Research Summary

I have published widely on breast imaging and the epidemiology of invasive breast cancer, DCIS and breast density, and risk prediction models for invasive breast cancer. I have extensive experience, expertise, and leadership in large-scale multi-disciplinary NIH-funded efforts of breast cancer screening, risk factors, and risk, including the U01 San Francisco Mammography Registry (SFMR), P50 UCSF Breast Cancer SPORE, P01 Breast Density Program Project, and the Breast Cancer Surveillance Consortium (BCSC) P01 Risk-based Breast Cancer Screening Program Project. As PI or co-PI on several these grants, I have developed cohorts of women at risk for invasive breast cancer and DCIS and developed comprehensive databases that include breast imaging, pathologic, clinical, biomarker, and risk factor data, as well as follow-up for subsequent disease and death. In addition, I have successfully administered projects (e.g., staffing, research protections, budget), collaborated with other researchers, and produced many peer-reviewed publications from each project. I have a demonstrated record of successful and productive research projects in areas of high relevance for breast cancer screening, breast density, DCIS, and risk prediction.

Research Funding

  • September 27, 2011 - May 31, 2022 - Risk-based Breast Cancer Screening and Surveillance in Community Practice, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: P01CA154292
  • April 1, 2017 - March 31, 2022 - Radiomic phenotypes of breast parenchyma and association with breast cancer risk and detection, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA207084
  • September 1, 2013 - August 31, 2018 - Automated Density Measures for Estimating Breast Cancer Risk and Therapy Response, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA177150
  • April 1, 2010 - January 31, 2015 - Risk factors for breast cancer molecular subtypes, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA140286

Education

Michigan State University, East Lansing, BS, 1978, Medical Technology
University of California, Berkeley, MS, 1984, Nutrition
University of California San Francisco, MD, 1988, Medicine
University of California San Francisco, 1988-1989, Medicine Internship
University of California San Francisco, 1989-1991, Primary Care Medicine Residency 
Veterans Affairs Medical Center, San Francisco, 1991-1993, Fellow in General Internal Medicine

Honors & Awards

  • 1975
    Tower Guard Award for Scholastic Achievement
  • 1975-77
    Honors College, Michigan State University
  • 1978
    Magna cum laude, Michigan State University
  • 1986
    Student Summer Research Fellowship, UCSF
  • 1987
    Alpha Omega Alpha
  • 1994-96
    American Cancer Society Award for Primary Care Physicians
  • 2009
    American Cancer Society Research Scholar
  • 2014
    SGIM Distinguished Professor in Cancer Research
  • 2016
    Journal of Women's Health Award for Outstanding Achievement in Women’s Health Research

Selected Publications

  1. Houssami N, Kerlikowske K. AI as a new paradigm for risk-based screening for breast cancer. Nat Med. 2022 Jan 13.  View on PubMed
  2. Kerlikowske K, Chen S, Golmakani MK, Sprague BL, Tice JA, Tosteson ANA, Rauscher GH, Henderson LM, Buist DSM, Lee JM, Gard CC, Miglioretti DL. Cumulative Advanced Breast Cancer Risk Prediction Model Developed in a Screening Mammography Population. J Natl Cancer Inst. 2022 Jan 13.  View on PubMed
  3. Advani S, Abraham L, Buist DSM, Kerlikowske K, Miglioretti DL, Sprague BL, Henderson LM, Onega T, Schousboe JT, Demb J, Zhang D, Walter LC, Lee CI, Braithwaite D, O'Meara ES, Breast Cancer Surveillance Consortium. Breast biopsy patterns and findings among older women undergoing screening mammography: The role of age and comorbidity. J Geriatr Oncol. 2021 Dec 09.  View on PubMed
  4. Tice JA, Gard CC, Miglioretti DL, Sprague BL, Tosteson ANA, Joe BN, Ho TH, Kerlikowske K. Comparing Mammographic Density Assessed by Digital Breast Tomosynthesis or Digital Mammography: The Breast Cancer Surveillance Consortium. Radiology. 2021 Nov 23; 204579.  View on PubMed
  5. Schousboe JT, Sprague BL, Abraham L, O'Meara ES, Onega T, Advani S, Henderson LM, Wernli KJ, Zhang D, Miglioretti DL, Braithwaite D, Kerlikowske K. Cost-Effectiveness of Screening Mammography Beyond Age 75 Years : A Cost-Effectiveness Analysis. Ann Intern Med. 2021 Nov 23.  View on PubMed
  6. Zhang D, Abraham L, Sprague BL, Onega T, Advani S, Demb J, Miglioretti DL, Henderson LM, Wernli KJ, Walter LC, Kerlikowske K, Schousboe JT, Chrischilles E, Braithwaite D, O'Meara ES, Breast Cancer Surveillance Consortium. Mammography adherence in relation to function-related indicators in older women. Prev Med. 2021 Nov 09; 154:106869.  View on PubMed
  7. Acciavatti RJ, Cohen EA, Maghsoudi OH, Gastounioti A, Pantalone L, Hsieh MK, Conant EF, Scott CG, Winham SJ, Kerlikowske K, Vachon C, Maidment ADA, Kontos D. Incorporating Robustness to Imaging Physics into Radiomic Feature Selection for Breast Cancer Risk Estimation. Cancers (Basel). 2021 Nov 01; 13(21).  View on PubMed
  8. Onega T, Zhu W, Kerlikowske K, Miglioretti DL, Lee CI, Henderson LM, Tosteson ANA, Wernli KJ, diFlorio R, Weaver DL, Buist DSM. Preoperative MRI in breast cancer: effect of breast density on biopsy rate and yield. Breast Cancer Res Treat. 2021 Oct 22.  View on PubMed
  9. Lowry KP, Bissell M, Miglioretti DL, Kerlikowske K, Alsheik N, Macarol T, Bowles EJA, Buist DSM, Tosteson ANA, Henderson L, Herschorn SD, Wernli KJ, Weaver DL, Stout NK, Sprague BL. Breast Biopsy Recommendations and Breast Cancers Diagnosed during the COVID-19 Pandemic. Radiology. 2021 Oct 19; 211808.  View on PubMed
  10. Zhu X, Wolfgruber TK, Leong L, Jensen M, Scott C, Winham S, Sadowski P, Vachon C, Kerlikowske K, Shepherd JA. Deep Learning Predicts Interval and Screening-detected Cancer from Screening Mammograms: A Case-Case-Control Study in 6369 Women. Radiology. 2021 Sep 07; 203758.  View on PubMed
  11. Sprague BL, Lowry KP, Miglioretti DL, Alsheik N, Bowles EJA, Tosteson ANA, Rauscher G, Herschorn SD, Lee JM, Trentham-Dietz A, Weaver DL, Stout NK, Kerlikowske K. Changes in Mammography Use by Women's Characteristics During the First 5 Months of the COVID-19 Pandemic. J Natl Cancer Inst. 2021 09 04; 113(9):1161-1167.  View on PubMed
  12. Advani SM, Zhu W, Demb J, Sprague BL, Onega T, Henderson LM, Buist DSM, Zhang D, Schousboe JT, Walter LC, Kerlikowske K, Miglioretti DL, Braithwaite D, Breast Cancer Surveillance Consortium. Association of Breast Density With Breast Cancer Risk Among Women Aged 65 Years or Older by Age Group and Body Mass Index. JAMA Netw Open. 2021 Aug 02; 4(8):e2122810.  View on PubMed
  13. van Ravesteyn NT, Schechter CB, Hampton JM, Alagoz O, van den Broek JJ, Kerlikowske K, Mandelblatt JS, Miglioretti DL, Sprague BL, Stout NK, de Koning HJ, Trentham-Dietz A, Tosteson ANA, Breast Cancer Surveillance Consortium and the Cancer Intervention and Surveillance Modeling Network. Trade-Offs Between Harms and Benefits of Different Breast Cancer Screening Intervals Among Low-Risk Women. J Natl Cancer Inst. 2021 Aug 02; 113(8):1017-1026.  View on PubMed
  14. Alagoz O, Lowry KP, Kurian AW, Mandelblatt JS, Ergun MA, Huang H, Lee SJ, Schechter CB, Tosteson ANA, Miglioretti DL, Trentham-Dietz A, Nyante SJ, Kerlikowske K, Sprague BL, Stout NK. Impact of the COVID-19 Pandemic on Breast Cancer Mortality in the US: Estimates From Collaborative Simulation Modeling. J Natl Cancer Inst. 2021 Jul 14.  View on PubMed
  15. Kerlikowske K, Bissell MCS, Sprague BL, Buist DSM, Henderson LM, Lee JM, Miglioretti DL. Advanced Breast Cancer Definitions by Staging System Examined in the Breast Cancer Surveillance Consortium. J Natl Cancer Inst. 2021 Jul 01; 113(7):909-916.  View on PubMed
  16. Kerlikowske K, Bissell MCS, Sprague BL, Buist DSM, Henderson LM, Lee JM, Miglioretti DL. Response to Pisano, Gastonis, Sparano, et al. J Natl Cancer Inst. 2021 Jul 01; 113(7):940-941.  View on PubMed
  17. Sprague BL, O'Meara ES, Lee CI, Lee JM, Henderson LM, Buist DSM, Alsheik N, Macarol T, Perry H, Tosteson ANA, Onega T, Kerlikowske K, Miglioretti DL. Prioritizing breast imaging services during the COVID pandemic: A survey of breast imaging facilities within the Breast Cancer Surveillance Consortium. Prev Med. 2021 10; 151:106540.  View on PubMed
  18. Schifferdecker KE, Vaclavik D, Wernli KJ, Buist DSM, Kerlikowske K, Sprague BL, Henderson LM, Johnson D, Budesky J, Jackson-Nefertiti G, Miglioretti DL, Tosteson ANA. Women's considerations and experiences for breast cancer screening and surveillance during the COVID-19 pandemic in the United States: A focus group study. Prev Med. 2021 10; 151:106542.  View on PubMed
  19. Heine J, Fowler E, Scott CG, Jensen MR, Shepherd J, Hruska CB, Winham SJ, Brandt KR, Wu FF, Norman AD, Pankratz VS, Miglioretti DL, Kerlikowske K, Vachon CM. Mammographic Variation Measures, Breast Density, and Breast Cancer Risk. AJR Am J Roentgenol. 2021 08; 217(2):326-335.  View on PubMed
  20. Zhang D, Abraham L, Demb J, Miglioretti DL, Advani S, Sprague BL, Henderson LM, Onega T, Wernli KJ, Walter LC, Kerlikowske K, Schousboe JT, O'Meara ES, Braithwaite D, Breast Cancer Surveillance Consortium. Function-related Indicators and Outcomes of Screening Mammography in Older Women: Evidence from the Breast Cancer Surveillance Consortium Cohort. Cancer Epidemiol Biomarkers Prev. 2021 Aug; 30(8):1582-1590.  View on PubMed

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