Research Summary

Dr. Kober is highly qualified to serve as a co-investigator, geneticist and bioinformatician for the proposed project. Dr. Kober has worked in this capacity both in the Academic (e.g., UC Santa Cruz Genome Browser) and non-Academic (e.g., Navigenics, Inc) environments. He has in-depth experience in computer science, biochemistry, and molecular evolution, the later which requires considered expertise in bioinformatics (i.e., scripting languages, data management and visualization, interrogation and deposition of data into public databases with strict formatting requirements). He has experience in molecular analysis of cancer related symptoms. He has worked both at the wet bench (i.e., molecular biologist) and in the dry laboratory (i.e., Bioinformatician) for over 10 years. He is experienced with the molecular and data analytic procedures described in the current application. Of note, Dr. Kober plays a key role in an NIH-funded Biostatistics and Bioinformatics Group as part of the NIH NIAID-funded Women’s Interagency HIV Study (WIHS), which currently focused primarily on genome wide association studies and large-scale molecular data analyses. He will bring these experiences to the proposed project.

Research Funding

  • July 3, 2019 - June 30, 2024 - An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R37CA233774

Education

University of California, Los Angeles, BS Biochemistry, 06/1996
University of California, Santa Cruz, MA Molecular Evolutionary Biology, 06/2009
University of California, Santa Cruz, PhD Molecular Evolutionary Biology, 06/2012
University of California, Irvine, Center for Complex Biological Systems, Systems Biology: Foundations for Interdisciplinary Careers Short Course, 01/2019

Honors & Awards

  • 2006
    Regents' Fellowship, University of California, Santa Cruz, CA
  • 2007
    STEPS Institute Graduate Research Grant Award, University of California, Santa Cruz, CA
  • 2007
    Student Research and Education Award Friends of Long Marine Lab, Santa Cruz, CA
  • 2011
    Graduate Student Support Award, CSHL Meeting on The Biology of Genomes
  • 2011
    Research Award, Dr. Earl H. Myers and Ethel M. Myers Oceanographic and Marine Biology Trust
  • 2013
    Annual Meeting Best Poster Nominee, American Pain Society
  • 2014
    New Investigator Abstract Award (Fatigue Study Group) Annual Meeting, Multinational Association of Supportive Care in Cancer
  • 2016
    Junior Investigator Abstract Award (Fatigue Study Group) Annual Meeting, Multinational Association of Supportive Care in Cancer
  • 2020
    Cancer Nursing 2020 Research Award, Cancer Nursing - Official Journal of the International Society of Nurses in Cancer Care

Selected Publications

  1. Calvo-Schimmel A, Paul SM, Cooper BA, Shin J, Harris C, Oppegaard K, Hammer MJ, Cartwright F, Conley YP, Kober KM, Levine JD, Miaskowski C. Oncology Outpatients With Worse Anxiety and Sleep Disturbance Profiles Are at Increased Risk for a Higher Symptom Burden and Poorer Quality of Life. Cancer Nurs. 2022 Jun 08.  View on PubMed
  2. Harris CS, Kober KM, Cooper B, Conley YP, Dhruva AA, Hammer MJ, Paul S, Levine JD, Miaskowski CA. Symptom clusters in outpatients with cancer using different dimensions of the symptom experience. Support Care Cancer. 2022 May 11.  View on PubMed
  3. Miaskowski C, Levine JD, Paul SM, Cooper B, Abrams G, Topp K, Cheung S, Henderson-Sabes J, Conley YP, Snowberg K, Alfaro E, Quinn M, Kober KM. SIMILARITIES IN THE NEUROPATHY PHENOTYPE OF CANCER SURVIVORS WHO RECEIVED DIFFERENT CLASSES OF CHEMOTHERAPY DRUGS. J Pain. 2022 May 06.  View on PubMed
  4. Calvo-Schimmel A, Paul SM, Cooper BA, Harris C, Shin J, Oppegaard K, Hammer MJ, Dunn LB, Conley YP, Kober KM, Levine JD, Miaskowski C. Oncology outpatients with worse depression and sleep disturbance profiles are at increased risk for a higher symptom burden and poorer quality of life outcomes. Sleep Med. 2022 Jul; 95:91-104.  View on PubMed
  5. Singh KP, Kober KM, Ernst B, Sachdev J, Brewer M, Zhu Q, Gu H, Melisko M, Paul SM, Cooper BA, Hammer M, Conley YP, Levine JD, Miaskowski C. Multiple Gastrointestinal Symptoms Are Associated With Chemotherapy-Induced Nausea in Patients With Breast Cancer. Cancer Nurs. 2022 May-Jun 01; 45(3):181-189.  View on PubMed
  6. Harris CS, Dodd M, Kober KM, Dhruva AA, Hammer MJ, Conley YP, Miaskowski CA. Advances in Conceptual and Methodological Issues in Symptom Cluster Research: A 20-Year Perspective. ANS Adv Nurs Sci. 2022 Apr 29.  View on PubMed
  7. Sass D, Fitzgerald W, Wolff BS, Torres I, Pagan-Mercado G, Armstrong TS, Miaskowski C, Margolis L, Saligan L, Kober KM. Differences in Circulating Extracellular Vesicle and Soluble Cytokines in Older Versus Younger Breast Cancer Patients With Distinct Symptom Profiles. Front Genet. 2022; 13:869044.  View on PubMed
  8. Allemann-Su YY, Vetter M, Koechlin H, Conley Y, Paul SM, Cooper BA, Kober KM, Levine JD, Miaskowski C, Katapodi MC. Distinct Cognitive Function Profiles Are Associated With a Higher Presurgery Symptom Burden in Patients With Breast Cancer. Cancer Nurs. 2022 Apr 12.  View on PubMed
  9. Shin J, Oppegaard K, Calvo-Schimmel A, Harris C, Cooper BA, Paul SM, Conley YP, Hammer MJ, Cartwright F, Kober KM, Levine JD, Miaskowski C. Distinct Worst Pain Profiles in Oncology Outpatients Undergoing Chemotherapy. Cancer Nurs. 2022 Apr 12.  View on PubMed
  10. Langford DJ, Eaton L, Kober KM, Paul SM, Cooper BA, Hammer MJ, Conley YP, Wright F, Dunn LB, Levine JD, Miaskowski C. A high stress profile is associated with severe pain in oncology patients receiving chemotherapy. Eur J Oncol Nurs. 2022 Mar 27; 58:102135.  View on PubMed
  11. Hammer MJ, Cooper B, Paul SM, Kober KM, Cartwright F, Conley YP, Wright F, Levine JD, Miaskowski C. Identification of Distinct Symptom Profiles in Cancer Patients Using a Pre-Specified Symptom Cluster. J Pain Symptom Manage. 2022 Mar 25.  View on PubMed
  12. Stacker T, Kober KM, Dunn L, Viele C, Paul SM, Hammer M, Conley YP, Levine JD, Miaskowski C. Associations Between Demographic, Clinical, and Symptom Characteristics and Stress in Oncology Patients Receiving Chemotherapy. Cancer Nurs. 2022 Mar 02.  View on PubMed
  13. Singh K, Pituch K, Zhu Q, Gu H, Ernst B, Tofthagen C, Brewer M, Kober KM, Cooper BA, Paul SM, Conley YP, Hammer M, Levine JD, Miaskowski C. Distinct Nausea Profiles Are Associated With Gastrointestinal Symptoms in Oncology Patients Receiving Chemotherapy. Cancer Nurs. 2022 Mar 02.  View on PubMed
  14. Fields AT, Lee MC, Mayer F, Santos YA, Bainton CMV, Matthay ZA, Callcut RA, Mayer N, Cuschieri J, Kober KM, Bainton RJ, Kornblith LZ. A new trauma frontier: Exploratory pilot study of platelet transcriptomics in trauma patients. J Trauma Acute Care Surg. 2022 02 01; 92(2):313-322.  View on PubMed
  15. Chou YJ, Kober KM, Yeh KH, Cooper BA, Kuo CH, Lin BR, Kuo TC, Tseng YJ, Miaskowski C, Shun SC. A pilot study of metabolomic pathways associated with fatigue in patients with colorectal cancer receiving chemotherapy. Eur J Oncol Nurs. 2022 Feb; 56:102096.  View on PubMed
  16. Moy S, Kober KM, Viele C, Paul SM, Hammer M, Melisko M, Wright F, Conley YP, Levine JD, Miaskowski C. Level of Exercise Influences the Severity of Fatigue, Energy Levels, and Sleep Disturbance in Oncology Outpatients Receiving Chemotherapy. Cancer Nurs. 2022 Jan-Feb 01; 45(1):3-11.  View on PubMed
  17. Harris CS, Kober KM, Conley YP, Dhruva AA, Hammer MJ, Miaskowski CA. Symptom clusters in patients receiving chemotherapy: A systematic review. BMJ Support Palliat Care. 2022 Mar; 12(1):10-21.  View on PubMed
  18. Smoot BJ, Mastick J, Shepherd J, Paul SM, Kober KM, Cooper BA, Conley YP, Dixit N, Hammer MJ, Fu MR, Abrams G, Miaskowski C. Use of Dual-Energy X-Ray Absorptiometry to Assess Soft Tissue Composition in Breast Cancer Survivors With and Without Lymphedema. Lymphat Res Biol. 2021 Nov 18.  View on PubMed
  19. Pozzar RA, Hammer MJ, Cooper BA, Kober KM, Chen LM, Paul SM, Conley YP, Cartwright F, Wright F, Levine JD, Miaskowski C. Stability of Symptom Clusters in Patients With Gynecologic Cancer Receiving Chemotherapy. Cancer Nurs. 2021 Sep 23.  View on PubMed
  20. Pozzar RA, Hammer MJ, Paul SM, Cooper BA, Kober KM, Conley YP, Levine JD, Miaskowski C. Distinct sleep disturbance profiles among patients with gynecologic cancer receiving chemotherapy. Gynecol Oncol. 2021 11; 163(2):419-426.  View on PubMed

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