Research Summary

Dr. Kober is highly qualified to serve as a co-investigator, geneticist and bioinformatician for the proposed project. Dr. Kober has worked in this capacity both in the Academic (e.g., UC Santa Cruz Genome Browser) and non-Academic (e.g., Navigenics, Inc) environments. He has in-depth experience in computer science, biochemistry, and molecular evolution, the later which requires considered expertise in bioinformatics (i.e., scripting languages, data management and visualization, interrogation and deposition of data into public databases with strict formatting requirements). He has experience in molecular analysis of cancer related symptoms. He has worked both at the wet bench (i.e., molecular biologist) and in the dry laboratory (i.e., Bioinformatician) for over 10 years. He is experienced with the molecular and data analytic procedures described in the current application. Of note, Dr. Kober plays a key role in an NIH-funded Biostatistics and Bioinformatics Group as part of the NIH NIAID-funded Women’s Interagency HIV Study (WIHS), which currently focused primarily on genome wide association studies and large-scale molecular data analyses. He will bring these experiences to the proposed project.

Research Funding

  • July 3, 2019 - June 30, 2024 - An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R37CA233774
  • July 3, 2019 - June 30, 2024 - An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R37CA233774
  • July 3, 2019 - June 30, 2024 - An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R37CA233774
  • July 3, 2019 - June 30, 2024 - An Investigation of the Molecular Mechanisms for and Prediction of the Severity of Cancer Chemotherapy-Related Fatigue Using a Multi-staged Integrated Omics Approach, Principal Investigator. Sponsor: NIH, Sponsor Award ID: R37CA233774

Education

University of California, Los Angeles, BS Biochemistry, 06/1996
University of California, Santa Cruz, MA Molecular Evolutionary Biology, 06/2009
University of California, Santa Cruz, PhD Molecular Evolutionary Biology, 06/2012
University of California, Irvine, Center for Complex Biological Systems, Systems Biology: Foundations for Interdisciplinary Careers Short Course, 01/2019

Honors & Awards

  • 2006
    Regents' Fellowship, University of California, Santa Cruz, CA
  • 2007
    STEPS Institute Graduate Research Grant Award, University of California, Santa Cruz, CA
  • 2007
    Student Research and Education Award Friends of Long Marine Lab, Santa Cruz, CA
  • 2011
    Graduate Student Support Award, CSHL Meeting on The Biology of Genomes
  • 2011
    Research Award, Dr. Earl H. Myers and Ethel M. Myers Oceanographic and Marine Biology Trust
  • 2013
    Annual Meeting Best Poster Nominee, American Pain Society
  • 2014
    New Investigator Abstract Award (Fatigue Study Group) Annual Meeting, Multinational Association of Supportive Care in Cancer
  • 2016
    Junior Investigator Abstract Award (Fatigue Study Group) Annual Meeting, Multinational Association of Supportive Care in Cancer
  • 2020
    Cancer Nursing 2020 Research Award, Cancer Nursing - Official Journal of the International Society of Nurses in Cancer Care

Selected Publications

  1. Oppegaard K, Harris CS, Shin J, Paul SM, Cooper BA, Chan A, Anguera JA, Levine J, Conley Y, Hammer M, Miaskowski CA, Chan RJ, Kober KM. Cancer-related cognitive impairment is associated with perturbations in inflammatory pathways. Cytokine. 2021 Aug 10; 148:155653.  View on PubMed
  2. Chan RJ, Cooper B, Gordon L, Hart N, Tan CJ, Koczwara B, Kober KM, Chan A, Conley YP, Paul SM, Miaskowski C. Distinct employment interference profiles in patients with breast cancer prior to and for 12 months following surgery. BMC Cancer. 2021 Aug 02; 21(1):883.  View on PubMed
  3. Miaskowski C, Paul SM, Harris CS, Shin J, Oppegaard K, Conley YP, Hammer M, Kober KM, Levine JD. Determination of Cutpoints for Symptom Burden in Oncology Patients Receiving Chemotherapy. J Pain Symptom Manage. 2021 Jul 29.  View on PubMed
  4. Shin J, Harris C, Oppegaard K, Kober KM, Paul SM, Cooper BA, Hammer M, Conley Y, Levine JD, Miaskowski C. Worst Pain Severity Profiles of Oncology Patients Are Associated With Significant Stress and Multiple Co-Occurring Symptoms. J Pain. 2021 Jul 21.  View on PubMed
  5. Morse L, Kober KM, Viele C, Cooper BA, Paul SM, Conley YP, Hammer M, Levine JD, Miaskowski C. Subgroups of patients undergoing chemotherapy with distinct cognitive fatigue and evening physical fatigue profiles. Support Care Cancer. 2021 Jul 04.  View on PubMed
  6. Pozzar RA, Hammer MJ, Cooper BA, Kober KM, Chen LM, Paul SM, Conley YP, Levine JD, Miaskowski C. Symptom Clusters in Patients With Gynecologic Cancer Receiving Chemotherapy. Oncol Nurs Forum. 2021 07 01; 48(4):441-452.  View on PubMed
  7. Singh KP, Kober KM, Ernst B, Sachdev J, Brewer M, Zhu Q, Gu H, Melisko M, Paul SM, Cooper BA, Hammer M, Conley YP, Levine JD, Miaskowski C. Multiple Gastrointestinal Symptoms Are Associated With Chemotherapy-Induced Nausea in Patients With Breast Cancer. Cancer Nurs. 2021 Jun 28.  View on PubMed
  8. Oppegaard K, Harris CS, Shin J, Paul SM, Cooper BA, Levine JD, Conley YP, Hammer M, Cartwright F, Wright F, Dunn L, Kober KM, Miaskowski C. Anxiety profiles are associated with stress, resilience and symptom severity in outpatients receiving chemotherapy. Support Care Cancer. 2021 Jun 26.  View on PubMed
  9. Lin Y, Bailey DE, Docherty SL, Porter LS, Cooper B, Paul S, Kober K, Hammer MJ, Wright F, Conley Y, Levine J, Miaskowski C. Distinct morning and evening fatigue profiles in gastrointestinal cancer during chemotherapy. BMJ Support Palliat Care. 2021 May 28.  View on PubMed
  10. Kober KM, Yom SS. Doc, I feel tired… oh really, so how's your mucositis? Cancer. 2021 Sep 15; 127(18):3294-3297.  View on PubMed
  11. Anand ST, Ryckman KK, Baer RJ, Charlton ME, Breheny PJ, Terry WW, Kober K, Oltman S, Rogers EE, Jelliffe-Pawlowski LL, Chrischilles EA. Metabolic differences among newborns born to mothers with a history of leukemia or lymphoma. J Matern Fetal Neonatal Med. 2021 May 12; 1-8.  View on PubMed
  12. Miaskowski C, Paul SM, Snowberg K, Abbott M, Borno HT, Chang SM, Chen LM, Cohen B, Cooper BA, Hammer MJ, Kenfield SA, Kober KM, Laffan A, Levine JD, Pozzar R, Rhoads K, Tsai KK, Van Blarigan EL, Van Loon K. Loneliness and symptom burden in oncology patients during the COVID-19 pandemic. Cancer. 2021 09 01; 127(17):3246-3253.  View on PubMed
  13. Harris CS, Miaskowski CA, Dhruva AA, Cataldo J, Kober KM. Multi-Staged Data-Integrated Multi-Omics Analysis for Symptom Science Research. Biol Res Nurs. 2021 Apr 08; 10998004211003980.  View on PubMed
  14. Mastick J, Smoot BJ, Paul SM, Kober KM, Cooper BA, Madden LK, Conley YP, Dixit N, Hammer MJ, Fu MR, Piper M, Cate SP, Shepherd J, Miaskowski C. Assessment of Arm Volume Using a Tape Measure Versus a 3D Optical Scanner in Survivors with Breast Cancer-Related Lymphedema. Lymphat Res Biol. 2021 Mar 23.  View on PubMed
  15. Kober KM, Roy R, Dhruva A, Conley YP, Chan RJ, Cooper B, Olshen A, Miaskowski C. Prediction of evening fatigue severity in outpatients receiving chemotherapy: less may be more. Fatigue. 2021; 9(1):14-32.  View on PubMed
  16. Mastick J, Smoot BJ, Paul SM, Kober KM, Hamolsky D, Madden LK, Conley YP, Dixit N, Hammer MJ, Fu MR, Miaskowski C. A Comparison of Supine Versus Stand-on Bioimpedance Devices to Assess Breast Cancer-Related Lymphedema. Lymphat Res Biol. 2021 Feb 09.  View on PubMed
  17. Lin Y, Bailey DE, Docherty SL, Porter LS, Cooper BA, Paul SM, Kober KM, Hammer MJ, Wright F, Dunn LB, Conley YP, Levine JD, Miaskowski C. Distinct profiles of multiple co-occurring symptoms in patients with gastrointestinal cancers receiving chemotherapy. Support Care Cancer. 2021 Aug; 29(8):4461-4471.  View on PubMed
  18. Joseph PV, Nolden A, Kober KM, Paul SM, Cooper BA, Conley YP, Hammer MJ, Wright F, Levine JD, Miaskowski C. Fatigue, Stress, and Functional Status are Associated With Taste Changes in Oncology Patients Receiving Chemotherapy. J Pain Symptom Manage. 2021 08; 62(2):373-382.e2.  View on PubMed
  19. Wilcoxon A, Kober KM, Viele C, Topp K, Smoot B, Abrams G, Chesney M, Paul SM, Conley YP, Levine JD, Miaskowski C. Association Between Physical Activity Levels and Chemotherapy-Induced Peripheral Neuropathy Severity in Cancer Survivors. Oncol Nurs Forum. 2020 11 01; 47(6):703-719.  View on PubMed
  20. Diaz R, Kober KM, Viele C, Cooper BA, Paul SM, Hammer M, Wright F, Conley YP, Levine JD, Miaskowski C. Distinct diarrhea profiles during outpatient chemotherapy. Support Care Cancer. 2021 May; 29(5):2363-2373.  View on PubMed

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