Research Summary

Dr. Lyu is an Assistant Professor in Residence at the UCSF Department of Radiation Oncology. She received her bachelor’s degree in physics from Nanjing University in 2016, and her PhD in Medical Physics from University of California, Los Angeles (UCLA) in 2021. From 2021 to 2023, she received clinical training from the UCLA Medical Physics Residency Program. Her research focuses on image reconstruction, dual-energy CT, treatment plan optimization, machine learning, etc. Dr. Lyu developed optimization algorithms that open new dimensions in image-guided radiotherapy.

Education

Residency, 06/2023 - Medical physics, University of California, Los Angeles
Ph.D., 06/2021 - Medical physics, University of California, Los Angeles
B.S., 06/2016 - Physics, Nanjing University

Honors & Awards

  • AAPM BEST award, AAPM, 2022
  • Early-Career Investigator Symposium, First place, AAPM, 2022
  • Norm Baily Awards, First place, AAPM South California Chapter, 2022
  • Science Council Associates Mentorship Program Associates, AAPM, 2021
  • Dissertation Year Fellowship, UCLA, 2020
  • Dr. Moses A. Greenfield Award, UCLA, 2020

Selected Publications

  1. Xu D, Yang Y, Liu H, Lyu Q, Descovich M, Ruan D, Sheng K TomoGRAF: An X-ray physics-driven generative radiance field framework for extremely sparse view CT reconstruction.  View on PubMed
  2. Xu Q, Lyu Q, Jiang L, Jing S, Ruan D, Sheng K An ultra-high performance parallel (UHPP) framework for complex 4πradiotherapy planning.  View on PubMed
  3. Xu D, Lyu Q, Ruan D, Sheng K. A Two-Step Framework for Multi-Material Decomposition of Dual Energy Computed Tomography from Projection Domain. Annu Int Conf IEEE Eng Med Biol Soc. 2024 Jul; 2024:1-7.  View on PubMed
  4. Frank CH, Ramesh P, Lyu Q, Ruan D, Park SJ, Chang AJ, Venkat PS, Kishan AU, Sheng K. Analytical HDR prostate brachytherapy planning with automatic catheter and isotope selection. Med Phys. 2023 Oct; 50(10):6525-6534.  View on PubMed
  5. Lyu Q, Neph R, Sheng K. Tomographic detection of photon pairs produced from high-energy X-rays for the monitoring of radiotherapy dosing. Nat Biomed Eng. 2023 03; 7(3):323-334.  View on PubMed
  6. Jiang L, Lyu Q, Abdelhamid AMH, Hui S, Sheng K. An efficient rectangular optimization method for sparse orthogonal collimator based small animal irradiation. Phys Med Biol. 2022 09 28; 67(19).  View on PubMed
  7. Ramesh P, Lyu Q, Gu W, Ruan D, Sheng K. Reformulated McNamara RBE-weighted beam orientation optimization for intensity modulated proton therapy. Med Phys. 2022 Apr; 49(4):2136-2149.  View on PubMed
  8. Neph R, Lyu Q, Huang Y, Yang YM, Sheng K. DeepMC: a deep learning method for efficient Monte Carlo beamlet dose calculation by predictive denoising in magnetic resonance-guided radiotherapy. Phys Med Biol. 2021 01 29; 66(3):035022.  View on PubMed
  9. Lyu Q, Neph R, O'Connor D, Ruan D, Boucher S, Sheng K. ROAD: ROtational direct Aperture optimization with a Decoupled ring-collimator for FLASH radiotherapy. Phys Med Biol. 2021 01 29; 66(3):035020.  View on PubMed
  10. Gu W, Ruan D, Lyu Q, Zou W, Dong L, Sheng K. A novel energy layer optimization framework for spot-scanning proton arc therapy. Med Phys. 2020 Jun; 47(5):2072-2084.  View on PubMed
  11. Lyu Q, Neph R, Yu VY, Ruan D, Boucher S, Sheng K. Many-isocenter optimization for robotic radiotherapy. Phys Med Biol. 2020 02 10; 65(4):045003.  View on PubMed
  12. Lyu Q, O'Connor D, Niu T, Sheng K. Image-domain multimaterial decomposition for dual-energy computed tomography with nonconvex sparsity regularization. J Med Imaging (Bellingham). 2019 Oct; 6(4):044004.  View on PubMed
  13. Jiang Y, Xue Y, Lyu Q, Xu L, Luo C, Yang P, Yang C, Wang J, Hu X, Zhang X, Sheng K, Niu T. Noise Suppression in Image-Domain Multi-Material Decomposition for Dual-Energy CT. IEEE Trans Biomed Eng. 2020 02; 67(2):523-535.  View on PubMed
  14. Lyu Q, Neph R, Yu VY, Ruan D, Sheng K. Single-arc VMAT optimization for dual-layer MLC. Phys Med Biol. 2019 05 02; 64(9):095028.  View on PubMed
  15. Lyu Q, Yu VY, Ruan D, Neph R, O'Connor D, Sheng K. A novel optimization framework for VMAT with dynamic gantry couch rotation. Phys Med Biol. 2018 06 13; 63(12):125013.  View on PubMed
  16. Lyu Q, O'Connor D, Ruan D, Yu V, Nguyen D, Sheng K. VMAT optimization with dynamic collimator rotation. Med Phys. 2018 Jun; 45(6):2399-2410.  View on PubMed
  17. Lyu Q, Yang C, Gao H, Xue Y, O'Connor D, Niu T, Sheng K. Technical Note: Iterative megavoltage CT (MVCT) reconstruction using block-matching 3D-transform (BM3D) regularization. Med Phys. 2018 Jun; 45(6):2603-2610.  View on PubMed
  18. Yang C, Wu P, Gong S, Wang J, Lyu Q, Tang X, Niu T. Shading correction assisted iterative cone-beam CT reconstruction. Phys Med Biol. 2017 Oct 27; 62(22):8495-8520.  View on PubMed
  19. Nguyen D, Lyu Q, Ruan D, O'Connor D, Low DA, Sheng K. A comprehensive formulation for volumetric modulated arc therapy planning. Med Phys. 2016 Jul; 43(7):4263.  View on PubMed

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