Research Summary

I am a practicing pulmonologist and intensivist and I maintain a basic science laboratory investigating acute lung injury. The long-term goal of my laboratory is to use experimental modeling to discover mechanisms responsible for the development of acute lung injury and to test novel therapeutics in clinically relevant experimental models.

Research Funding

  • September 17, 2021 - August 31, 2026 - Mechanisms and pathogenicity of SARS-CoV-2-induced neutrophil extracellular traps , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI160167
  • January 1, 2019 - December 31, 2022 - Mechanisms of antibody-mediated lung Injury after blood transfusion , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL138673
  • June 1, 2016 - May 31, 2021 - Fine-tuning the Neutrophilic Response to Pneumonia , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI125445
  • April 1, 2011 - April 30, 2021 - Platelet and megakaryocyte biology in the normal and injured lung , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL107386

Education

Lipscomb University, Nashville, TN, B.S., 06/1994, Chemistry
University of Tennessee, Memphis, TN, M.D., 06/1998, Medicine
University of California, San Francisco, CA, Residency, 06/2001, Internal Medicine
University of California, San Francisco, CA, Fellow, 06/2004, Pulmonary/Critical Care

Honors & Awards

  • 1994
    Summa cum laude, Lipscomb University
  • 1995
    McGraw-Hill Award for Academic Achievement, University of Tennessee, Memphis
  • 1996
    Herman Bensdorf Scholarship, University of Tennessee, Memphis
  • 1997
    Alpha Omega Alpha, University of Tennessee, Memphis
  • 1998
    Alpha Omega Alpha Distinguished Graduate Award, University of Tennessee, Memphis
  • 1998
    Faculty Medal for Academic Achievement, University of Tennessee, Memphis
  • 2002
    Will Rogers Fellowship Award, University of California, San Francisco
  • 2004
    GlaxoSmithKline Pulmonary Fellowship Award
  • 2009
    Carl Booberg Research Award, American Thoracic Society
  • 2010
    Jean Julliard Prize, International Society of Blood Transfusion (ISBT)
  • 2013
    Member, The American Society for Clinical Investigation

Selected Publications

  1. Martin TR, Zemans RL, Ware LB, Schmidt EP, Riches DWH, Bastarache L, Calfee CS, Desai TJ, Herold S, Hough CL, Looney MR, Matthay MA, Meyer N, Parikh SM, Stevens T, Thompson BT. New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021. Am J Respir Cell Mol Biol. 2022 Jun 09.  View on PubMed
  2. Looney M, Magnen M, You R, Rao A, Davis R, Rodriguez L, Simoneau C, Hysenaj L, Hu K, Love C, Woodruff P, Erle D, Hendrickson C, Calfee C, Matthay M, Roose J, Sil A, Ott M, Langelier C, Krummel M. Immediate myeloid depot for SARS-CoV-2 in the human lung. Res Sq. 2022 May 17.  View on PubMed
  3. Magnen M, You R, Rao AA, Davis RT, Rodriguez L, Simoneau CR, Hysenaj L, Hu KH, UCSF COMET Consortium, Love C, Woodruff PG, Erle DJ, Hendrickson CM, Calfee CS, Matthay MA, Roose JP, Sil A, Ott M, Langelier CR, Krummel MF, Looney MR. Immediate myeloid depot for SARS-CoV-2 in the human lung. bioRxiv. 2022 May 11.  View on PubMed
  4. Toy P, Looney MR, Popovsky M, Palfi M, Berlin G, Chapman CE, Bolton-Maggs P, Matthay MA. Transfusion-related Acute Lung Injury: 36 Years of Progress (1985-2021). Ann Am Thorac Soc. 2022 May; 19(5):705-712.  View on PubMed
  5. Valet C, Magnen M, Qiu L, Cleary SJ, Wang KM, Ranucci S, Grockowiak E, Boudra R, Conrad C, Seo Y, Calabrese DR, Greenland JR, Leavitt AD, Passegué E, Méndez-Ferrer S, Swirski FK, Looney MR. Sepsis promotes splenic production of a protective platelet pool with high CD40 ligand expression. J Clin Invest. 2022 Apr 01; 132(7).  View on PubMed
  6. De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG. GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA. Cell. 2022 Mar 17; 185(6):1103-1104.  View on PubMed
  7. Liu D, Duan L, Rodda LB, Lu E, Xu Y, An J, Qiu L, Liu F, Looney MR, Yang Z, Allen CDC, Li Z, Marson A, Cyster JG. CD97 promotes spleen dendritic cell homeostasis through the mechanosensing of red blood cells. Science. 2022 02 11; 375(6581):eabi5965.  View on PubMed
  8. De Giovanni M, Tam H, Valet C, Xu Y, Looney MR, Cyster JG. GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA. Cell. 2022 03 03; 185(5):815-830.e19.  View on PubMed
  9. Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK, CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW. ADAM8 signaling drives neutrophil migration and ARDS severity. JCI Insight. 2022 02 08; 7(3).  View on PubMed
  10. Kulkarni HS, Lee JS, Bastarache JA, Kuebler WM, Downey GP, Albaiceta GM, Altemeier WA, Artigas A, Bates JHT, Calfee CS, Dela Cruz CS, Dickson RP, Englert JA, Everitt JI, Fessler MB, Gelman AE, Gowdy KM, Groshong SD, Herold S, Homer RJ, Horowitz JC, Hsia CCW, Kurahashi K, Laubach VE, Looney MR, Lucas R, Mangalmurti NS, Manicone AM, Martin TR, Matalon S, Matthay MA, McAuley DF, McGrath-Morrow SA, Mizgerd JP, Montgomery SA, Moore BB, Noël A, Perlman CE, Reilly JP, Schmidt EP, Skerrett SJ, Suber TL, Summers C, Suratt BT, Takata M, Tuder R, Uhlig S, Witzenrath M, Zemans RL, Matute-Bello G. Update on the Features and Measurements of Experimental Acute Lung Injury in Animals: An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2022 02; 66(2):e1-e14.  View on PubMed
  11. Zhao N, Bardine C, Lourenço AL, Wang YH, Huang Y, Cleary SJ, Wilson DM, Oh DY, Fong L, Looney MR, Evans MJ, Craik CS. In Vivo Measurement of Granzyme Proteolysis from Activated Immune Cells with PET. ACS Cent Sci. 2021 Oct 27; 7(10):1638-1649.  View on PubMed
  12. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19. Nature. 2021 Aug; 596(7872):E8.  View on PubMed
  13. Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S. Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice. Proc Natl Acad Sci U S A. 2021 07 13; 118(28).  View on PubMed
  14. E. Aminian, B. Mallavia, F. Liu, S. Cleary, P. Wang, J.P. Singer, S.R. Hays, J.A. Golden, J. Kukreja, D. Dugger, M. Nakamura, L.L. Lanier, M.R. Looney, J.R. Greenland, D.R. Calabrese. Natural Killer Cells Recognize Pulmonary Epithelial Stress Molecules during Primary Graft Dysfunction. The Journal of Heart and Lung Transplantation. 2021 Apr 1; 40(4):s147.  View on PubMed
  15. Cleary SJ, Looney MR. Chewing the fat on TRALI. Blood. 2021 02 04; 137(5):586-587.  View on PubMed
  16. Calabrese DR, Aminian E, Mallavia B, Liu F, Cleary SJ, Aguilar OA, Wang P, Singer JP, Hays SR, Golden JA, Kukreja J, Dugger D, Nakamura M, Lanier LL, Looney MR, Greenland JR. Natural killer cells activated through NKG2D mediate lung ischemia-reperfusion injury. J Clin Invest. 2021 02 01; 131(3).  View on PubMed
  17. Hilt ZT, Maurya P, Tesoro L, Pariser DN, Ture SK, Cleary SJ, Looney MR, McGrath KE, Morrell CN. β2M Signals Monocytes Through Non-Canonical TGFβ Receptor Signal Transduction. Circ Res. 2021 03 05; 128(5):655-669.  View on PubMed
  18. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Chew NW, Cleary SJ, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Im KW, Serwas NK, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, UCSF COMET Consortium, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. Global absence and targeting of protective immune states in severe COVID-19. Nature. 2021 03; 591(7848):124-130.  View on PubMed
  19. Pariser DN, Hilt ZT, Ture SK, Blick-Nitko SK, Looney MR, Cleary SJ, Roman-Pagan E, Saunders J, Georas SN, Veazey J, Madere F, Santos LT, Arne A, Huynh NP, Livada AC, Guerrero-Martin SM, Lyons C, Metcalf-Pate KA, McGrath KE, Palis J, Morrell CN. Lung megakaryocytes are immune modulatory cells. J Clin Invest. 2021 01 04; 131(1).  View on PubMed
  20. Hyun YM, Seo SU, Choi WS, Kwon HJ, Kim DY, Jeong S, Kang GY, Yi E, Kim M, Ryu HJ, Looney MR, Choi EY, Kim HS. Endogenous DEL-1 restrains melanoma lung metastasis by limiting myeloid cell-associated lung inflammation. Sci Adv. 2020 11; 6(45).  View on PubMed

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