Research Summary

Dr. Shawn Hervey-Jumper is a neurosurgeon with subspecialty focus on neuro-oncology. His clinical practice is focused on the surgical management of patients with brain cancer within functional areas using physiological mapping. Dr. Hervey-Jumper's research focuses on the mechanisms by which intrinsic brain tumors, such as low- and high-grade gliomas, interface with neural networks and how repair of these networks impacts cognition. Though the survival of some may be short, it is increasingly understood that many glioma patients will survive for years with extensive language, motor, and cognitive disabilities that impact the quality of their lives. Despite the prevailing assumption that gliomas represent an ablative process, we now know that interactions between glioma cells and the neuronal microenvironment influence tumor growth, invasiveness, and potentially cognition. In his research laboratory he uses neurophysiology in order to address questions in human cognition as well as tumor-network dynamics.

Research Funding

  • May 1, 2019 - April 30, 2024 - Intratumoral functional connectivity with implications on synaptogenesis and aphasia recovery in adult astrocytic WHO II-III glioma , Principal Investigator . Sponsor: NINDS, Sponsor Award ID: 1K08NS110919-01
  • February 1, 2018 - February 28, 2023 - IDH1 Mutant Glioma Model: Tumor Progression and Impact on Therapeutics , Co-Investigator . Sponsor: NINDS, Sponsor Award ID: P0523121
  • July 1, 2017 - July 1, 2021 - The consequences of brain irradiation on white matter repair and language pathways reorganization in adult glioma , Principal Investigator . Sponsor: Robert Wood Johnson Foundation, Sponsor Award ID: 74259
  • July 1, 2017 - June 30, 2020 - Neurogenesis mediated Aphasia Recovery in Adult High Grade Glioma , Principal Investigator . Sponsor: University of California San Francisco, Sponsor Award ID: Dean's Diversity Fund
  • October 10, 2017 - October 1, 2019 - NIH NCI SPORE Career Enhancement Award Language network repair and white matter recovery in WHO IV glioma , Co-Investigator . Sponsor: NCI, Sponsor Award ID: 5P50CA097257-15

Education

Oakwood College, Huntsville, AL, B.S., 05/2001, Biology
The Ohio State University, Columbus, OH, M.D., 06/2006,Medicine
University of Michigan, Ann Arbor, MI, Internship, 06/2007, Transitional
University of Michigan, Ann Arbor, MI, Research Fellowship, 01/2012, Neuro-Oncology
University of Michigan, Ann Arbor, MI, Resident, 06/2012, Neurosurgery
University of Michigan, Ann Arbor, MI, Chief Resident, 06/2013, Neurosurgery
University of California San Francisco, SF, CA, Clinical Fellowship, 06/2014, Neuro-Oncology

Honors & Awards

  • 2005
    Alpha Omega Alpha Medical Honors Society, Ohio State University
  • 2005
    Gold Humanism Honor Society, The Ohio State University
  • 2006
    Landacre Research Honors Society, Ohio State University
  • 2006
    Watchman Achievement Award, Alpha Omega Alpha Medical Honors Society
  • 2007
    National Scholars Honor Society, The Ohio State University
  • 2007
    Arnold G. Coran Teaching Award, University of Michigan
  • 2010
    Health Policy Scholar, Ruben J Williams (RJW) Foundation
  • 2011
    Wilder Penfield Award, Congress of Neurological Surgeons
  • 2011
    NREF/AAcNS Research Award
  • 2013
    Chandler-McGillicuddy leadership award, University of Michigan
  • 2013
    Max Peet Teaching Award, University of Michigan
  • 2014
    Ronald L. Bittner Award in Brain Tumor Research, AANS/CNS Section on Tumors
  • 2016
    Alfred Taubman Medical Research Institute Emerging Scholar
  • 2017
    Robert Wood Johnson Foundation Harold Amos Fellow
  • 2017
    John A. Watson Faculty Scholar
  • 2022
    Weill Award for Clinician-Scientists in the Neurosciences

Selected Publications

  1. Mehari M, Warrier G, Dada A, Kabir A, Haskell-Mendoza AP, Tripathy A, Jha R, Nieblas-Bedolla E, Jackson JD, Gonzalez AT, Reason EH, Flusche AM, Reihl S, Dalton T, Negussie M, Gonzales CN, Ambati VS, Desjardins A, Daniel AGS, Krishna S, Chang S, Porter A, Fecci PE, Hollon T, Chukwueke UN, Badal K, Molinaro AM, Hervey-Jumper SL. Predicting therapeutic clinical trial enrollment for adult patients with low- and high-grade glioma using supervised machine learning. Sci Adv. 2025 Jun 06; 11(23):eadt5708.  View on PubMed
  2. Barrios J, Porter E, Capaldi DPI, Upadhaya T, Chen WC, Perks JR, Apte A, Aristophanous M, LoCastro E, Hsu D, Stone PH, Villanueva-Meyer JE, Valdes G, Jiang F, Maddalena M, Ballangrud A, Prezelski K, Lin H, Sun JY, Aldin MAK, Chau OW, Ziemer B, Seaberg M, Sneed PK, Nakamura JL, Boreta LC, Fogh SE, Raleigh DR, Chew J, Vasudevan H, Cha S, Hess C, Fragoso R, Shultz DB, Pike L, Hervey-Jumper SL, Tsang DS, Theodosopoulos P, Cooke D, Benedict SH, Sheng K, Seuntjens J, Coolens C, Deasy JO, Braunstein S, Morin O. Author Correction: Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy. Nat Commun. 2025 Jun 02; 16(1):5096.  View on PubMed
  3. Nejo T, Krishna S, Yamamichi A, Lakshmanachetty S, Jimenez C, Lee KY, Baker DL, Young JS, Chen T, Phyu SSS, Phung L, Gallus M, Maldonado GC, Okada K, Ogino H, Watchmaker PB, Diebold D, Choudhury A, Daniel AGS, Cadwell CR, Raleigh DR, Hervey-Jumper SL, Okada H. Glioma-neuronal circuit remodeling induces regional immunosuppression. Nat Commun. 2025 May 22; 16(1):4770.  View on PubMed
  4. Rammeloo E, Young JS, Schouten JW, Bos EM, Hervey-Jumper SL, Jungk C, Krieg SM, Smith T, Rincon-Torroella J, Bettegowda C, Maruyama T, Wagner A, Schucht P, Broekman MLD, De Vleeschouwer S, Nahed BV, Berger MS, Vincent AJPE, Gerritsen JKW Preoperative assessment of tumor eloquence and resectability: an international survey.  View on PubMed
  5. Bernstock JD, Mehari M, E Gerstl JV, Meredith DM, Valdes PA, Heesen P, Ambati VS, Krishna S, Chen JA, Arora H, Johnston BR, Negussie M, Grieco K, Nava Gonzales C, Dada A, Lebouille-Veldman AB, Kabir A, Spanehl L, Kaur J, Oten S, Sibih YE, Mekary RA, Daniel A, de Groot JF, Izzy S, Gessler FA, Stone S, Arnaout O, Lu Y, Choi BD, Hall MD, Mehta MP, Odia Y, Friedman GK, Chiocca EA, Peruzzi PP, Smith TR, Hervey-Jumper SL Gabapentinoids confer survival benefit in human glioblastoma.  View on PubMed
  6. Barrios J, Porter E, Capaldi DPI, Upadhaya T, Chen WC, Perks JR, Apte A, Aristophanous M, LoCastro E, Hsu D, Stone PH, Villanueva-Meyer JE, Valdes G, Jiang F, Maddalena M, Ballangrud A, Prezelski K, Lin H, Sun JY, Aldin MAK, Chau OW, Ziemer B, Seaberg M, Sneed PK, Nakamura JL, Boreta LC, Fogh SE, Raleigh DR, Chew J, Vasudevan H, Cha S, Hess C, Fragoso R, Shultz DB, Pike L, Hervey-Jumper SL, Tsang DS, Theodosopoulos P, Cooke D, Benedict SH, Sheng K, Seuntjens J, Coolens C, Deasy JO, Braunstein S, Morin O. Multi-institutional atlas of brain metastases informs spatial modeling for precision imaging and personalized therapy. Nat Commun. 2025 May 15; 16(1):4536.  View on PubMed
  7. Oten S, Herr S, Ambati V, Sibih Y, Lu K, Kaur J, Hervey-Jumper SL, Brang D BrainTRACE (Brain Tumor Registration and Cortical Electrocorticography): A Novel Tool for Localizing Electrocorticography Electrodes in Patients with Brain Tumors.  View on PubMed
  8. Raleigh D, Mirchia K, Oten S, Picart T, Nguyen M, Ambati V, Vasudevan H, Young J, Taylor J, Krishna S, Brang D, Phillips J, Perry A, Berger M, Chang S, de Groot J, Hervey-Jumper S. Spatial synaptic connectivity underlies oligodendroglioma evolution and recurrence. Res Sq. 2025 Apr 04.  View on PubMed
  9. Drexler R, Lim M, Hervey-Jumper SL Molecular-based decision-making in glioblastoma surgery: when to aim for supramaximal resection.  View on PubMed
  10. Kwok DW, Stevers NO, Etxeberria I, Nejo T, Colton Cove M, Chen LH, Jung J, Okada K, Lakshmanachetty S, Gallus M, Barpanda A, Hong C, Chan GKL, Liu J, Wu SH, Ramos E, Yamamichi A, Watchmaker PB, Ogino H, Saijo A, Du A, Grishanina NR, Woo J, Diaz A, Hervey-Jumper SL, Chang SM, Phillips JJ, Wiita AP, Klebanoff CA, Costello JF, Okada H. Tumour-wide RNA splicing aberrations generate actionable public neoantigens. Nature. 2025 Mar; 639(8054):463-473.  View on PubMed
  11. Shukla PD, Nguyen MP, Lui A, Catalan T, Young JS, Berger MS, Theodosopoulos PV, Hervey-Jumper SL, Huppert LA, Aghi MK, Vasudevan HN, Morshed RA. Association of lower tumor mutation burden with rapid local progression in patients with brain metastases. J Neurosurg. 2025 Jun 01; 142(6):1701-1709.  View on PubMed
  12. Rodriguez Almaraz E, Guerra GA, Al-Adli NN, Young JS, Dada A, Quintana D, Taylor JW, Oberheim Bush NA, Clarke JL, Butowski NA, de Groot J, Pekmezci M, Perry A, Bollen AW, Scheffler AW, Glidden DV, Phillips JJ, Costello JF, Chang EF, Hervey-Jumper S, Berger MS, Francis SS, Chang SM, Solomon DA. Longitudinal profiling of IDH-mutant astrocytomas reveals acquired RAS-MAPK pathway mutations associated with inferior survival. Neurooncol Adv. 2025 Jan-Dec; 7(1):vdaf024.  View on PubMed
  13. Majewska P, Holden Helland R, Ferles A, Pedersen A, Kommers I, Ardon H, Barkhof F, Bello L, Berger MS, Dunås T, Conti Nibali M, Furtner J, Hervey-Jumper SL, Idema AJS, Kiesel B, Nandoe Tewarie R, Mandonnet E, Müller DMJ, Robe PA, Rossi M, Sciortino T, Aalders T, Wagemakers M, Widhalm G, Zwinderman AH, De Witt Hamer PC, Eijgelaar RS, Sagberg LM, Jakola AS, Thurin E, Reinertsen I, Bouget D, Solheim O. Prognostic value of manual versus automatic methods for assessing extents of resection and residual tumor volume in glioblastoma. J Neurosurg. 2025 Jan 17; 1-9.  View on PubMed
  14. Lim-Fat MJ, Bennett J, Ostrom Q, Touat M, Franceschi E, Schulte J, Bindra RS, Fangusaro J, Dhall G, Nicholson J, Jackson S, Davidson TB, Calaminus G, Robinson G, Whittle JR, Hau P, Ramaswamy V, Pajtler KW, Rudà R, Foreman NK, Hervey-Jumper SL, Das S, Dirks P, Bi WL, Huang A, Merchant TE, Fouladi M, Aldape K, Van den Bent MJ, Packer RJ, Miller JJ, Reardon DA, Chang SM, Haas-Kogan D, Tabori U, Hawkins C, Monje M, Wen PY, Bouffet E, Yeo KK. Central nervous system tumors in adolescents and young adults: A Society for Neuro-Oncology Consensus Review on diagnosis, management, and future directions. Neuro Oncol. 2025 Jan 12; 27(1):13-32.  View on PubMed
  15. Lucas CG, Al-Adli NN, Young JS, Gupta R, Morshed RA, Wu J, Ravindranathan A, Shai A, Oberheim Bush NA, Taylor JW, de Groot J, Villanueva-Meyer JE, Pekmezci M, Perry A, Bollen AW, Theodosopoulos PV, Aghi MK, Chang EF, Hervey-Jumper SL, Raleigh DR, Molinaro AM, Costello JF, Diaz AA, Clarke JL, Butowski NA, Phillips JJ, Chang SM, Berger MS, Solomon DA. Longitudinal multimodal profiling of IDH-wildtype glioblastoma reveals the molecular evolution and cellular phenotypes underlying prognostically different treatment responses. Neuro Oncol. 2025 Jan 12; 27(1):89-105.  View on PubMed
  16. Carrasquilla A, Asfaw ZK, Tomalin LE, D'Amico RS, Hervey-Jumper SL, Ivan ME, Sivakumar W, Germano IM Enhanced Recovery After Adult Brain Tumor Surgery: A Proposed Succinct Evidence-Based Protocol.  View on PubMed
  17. de la Fuente MI, Touat M, van den Bent MJ, Preusser M, Peters KB, Young RJ, Huang RY, Ellingson BM, Capper D, Phillips JJ, Halasz LM, Shih HA, Rudà R, Lim-Fat MJ, Blumenthal DT, Weller M, Arakawa Y, Whittle JR, Ducray F, Reardon DA, Bi WL, Minniti G, Rahman R, Hervey-Jumper S, Chang SM, Wen PY. The role of vorasidenib in the treatment of isocitrate dehydrogenase-mutant glioma. Neuro Oncol. 2024 Dec 25.  View on PubMed
  18. Gerritsen JKW, Karschnia P, Young JS, van den Bent MJ, Chang SM, Smith TR, Nahed BV, Rincon-Torroella J, Bettegowda C, Sanai N, Krieg SM, Maruyama T, Schucht P, Broekman MLD, Tonn JC, Wen PY, De Vleeschouwer S, Vincent AJPE, Hervey-Jumper S, Berger MS, Mekary RA, Molinaro AM. Practical and statistical aspects of subgroup analyses in surgical neuro-oncology: A comprehensive review from the PIONEER Consortium. Neuro Oncol. 2024 Dec 07.  View on PubMed
  19. Darlix A, Preusser M, Hervey-Jumper SL, Shih HA, Mandonnet E, Taylor JW. Who will benefit from vorasidenib? Review of data from the literature and open questions. Neurooncol Pract. 2025 Feb; 12(Suppl 1):i6-i18.  View on PubMed
  20. Kondepudi A, Pekmezci M, Hou X, Scotford K, Jiang C, Rao A, Harake ES, Chowdury A, Al-Holou W, Wang L, Pandey A, Lowenstein PR, Castro MG, Koerner LI, Roetzer-Pejrimovsky T, Widhalm G, Camelo-Piragua S, Movahed-Ezazi M, Orringer DA, Lee H, Freudiger C, Berger M, Hervey-Jumper S, Hollon T. Foundation models for fast, label-free detection of glioma infiltration. Nature. 2025 Jan; 637(8045):439-445.  View on PubMed

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