Research Summary

Dr. Kober is highly qualified to serve as a co-investigator, geneticist and bioinformatician for the proposed project. Dr. Kober has worked in this capacity both in the Academic (e.g., UC Santa Cruz Genome Browser) and non-Academic (e.g., Navigenics, Inc) environments. He has in-depth experience in computer science, biochemistry, and molecular evolution, the later which requires considered expertise in bioinformatics (i.e., scripting languages, data management and visualization, interrogation and deposition of data into public databases with strict formatting requirements). He has experience in molecular analysis of cancer related symptoms. He has worked both at the wet bench (i.e., molecular biologist) and in the dry laboratory (i.e., Bioinformatician) for over 10 years. He is experienced with the molecular and data analytic procedures described in the current application. Of note, Dr. Kober plays a key role in an NIH-funded Biostatistics and Bioinformatics Group as part of the NIH NIAID-funded Women’s Interagency HIV Study (WIHS), which currently focused primarily on genome wide association studies and large-scale molecular data analyses. He will bring these experiences to the proposed project.

Research Funding

  • July 3, 2019 - June 30, 2024 - An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R37CA233774
  • July 3, 2019 - June 30, 2024 - An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R37CA233774
  • July 3, 2019 - June 30, 2024 - An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R37CA233774
  • July 3, 2019 - June 30, 2024 - An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R37CA233774

Education

University of California, Los Angeles, BS Biochemistry, 06/1996
University of California, Santa Cruz, MA Molecular Evolutionary Biology, 06/2009
University of California, Santa Cruz, PhD Molecular Evolutionary Biology, 06/2012
University of California, Irvine, Center for Complex Biological Systems, Systems Biology: Foundations for Interdisciplinary Careers Short Course, 01/2019

Honors & Awards

  • 2006
    Regents' Fellowship, University of California, Santa Cruz, CA
  • 2007
    STEPS Institute Graduate Research Grant Award, University of California, Santa Cruz, CA
  • 2007
    Student Research and Education Award Friends of Long Marine Lab, Santa Cruz, CA
  • 2011
    Graduate Student Support Award, CSHL Meeting on The Biology of Genomes
  • 2011
    Research Award, Dr. Earl H. Myers and Ethel M. Myers Oceanographic and Marine Biology Trust
  • 2013
    Annual Meeting Best Poster Nominee, American Pain Society
  • 2014
    New Investigator Abstract Award (Fatigue Study Group) Annual Meeting, Multinational Association of Supportive Care in Cancer
  • 2016
    Junior Investigator Abstract Award (Fatigue Study Group) Annual Meeting, Multinational Association of Supportive Care in Cancer
  • 2020
    Cancer Nursing 2020 Research Award, Cancer Nursing - Official Journal of the International Society of Nurses in Cancer Care

Selected Publications

  1. A Comparison of Supine Versus Stand-on Bioimpedance Devices to Assess Breast Cancer-Related Lymphedema.  View on PubMed
  2. Lin Y, Bailey DE, Docherty SL, Porter LS, Cooper BA, Paul SM, Kober KM, Hammer MJ, Wright F, Dunn LB, Conley YP, Levine JD, Miaskowski C Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy.  View on PubMed
  3. Joseph PV, Nolden A, Kober KM, Paul SM, Cooper BA, Conley YP, Hammer MJ, Wright F, Levine JD, Miaskowski C Fatigue, Stress, and Functional Status Are Associated with Taste Changes in Oncology Patients Receiving Chemotherapy.  View on PubMed
  4. Wilcoxon A, Kober KM, Viele C, Topp K, Smoot B, Abrams G, Chesney M, Paul SM, Conley YP, Levine JD, Miaskowski C Association Between Physical Activity Levels and Chemotherapy-Induced Peripheral Neuropathy Severity in Cancer Survivors.  View on PubMed
  5. Diaz R, Kober KM, Viele C, Cooper BA, Paul SM, Hammer M, Wright F, Conley YP, Levine JD, Miaskowski C Distinct diarrhea profiles during outpatient chemotherapy.  View on PubMed
  6. Chan R, Cooper B, Paul S, Conley Y, Kober K, Koczwara B, Chan A, Tan CJ, Gordon L, Thomy L, Levine J, Miaskowski C Distinct financial distress profiles in patients with breast cancer prior to and for 12 months following surgery.  View on PubMed
  7. Moy S, Kober KM, Viele C, Paul SM, Hammer M, Melisko M, Wright F, Conley YP, Levine JD, Miaskowski C Level of Exercise Influences the Severity of Fatigue, Energy Levels, and Sleep Disturbance in Oncology Outpatients Receiving Chemotherapy.  View on PubMed
  8. Miaskowski C, Paul SM, Snowberg K, Abbott M, Borno H, Chang S, Chen LM, Cohen B, Hammer MJ, Kenfield SA, Kober KM, Levine JD, Pozzar R, Rhoads KF, Van Blarigan EL, Van Loon K Stress and Symptom Burden in Oncology Patients During the COVID-19 Pandemic.  View on PubMed
  9. Oppegaard KR, Dunn LB, Kober KM, Mackin L, Hammer MJ, Conley YP, Levine J, Miaskowski C Gender Differences in the Use of Engagement and Disengagement Coping Strategies in Patients With Cancer Receiving Chemotherapy.  View on PubMed
  10. Singh K, Cao H, Miaskowski C, Conley YP, Hammer M, Wright F, Levine JD, Kober KM Perturbations in Endocytotic and Apoptotic Pathways Are Associated With Chemotherapy-Induced Nausea.  View on PubMed
  11. Utne I, Cooper BA, Ritchie C, Wong M, Dunn LB, Loyland B, Grov EK, Hammer MJ, Paul SM, Levine JD, Conley YP, Kober KM, Miaskowski C Co-occurrence of decrements in physical and cognitive function is common in older oncology patients receiving chemotherapy.  View on PubMed
  12. Jakovljevic K, Kober KM, Block A, Cooper BA, Paul SM, Hammer MJ, Cartwright F, Conley YP, Wright F, Dunn LB, Levine JD, Miaskowski C Higher Levels of Stress Are Associated With a Significant Symptom Burden in Oncology Outpatients Receiving Chemotherapy.  View on PubMed
  13. Chou YJ, Kober KM, Kuo CH, Yeh KH, Kuo TC, Tseng YJ, Miaskowski C, Liang JT, Shun SC A Pilot Study of Metabolomic Pathways Associated With Fatigue in Survivors of Colorectal Cancer.  View on PubMed
  14. Langford DJ, Morgan S, Cooper B, Paul S, Kober K, Wright F, Hammer MJ, Conley YP, Levine JD, Miaskowski C, Dunn LB Association of personality profiles with coping and adjustment to cancer among patients undergoing chemotherapy.  View on PubMed
  15. Chambers BD, Arabia SE, Arega HA, Altman MR, Berkowitz R, Feuer SK, Franck LS, Gomez AM, Kober K, Pacheco-Werner T, Paynter RA, Prather AA, Spellen SA, Stanley D, Jelliffe-Pawlowski LL, McLemore MR Exposures to structural racism and racial discrimination among pregnant and early post-partum Black women living in Oakland, California.  View on PubMed
  16. Wright F, Kober KM, Cooper BA, Paul SM, Conley YP, Hammer M, Levine JD, Miaskowski C Higher levels of stress and different coping strategies are associated with greater morning and evening fatigue severity in oncology patients receiving chemotherapy.  View on PubMed
  17. Chan RJ, Cooper B, Koczwara B, Chan A, Tan CJ, Paul SM, Dunn LB, Conley YP, Kober KM, Levine JD, Miaskowski C A longitudinal analysis of phenotypic and symptom characteristics associated with inter-individual variability in employment interference in patients with breast cancer.  View on PubMed
  18. Kohler C, Chang M, Allemann-Su YY, Vetter M, Jung M, Jung M, Conley Y, Paul S, Kober KM, Cooper BA, Smoot B, Levine JD, Miaskowski C, Katapodi MC Changes in Attentional Function in Patients From Before Through 12 Months After Breast Cancer Surgery.  View on PubMed
  19. Singh KP, Dhruva A, Flowers E, Paul SM, Hammer MJ, Wright F, Cartwright F, Conley YP, Melisko M, Levine JD, Miaskowski C, Kober KM Alterations in Patterns of Gene Expression and Perturbed Pathways in the Gut-Brain Axis Are Associated With Chemotherapy-Induced Nausea.  View on PubMed
  20. Kober KM, Lee MC, Olshen A, Conley YP, Sirota M, Keiser M, Hammer MJ, Abrams G, Schumacher M, Levine JD, Miaskowski C Differential methylation and expression of genes in the hypoxia-inducible factor 1 signaling pathway are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors and with preclinical models of chemotherapy-induced neuropathic pa  View on PubMed

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