Lorriana Leard, MD

Lorriana Leard, MD

Professor of Clinical Medicine; Vice Chief of Clinical Activities, Pulmonary, Critical Care, Allergy & Sleep Medicine; Associate Director, Pulmonary & Critical Care Fellowship Program, UCSF

Phone: (415) 885-3882

Box 0111, UCSF
San Francisco, CA 94143-0111

Physician Biography

UCSF Profiles

Research Summary

Dr. Lorri Leard received her undergraduate degree from Stanford University and her M.D. from the University of California San Diego. After completing her Internal Medicine residency at the University of Texas Southwestern in Dallas, she came to the University of California San Francisco for her Pulmonary and Critical Care Fellowship. She completed an additional subspecialty fellowship in Lung Transplantation at the University of California San Francisco and joined the faculty in 2006. She pursued further training in medical education in the UCSF Teaching Scholars program and was selected to join the Academy of Medical Educators in 2011.

Dr. Leard is Associate Dean for Continuing Medical Education for the UCSF School of Medicine and Vice Chief of Clinical Operations for the UCSF Division of Pulmonary, Critical Care, Allergy and Sleep Medicine. Her major academic interests include Medical Education, Lung Transplantation and Lung Cancer. She cares for patients on the Advanced Lung Disease Service at UCSF Moffitt-Long Hospital, and sees patients at the Mt. Zion Comprehensive Cancer Center.

She is a past president of the California Thoracic Society. She serves on Item Review Committees for the National Board of Medical Educators and is an Editorial Board Consultant for the Journal of Heart and Lung Transplantation. She is Vice Chair (2023-2024) of the Committee on Academic Personnel -Gold Committee.

Education

  • 2019 - Relationship-Centered Communication Skills for Racial Equity in Healthcare, University of California
  • 2018 - Diversity, Equity, and Inclusion Champion Training, University of California
  • Fellowship, 2006 - Lung Transplantation, University of California
  • Fellowship, 2005 - Pulmonary and Critical Care Medicine, University of California
  • Internship & Residency, 2001 - Internal Medicine, University of Texas Southwestern
  • M.D., 1998 - School of Medicine, University of California

Honors & Awards

  • V. Courtney Broaddus Award for Leadership and Service, UCSF, 2022
  • Academy of Medical Educators, UCSF, 2011
  • Michael S. Stulbarg Outstanding Teaching Award, UCSF, 2007

Selected Publications

  1. Bromberger BJ, Gesthalter YB, Estrada AV, Kolaitis NA, Shah RJ, Singer JP, Leard LE, Seijo L, Maheshwari JA, Kleinhenz ME, Perez A, Hays SR, Kukreja J, Trinh BN. Robotic-assisted lung decortication in the management of pleural space complications after lung transplant. JHLT Open. 2026 Aug; 13:100604. View on PubMed
  2. Mohanty RP, Calabrese DR, Moghbeli K, Iasella CJ, Devonshire K, Zeng A, Chen K, Singer JP, Hays SR, Leard LE, Estrada AV, Shah RJ, Kolaitis NA, Golden JA, Langelier CR, McDyer JF, Greenland JR. Airway molecular signatures in antibody-mediated lung transplant rejection. Am J Transplant. 2026 Jul; 26(7):1661-1672. View on PubMed
  3. Moghbeli K, Popescu I, Iasella CJ, Lieber S, Snyder ME, Sciullo M, Koshy R, Zeng A, Mohanty RP, Langelier C, Lendermon EA, Shah R, Johnson B, Zhu D, Martinu T, Leard LE, Kleinhenz ME, Hays SR, Singer JP, Shigemura N, Pilewski JM, Hage CA, Chen K, Greenland JR, McDyer JF. Immune gene correlation networks differentiate both chronic lung allograft dysfunction and survival. Am J Transplant. 2026 Jun; 26(6):1418-1433. View on PubMed
  4. Perez AA, Leard LE. A closer examination of the ethical principles when considering active smokers as candidates for lung transplant. Am J Transplant. 2025 Sep; 25(9):1816-1817. View on PubMed
  5. Maheshwari JA, Leard LE. Considering candidates: modifiable and nonmodifiable risk factors for lung transplantation. Curr Opin Pulm Med. 2025 07 01; 31(4):359-365. View on PubMed
  6. Brunet-Ratnasingham E, Yellamilli S, Guo R, Mohanty RP, Duong A, Kolaitis NA, Hays SR, Shah RJ, Venado A, Maheshwari JA, Kleinhenz ME, Leard LE, McDyer J, Martinu T, Combes AJ, Calabrese DR, Singer JP, Greenland JR. Persistent and progressive acute lung allograft dysfunction is linked to cell compositional and transcriptional changes in small airways. J Heart Lung Transplant. 2025 Sep; 44(9):1482-1492. View on PubMed
  7. Wood DE, Kazerooni EA, Aberle DR, Argento C, Baines J, Boer B, Brown LM, Donington J, Eapen GA, Ferguson JS, Hou L, Klippenstein D, Kolansky AS, Kumar R, Leard LE, Leung ANC, Mazzone P, Merritt RE, Norris K, Onaitis M, Pipavath S, Puri V, Raz D, Reddy C, Reid ME, Sandler KL, Sands J, Schabath MB, Sears CR, Studts JL, Tanoue L, Thacker AL, Tong BC, Travis WD, Wei B, Westover K, McCullough B, Ramakrishnan S. NCCN Guidelines® Insights: Lung Cancer Screening, Version 1.2025. J Natl Compr Canc Netw. 2025 01; 23(1). View on PubMed
  8. Calabrese DR, Leard LE. Improving the odds: Reducing diagnostic uncertainty with bronchoalveolar lavage cytokine profiling. J Heart Lung Transplant. 2025 Apr; 44(4):643-644. View on PubMed
  9. Leard LE, Blebea C. The transformation of transplant medicine with artificial intelligence-assisted tacrolimus dosing. J Heart Lung Transplant. 2025 Mar; 44(3):362-363. View on PubMed
  10. Mohanty RP, Moghbeli K, Singer JP, Calabrese DR, Hays SR, Iasella C, Lieber S, Leard LE, Shah RJ, Venado A, Kleinhenz ME, Golden JA, Martinu T, Love C, Ward R, Langelier CR, McDyer J, Greenland JR. Small airway brush gene expression predicts chronic lung allograft dysfunction and mortality. J Heart Lung Transplant. 2024 11; 43(11):1820-1832. View on PubMed
  11. Calabrese DR, Ekstrand CA, Yellamilli S, Singer JP, Hays SR, Leard LE, Shah RJ, Venado A, Kolaitis NA, Perez A, Combes A, Greenland JR. Macrophage and CD8 T cell discordance are associated with acute lung allograft dysfunction progression. J Heart Lung Transplant. 2024 07; 43(7):1074-1086. View on PubMed
  12. Santos J, Wang P, Shemesh A, Liu F, Tsao T, Aguilar OA, Cleary SJ, Singer JP, Gao Y, Hays SR, Golden JA, Leard L, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Kukreja J, Weigt SS, Belperio JA, Lanier LL, Looney MR, Greenland JR, Calabrese DR. CCR5 drives NK cell-associated airway damage in pulmonary ischemia-reperfusion injury. JCI Insight. 2023 11 08; 8(21). View on PubMed
  13. Santos J, Hays SR, Golden JA, Calabrese DR, Kolaitis N, Kleinhenz ME, Shah R, Estrada AV, Leard LE, Kukreja J, Singer JP, Greenland JR. Decreased Lymphocytic Bronchitis Severity in the Era of Azithromycin Prophylaxis. Transplant Direct. 2023 Sep; 9(9):e1495. View on PubMed
  14. Singer JP, Christie JD, Diamond JM, Anderson MA, Benvenuto LA, Gao Y, Arcasoy SM, Lederer DJ, Calabrese D, Wang P, Hays SR, Kukreja J, Venado A, Kolaitis NA, Leard LE, Shah RJ, Kleinhenz ME, Golden J, Betancourt L, Oyster M, Zaleski D, Adler J, Kalman L, Balar P, Patel S, Medikonda N, Koons B, Tevald M, Covinsky KE, Greenland JR, Katz PK. Development of the Lung Transplant Frailty Scale (LT-FS). J Heart Lung Transplant. 2023 07; 42(7):892-904. View on PubMed
  15. Odisho AY, Liu AW, Maiorano AR, Bigazzi MOA, Medina E, Leard LE, Shah R, Venado A, Perez A, Golden J, Kleinhenz ME, Kolaitis NA, Maheshwari J, Trinh BN, Kukreja J, Greenland J, Calabrese D, Neinstein AB, Singer JP, Hays SR. Design and implementation of a digital health home spirometry intervention for remote monitoring of lung transplant function. J Heart Lung Transplant. 2023 06; 42(6):828-837. View on PubMed
  16. Kolaitis NA, Chen H, Calabrese DR, Kumar K, Obata J, Bach C, Golden JA, Simon MA, Kukreja J, Hays SR, Leard LE, Singer JP, De Marco T. The Lung Allocation Score Remains Inequitable for Patients with Pulmonary Arterial Hypertension, Even after the 2015 Revision. Am J Respir Crit Care Med. 2023 02 01; 207(3):300-311. View on PubMed
  17. Calabrese DR, Chong T, Singer JP, Rajalingam R, Hays SR, Kukreja J, Leard L, Golden JA, Lanier LL, Greenland JR. CD16+ natural killer cells in bronchoalveolar lavage are associated with antibody-mediated rejection and chronic lung allograft dysfunction. Am J Transplant. 2023 01; 23(1):37-44. View on PubMed
  18. Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR. NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI Insight. 2022 12 22; 7(24). View on PubMed
  19. Wood DE, Kazerooni EA, Aberle D, Berman A, Brown LM, Eapen GA, Ettinger DS, Ferguson JS, Hou L, Kadaria D, Klippenstein D, Kumar R, Lackner RP, Leard LE, Lennes IT, Leung ANC, Mazzone P, Merritt RE, Midthun DE, Onaitis M, Pipavath S, Pratt C, Puri V, Raz D, Reddy C, Reid ME, Sandler KL, Sands J, Schabath MB, Studts JL, Tanoue L, Tong BC, Travis WD, Wei B, Westover K, Yang SC, McCullough B, Hughes M. NCCN Guidelines® Insights: Lung Cancer Screening, Version 1.2022. J Natl Compr Canc Netw. 2022 07; 20(7):754-764. View on PubMed
  20. Solomon M, Willemse BWM, Ramos KJ, Leard LE. Response to selection of lung transplant candidates: A pediatric perspective on the ISHLT consensus document. J Heart Lung Transplant. 2022 07; 41(7):1000-1001. View on PubMed

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