Research Summary

My research focuses on developing advanced computational frameworks that integrate imaging, biological, and clinical data to transform cancer diagnosis, prognosis, and therapeutic decision-making. With a particular emphasis on advancing brain cancer care with Artificial Intelligence, I aim to bridge the gap between cutting-edge technology and clinical practice, driving innovation to improve brain cancer patient outcomes.

Research Funding

  • November 1, 2024 - October 31, 2025 - Integrating Multi-Modal Data to Enhance Glioblastoma Progression Prediction , . Sponsor: UCSF Brain Tumor SPORE, Sponsor Award ID:
  • September 1, 2022 - August 31, 2025 - Integrating Metabolic and Physiologic MRI for Personalized Glioblastoma Radiotherapy Planning , Co-Investigator . Sponsor: Department of Defense, Sponsor Award ID: W81XWH-22-1-0695
  • May 1, 2024 - April 30, 2025 - Building a Multimodal Vision-Language Model for Precise Spatial-Temporal Prediction of Glioblastoma , . Sponsor: HDFCCC Computational Cancer Research, Sponsor Award ID:
  • January 1, 2023 - December 31, 2023 - Developing Multimodal Deep Learning for Outcome Prediction in Glioblastoma Patients After Radiation Therapy , Principal Invstigator . Sponsor: Uncle Kory Foundation, Sponsor Award ID:
  • September 1, 2019 - December 31, 2021 - Tumor Motion Prediction and Spatiotemporal Learning for Motion Robustness Forecasting to Improve Motion Management Strategies , Co-Investigator . Sponsor: Varian Artificial Intelligence Research Grant, Sponsor Award ID:

Education

06/2021 - Residency in Therapeutic Medical Physics, University of Pennsylvania
PhD, 08/2018 - Nuclear Science and Engineering, Rensselaer Polytechnic Institute
BS, 07/2013 - Nuclear Engineering, Xi'An Jiaotong University (Special Class for Gifted Young)

Honors & Awards

  • Career Enhance Program award, UCSF Brain Tumor SPORE, 2024-2025
  • Best in Physics abstract (Senior Author), American Association of Physicists in Medicine, 2024
  • Top scored abstract by Science Council (First Author), American Association of Physicists in Medicine, 2023
  • Best Poster Award (Second Author), American Association of Physicists in Medicine Spring Clinical Meeting, 2021
  • Best Physics Abstract Resident Challenge (Second Author), The Radiosurgery Society Scientific Meeting, 2021
  • Resident Poster Viewing Recognition Award (First Author), American Society for Radiation Oncology, 2020
  • Health Physics Society Fellowship, Health Physics Society, 2015
  • Meritorious Winner, COMAP International Mathematical Contest in Modeling, 2011

Selected Publications

  1. Mohiuddin JJ, Jethwa KR, Grandhi N, Breen WG, Wang X, Anvari A, Lin H, Sandhyavenu H, Doucette A, Plastaras JP, Rule WG, Metz JM, Merrell KW, Sio TT, Ashman JB, Haddock MG, Ben-Josef E, Hallemeier CL, Wojcieszynski AP. Multi-institutional Comparison of Intensity Modulated Photon Versus Proton Radiation Therapy in the Management of Squamous Cell Carcinoma of the Anus. Adv Radiat Oncol. 2021 Sep-Oct; 6(5):100744.  View on PubMed
  2. Barsky AR, Lin H, Mendes A, Dreyfuss A, Wright C, Anstadt EJ, Berman AT, Levin WP, Cengel KA, Anderson N, Dong L, Metz JM, Li T, Feigenberg S. Initial Clinical Experience Treating Patients With Lung Cancer on a 6MV-Flattening-Filter-Free O-Ring Linear Accelerator. Cureus. 2020 Sep 09; 12(9):e10325.  View on PubMed
  3. Yoon SW, Lin H, Alonso-Basanta M, Anderson N, Apinorasethkul O, Cooper K, Dong L, Kempsey B, Marcel J, Metz J, Scheuermann R, Li T. Initial Evaluation of a Novel Cone-Beam CT-Based Semi-Automated Online Adaptive Radiotherapy System for Head and Neck Cancer Treatment - A Timing and Automation Quality Study. Cureus. 2020 Aug 11; 12(8):e9660.  View on PubMed
  4. Lin H, Zou W, Li T, Feigenberg SJ, Teo BK, Dong L. A Super-Learner Model for Tumor Motion Prediction and Management in Radiation Therapy: Development and Feasibility Evaluation. Sci Rep. 2019 10 16; 9(1):14868.  View on PubMed
  5. Mao L, Liu T, Caracappa PF, Lin H, Gao Y, Dauer LT, Xu XG. Influences of operator head posture and protective eyewear on eye lens doses in interventional radiology: A Monte Carlo Study. Med Phys. 2019 Jun; 46(6):2744-2751.  View on PubMed
  6. Lin HA, Varma DM, Hom WW, Cruz MA, Nasser PR, Phelps RG, Iatridis JC, Nicoll SB Injectable cellulose-based hydrogels as nucleus pulposus replacements: Assessment of in vitro structural stability, ex vivo herniation risk, and in vivo biocompatibility.  View on PubMed
  7. Lin H, Shi C, Wang B, Chan MF, Tang X, Ji W. Towards real-time respiratory motion prediction based on long short-term memory neural networks. Phys Med Biol. 2019 04 10; 64(8):085010.  View on PubMed
  8. Lin H, Liu T, Shi C, Petillion S, Kindts I, Weltens C, Depuydt T, Song Y, Saleh Z, Xu XG, Tang X. Feasibility study of individualized optimal positioning selection for left-sided whole breast radiotherapy: DIBH or prone. J Appl Clin Med Phys. 2018 Mar; 19(2):218-229.  View on PubMed

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