Research Summary

I have published widely on breast imaging and the epidemiology of invasive breast cancer, DCIS and breast density, and risk prediction models for invasive breast cancer. I have extensive experience, expertise, and leadership in large-scale multi-disciplinary NIH-funded efforts of breast cancer screening, risk factors, and risk, including the U01 San Francisco Mammography Registry (SFMR), P50 UCSF Breast Cancer SPORE, P01 Breast Density Program Project, and the Breast Cancer Surveillance Consortium (BCSC) P01 Risk-based Breast Cancer Screening Program Project. As PI or co-PI on several these grants, I have developed cohorts of women at risk for invasive breast cancer and DCIS and developed comprehensive databases that include breast imaging, pathologic, clinical, biomarker, and risk factor data, as well as follow-up for subsequent disease and death. In addition, I have successfully administered projects (e.g., staffing, research protections, budget), collaborated with other researchers, and produced many peer-reviewed publications from each project. I have a demonstrated record of successful and productive research projects in areas of high relevance for breast cancer screening, breast density, DCIS, and risk prediction.

Research Funding

  • September 27, 2011 - May 31, 2022 - Risk-based Breast Cancer Screening and Surveillance in Community Practice, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: P01CA154292
  • April 1, 2017 - March 31, 2022 - Radiomic phenotypes of breast parenchyma and association with breast cancer risk and detection, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA207084
  • September 1, 2013 - August 31, 2018 - Automated Density Measures for Estimating Breast Cancer Risk and Therapy Response, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA177150
  • April 1, 2010 - January 31, 2015 - Risk factors for breast cancer molecular subtypes, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA140286

Education

Michigan State University, East Lansing, BS, 1978, Medical Technology
University of California, Berkeley, MS, 1984, Nutrition
University of California San Francisco, MD, 1988, Medicine
University of California San Francisco, 1988-1989, Medicine Internship
University of California San Francisco, 1989-1991, Primary Care Medicine Residency 
Veterans Affairs Medical Center, San Francisco, 1991-1993, Fellow in General Internal Medicine

Honors & Awards

  • 1975
    Tower Guard Award for Scholastic Achievement
  • 1975-77
    Honors College, Michigan State University
  • 1978
    Magna cum laude, Michigan State University
  • 1986
    Student Summer Research Fellowship, UCSF
  • 1987
    Alpha Omega Alpha
  • 1994-96
    American Cancer Society Award for Primary Care Physicians
  • 2009
    American Cancer Society Research Scholar
  • 2014
    SGIM Distinguished Professor in Cancer Research
  • 2016
    Journal of Women's Health Award for Outstanding Achievement in Women’s Health Research

Selected Publications

  1. Kerlikowske K, Bibbins-Domingo K Toward Risk-Based Breast Cancer Screening.  View on PubMed
  2. Comparative Access to and Use of Digital Breast Tomosynthesis Screening by Women's Race/Ethnicity and Socioeconomic Status.  View on PubMed
  3. van Ravesteyn NT, Schechter CB, Hampton JM, Alagoz O, van den Broek JJ, Kerlikowske K, Mandelblatt JS, Miglioretti DL, Sprague BL, Stout NK, de Koning HJ, Trentham-Dietz A, Tosteson ANA Trade-Offs Between Harms and Benefits of Different Breast Cancer Screening Intervals Among Low-Risk Women.  View on PubMed
  4. Kleinstern G, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Bertrand KA, Norman AD, Visscher DW, Couch FJ, Brandt K, Shepherd J, Wu FF, Chen YY, Cummings SR, Winham S, Kerlikowske K, Vachon CM Association of mammographic density measures and breast cancer "intrinsic" molecular subtypes.  View on PubMed
  5. Kerlikowske K, Bissell MCS, Sprague BL, Buist DSM, Henderson LM, Lee JM, Miglioretti DL Advanced Breast Cancer Definitions by Staging System Examined in the Breast Cancer Surveillance Consortium.  View on PubMed
  6. Durham DD, Roberts MC, Khan CP, Abraham LA, Smith RA, Kerlikowske K, Miglioretti DL Age at initiation of screening mammography by family history of breast cancer in the breast cancer surveillance consortium.  View on PubMed
  7. Wernli KJ, Callaway KA, Henderson LM, Kerlikowske K, Lee JM, Ross-Degnan D, Wallace JK, Wharam JF, Zhang F, Stout NK Trends in screening breast magnetic resonance imaging use among US women, 2006 to 2016.  View on PubMed
  8. Bissell MCS, Kerlikowske K, Sprague BL, Tice JA, Gard CC, Tossas KY, Rauscher GH, Trentham-Dietz A, Henderson LM, Onega T, Keegan THM, Miglioretti DL Breast Cancer Population Attributable Risk Proportions Associated with Body Mass Index and Breast Density by Race/Ethnicity and Menopausal Status.  View on PubMed
  9. Lowry KP, Coley RY, Miglioretti DL, Kerlikowske K, Henderson LM, Onega T, Sprague BL, Lee JM, Herschorn S, Tosteson ANA, Rauscher G, Lee CI Screening Performance of Digital Breast Tomosynthesis vs Digital Mammography in Community Practice by Patient Age, Screening Round, and Breast Density.  View on PubMed
  10. Kenny JD, Karliner LS, Kerlikowske K, Kaplan CP, Fernandez-Lamothe A, Burke NJ Organization Communication Factors and Abnormal Mammogram Follow-up: a Qualitative Study Among Ethnically Diverse Women Across Three Healthcare Systems.  View on PubMed
  11. Lowry KP, Trentham-Dietz A, Schechter CB, Alagoz O, Barlow WE, Burnside ES, Conant EF, Hampton JM, Huang H, Kerlikowske K, Lee SJ, Miglioretti DL, Sprague BL, Tosteson ANA, Yaffe MJ, Stout NK Long-Term Outcomes and Cost-Effectiveness of Breast Cancer Screening With Digital Breast Tomosynthesis in the United States.  View on PubMed
  12. Demb J, Abraham L, Miglioretti DL, Sprague BL, O'Meara ES, Advani S, Henderson LM, Onega T, Buist DSM, Schousboe JT, Walter LC, Kerlikowske K, Braithwaite D Screening Mammography Outcomes: Risk of Breast Cancer and Mortality by Comorbidity Score and Age.  View on PubMed
  13. Gastounioti A, Kasi CD, Scott CG, Brandt KR, Jensen MR, Hruska CB, Wu FF, Norman AD, Conant EF, Winham SJ, Kerlikowske K, Kontos D, Vachon CM Evaluation of LIBRA Software for Fully Automated Mammographic Density Assessment in Breast Cancer Risk Prediction.  View on PubMed
  14. Sprague BL, Miglioretti DL, Lee CI, Perry H, Tosteson AAN, Kerlikowske K New mammography screening performance metrics based on the entire screening episode.  View on PubMed
  15. Henderson LM, O'Meara ES, Haas JS, Lee CI, Kerlikowske K, Sprague BL, Alford-Teaster J, Onega T The Role of Social Determinants of Health in Self-Reported Access to Health Care Among Women Undergoing Screening Mammography.  View on PubMed
  16. Sprague BL, Coley RY, Kerlikowske K, Rauscher GH, Henderson LM, Onega T, Lee CI, Herschorn SD, Tosteson ANA, Miglioretti DL Assessment of Radiologist Performance in Breast Cancer Screening Using Digital Breast Tomosynthesis vs Digital Mammography.  View on PubMed
  17. Shieh Y, Ziv E, Kerlikowske K Interval breast cancers - insights into a complex phenotype.  View on PubMed
  18. Buist DSM, Ichikawa L, Wernli KJ, Lee CI, Henderson LM, Kerlikowske K, Bowles EJA, Miglioretti DL, Specht J, Rauscher GH, Sprague BL, Onega T, Lee JM Facility Variability in Examination Indication Among Women With Prior Breast Cancer: Implications and the Need for Standardization.  View on PubMed
  19. Schifferdecker KE, Tosteson ANA, Kaplan C, Kerlikowske K, Buist DSM, Henderson LM, Johnson D, Jaworski J, Jackson-Nefertiti G, Ehrlich K, Marsh MW, Vu L, Onega T, Wernli KJ Knowledge and Perception of Breast Density, Screening Mammography, and Supplemental Screening: in Search of "Informed".  View on PubMed
  20. Brandt KR, Scott CG, Miglioretti DL, Jensen MR, Mahmoudzadeh AP, Hruska C, Ma L, Wu FF, Cummings SR, Norman AD, Engmann NJ, Shepherd JA, Winham SJ, Kerlikowske K, Vachon CM Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer.  View on PubMed

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