Research Funding

  • July 1, 1979 - June 30, 2021 - Cell Biology, Genetics, and Biochemistry Training Grant , Principal Investigator . Sponsor: NIH, Sponsor Award ID: T32GM007810
  • July 1, 2009 - November 30, 2020 - The transcriptional circuitry controlling biofilm development in Candida albicans , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI083311
  • August 1, 1986 - March 31, 2019 - Mechanism of Yeast Transcriptional Regulators , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM037049
  • March 1, 2001 - November 30, 2016 - Regulatory Circuits and Virulence in Candida albicans , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI049187
  • September 30, 1996 - June 30, 2016 - Comprehensive Biology: Exploiting the Yeast Genome , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P41RR011823
  • March 15, 2004 - February 28, 2010 - Chromosome loss in the fungal pathogen C. albicans , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI059401
  • September 1, 1976 - June 30, 2006 - Molecular Biology of Eukaryotic Cells and Viruses , Principal Investigator . Sponsor: NIH, Sponsor Award ID: T32CA009270
  • August 4, 2000 - July 31, 2001 - TRANSCRIPTIONAL REGULATION IN GROWTH,DIFF,DEVELOPMENT , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R13HD038716
  • September 30, 1995 - March 31, 2000 - CHROMOSOME POSITION EFFECTS ON GENE EXPRESSION IN YEAST , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM053452
  • September 1, 1976 - August 31, 1996 - DNA-PROTEIN INTERACTIONS IN DNA-REPLICATION CONTROL , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM024020
  • April 1, 1991 - March 31, 1994 - MEIOTIC PAIRING OF CHROMOSOMES IN YEAST , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM044532

Education

Vanderbilt University, Nashville TN, B.A., 1974, Biochemistry
Harvard University, Cambridge MA, M.A., Ph.D., 1980, Biochemistry
University of California, San Francisco, Postdoctoral, 1981-85, Biochemistry

Honors & Awards

  • B.A. summa cum laude, 1974
  • Phi Beta Kappa, 1974
  • Dreyfus Scholarship, 1974-1977
  • Damon Runyon-Walter Winchell Postdoctoral Fellowship, 1981-1983
  • Pew Scholarship, 1986-1990
  • Elected to American Academy of Microbiology, 1998
  • Burroughs Wellcome Merit Award, 1999 - 2004
  • Ellison Medical Foundation Senior Scholar in Global Infectious Diseases, 2004-2008
  • Elected to American Academy of Arts and Sciences, 2007
  • The Emil Christian Hansen Award for Microbiology, 2009
  • Elected to the National Academy of Sciences, 2011

Selected Publications

  1. Lohse MB, Ziv N, Johnson AD. Variation in transcription regulator expression underlies differences in white-opaque switching between the SC5314 reference strain and the majority of Candida albicans clinical isolates. Genetics. 2023 11 01; 225(3).  View on PubMed
  2. Lohse MB, Laurie MT, Levan S, Ziv N, Ennis CL, Nobile CJ, DeRisi J, Johnson AD. Broad susceptibility of Candida auris strains to 8-hydroxyquinolines and mechanisms of resistance. mBio. 2023 08 31; 14(4):e0137623.  View on PubMed
  3. Fowler KR, Leon F, Johnson AD. Ancient transcriptional regulators can easily evolve new pair-wise cooperativity. Proc Natl Acad Sci U S A. 2023 07 11; 120(28):e2302445120.  View on PubMed
  4. Del Frate F, Garber ME, Johnson AD. Evolution of a new form of haploid-specific gene regulation appearing in a limited clade of ascomycete yeast species. Genetics. 2023 05 26; 224(2).  View on PubMed
  5. Lee CD, Ziv N, Johnson AD. Cell-type memory in a single-cell eukaryote requires the continuous presence of a specific transcription regulator. Proc Natl Acad Sci U S A. 2023 05 23; 120(21):e2220568120.  View on PubMed
  6. Lohse MB, Laurie MT, Levan S, Ziv N, Ennis CL, Nobile CJ, DeRisi J, Johnson AD. Broad sensitivity of Candida auris strains to quinolones and mechanisms of resistance. bioRxiv. 2023 Feb 17.  View on PubMed
  7. Brenes LR, Johnson AD, Lohse MB. Farnesol and phosphorylation of the transcriptional regulator Efg1 affect Candida albicans white-opaque switching rates. PLoS One. 2023; 18(1):e0280233.  View on PubMed
  8. Mancera E, Nocedal I, Hammel S, Gulati M, Mitchell KF, Andes DR, Nobile CJ, Butler G, Johnson AD. Evolution of the complex transcription network controlling biofilm formation in Candida species. Elife. 2021 04 07; 10.  View on PubMed
  9. Singh-Babak SD, Babak T, Fraser HB, Johnson AD. Lineage-specific selection and the evolution of virulence in the Candida clade. Proc Natl Acad Sci U S A. 2021 03 23; 118(12).  View on PubMed
  10. Lohse MB, Ennis CL, Hartooni N, Johnson AD, Nobile CJ. A Screen for Small Molecules to Target Candida albicans Biofilms. J Fungi (Basel). 2020 Dec 27; 7(1).  View on PubMed
  11. Lohse MB, Brenes LR, Ziv N, Winter MB, Craik CS, Johnson AD. An Opaque Cell-Specific Expression Program of Secreted Proteases and Transporters Allows Cell-Type Cooperation in Candida albicans. Genetics. 2020 10; 216(2):409-429.  View on PubMed
  12. Brenes LR, Lohse MB, Hartooni N, Johnson AD. A Set of Diverse Genes Influence the Frequency of White-Opaque Switching in Candida albicans. G3 (Bethesda). 2020 08 05; 10(8):2593-2600.  View on PubMed
  13. Lohse MB, Gulati M, Craik CS, Johnson AD, Nobile CJ. Combination of Antifungal Drugs and Protease Inhibitors Prevent Candida albicans Biofilm Formation and Disrupt Mature Biofilms. Front Microbiol. 2020; 11:1027.  View on PubMed
  14. Nobile CJ, Ennis CL, Hartooni N, Johnson AD, Lohse MB. A Selective Serotonin Reuptake Inhibitor, a Proton Pump Inhibitor, and Two Calcium Channel Blockers Inhibit Candida albicans Biofilms. Microorganisms. 2020 May 18; 8(5).  View on PubMed
  15. Mancera E, Frazer C, Porman AM, Ruiz-Castro S, Johnson AD, Bennett RJ. Corrigendum: Genetic Modification of Closely Related Candida Species. Front Microbiol. 2020; 11:713.  View on PubMed
  16. Britton CS, Sorrells TR, Johnson AD. Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit. Science. 2020 01 03; 367(6473):96-100.  View on PubMed
  17. Dalal CK, Zuleta IA, Lohse MB, Zordan RE, El-Samad H, Johnson AD. A population shift between two heritable cell types of the pathogen Candida albicans is based both on switching and selective proliferation. Proc Natl Acad Sci U S A. 2019 Dec 26; 116(52):26918-26924.  View on PubMed
  18. Takagi J, Singh-Babak SD, Lohse MB, Dalal CK, Johnson AD. Candida albicans white and opaque cells exhibit distinct spectra of organ colonization in mouse models of infection. PLoS One. 2019; 14(6):e0218037.  View on PubMed
  19. Mancera E, Frazer C, Porman AM, Ruiz-Castro S, Johnson AD, Bennett RJ. Genetic Modification of Closely Related Candida Species. Front Microbiol. 2019; 10:357.  View on PubMed
  20. Sorrells TR, Johnson AN, Howard CJ, Britton CS, Fowler KR, Feigerle JT, Weil PA, Johnson AD. Intrinsic cooperativity potentiates parallel cis-regulatory evolution. Elife. 2018 09 10; 7.  View on PubMed

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