Lorriana Leard, MD

Professor of Clinical Medicine; Vice Chief of Clinical Activities, Pulmonary, Critical Care, Allergy & Sleep Medicine; Associate Director, Pulmonary & Critical Care Fellowship Program, UCSF

Research Summary

Dr. Lorri Leard received her undergraduate degree from Stanford University and her M.D. from the University of California San Diego. After completing her Internal Medicine residency at the University of Texas Southwestern in Dallas, she came to the University of California San Francisco for her Pulmonary and Critical Care Fellowship. She completed an additional subspecialty fellowship in Lung Transplantation at the University of California San Francisco and joined the faculty in 2006. She pursued further training in medical education in the UCSF Teaching Scholars program and was selected to join the Academy of Medical Educators in 2011. She is a Coach for UCSF medical students, and her major academic interests include Medical Education, Lung Transplantation and Lung Cancer. She cares for patients on the Advanced Lung Disease Service at UCSF Moffitt-Long Hospital, and sees patients at the Mt. Zion Comprehensive Cancer Center.

Dr. Leard is the immediate past president of the California Thoracic Society. She serves on Item Review Committees for the National Board of Medical Educators and is an Editorial Board Consultant for the Journal of Heart and Lung Transplantation.

Education

  • 2019 - Relationship-Centered Communication Skills for Racial Equity in Healthcare, University of California
  • 2018 - Diversity, Equity, and Inclusion Champion Training, University of California
  • Fellowship, 2006 - Lung Transplantation, University of California
  • Fellowship, 2005 - Pulmonary and Critical Care Medicine, University of California
  • Internship & Residency, 2001 - Internal Medicine, University of Texas Southwestern
  • M.D., 1998 - School of Medicine, University of California

Honors & Awards

  • Academy of Medical Educators, UCSF, 2011
  • Michael S. Stulbarg Outstanding Teaching Award, UCSF, 2007

Selected Publications

  1. Solomon M, Willemse BWM, Ramos KJ, Leard LE. Response to selection of lung transplant candidates: A pediatric perspective on the ISHLT consensus document. J Heart Lung Transplant. 2022 Apr 06.  View on PubMed
  2. Kolaitis NA, Gao Y, Soong A, Greenland JR, Hays SR, Golden JA, Venado A, Leard LE, Shah RJ, Kleinhenz ME, Katz PP, Kukreja J, Blanc PD, Smith PJ, Singer JP. Depressive symptoms in lung transplant recipients: trajectory and association with mortality and allograft dysfunction. Thorax. 2022 Mar 30.  View on PubMed
  3. Greenland NY, Deiter F, Calabrese DR, Hays SR, Kukreja J, Leard LE, Kolaitis NA, Golden JA, Singer JP, Greenland JR. Inflammation on bronchoalveolar lavage cytology is associated with decreased chronic lung allograft dysfunction-free survival. Clin Transplant. 2022 Mar 05; e14639.  View on PubMed
  4. Warrior K, Leard LE, Nair AR, Gries CJ, Fisher AJ, Johnson SR, McCormack FX, Dilling DF. A survey of use of mTOR inhibitors in patients with lymphangioleiomyomatosis listed for lung transplant. Respir Med. 2022 Apr-May; 195:106779.  View on PubMed
  5. Perez AA, Leard LE. What's in a name: The importance of lung transplant at Cystic Fibrosis Foundation Accredited Care Centers for patients with Cystic Fibrosis. J Heart Lung Transplant. 2022 03; 41(3):308-310.  View on PubMed
  6. Dugger DT, Calabrese DR, Gao Y, Deiter F, Tsao T, Maheshwari J, Hays SR, Leard L, Kleinhenz ME, Shah R, Golden J, Kukreja J, Gordon ED, Singer JP, Greenland JR. Lung Allograft Epithelium DNA Methylation Age Is Associated With Graft Chronologic Age and Primary Graft Dysfunction. Front Immunol. 2021; 12:704172.  View on PubMed
  7. Maheshwari JA, Kolaitis NA, Anderson MR, Benvenuto L, Gao Y, Katz PP, Greenland J, Wolters PJ, Covinsky K, Hays SR, Kukreja J, Calabrese DR, Venado A, Shah RJ, Leard LE, Trinh B, Huang CY, Glidden D, Kleinhenz ME, Golden JA, Sutter N, Tietje-Ulrich G, Criner RN, Arcasoy SM, Christie JD, Diamond J, Singer JP. Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates. Ann Am Thorac Soc. 2021 09; 18(9):1464-1474.  View on PubMed
  8. Lew J, Casey M, Leard LE, Hays S, Otani IM. Perceptions Around Lung Transplant-Associated Hypogammaglobulinemia. J Clin Immunol. 2021 11; 41(8):1940-1942.  View on PubMed
  9. Leard LE, Holm AM, Valapour M, Glanville AR, Attawar S, Aversa M, Campos SV, Christon LM, Cypel M, Dellgren G, Hartwig MG, Kapnadak SG, Kolaitis NA, Kotloff RM, Patterson CM, Shlobin OA, Smith PJ, Solé A, Solomon M, Weill D, Wijsenbeek MS, Willemse BWM, Arcasoy SM, Ramos KJ. Consensus document for the selection of lung transplant candidates: An update from the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2021 11; 40(11):1349-1379.  View on PubMed
  10. DeBolt CL, Gao Y, Sutter N, Soong A, Leard L, Jeffrey G, Kleinhenz ME, Calabrese D, Greenland J, Venado A, Hays SR, Shah R, Kukreja J, Trinh B, Kolaitis NA, Douglas V, Diamond JM, Smith P, Singer J. The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation. Clin Transplant. 2021 05; 35(5):e14275.  View on PubMed
  11. Tsou S, Chen J, Brzezinski M, Hays S, Leard L, Singer JP, Trinh B, Kukreja J. Lung transplantation from swimming pool drowning victims: A case series. Am J Transplant. 2021 06; 21(6):2273-2278.  View on PubMed
  12. Iasella CJ, Hoji A, Popescu I, Wei J, Snyder ME, Zhang Y, Xu W, Iouchmanov V, Koshy R, Brown M, Fung M, Langelier C, Lendermon EA, Dugger D, Shah R, Lee J, Johnson B, Golden J, Leard LE, Ellen Kleinhenz M, Kilaru S, Hays SR, Singer JP, Sanchez PG, Morrell MR, Pilewski JM, Greenland JR, Chen K, McDyer JF. Type-1 immunity and endogenous immune regulators predominate in the airway transcriptome during chronic lung allograft dysfunction. Am J Transplant. 2021 06; 21(6):2145-2160.  View on PubMed
  13. Dugger DT, Fung M, Hays SR, Singer JP, Kleinhenz ME, Leard LE, Golden JA, Shah RJ, Lee JS, Deiter F, Greenland NY, Jones KD, Langelier CR, Greenland JR. Chronic lung allograft dysfunction small airways reveal a lymphocytic inflammation gene signature. Am J Transplant. 2021 01; 21(1):362-371.  View on PubMed
  14. Kolaitis NA, Gao Y, Soong A, Greenland JR, Hays SR, Golden J, Leard LE, Shah RJ, Kleinhenz ME, Katz PP, Venado A, Kukreja J, Blanc PD, Singer JP. Primary graft dysfunction attenuates improvements in health-related quality of life after lung transplantation, but not disability or depression. Am J Transplant. 2021 02; 21(2):815-824.  View on PubMed
  15. Dugger DT, Fung M, Zlock L, Caldera S, Sharp L, Hays SR, Singer JP, Leard LE, Golden JA, Shah RJ, Kukreja J, Gordon E, Finkbeiner W, Kleinhenz ME, Langelier C, Greenland JR. Cystic Fibrosis Lung Transplant Recipients Have Suppressed Airway Interferon Responses during Pseudomonas Infection. Cell Rep Med. 2020 07 21; 1(4).  View on PubMed
  16. Venado A, Kolaitis NA, Huang CY, Gao Y, Glidden DV, Soong A, Sutter N, Katz PP, Greenland JR, Calabrese DR, Hays SR, Golden JA, Shah RJ, Leard LE, Kukreja J, Deuse T, Wolters PJ, Covinsky K, Blanc PD, Singer JP. Frailty after lung transplantation is associated with impaired health-related quality of life and mortality. Thorax. 2020 08; 75(8):669-678.  View on PubMed
  17. Perez AA, Hays SR, Soong A, Gao Y, Greenland JR, Leard LE, Shah RJ, Golden J, Kukreja J, Venado A, Kleinhenz ME, Singer JP. Improvements in frailty contribute to substantial improvements in quality of life after lung transplantation in patients with cystic fibrosis. Pediatr Pulmonol. 2020 06; 55(6):1406-1413.  View on PubMed
  18. Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, Golden JA, Leard LE, Shah RJ, Kleinhenz ME, Venado A, Kukreja J, Singer JP, Looney MR. Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction. Am J Respir Cell Mol Biol. 2020 03; 62(3):364-372.  View on PubMed
  19. Kolaitis NA, Calabrese DR, Ahearn P, Venado A, Florez R, Lei HL, Isaak K, Henricksen E, Martinez E, Chong T, Shah RJ, Leard LE, Kleinhenz ME, Golden J, De Marco T, Greenland JR, Kukreja J, Hays SR, Blanc PD, Singer JP. Tacrolimus trough monitoring guided by mass spectrometry without accounting for assay differences is associated with acute kidney injury in lung transplant recipients. Am J Health Syst Pharm. 2019 12 02; 76(24):2019-2027.  View on PubMed
  20. Perez AA, Singer JP, Schwartz BS, Chin-Hong P, Shah RJ, Kleinhenz ME, Gao Y, Venado A, Leard LE, Golden JA, Kukreja J, Greenland JR, Hays SR. Management and clinical outcomes after lung transplantation in patients with pre-transplant Mycobacterium abscessus infection: A single center experience. Transpl Infect Dis. 2019 Jun; 21(3):e13084.  View on PubMed

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