Research Summary

I have published widely on breast imaging and the epidemiology of invasive breast cancer, DCIS and breast density, and risk prediction models for invasive breast cancer. I have extensive experience, expertise, and leadership in large-scale multi-disciplinary NIH-funded efforts of breast cancer screening, risk factors, and risk, including the U01 San Francisco Mammography Registry (SFMR), P50 UCSF Breast Cancer SPORE, P01 Breast Density Program Project, and the Breast Cancer Surveillance Consortium (BCSC) P01 Risk-based Breast Cancer Screening Program Project. As PI or co-PI on several these grants, I have developed cohorts of women at risk for invasive breast cancer and DCIS and developed comprehensive databases that include breast imaging, pathologic, clinical, biomarker, and risk factor data, as well as follow-up for subsequent disease and death. In addition, I have successfully administered projects (e.g., staffing, research protections, budget), collaborated with other researchers, and produced many peer-reviewed publications from each project. I have a demonstrated record of successful and productive research projects in areas of high relevance for breast cancer screening, breast density, DCIS, and risk prediction.

Research Funding

  • September 27, 2011 - May 31, 2022 - Risk-based Breast Cancer Screening and Surveillance in Community Practice, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: P01CA154292
  • April 1, 2017 - March 31, 2022 - Radiomic phenotypes of breast parenchyma and association with breast cancer risk and detection, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA207084
  • September 1, 2013 - August 31, 2018 - Automated Density Measures for Estimating Breast Cancer Risk and Therapy Response, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA177150
  • April 1, 2010 - January 31, 2015 - Risk factors for breast cancer molecular subtypes, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA140286

Education

Michigan State University, East Lansing, BS, 1978, Medical Technology
University of California, Berkeley, MS, 1984, Nutrition
University of California San Francisco, MD, 1988, Medicine
University of California San Francisco, 1988-1989, Medicine Internship
University of California San Francisco, 1989-1991, Primary Care Medicine Residency 
Veterans Affairs Medical Center, San Francisco, 1991-1993, Fellow in General Internal Medicine

Honors & Awards

  • 1975
    Tower Guard Award for Scholastic Achievement
  • 1975-77
    Honors College, Michigan State University
  • 1978
    Magna cum laude, Michigan State University
  • 1986
    Student Summer Research Fellowship, UCSF
  • 1987
    Alpha Omega Alpha
  • 1994-96
    American Cancer Society Award for Primary Care Physicians
  • 2009
    American Cancer Society Research Scholar
  • 2014
    SGIM Distinguished Professor in Cancer Research
  • 2016
    Journal of Women's Health Award for Outstanding Achievement in Women’s Health Research

Selected Publications

  1. Advani SM, Zhu W, Demb J, Sprague BL, Onega T, Henderson LM, Buist DSM, Zhang D, Schousboe JT, Walter LC, Kerlikowske K, Miglioretti DL, Braithwaite D, Breast Cancer Surveillance Consortium . Association of Breast Density With Breast Cancer Risk Among Women Aged 65 Years or Older by Age Group and Body Mass Index. JAMA Netw Open. 2021 Aug 02; 4(8):e2122810.  View on PubMed
  2. van Ravesteyn NT, Schechter CB, Hampton JM, Alagoz O, van den Broek JJ, Kerlikowske K, Mandelblatt JS, Miglioretti DL, Sprague BL, Stout NK, de Koning HJ, Trentham-Dietz A, Tosteson ANA, Breast Cancer Surveillance Consortium and the Cancer Intervention and Surveillance Modeling Network . Trade-Offs Between Harms and Benefits of Different Breast Cancer Screening Intervals Among Low-Risk Women. J Natl Cancer Inst. 2021 Aug 02; 113(8):1017-1026.  View on PubMed
  3. Alagoz O, Lowry KP, Kurian AW, Mandelblatt JS, Ergun MA, Huang H, Lee SJ, Schechter CB, Tosteson ANA, Miglioretti DL, Trentham-Dietz A, Nyante SJ, Kerlikowske K, Sprague BL, Stout NK. Impact of the COVID-19 Pandemic on Breast Cancer Mortality in the US: Estimates From Collaborative Simulation Modeling. J Natl Cancer Inst. 2021 Jul 14.  View on PubMed
  4. Kerlikowske K, Bissell MCS, Sprague BL, Buist DSM, Henderson LM, Lee JM, Miglioretti DL. Advanced Breast Cancer Definitions by Staging System Examined in the Breast Cancer Surveillance Consortium. J Natl Cancer Inst. 2021 Jul 01; 113(7):909-916.  View on PubMed
  5. Kerlikowske K, Bissell MCS, Sprague BL, Buist DSM, Henderson LM, Lee JM, Miglioretti DL. Response to Pisano, Gastonis, Sparano, et al. J Natl Cancer Inst. 2021 Jul 01; 113(7):940-941.  View on PubMed
  6. Sprague BL, O'Meara ES, Lee CI, Lee JM, Henderson LM, Buist DSM, Alsheik N, Macarol T, Perry H, Tosteson ANA, Onega T, Kerlikowske K, Miglioretti DL. Prioritizing breast imaging services during the COVID pandemic: A survey of breast imaging facilities within the Breast Cancer Surveillance Consortium. Prev Med. 2021 10; 151:106540.  View on PubMed
  7. Schifferdecker KE, Vaclavik D, Wernli KJ, Buist DSM, Kerlikowske K, Sprague BL, Henderson LM, Johnson D, Budesky J, Jackson-Nefertiti G, Miglioretti DL, Tosteson ANA. Women's considerations and experiences for breast cancer screening and surveillance during the COVID-19 pandemic in the United States: A focus group study. Prev Med. 2021 10; 151:106542.  View on PubMed
  8. Heine J, Fowler E, Scott CG, Jensen MR, Shepherd J, Hruska CB, Winham SJ, Brandt KR, Wu FF, Norman AD, Pankratz VS, Miglioretti DL, Kerlikowske K, Vachon CM. Mammographic Variation Measures, Breast Density, and Breast Cancer Risk. AJR Am J Roentgenol. 2021 08; 217(2):326-335.  View on PubMed
  9. Zhang D, Abraham L, Demb J, Miglioretti DL, Advani S, Sprague BL, Henderson LM, Onega T, Wernli KJ, Walter LC, Kerlikowske K, Schousboe JT, O'Meara ES, Braithwaite D, Breast Cancer Surveillance Consortium . Function-related Indicators and Outcomes of Screening Mammography in Older Women: Evidence from the Breast Cancer Surveillance Consortium Cohort. Cancer Epidemiol Biomarkers Prev. 2021 Aug; 30(8):1582-1590.  View on PubMed
  10. Lee JM, Ichikawa LE, Wernli KJ, Bowles E, Specht JM, Kerlikowske K, Miglioretti DL, Lowry KP, Tosteson ANA, Stout NK, Houssami N, Onega T, Buist DSM. Digital Mammography and Breast Tomosynthesis Performance in Women with a Personal History of Breast Cancer, 2007-2016. Radiology. 2021 Aug; 300(2):290-300.  View on PubMed
  11. Sprague BL, Lowry KP, Miglioretti DL, Alsheik N, Bowles EJA, Tosteson ANA, Rauscher G, Herschorn SD, Lee JM, Trentham-Dietz A, Weaver DL, Stout NK, Kerlikowske K. Changes in Mammography Utilization by Women's Characteristics during the First 5 Months of the COVID-19 Pandemic. J Natl Cancer Inst. 2021 Mar 29.  View on PubMed
  12. Miglioretti DL, Bissell MCS, Kerlikowske K, Buist DSM, Cummings SR, Henderson LM, Onega T, O'Meara ES, Rauscher GH, Sprague BL, Tosteson ANA, Wernli KJ, Lee JM, Lee CI. Assessment of a Risk-Based Approach for Triaging Mammography Examinations During Periods of Reduced Capacity. JAMA Netw Open. 2021 03 01; 4(3):e211974.  View on PubMed
  13. Kerlikowske K, Bibbins-Domingo K. Toward Risk-Based Breast Cancer Screening. Ann Intern Med. 2021 05; 174(5):710-711.  View on PubMed
  14. Rustagi AS, Scott CG, Winham SJ, Brandt KR, Norman AD, Jensen MR, Shepherd JA, Hruska C, Heine JJ, Pankratz VS, Kerlikowske K, Vachon CM. Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk. JNCI Cancer Spectr. 2021 Apr; 5(2):pkaa124.  View on PubMed
  15. Lee CI, Zhu W, Onega T, Henderson LM, Kerlikowske K, Sprague BL, Rauscher GH, O'Meara ES, Tosteson ANA, Haas JS, diFlorio-Alexander R, Kaplan C, Miglioretti DL. Comparative Access to and Use of Digital Breast Tomosynthesis Screening by Women's Race/Ethnicity and Socioeconomic Status. JAMA Netw Open. 2021 02 01; 4(2):e2037546.  View on PubMed
  16. Kleinstern G, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Bertrand KA, Norman AD, Visscher DW, Couch FJ, Brandt K, Shepherd J, Wu FF, Chen YY, Cummings SR, Winham S, Kerlikowske K, Vachon CM. Association of mammographic density measures and breast cancer "intrinsic" molecular subtypes. Breast Cancer Res Treat. 2021 May; 187(1):215-224.  View on PubMed
  17. Durham DD, Roberts MC, Khan CP, Abraham LA, Smith RA, Kerlikowske K, Miglioretti DL. Age at initiation of screening mammography by family history of breast cancer in the breast cancer surveillance consortium. Cancer Causes Control. 2021 Jan; 32(1):103-107.  View on PubMed
  18. Wernli KJ, Callaway KA, Henderson LM, Kerlikowske K, Lee JM, Ross-Degnan D, Wallace JK, Wharam JF, Zhang F, Stout NK. Trends in screening breast magnetic resonance imaging use among US women, 2006 to 2016. Cancer. 2020 12 15; 126(24):5293-5302.  View on PubMed
  19. Bissell MCS, Kerlikowske K, Sprague BL, Tice JA, Gard CC, Tossas KY, Rauscher GH, Trentham-Dietz A, Henderson LM, Onega T, Keegan THM, Miglioretti DL, Breast Cancer Surveillance Consortium . Breast Cancer Population Attributable Risk Proportions Associated with Body Mass Index and Breast Density by Race/Ethnicity and Menopausal Status. Cancer Epidemiol Biomarkers Prev. 2020 10; 29(10):2048-2056.  View on PubMed
  20. Lowry KP, Coley RY, Miglioretti DL, Kerlikowske K, Henderson LM, Onega T, Sprague BL, Lee JM, Herschorn S, Tosteson ANA, Rauscher G, Lee CI. Screening Performance of Digital Breast Tomosynthesis vs Digital Mammography in Community Practice by Patient Age, Screening Round, and Breast Density. JAMA Netw Open. 2020 07 01; 3(7):e2011792.  View on PubMed

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