Research Summary

I am a practicing pulmonologist and intensivist and I maintain a basic science laboratory investigating acute lung injury. The long-term goal of my laboratory is to use experimental modeling to discover mechanisms responsible for the development of acute lung injury and to test novel therapeutics in clinically relevant experimental models.

Research Funding

  • January 1, 2019 - December 31, 2022 - Mechanisms of antibody-mediated lung Injury after blood transfusion, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL138673
  • June 1, 2016 - May 31, 2021 - Fine-tuning the Neutrophilic Response to Pneumonia, Principal Investigator. Sponsor: NIH/NIAID, Sponsor Award ID: R01AI125445
  • January 1, 2016 - December 31, 2019 - Innate Immune Mechanisms of Primary Graft Dysfunction after Lung Transplantation, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL130324
  • April 1, 2011 - March 31, 2016 - Platelet and megakaryocyte biology in the normal and injured lung, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL107386

Education

Lipscomb University, Nashville, TN, B.S., 06/1994, Chemistry
University of Tennessee, Memphis, TN, M.D., 06/1998, Medicine
University of California, San Francisco, CA, Residency, 06/2001, Internal Medicine
University of California, San Francisco, CA, Fellow, 06/2004, Pulmonary/Critical Care

Honors & Awards

  • 1994
    Summa cum laude, Lipscomb University
  • 1995
    McGraw-Hill Award for Academic Achievement, University of Tennessee, Memphis
  • 1996
    Herman Bensdorf Scholarship, University of Tennessee, Memphis
  • 1997
    Alpha Omega Alpha, University of Tennessee, Memphis
  • 1998
    Alpha Omega Alpha Distinguished Graduate Award, University of Tennessee, Memphis
  • 1998
    Faculty Medal for Academic Achievement, University of Tennessee, Memphis
  • 2002
    Will Rogers Fellowship Award, University of California, San Francisco
  • 2004
    GlaxoSmithKline Pulmonary Fellowship Award
  • 2009
    Carl Booberg Research Award, American Thoracic Society
  • 2010
    Jean Julliard Prize, International Society of Blood Transfusion (ISBT)
  • 2013
    Member, The American Society for Clinical Investigation

Selected Publications

  1. Cleary SJ, Looney MR Chewing the fat on TRALI.  View on PubMed
  2. Hilt ZT, Maurya P, Tesoro L, Pariser DN, Ture SK, Cleary SJ, Looney MR, McGrath K, Morrell C ß2M Signals Monocytes Through Non-Canonical TGFß Receptor Signal Transduction.  View on PubMed
  3. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium , Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF Global absence and targeting of protective immune states in severe COVID-19.  View on PubMed
  4. Pariser DN, Hilt ZT, Ture SK, Blick-Nitko SK, Looney MR, Cleary SJ, Roman-Pagan E, Saunders J, Georas SN, Veazey J, Madere F, Santos LT, Arne A, Huynh NP, Livada AC, Guerrero-Martin SM, Lyons C, Metcalf-Pate KA, McGrath KE, Palis J, Morrell CN Lung megakaryocytes are immune modulatory cells.  View on PubMed
  5. Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Hoover J, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger DT, Nakamura M, Lanier LL, Looney MR, Greenland JR Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury.  View on PubMed
  6. Hyun YM, Seo SU, Choi WS, Kwon HJ, Kim DY, Jeong S, Kang GY, Yi E, Kim M, Ryu HJ, Looney MR, Choi EY, Kim HS Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell-associated lung inflammation.  View on PubMed
  7. Cleary SJ, Kwaan N, Tian JJ, Calabrese DR, Mallavia B, Magnen M, Greenland JR, Urisman A, Singer JP, Hays SR, Kukreja J, Hay AM, Howie HL, Toy P, Lowell CA, Morrell CN, Zimring JC, Looney MR Complement activation on endothelium initiates antibody-mediated acute lung injury.  View on PubMed
  8. Cleary SJ, Magnen M, Looney MR, Page CP Update on animal models for COVID-19 research.  View on PubMed
  9. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF Global Absence and Targeting of Protective Immune States in Severe COVID-19.  View on PubMed
  10. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF Global Absence and Targeting of Protective Immune States in Severe COVID-19.  View on PubMed
  11. Zhao Y, Magaña LC, Cui H, Huang J, McHale CM, Yang X, Looney MR, Li R, Zhang L Formaldehyde-induced hematopoietic stem and progenitor cell toxicity in mouse lung and nose.  View on PubMed
  12. Roubinian NH, Chowdhury D, Hendrickson JE, Triulzi DJ, Gottschall JL, Looney MR, Matthay MA, Kor DJ, Brambilla D, Kleinman SH, Murphy EL NT-proBNP levels in the identification and classification of pulmonary transfusion reactions.  View on PubMed
  13. Cleary SJ, Pitchford SC, Amison RT, Carrington R, Robaina Cabrera CL, Magnen M, Looney MR, Gray E, Page CP Animal models of mechanisms of SARS-CoV-2 infection and COVID-19 pathology.  View on PubMed
  14. Barnes BJ, Adrover JM, Baxter-Stoltzfus A, Borczuk A, Cools-Lartigue J, Crawford JM, Daßler-Plenker J, Guerci P, Huynh C, Knight JS, Loda M, Looney MR, McAllister F, Rayes R, Renaud S, Rousseau S, Salvatore S, Schwartz RE, Spicer JD, Yost CC, Weber A, Zuo Y, Egeblad M Targeting potential drivers of COVID-19: Neutrophil extracellular traps.  View on PubMed
  15. Ortiz-Muñoz G, Yu MA, Lefrançais E, Mallavia B, Valet C, Tian JJ, Ranucci S, Wang KM, Liu Z, Kwaan N, Dawson D, Kleinhenz ME, Khasawneh FT, Haggie PM, Verkman AS, Looney MR Cystic fibrosis transmembrane conductance regulator dysfunction in platelets drives lung hyperinflammation.  View on PubMed
  16. Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, Golden JA, Leard LE, Shah RJ, Kleinhenz ME, Venado A, Kukreja J, Singer JP, Looney MR Mitochondrial DNA Stimulates TLR9-Dependent Neutrophil Extracellular Trap Formation in Primary Graft Dysfunction.  View on PubMed
  17. Lefrançais E, Looney MR Platelet Biogenesis in the Lung Circulation.  View on PubMed
  18. Qu J, Prasad NK, Yu MA, Chen S, Lyden A, Herrera N, Silvis MR, Crawford E, Looney MR, Peters JM, Rosenberg OS Modulating Pathogenesis with Mobile-CRISPRi.  View on PubMed
  19. Cleary SJ, Hobbs C, Amison RT, Arnold S, O'Shaughnessy BG, Lefrançais E, Mallavia B, Looney MR, Page CP, Pitchford SC LPS-induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-Selectin.  View on PubMed
  20. Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S An update of the transfusion-related acute lung injury (TRALI) definition.  View on PubMed

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