Research Summary

I have published widely on breast imaging and the epidemiology of invasive breast cancer, DCIS and breast density, and risk prediction models for invasive breast cancer. I have extensive experience, expertise, and leadership in large-scale multi-disciplinary NIH-funded efforts of breast cancer screening, risk factors, and risk, including the U01 San Francisco Mammography Registry (SFMR), P50 UCSF Breast Cancer SPORE, P01 Breast Density Program Project, and the Breast Cancer Surveillance Consortium (BCSC) P01 Risk-based Breast Cancer Screening Program Project. As PI or co-PI on several these grants, I have developed cohorts of women at risk for invasive breast cancer and DCIS and developed comprehensive databases that include breast imaging, pathologic, clinical, biomarker, and risk factor data, as well as follow-up for subsequent disease and death. In addition, I have successfully administered projects (e.g., staffing, research protections, budget), collaborated with other researchers, and produced many peer-reviewed publications from each project. I have a demonstrated record of successful and productive research projects in areas of high relevance for breast cancer screening, breast density, DCIS, and risk prediction.

Research Funding

  • September 27, 2011 - May 31, 2022 - Risk-based Breast Cancer Screening and Surveillance in Community Practice , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: P01CA154292
  • April 1, 2017 - March 31, 2022 - Radiomic phenotypes of breast parenchyma and association with breast cancer risk and detection , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA207084
  • September 1, 2013 - August 31, 2019 - Automated Density Measures for Estimating Breast Cancer Risk and Therapy Response , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA177150
  • April 1, 2010 - January 31, 2016 - Risk factors for breast cancer molecular subtypes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA140286

Education

Michigan State University, East Lansing, BS, 1978, Medical Technology
University of California, Berkeley, MS, 1984, Nutrition
University of California San Francisco, MD, 1988, Medicine
University of California San Francisco, 1988-1989, Medicine Internship
University of California San Francisco, 1989-1991, Primary Care Medicine Residency 
Veterans Affairs Medical Center, San Francisco, 1991-1993, Fellow in General Internal Medicine

Honors & Awards

  • 1975
    Tower Guard Award for Scholastic Achievement
  • 1975-77
    Honors College, Michigan State University
  • 1978
    Magna cum laude, Michigan State University
  • 1986
    Student Summer Research Fellowship, UCSF
  • 1987
    Alpha Omega Alpha
  • 1994-96
    American Cancer Society Award for Primary Care Physicians
  • 2009
    American Cancer Society Research Scholar
  • 2014
    SGIM Distinguished Professor in Cancer Research
  • 2016
    Journal of Women's Health Award for Outstanding Achievement in Women’s Health Research

Selected Publications

  1. Lawson MB, Bissell MCS, Miglioretti DL, Eavey J, Chapman CH, Mandelblatt JS, Onega T, Henderson LM, Rauscher GH, Kerlikowske K, Sprague BL, Bowles EJA, Gard CC, Parsian S, Lee CI. Multilevel Factors Associated With Time to Biopsy After Abnormal Screening Mammography Results by Race and Ethnicity. JAMA Oncol. 2022 08 01; 8(8):1115-1126.  View on PubMed
  2. Nyante SJ, Abraham L, Aiello Bowles EJ, Lee CI, Kerlikowske K, Miglioretti DL, Sprague BL, Henderson LM, Breast Cancer Surveillance Consortium. Diagnostic Mammography Performance across Racial and Ethnic Groups in a National Network of Community-Based Breast Imaging Facilities. Cancer Epidemiol Biomarkers Prev. 2022 07 01; 31(7):1324-1333.  View on PubMed
  3. Wernli KJ, Smith RE, Henderson LM, Zhao W, Durham DD, Schifferdecker K, Kaplan C, Buist DSM, Kerlikowske K, Miglioretti DL, Onega T, Alsheik NH, Sprague BL, Jackson-Nefertiti G, Budesky J, Johnson D, Tosteson ANA. Decision quality and regret with treatment decisions in women with breast cancer: Pre-operative breast MRI and breast density. Breast Cancer Res Treat. 2022 Aug; 194(3):607-616.  View on PubMed
  4. Kerlikowske K, Su YR, Sprague BL, Tosteson ANA, Buist DSM, Onega T, Henderson LM, Alsheik N, Bissell MCS, O'Meara ES, Lee CI, Miglioretti DL. Association of Screening With Digital Breast Tomosynthesis vs Digital Mammography With Risk of Interval Invasive and Advanced Breast Cancer. JAMA. 2022 06 14; 327(22):2220-2230.  View on PubMed
  5. Kerlikowske K, Chen S, Golmakani MK, Sprague BL, Tice JA, Tosteson ANA, Rauscher GH, Henderson LM, Buist DSM, Lee JM, Gard CC, Miglioretti DL. Cumulative Advanced Breast Cancer Risk Prediction Model Developed in a Screening Mammography Population. J Natl Cancer Inst. 2022 05 09; 114(5):676-685.  View on PubMed
  6. Lowry KP, Geuzinge HA, Stout NK, Alagoz O, Hampton J, Kerlikowske K, de Koning HJ, Miglioretti DL, van Ravesteyn NT, Schechter C, Sprague BL, Tosteson ANA, Trentham-Dietz A, Weaver D, Yaffe MJ, Yeh JM, Couch FJ, Hu C, Kraft P, Polley EC, Mandelblatt JS, Kurian AW, Robson ME, Breast Working Group of the Cancer Intervention and Surveillance Modeling Network (CISNET), in colla. Breast Cancer Screening Strategies for Women With ATM, CHEK2, and PALB2 Pathogenic Variants: A Comparative Modeling Analysis. JAMA Oncol. 2022 04 01; 8(4):587-596.  View on PubMed
  7. Lowry KP, Callaway KA, Lee JM, Zhang F, Ross-Degnan D, Wharam JF, Kerlikowske K, Wernli KJ, Kurian AW, Henderson LM, Stout NK. Trends in Annual Surveillance Mammography Participation Among Breast Cancer Survivors From 2004 to 2016. J Natl Compr Canc Netw. 2022 04; 20(4):379-386.e9.  View on PubMed
  8. Smith RE, Sprague B, Henderson LM, Kerlikowske K, Miglioretti DL, Buist DSM, Wernli KJ, Onega T, Schifferdecker K, Jackson-Nefertiti G, Johnson D, Budesky J, Tosteson ANA. Breast Density Knowledge in a Screening Mammography Population Exposed to Density Notification. J Am Coll Radiol. 2022 05; 19(5):615-624.  View on PubMed
  9. Ho TH, Bissell MCS, Kerlikowske K, Hubbard RA, Sprague BL, Lee CI, Tice JA, Tosteson ANA, Miglioretti DL. Cumulative Probability of False-Positive Results After 10 Years of Screening With Digital Breast Tomosynthesis vs Digital Mammography. JAMA Netw Open. 2022 03 01; 5(3):e222440.  View on PubMed
  10. Grayek E, Yang Y, Fischhoff B, Schifferdecker KE, Woloshin S, Kerlikowske K, Miglioretti DL, Tosteson ANA. A Procedure for Eliciting Women's Preferences for Breast Cancer Screening Frequency. Med Decis Making. 2022 08; 42(6):783-794.  View on PubMed
  11. Houssami N, Kerlikowske K. AI as a new paradigm for risk-based screening for breast cancer. Nat Med. 2022 01; 28(1):29-30.  View on PubMed
  12. Advani S, Abraham L, Buist DSM, Kerlikowske K, Miglioretti DL, Sprague BL, Henderson LM, Onega T, Schousboe JT, Demb J, Zhang D, Walter LC, Lee CI, Braithwaite D, O'Meara ES, Breast Cancer Surveillance Consortium. Breast biopsy patterns and findings among older women undergoing screening mammography: The role of age and comorbidity. J Geriatr Oncol. 2022 03; 13(2):161-169.  View on PubMed
  13. Tice JA, Gard CC, Miglioretti DL, Sprague BL, Tosteson ANA, Joe BN, Ho TH, Kerlikowske K. Comparing Mammographic Density Assessed by Digital Breast Tomosynthesis or Digital Mammography: The Breast Cancer Surveillance Consortium. Radiology. 2022 02; 302(2):286-292.  View on PubMed
  14. Schousboe JT, Sprague BL, Abraham L, O'Meara ES, Onega T, Advani S, Henderson LM, Wernli KJ, Zhang D, Miglioretti DL, Braithwaite D, Kerlikowske K. Cost-Effectiveness of Screening Mammography Beyond Age 75 Years : A Cost-Effectiveness Analysis. Ann Intern Med. 2022 01; 175(1):11-19.  View on PubMed
  15. Zhang D, Abraham L, Sprague BL, Onega T, Advani S, Demb J, Miglioretti DL, Henderson LM, Wernli KJ, Walter LC, Kerlikowske K, Schousboe JT, Chrischilles E, Braithwaite D, O'Meara ES, Breast Cancer Surveillance Consortium. Mammography adherence in relation to function-related indicators in older women. Prev Med. 2022 01; 154:106869.  View on PubMed
  16. Alagoz O, Lowry KP, Kurian AW, Mandelblatt JS, Ergun MA, Huang H, Lee SJ, Schechter CB, Tosteson ANA, Miglioretti DL, Trentham-Dietz A, Nyante SJ, Kerlikowske K, Sprague BL, Stout NK, from the CISNET Breast Working Group. Impact of the COVID-19 Pandemic on Breast Cancer Mortality in the US: Estimates From Collaborative Simulation Modeling. J Natl Cancer Inst. 2021 11 02; 113(11):1484-1494.  View on PubMed
  17. Acciavatti RJ, Cohen EA, Maghsoudi OH, Gastounioti A, Pantalone L, Hsieh MK, Conant EF, Scott CG, Winham SJ, Kerlikowske K, Vachon C, Maidment ADA, Kontos D. Incorporating Robustness to Imaging Physics into Radiomic Feature Selection for Breast Cancer Risk Estimation. Cancers (Basel). 2021 Nov 01; 13(21).  View on PubMed
  18. Onega T, Zhu W, Kerlikowske K, Miglioretti DL, Lee CI, Henderson LM, Tosteson ANA, Wernli KJ, diFlorio R, Weaver DL, Buist DSM. Preoperative MRI in breast cancer: effect of breast density on biopsy rate and yield. Breast Cancer Res Treat. 2022 Jan; 191(1):177-190.  View on PubMed
  19. Lowry KP, Bissell MCS, Miglioretti DL, Kerlikowske K, Alsheik N, Macarol T, Bowles EJA, Buist DSM, Tosteson ANA, Henderson L, Herschorn SD, Wernli KJ, Weaver DL, Stout NK, Sprague BL. Breast Biopsy Recommendations and Breast Cancers Diagnosed during the COVID-19 Pandemic. Radiology. 2022 05; 303(2):287-294.  View on PubMed
  20. Zhu X, Wolfgruber TK, Leong L, Jensen M, Scott C, Winham S, Sadowski P, Vachon C, Kerlikowske K, Shepherd JA. Deep Learning Predicts Interval and Screening-detected Cancer from Screening Mammograms: A Case-Case-Control Study in 6369 Women. Radiology. 2021 12; 301(3):550-558.  View on PubMed

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