Research Summary

John Kurhanewicz, PhD is a Professor in Residence in the Departments of Radiology and Biomedical Imaging, Urology and Pharmaceutical Chemistry at University of California, San Francisco, and a member of the California Institute for Quantitative Biology and UCSF Cancer Center, and faculty in the UCSF-UCB Bioengineering Graduate Group. He is the Director of the UCSF Body Research Interest Group, the Biomedical NMR lab, and the Kurhanewicz Laboratory at UCSF. Dr. Kurhanewicz received his BS in Chemistry from the University of South Florida/New College in 1982, and obtained his PhD in Physical Organic Chemistry from the University of South Florida, Tampa in 1987, followed by a postdoctoral fellowship in MRI/MRS from the University of California, San Francisco in 1990.

Dr. Kurhanewicz and his colleagues have developed a large prostate cancer imaging program at UCSF, involving the application of advanced magnetic resonance imaging techniques (metabolic, diffusion and perfusion weighted MRI) to provide a more accurate assessment of the extent and aggressiveness of prostate cancer in individual patients. This multiparametric 1H MRI prostate cancer staging exam is currently being used to help over a 1,000 men diagnosed with prostate cancer a year at UCSF to decide on their best therapeutic course. He is also currently involved in the development and clinical translation of an extraordinary new molecular imaging technique utilizing hyperpolarized 13C labeled metabolic substrates that has the potential to revolutionize the way MR imaging is used in the risk assessment of prostate cancer patients. He led the first clinical trial of this technology at UCSF and is involved in three ongoing clinical trials investigating its clinical utility.

Dr. Kurhanewicz has published over 230 peer-reviewed manuscripts and19 book chapters, and has been cited 16,089 times (citation indices: h-index of 69, i10-index - 180). He is a member of 7 scientific societies, serves on numerous scientific review panels for the National Institute of Health, Department of Defense and American Cancer Society and reviews for over 20 different journals. He has 25 years of mentoring in the areas of advanced MR cancer imaging and molecular imaging, and has mentored over 120 graduate and under-graduate students, medical fellows and junior faculty.

Research Funding

  • September 7, 2020 - August 31, 2025 - Co-Clinical Quantitative Imaging of Small Cell Neuroendocrine Prostate Cancer Using Hyperpolarized 13C MRI, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U24CA253377
  • September 1, 2017 - July 31, 2022 - Metabolic imaging comparisons of patient-derived models of renal cell carcinoma, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA217456
  • June 1, 2017 - May 31, 2022 - Targeting Neuroendocrine Prostate Cancer Using Multi-Probe Hyperpolarized 13C MRI for Improved Treatment and Therapeutic Monitoring, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA215694
  • March 6, 2017 - February 28, 2022 - CLINICAL TRANSLATION OF HYPERPOLARIZED 13C-UREA FOR CANCER MR MOLECULAR IMAGING, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA214554

Education

New College, Sarasota, FL, B.S., 1976-1982, Chemistry
University of South Florida, Tampa, FL, Ph.D., 1982-1987, Chemistry
University of California San Francisco, CA, Post-Doc., 1987-1990, In vivo Spectroscopy

Honors & Awards

  • Phi Beta Kappa (scholastic honorary)
  • Outstanding Chemistry Alumnus, University of South Florida

Selected Publications

  1. Ahamed F, Van Criekinge M, Wang ZJ, Kurhanewicz J, Larson P, Sriram R Modeling hyperpolarized lactate signal dynamics in cells, patient-derived tissue slice cultures and murine models.  View on PubMed
  2. Fendler WP, Calais J, Eiber M, Simko JP, Kurhanewicz J, Santos RD, Feng FY, Reiter RE, Rettig MB, Nickols NG, Kishan AU, Slavik R, Carroll PR, Lawhn-Heath C, Herrmann K, Czernin J, Hope TA False positive PSMA PET for tumor remnants in the irradiated prostate and other interpretation pitfalls in a prospective multi-center trial.  View on PubMed
  3. Chen HY, Autry AW, Brender JR, Kishimoto S, Krishna MC, Vareth M, Bok RA, Reed GD, Carvajal L, Gordon JW, van Criekinge M, Korenchan DE, Chen AP, Xu D, Li Y, Chang SM, Kurhanewicz J, Larson PEZ, Vigneron DB Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13 C MRSI.  View on PubMed
  4. Qin H, Zhang V, Bok RA, Santos RD, Cunha JA, Hsu IC, Santos Bs JD, Lee JE, Sukumar S, Larson PEZ, Vigneron DB, Wilson DM, Sriram R, Kurhanewicz J Simultaneous Metabolic and Perfusion Imaging Using Hyperpolarized 13C MRI Can Evaluate Early and Dose-Dependent Response to Radiation Therapy in a Prostate Cancer Mouse Model.  View on PubMed
  5. Crane JC, Gordon JW, Chen HY, Autry AW, Li Y, Olson MP, Kurhanewicz J, Vigneron DB, Larson PEZ, Xu D Hyperpolarized 13 C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco.  View on PubMed
  6. Sriram R, Van Criekinge M, DeLos Santos J, Ahamed F, Qin H, Nolley R, Santos RD, Tabatabai ZL, Bok RA, Keshari KR, Vigneron DB, Peehl DM, Kurhanewicz J Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures.  View on PubMed
  7. Chen HY, Aggarwal R, Bok RA, Ohliger MA, Zhu Z, Lee P, Gordon JW, van Criekinge M, Carvajal L, Slater JB, Larson PEZ, Small EJ, Kurhanewicz J, Vigneron DB Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study.  View on PubMed
  8. Korenchan DE, Bok R, Sriram R, Liu K, Santos RD, Qin H, Lobach I, Korn N, Wilson DM, Kurhanewicz J, Flavell RR Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer.  View on PubMed
  9. Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil MM, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism.  View on PubMed
  10. Wang S, Korenchan DE, Perez PM, Taglang C, Hayes TR, Sriram R, Bok R, Hong AS, Wu Y, Li H, Wang Z, Kurhanewicz J, Wilson DM, Flavell RR Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13 C Magnetic Resonance Spectroscopy.  View on PubMed
  11. Barskiy DA, Tayler MCD, Marco-Rius I, Kurhanewicz J, Vigneron DB, Cikrikci S, Aydogdu A, Reh M, Pravdivtsev AN, Hövener JB, Blanchard JW, Wu T, Budker D, Pines A Zero-field nuclear magnetic resonance of chemically exchanging systems.  View on PubMed
  12. Korenchan DE, Gordon JW, Subramaniam S, Sriram R, Baligand C, VanCriekinge M, Bok R, Vigneron DB, Wilson DM, Larson PEZ, Kurhanewicz J, Flavell RR Using bidirectional chemical exchange for improved hyperpolarized [13 C]bicarbonate pH imaging.  View on PubMed
  13. Muir RK, Zhao N, Wei J, Wang YH, Moroz A, Huang Y, Chen YC, Sriram R, Kurhanewicz J, Ruggero D, Renslo AR, Evans MJ Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography.  View on PubMed
  14. Bancroft Brown J, Sriram R, VanCriekinge M, Delos Santos R, Sun J, Delos Santos J, Tabatabai ZL, Shinohara K, Nguyen H, Peehl DM, Kurhanewicz J NMR quantification of lactate production and efflux and glutamate fractional enrichment in living human prostate biopsies cultured with [1,6-13 C2 ]glucose.  View on PubMed
  15. Wang ZJ, Ohliger MA, Larson PEZ, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB Hyperpolarized 13C MRI: State of the Art and Future Directions.  View on PubMed
  16. Bok R, Lee J, Sriram R, Keshari K, Sukumar S, Daneshmandi S, Korenchan DE, Flavell RR, Vigneron DB, Kurhanewicz J, Seth P The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI.  View on PubMed
  17. Zhu Z, Zhu X, Ohliger MA, Tang S, Cao P, Carvajal L, Autry AW, Li Y, Kurhanewicz J, Chang S, Aggarwal R, Munster P, Xu D, Larson PEZ, Vigneron DB, Gordon JW Coil combination methods for multi-channel hyperpolarized 13C imaging data from human studies.  View on PubMed
  18. Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, van Criekinge M, Milshteyn E, Carvajal L, Hurd RE, Kurhanewicz J, Vigneron DB, Larson PEZ Pulse sequence considerations for quantification of pyruvate-to-lactate conversion kPL in hyperpolarized 13 C imaging.  View on PubMed
  19. Kurhanewicz J, Vigneron DB, Ardenkjaer-Larsen JH, Bankson JA, Brindle K, Cunningham CH, Gallagher FA, Keshari KR, Kjaer A, Laustsen C, Mankoff DA, Merritt ME, Nelson SJ, Pauly JM, Lee P, Ronen S, Tyler DJ, Rajan SS, Spielman DM, Wald L, Zhang X, Malloy CR, Rizi R Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology.  View on PubMed
  20. Behr SC, Aggarwal R, VanBrocklin HF, Flavell RR, Gao K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, Greene KL, Langton-Webster B, Berkman CE, Seo Y Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrane Antigen in Prostate Cancer.  View on PubMed

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