Research Summary

I have published widely on breast imaging and the epidemiology of invasive breast cancer, DCIS and breast density, and risk prediction models for invasive breast cancer. I have extensive experience, expertise, and leadership in large-scale multi-disciplinary NIH-funded efforts of breast cancer screening, risk factors, and risk, including the U01 San Francisco Mammography Registry (SFMR), P50 UCSF Breast Cancer SPORE, P01 Breast Density Program Project, and the Breast Cancer Surveillance Consortium (BCSC) P01 Risk-based Breast Cancer Screening Program Project. As PI or co-PI on several these grants, I have developed cohorts of women at risk for invasive breast cancer and DCIS and developed comprehensive databases that include breast imaging, pathologic, clinical, biomarker, and risk factor data, as well as follow-up for subsequent disease and death. In addition, I have successfully administered projects (e.g., staffing, research protections, budget), collaborated with other researchers, and produced many peer-reviewed publications from each project. I have a demonstrated record of successful and productive research projects in areas of high relevance for breast cancer screening, breast density, DCIS, and risk prediction.

Research Funding

  • September 27, 2011 - May 31, 2022 - Risk-based Breast Cancer Screening and Surveillance in Community Practice , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: P01CA154292
  • April 1, 2017 - March 31, 2022 - Radiomic phenotypes of breast parenchyma and association with breast cancer risk and detection , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA207084
  • September 1, 2013 - August 31, 2019 - Automated Density Measures for Estimating Breast Cancer Risk and Therapy Response , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA177150
  • April 1, 2010 - January 31, 2016 - Risk factors for breast cancer molecular subtypes , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA140286


Michigan State University, East Lansing, BS, 1978, Medical Technology
University of California, Berkeley, MS, 1984, Nutrition
University of California San Francisco, MD, 1988, Medicine
University of California San Francisco, 1988-1989, Medicine Internship
University of California San Francisco, 1989-1991, Primary Care Medicine Residency 
Veterans Affairs Medical Center, San Francisco, 1991-1993, Fellow in General Internal Medicine

Honors & Awards

  • 1975
    Tower Guard Award for Scholastic Achievement
  • 1975-77
    Honors College, Michigan State University
  • 1978
    Magna cum laude, Michigan State University
  • 1986
    Student Summer Research Fellowship, UCSF
  • 1987
    Alpha Omega Alpha
  • 1994-96
    American Cancer Society Award for Primary Care Physicians
  • 2009
    American Cancer Society Research Scholar
  • 2014
    SGIM Distinguished Professor in Cancer Research
  • 2016
    Journal of Women's Health Award for Outstanding Achievement in Women’s Health Research

Selected Publications

  1. Onega T, Abraham L, Miglioretti DL, Lee CI, Henderson LM, Kerlikowske K, Tosteson ANA, Weaver D, Sprague BL, Bowles EJA, di Florio-Alexander RM. Digital mammography and digital breast tomosynthesis for detecting invasive lobular and ductal carcinoma. Breast Cancer Res Treat. 2023 Sep 11.  View on PubMed
  2. Lee JM, Ichikawa LE, Wernli KJ, Bowles EJA, Specht JM, Kerlikowske K, Miglioretti DL, Lowry KP, Tosteson ANA, Stout NK, Houssami N, Onega T, Buist DSM. Impact of Surveillance Mammography Intervals Less Than One Year on Performance Measures in Women With a Personal History of Breast Cancer. Korean J Radiol. 2023 08; 24(8):729-738.  View on PubMed
  3. Nyante SJ, Abraham L, Aiello Bowles EJ, Lee CI, Kerlikowske K, Miglioretti DL, Sprague BL, Henderson LM. Racial and ethnic variation in diagnostic mammography performance among women reporting a breast lump. Cancer Epidemiol Biomarkers Prev. 2023 Jul 13.  View on PubMed
  4. Sprague BL, Ichikawa L, Eavey J, Lowry KP, Rauscher G, O'Meara ES, Miglioretti DL, Chen S, Lee JM, Stout NK, Mandelblatt JS, Alsheik N, Herschorn SD, Perry H, Weaver DL, Kerlikowske K. Breast cancer risk characteristics of women undergoing whole-breast ultrasound screening versus mammography alone. Cancer. 2023 08 15; 129(16):2456-2468.  View on PubMed
  5. Kerlikowske K, Bissell MCS, Sprague BL, Tice JA, Tossas KY, Bowles EJA, Ho TH, Keegan THM, Miglioretti DL. Impact of BMI on Prevalence of Dense Breasts by Race and Ethnicity. Cancer Epidemiol Biomarkers Prev. 2023 Jun 07; OF1-OF7.  View on PubMed
  6. Sprague BL, Coley RY, Lowry KP, Kerlikowske K, Henderson LM, Su YR, Lee CI, Onega T, Bowles EJA, Herschorn SD, diFlorio-Alexander RM, Miglioretti DL. Digital Breast Tomosynthesis versus Digital Mammography Screening Performance on Successive Screening Rounds from the Breast Cancer Surveillance Consortium. Radiology. 2023 06; 307(5):e223142.  View on PubMed
  7. Vachon CM, Scott CG, Norman AD, Khanani SA, Jensen MR, Hruska CB, Brandt KR, Winham SJ, Kerlikowske K. Impact of Artificial Intelligence System and Volumetric Density on Risk Prediction of Interval, Screen-Detected, and Advanced Breast Cancer. J Clin Oncol. 2023 06 10; 41(17):3172-3183.  View on PubMed
  8. Lee CI, Abraham L, Miglioretti DL, Onega T, Kerlikowske K, Lee JM, Sprague BL, Tosteson ANA, Rauscher GH, Bowles EJA, diFlorio-Alexander RM, Henderson LM, Breast Cancer Surveillance Consortium. National Performance Benchmarks for Screening Digital Breast Tomosynthesis: Update from the Breast Cancer Surveillance Consortium. Radiology. 2023 05; 307(4):e222499.  View on PubMed
  9. Su YR, Buist DSM, Lee JM, Ichikawa L, Miglioretti DL, Bowles EJA, Wernli KJ, Kerlikowske K, Tosteson A, Lowry KP, Henderson LM, Sprague BL, Hubbard RA. Performance of Statistical and Machine Learning Risk Prediction Models for Surveillance Benefits and Failures in Breast Cancer Survivors. Cancer Epidemiol Biomarkers Prev. 2023 04 03; 32(4):561-571.  View on PubMed
  10. Lowry KP, Ichikawa L, Hubbard RA, Buist DSM, Bowles EJA, Henderson LM, Kerlikowske K, Specht JM, Sprague BL, Wernli KJ, Lee JM. Variation in second breast cancer risk after primary invasive cancer by time since primary cancer diagnosis and estrogen receptor status. Cancer. 2023 04 15; 129(8):1173-1182.  View on PubMed
  11. Sprague BL, Chen S, Miglioretti DL, Gard CC, Tice JA, Hubbard RA, Aiello Bowles EJ, Kaufman PA, Kerlikowske K. Cumulative 6-Year Risk of Screen-Detected Ductal Carcinoma In Situ by Screening Frequency. JAMA Netw Open. 2023 02 01; 6(2):e230166.  View on PubMed
  12. Flynn SJ, Livaudais-Toman J, Kaplan CP, Kerlikowske K, Burke NJ, Pathak S, Karliner LS. Primary Care Physicians' Perceived Barriers to Follow-Up of Abnormal Mammogram Results: Opportunities for Systems-Level Interventions. J Gen Intern Med. 2023 05; 38(7):1786-1788.  View on PubMed
  13. Tosteson ANA, Schifferdecker KE, Smith RE, Wernli KJ, Zhao W, Kaplan CP, Buist DSM, Henderson LM, Sprague BL, Onega T, Budesky J, Jackson-Nefertiti G, Johnson D, Miglioretti DL, Kerlikowske K. Women's Breast Cancer Screening Confidence by Screening Modality and Breast Density: A Breast Cancer Surveillance Consortium Survey Study. J Womens Health (Larchmt). 2022 Nov; 31(11):1547-1556.  View on PubMed
  14. Ho TH, Bissell MCS, Lee CI, Lee JM, Sprague BL, Tosteson ANA, Wernli KJ, Henderson LM, Kerlikowske K, Miglioretti DL. Prioritizing Screening Mammograms for Immediate Interpretation and Diagnostic Evaluation on the Basis of Risk for Recall. J Am Coll Radiol. 2023 03; 20(3):299-310.  View on PubMed
  15. Durham DD, Abraham LA, Roberts MC, Khan CP, Smith RA, Kerlikowske K, Miglioretti DL. Breast cancer incidence among women with a family history of breast cancer by relative's age at diagnosis. Cancer. 2022 Dec 15; 128(24):4232-4240.  View on PubMed
  16. Lawson MB, Bissell MCS, Miglioretti DL, Eavey J, Chapman CH, Mandelblatt JS, Onega T, Henderson LM, Rauscher GH, Kerlikowske K, Sprague BL, Bowles EJA, Gard CC, Parsian S, Lee CI. Multilevel Factors Associated With Time to Biopsy After Abnormal Screening Mammography Results by Race and Ethnicity. JAMA Oncol. 2022 08 01; 8(8):1115-1126.  View on PubMed
  17. Nyante SJ, Abraham L, Aiello Bowles EJ, Lee CI, Kerlikowske K, Miglioretti DL, Sprague BL, Henderson LM, Breast Cancer Surveillance Consortium. Diagnostic Mammography Performance across Racial and Ethnic Groups in a National Network of Community-Based Breast Imaging Facilities. Cancer Epidemiol Biomarkers Prev. 2022 07 01; 31(7):1324-1333.  View on PubMed
  18. Wernli KJ, Smith RE, Henderson LM, Zhao W, Durham DD, Schifferdecker K, Kaplan C, Buist DSM, Kerlikowske K, Miglioretti DL, Onega T, Alsheik NH, Sprague BL, Jackson-Nefertiti G, Budesky J, Johnson D, Tosteson ANA. Decision quality and regret with treatment decisions in women with breast cancer: Pre-operative breast MRI and breast density. Breast Cancer Res Treat. 2022 Aug; 194(3):607-616.  View on PubMed
  19. Kerlikowske K, Su YR, Sprague BL, Tosteson ANA, Buist DSM, Onega T, Henderson LM, Alsheik N, Bissell MCS, O'Meara ES, Lee CI, Miglioretti DL. Association of Screening With Digital Breast Tomosynthesis vs Digital Mammography With Risk of Interval Invasive and Advanced Breast Cancer. JAMA. 2022 06 14; 327(22):2220-2230.  View on PubMed
  20. Kerlikowske K, Chen S, Golmakani MK, Sprague BL, Tice JA, Tosteson ANA, Rauscher GH, Henderson LM, Buist DSM, Lee JM, Gard CC, Miglioretti DL. Cumulative Advanced Breast Cancer Risk Prediction Model Developed in a Screening Mammography Population. J Natl Cancer Inst. 2022 05 09; 114(5):676-685.  View on PubMed

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