Research Summary

I have published widely on breast imaging and the epidemiology of invasive breast cancer, DCIS and breast density, and risk prediction models for invasive breast cancer. I have extensive experience, expertise, and leadership in large-scale multi-disciplinary NIH-funded efforts of breast cancer screening, risk factors, and risk, including the U01 San Francisco Mammography Registry (SFMR), P50 UCSF Breast Cancer SPORE, P01 Breast Density Program Project, and the Breast Cancer Surveillance Consortium (BCSC) P01 Risk-based Breast Cancer Screening Program Project. As PI or co-PI on several these grants, I have developed cohorts of women at risk for invasive breast cancer and DCIS and developed comprehensive databases that include breast imaging, pathologic, clinical, biomarker, and risk factor data, as well as follow-up for subsequent disease and death. In addition, I have successfully administered projects (e.g., staffing, research protections, budget), collaborated with other researchers, and produced many peer-reviewed publications from each project. I have a demonstrated record of successful and productive research projects in areas of high relevance for breast cancer screening, breast density, DCIS, and risk prediction.

Research Funding

  • September 17, 2024 - August 31, 2029 - Evaluation of Commercial Mammography-Based Artificial Intelligence Algorithms for Breast Cancer Risk Prediction in U.S. Screening Populations , Co-investigator . Sponsor: NCI, Sponsor Award ID: R01CA292399
  • September 19, 2023 - August 31, 2028 - Clinical breast cancer risk prediction models for women with a high risk benign breast diagnosis , Co-investigator . Sponsor: NIH, Sponsor Award ID: R01CA282725
  • March 8, 2023 - February 28, 2028 - Hawaii Pacific Islands Mammography Registry , Co-Principal investigator . Sponsor: NIH, Sponsor Award ID: 1R01CA263491
  • March 1, 2023 - February 28, 2028 - Evaluation of novel tomosynthesis density measures in breast cancer risk prediction , Co-Principal investigator . Sponsor: NIH, Sponsor Award ID: 1R01CA275074
  • July 1, 2022 - June 30, 2027 - Population-Based Evaluation of Artificial Intelligence for Mammography Prior to Widespread Clinical Translation , Co-investigator . Sponsor: NIH, Sponsor Award ID: R01CA262023
  • September 16, 2022 - May 31, 2027 - Advancing Equitable Risk-based Breast Cancer Screening and Surveillance in Community Practice , Co-Principal investigator . Sponsor: NIH, Sponsor Award ID: P01CA154292
  • June 1, 2021 - May 31, 2026 - Racial and Socioeconomic Disparities in Breast Cancer Diagnostic Work Up and Outcomes , Co-investigator . Sponsor: NIH, Sponsor Award ID: R01CA266377
  • March 1, 2020 - February 28, 2025 - Identifying Effective Risk-based Supplemental Ultrasound Screening Strategies for Women with Dense Breasts , Co-investigator . Sponsor: NIH, Sponsor Award ID: R01CA248068
  • September 27, 2011 - May 31, 2022 - Risk-based Breast Cancer Screening and Surveillance in Community Practice , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: P01CA154292
  • April 1, 2017 - March 31, 2022 - Radiomic phenotypes of breast parenchyma and association with breast cancer risk and detection , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA207084
  • September 1, 2013 - August 31, 2019 - Automated Density Measures for Estimating Breast Cancer Risk and Therapy Response , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA177150
  • April 1, 2010 - January 31, 2016 - Risk factors for breast cancer molecular subtypes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA140286
  • August 10, 2006 - February 28, 2013 - Biological Basis of Breast Density and Cancer Risk , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P01CA107584
  • September 30, 2009 - August 31, 2012 - Comparative effectiveness of breast imaging strategies in community practice , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: UC2CA148577
  • June 1, 1994 - July 31, 2012 - San Francisco Mammography Registry-A Research Source , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01CA063740
  • September 30, 2009 - August 31, 2011 - Comparative effectiveness of breast imaging strategies in community practice , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: RC2CA148577

Education

Michigan State University, East Lansing, BS, 1978, Medical Technology
University of California, Berkeley, MS, 1984, Nutrition
University of California San Francisco, MD, 1988, Medicine
University of California San Francisco, 1988-1989, Medicine Internship
University of California San Francisco, 1989-1991, Primary Care Medicine Residency 
Veterans Affairs Medical Center, San Francisco, 1991-1993, Fellow in General Internal Medicine

Honors & Awards

  • 1975
    Tower Guard Award for Scholastic Achievement
  • 1975-77
    Honors College, Michigan State University
  • 1978
    Magna cum laude, Michigan State University
  • 1986
    Student Summer Research Fellowship, UCSF
  • 1987
    Alpha Omega Alpha
  • 1994-96
    American Cancer Society Award for Primary Care Physicians
  • 2009
    American Cancer Society Research Scholar
  • 2014
    SGIM Distinguished Professor in Cancer Research
  • 2016
    Journal of Women's Health Award for Outstanding Achievement in Women’s Health Research
  • 2023
    Elected Association of American Physicians

Selected Publications

  1. Kerlikowske K, Esserman L, Tice JA. Screening Mammography for 40-Year-Old Women-Whose Decision? JAMA Intern Med. 2024 Nov 01; 184(11):1281-1282.  View on PubMed
  2. Foster VM, Trentham-Dietz A, Stout NK, Lee CI, Ichikawa LE, Eavey J, Henderson L, Miglioretti DL, Tosteson ANA, Bowles EA, Kerlikowske K, Sprague BL. Supplemental breast cancer screening after negative mammography in U.S. women with dense breasts. J Natl Cancer Inst. 2024 Oct 30.  View on PubMed
  3. Stout NK, Miglioretti DL, Su YR, Lee CI, Abraham L, Alagoz O, de Koning HJ, Hampton JM, Henderson L, Lowry KP, Mandelblatt JS, Onega T, Schechter CB, Sprague BL, Stein S, Trentham-Dietz A, van Ravesteyn NT, Wernli KJ, Kerlikowske K, Tosteson ANA. Breast Cancer Screening Using Mammography, Digital Breast Tomosynthesis, and Magnetic Resonance Imaging by Breast Density. JAMA Intern Med. 2024 Oct 01; 184(10):1222-1231.  View on PubMed
  4. Miglioretti DL, Abraham L, Sprague BL, Lee CI, Bissell MCS, Ho TH, Bowles EJA, Henderson LM, Hubbard RA, Tosteson ANA, Kerlikowske K. Association Between False-Positive Results and Return to Screening Mammography in the Breast Cancer Surveillance Consortium Cohort. Ann Intern Med. 2024 Oct; 177(10):1297-1307.  View on PubMed
  5. Sprague BL, Ichikawa L, Eavey J, Lowry KP, Rauscher GH, O'Meara ES, Miglioretti DL, Lee JM, Stout NK, Herschorn SD, Perry H, Weaver DL, Kerlikowske K. Performance of Supplemental US Screening in Women with Dense Breasts and Varying Breast Cancer Risk: Results from the Breast Cancer Surveillance Consortium. Radiology. 2024 08; 312(2):e232380.  View on PubMed
  6. Lee JM, Ichikawa L, Kerlikowske K, Buist DSM, Lee CI, Sprague BL, Henderson LM, Onega T, Wernli KJ, Lowry KP, Stout NK, Tosteson ANA, Miglioretti DL. Relative Timing of Mammography and MRI for Breast Cancer Screening: Impact on Performance Evaluation. J Am Coll Radiol. 2024 Jul 03.  View on PubMed
  7. Horng H, Scott C, Winham S, Jensen M, Pantalone L, Mankowski W, Kerlikowske K, Vachon CM, Kontos D, Shinohara RT. Multivariate testing and effect size measures for batch effect evaluation in radiomic features. Sci Rep. 2024 06 17; 14(1):13923.  View on PubMed
  8. Trentham-Dietz A, Chapman CH, Jayasekera J, Lowry KP, Heckman-Stoddard BM, Hampton JM, Caswell-Jin JL, Gangnon RE, Lu Y, Huang H, Stein S, Sun L, Gil Quessep EJ, Yang Y, Lu Y, Song J, Muñoz DF, Li Y, Kurian AW, Kerlikowske K, O'Meara ES, Sprague BL, Tosteson ANA, Feuer EJ, Berry D, Plevritis SK, Huang X, de Koning HJ, van Ravesteyn NT, Lee SJ, Alagoz O, Schechter CB, Stout NK, Miglioretti DL, Mandelblatt JS. Collaborative Modeling to Compare Different Breast Cancer Screening Strategies: A Decision Analysis for the US Preventive Services Task Force. JAMA. 2024 06 11; 331(22):1947-1960.  View on PubMed
  9. Hubbard RA, Su YR, Bowles EJA, Ichikawa L, Kerlikowske K, Lowry KP, Miglioretti DL, Tosteson ANA, Wernli KJ, Lee JM. Predicting five-year interval second breast cancer risk in women with prior breast cancer. J Natl Cancer Inst. 2024 Jun 07; 116(6):929-937.  View on PubMed
  10. Smith RE, Sprague BL, Henderson LM, Kerlikowske K, Miglioretti DL, Wernli KJ, Onega T, diFlorio-Alexander RM, Tosteson ANA. Breast density knowledge and willingness to delay treatment for pre-operative breast cancer imaging among women with a personal history of breast cancer. Breast Cancer Res. 2024 Apr 29; 26(1):73.  View on PubMed
  11. Kerlikowske K, Zhu W, Su YR, Sprague BL, O'Meara ES, Tosteson ANA, Wernli KJ, Miglioretti DL. Response to Omoleye, Esserman, Olufunmilayo. J Natl Cancer Inst. 2024 Apr 05; 116(4):629-630.  View on PubMed
  12. Kerlikowske K, Zhu W, Su YR, Sprague BL, Stout NK, Onega T, O'Meara ES, Henderson LM, Tosteson ANA, Wernli K, Miglioretti DL. Supplemental magnetic resonance imaging plus mammography compared with magnetic resonance imaging or mammography by extent of breast density. J Natl Cancer Inst. 2024 Feb 08; 116(2):249-257.  View on PubMed
  13. Kerlikowske K, Chen S, Bissell MCS, Lee CI, Tice JA, Sprague BL, Miglioretti DL. Population Attributable Risk of Advanced-Stage Breast Cancer by Race and Ethnicity. JAMA Oncol. 2024 Feb 01; 10(2):167-175.  View on PubMed
  14. George MF, Paff S, Rojo J, Powell M, Benz C, Pope K, Kerlikowske K, Shepard J, Willis M, Ereman R, Prebil L. Assessment of salivary cadmium levels and breast density in the Marin Women's Study. Cancer Med. 2024 Jan; 13(2):e6973.  View on PubMed
  15. Gard CC, Tice JA, Miglioretti DL, Sprague BL, Bissell MCS, Henderson LM, Kerlikowske K. Extending the Breast Cancer Surveillance Consortium Model of Invasive Breast Cancer. J Clin Oncol. 2024 Mar 01; 42(7):779-789.  View on PubMed
  16. Kerlikowske K, Bissell MCS, Sprague BL, Tice JA, Tossas KY, Bowles EJA, Ho TH, Keegan THM, Miglioretti DL. Impact of BMI on Prevalence of Dense Breasts by Race and Ethnicity. Cancer Epidemiol Biomarkers Prev. 2023 11 01; 32(11):1524-1530.  View on PubMed
  17. Nyante SJ, Abraham L, Aiello Bowles EJ, Lee CI, Kerlikowske K, Miglioretti DL, Sprague BL, Henderson LM, Breast Cancer Surveillance Consortium. Racial and Ethnic Variation in Diagnostic Mammography Performance among Women Reporting a Breast Lump. Cancer Epidemiol Biomarkers Prev. 2023 11 01; 32(11):1542-1551.  View on PubMed
  18. Caruso JA, Wang X, Murrow LM, Rodriguez CI, Chen-Tanyolac C, Vu L, Chen YY, Gascard P, Gartner ZJ, Kerlikowske K, Tlsty TD. Loss of PPARγ activity characterizes early protumorigenic stromal reprogramming and dictates the therapeutic window of opportunity. Proc Natl Acad Sci U S A. 2023 10 17; 120(42):e2303774120.  View on PubMed
  19. Onega T, Abraham L, Miglioretti DL, Lee CI, Henderson LM, Kerlikowske K, Tosteson ANA, Weaver D, Sprague BL, Bowles EJA, di Florio-Alexander RM. Digital mammography and digital breast tomosynthesis for detecting invasive lobular and ductal carcinoma. Breast Cancer Res Treat. 2023 Dec; 202(3):505-514.  View on PubMed
  20. Lee JM, Ichikawa LE, Wernli KJ, Bowles EJA, Specht JM, Kerlikowske K, Miglioretti DL, Lowry KP, Tosteson ANA, Stout NK, Houssami N, Onega T, Buist DSM. Impact of Surveillance Mammography Intervals Less Than One Year on Performance Measures in Women With a Personal History of Breast Cancer. Korean J Radiol. 2023 08; 24(8):729-738.  View on PubMed

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