July 1, 1979 - June 30, 2021 - Cell Biology, Genetics, and Biochemistry Training Grant, Principal Investigator. Sponsor: NIH/NIGMS, Sponsor Award ID: T32GM007810
July 1, 2009 - November 30, 2020 - The transcriptional circuitry controlling biofilm development in Candida albicans, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R01AI083311
August 1, 1986 - March 31, 2019 - Mechanism of Yeast Transcriptional Regulators, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R01GM037049
March 1, 2001 - November 30, 2016 - Regulatory Circuits and Virulence in Candida albicans, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R01AI049187
Education
Vanderbilt University, Nashville TN, B.A., 1974, Biochemistry Harvard University, Cambridge MA, M.A., Ph.D., 1980, Biochemistry University of California, San Francisco, Postdoctoral, 1981-85, Biochemistry
Ellison Medical Foundation Senior Scholar in Global Infectious Diseases, 2004-2008
Elected to American Academy of Arts and Sciences, 2007
The Emil Christian Hansen Award for Microbiology, 2009
Elected to the National Academy of Sciences, 2011
Selected Publications
Lohse MB, Ennis CL, Hartooni N, Johnson AD, Nobile CJ
A Screen for Small Molecules to Target Candida albicans Biofilms.
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Lohse MB, Brenes LR, Ziv N, Winter MB, Craik CS, Johnson AD
An Opaque Cell-Specific Expression Program of Secreted Proteases and Transporters Allows Cell-Type Cooperation in Candida albicans.
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Brenes LR, Lohse MB, Hartooni N, Johnson AD
A Set of Diverse Genes Influence the Frequency of White-Opaque Switching in Candida albicans.
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Lohse MB, Gulati M, Craik CS, Johnson AD, Nobile CJ
Combination of Antifungal Drugs and Protease Inhibitors Prevent Candida albicans Biofilm Formation and Disrupt Mature Biofilms.
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Nobile CJ, Ennis CL, Hartooni N, Johnson AD, Lohse MB
A Selective Serotonin Reuptake Inhibitor, a Proton Pump Inhibitor, and Two Calcium Channel Blockers Inhibit Candida albicans Biofilms.
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Mancera E, Frazer C, Porman AM, Ruiz-Castro S, Johnson AD, Bennett RJ
Corrigendum: Genetic Modification of Closely Related Candida Species.
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Britton CS, Sorrells TR, Johnson AD
Protein-coding changes preceded cis-regulatory gains in a newly evolved transcription circuit.
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Dalal CK, Zuleta IA, Lohse MB, Zordan RE, El-Samad H, Johnson AD
A population shift between two heritable cell types of the pathogen Candida albicans is based both on switching and selective proliferation.
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Takagi J, Singh-Babak SD, Lohse MB, Dalal CK, Johnson AD
Candida albicans white and opaque cells exhibit distinct spectra of organ colonization in mouse models of infection.
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Mancera E, Frazer C, Porman AM, Ruiz-Castro S, Johnson AD, Bennett RJ
Genetic Modification of Closely Related Candida Species.
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Sorrells TR, Johnson AN, Howard CJ, Britton CS, Fowler KR, Feigerle JT, Weil PA, Johnson AD
Intrinsic cooperativity potentiates parallel cis-regulatory evolution.
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Johnson AD
The rewiring of transcription circuits in evolution.
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Lohse MB, Gulati M, Johnson AD, Nobile CJ
Development and regulation of single- and multi-species Candida albicans biofilms.
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Craik VB, Johnson AD, Lohse MB
Sensitivity of White and Opaque Candida albicans Cells to Antifungal Drugs.
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Dalal CK, Johnson AD
How transcription circuits explore alternative architectures while maintaining overall circuit output.
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Lohse MB, Gulati M, Valle Arevalo A, Fishburn A, Johnson AD, Nobile CJ
Assessment and Optimizations of Candida albicans In Vitro Biofilm Assays.
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Nocedal I, Mancera E, Johnson AD
Gene regulatory network plasticity predates a switch in function of a conserved transcription regulator.
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Guajardo I, Ayer A, Johnson AD, Ganz P, Mills C, Donovan C, Scherzer R, Shah SJ, Peralta CA, Dubin RF
Sex differences in vascular dysfunction and cardiovascular outcomes: The cardiac, endothelial function, and arterial stiffness in ESRD (CERES) study.
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Ene IV, Lohse MB, Vladu AV, Morschhäuser J, Johnson AD, Bennett RJ
Phenotypic Profiling Reveals that Candida albicans Opaque Cells Represent a Metabolically Specialized Cell State Compared to Default White Cells.
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Winter MB, Salcedo EC, Lohse MB, Hartooni N, Gulati M, Sanchez H, Takagi J, Hube B, Andes DR, Johnson AD, Craik CS, Nobile CJ
Global Identification of Biofilm-Specific Proteolysis in Candida albicans.
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