, Oberheim Bush NA, Daras M, Taylor JW, Butowski NA, de Groot J, Clarke JL, Raleigh DR, Costello JF, Phillips JJ, Reddy AT, Chang SM, Berger MS, Solomon DA. Multiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1. Acta Neuropathol. 2022 10; 144(4):747-765.  View on PubMed
  14. Reihl SJ, Patil N, Morshed RA, Mehari M, Aabedi A, Chukwueke UN, Porter AB, Fontil V, Cioffi G, Waite K, Kruchko C, Ostrom Q, Barnholtz-Sloan J, Hervey-Jumper SL. A population study of clinical trial accrual for women and minorities in neuro-oncology following the NIH Revitalization Act. Neuro Oncol. 2022 08 01; 24(8):1341-1349.  View on PubMed
  15. Bouget D, Pedersen A, Jakola AS, Kavouridis V, Emblem KE, Eijgelaar RS, Kommers I, Ardon H, Barkhof F, Bello L, Berger MS, Conti Nibali M, Furtner J, Hervey-Jumper S, Idema AJS, Kiesel B, Kloet A, Mandonnet E, M?ller DMJ, Robe PA, Rossi M, Sciortino T, Van den Brink WA, Wagemakers M, Widhalm G, Witte MG, Zwinderman AH, De Witt Hamer PC, Solheim O, Reinertsen I. Preoperative Brain Tumor Imaging: Models and Software for Segmentation and Standardized Reporting. Front Neurol. 2022; 13:932219.  View on PubMed
  16. Lucas CG, Davidson CJ, Alashari M, Putnam AR, Whipple NS, Bruggers CS, Mendez JS, Cheshier SH, Walker JB, Ramani B, Cadwell CR, Sullivan DV, Lu R, Mirchia K, Van Ziffle J, Devine P, Goldschmidt E, Hervey-Jumper SL, Gupta N, Oberheim Bush NA, Raleigh DR, Bollen A, Tihan T, Pekmezci M, Solomon DA, Phillips JJ, Perry A. Targeted Next-Generation Sequencing Reveals Divergent Clonal Evolution in Components of Composite Pleomorphic Xanthoastrocytoma-Ganglioglioma. J Neuropathol Exp Neurol. 2022 07 19; 81(8):650-657.  View on PubMed
  17. Aabedi AA, Young JS, Chang EF, Berger MS, Hervey-Jumper SL. Involvement of White Matter Language Tracts in Glioma: Clinical Implications, Operative Management, and Functional Recovery After Injury. Front Neurosci. 2022; 16:932478.  View on PubMed
  18. Krishna S, Hervey-Jumper SL. Neural Regulation of Cancer: Cancer-Induced Remodeling of the Central Nervous System. Adv Biol (Weinh). 2022 Sep; 6(9):e2200047.  View on PubMed
  19. Sneed PK, Chan JW, Ma L, Braunstein SE, Theodosopoulos PV, Fogh SE, Nakamura JL, Boreta L, Raleigh DR, Ziemer BP, Morin O, Hervey-Jumper SL, McDermott MW. Adverse radiation effect and freedom from progression following repeat stereotactic radiosurgery for brain metastases. J Neurosurg. 2023 01 01; 138(1):104-112.  View on PubMed
  20. Weyer-Jamora C, Brie MS, Luks TL, Smith EM, Hervey-Jumper SL, Taylor JW. In Reply: Postacute Cognitive Rehabilitation for Adult Brain Tumor Patients. Neurosurgery. 2022 07 01; 91(1):e29.  View on PubMed

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