Research Funding

  • April 1, 2005 - December 31, 2022 - Mechanisms of Gene Silencing , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01GM071801
  • May 1, 2012 - May 31, 2022 - Cryptococcus knockout and tag resource , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI100272
  • January 22, 2020 - December 31, 2021 - Intracellular Recognition of Fungi by the Innate Immune System , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21AI150083
  • July 1, 2015 - June 30, 2021 - Epigenetic control of virulence in a fungal meningitis pathogen , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AI120464

Education

Stanford University, Stanford, California, B.S., M.S., 1986, Biological Sciences
University of California, San Francisco, Ph.D., 1993, Genetics
University of California, San Francisco, M.D., 1995, Medicine
Whitehead Institute, Cambridge, Massachusetts, Postdoctoral, 1995-1999, Signal Transduction

Honors & Awards

  • 1987
    Dean's Prize for Student Research, University of California, San Francisco
  • 1988
    Dean's Prize for Student Research, University of California, San Francisco
  • 1991-1992
    Chancellor's Fellowship, University of California, San Francisco
  • 1996
    Finalist, Pharmacia-Science Prize
  • 1995-1998
    Helen Hay Whitney Foundation Postdoctoral Research Fellowship
  • 1998-1999
    Burroughs-Wellcome Fund Career Development Award
  • 2000-2005
    David and Lucile Packard Foundation Fellowship for Scientists and Engineers
  • 1999-2002
    Burroughs-Wellcome Fund Career Development Award
  • 2005-2010
    Leukemia and Lymphoma Society Scholar
  • 2017
    Named to first cohort of Chan Zuckerberg Biohub Investigators

Selected Publications

  1. Basso P, Dang EV, Urisman A, Cowen LE, Madhani HD, Noble SM. Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response. Cell Host Microbe. 2022 11 09; 30(11):1589-1601.e5.  View on PubMed
  2. Mayerle M, Madhani HD, Maeder C. Christine Guthrie (1945-2022): a tribute from her trainees. RNA. 2022 Sep 30.  View on PubMed
  3. David A. Brow, Hiten D. Madhani. Christine Guthrie (1945–2022). Cell. 2022 Sep 1; 185(20):3639-3642.  View on PubMed
  4. Huang MY, Madhani HD. Telomere transposon takeover in Cryptococcus. Nat Microbiol. 2022 08; 7(8):1108-1109.  View on PubMed
  5. Dang EV, Lei S, Radkov A, Volk RF, Zaro BW, Madhani HD. Secreted fungal virulence effector triggers allergic inflammation via TLR4. Nature. 2022 08; 608(7921):161-167.  View on PubMed
  6. Wang J, Catania S, Wang C, de la Cruz MJ, Rao B, Madhani HD, Patel DJ. Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance. Mol Cell. 2022 03 17; 82(6):1186-1198.e6.  View on PubMed
  7. Huang MY, Joshi MB, Boucher MJ, Lee S, Loza LC, Gaylord EA, Doering TL, Madhani HD. Short homology-directed repair using optimized Cas9 in the pathogen Cryptococcus neoformans enables rapid gene deletion and tagging. Genetics. 2022 01 04; 220(1).  View on PubMed
  8. Bellen HJ, Hubbard EJA, Lehmann R, Madhani HD, Solnica-Krezel L, Southard-Smith EM. Model organism databases are in jeopardy. Development. 2021 10 01; 148(19).  View on PubMed
  9. Sales-Lee J, Perry DS, Bowser BA, Diedrich JK, Rao B, Beusch I, Yates JR, Roy SW, Madhani HD. Coupling of spliceosome complexity to intron diversity. Curr Biol. 2021 11 22; 31(22):4898-4910.e4.  View on PubMed
  10. Kryštufek R, Šácha P, Starková J, Brynda J, Hradilek M, Tloušt'ová E, Grzymska J, Rut W, Boucher MJ, Drag M, Majer P, Hájek M, Rezácová P, Madhani HD, Craik CS, Konvalinka J. Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery. J Med Chem. 2021 05 27; 64(10):6706-6719.  View on PubMed
  11. Madhani HD. Unbelievable but True: Epigenetics and Chromatin in Fungi. Trends Genet. 2021 01; 37(1):12-20.  View on PubMed
  12. Summers DK, Perry DS, Rao B, Madhani HD. Coordinate genomic association of transcription factors controlled by an imported quorum sensing peptide in Cryptococcus neoformans. PLoS Genet. 2020 09; 16(9):e1008744.  View on PubMed
  13. Dang EV, Madhani HD, Vance RE. Cholesterol in quarantine. Nat Immunol. 2020 07; 21(7):716-717.  View on PubMed
  14. Dumesic PA, Stoddard CI, Catania S, Narlikar GJ, Madhani HD. ATP Hydrolysis by the SNF2 Domain of Dnmt5 Is Coupled to Both Specific Recognition and Modification of Hemimethylated DNA. Mol Cell. 2020 07 02; 79(1):127-139.e4.  View on PubMed
  15. Wallace EWJ, Maufrais C, Sales-Lee J, Tuck LR, de Oliveira L, Feuerbach F, Moyrand F, Natarajan P, Madhani HD, Janbon G. Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom. Nucleic Acids Res. 2020 03 18; 48(5):2312-2331.  View on PubMed
  16. Catania S, Dumesic PA, Pimentel H, Nasif A, Stoddard CI, Burke JE, Diedrich JK, Cooke S, Shea T, Gienger E, Lintner R, Yates JR, Hajkova P, Narlikar GJ, Cuomo CA, Pritchard JK, Madhani HD. Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase. Cell. 2020 Feb 20; 180(4):816.  View on PubMed
  17. Catania S, Dumesic PA, Pimentel H, Nasif A, Stoddard CI, Burke JE, Diedrich JK, Cook S, Shea T, Geinger E, Lintner R, Yates JR, Hajkova P, Narlikar GJ, Cuomo CA, Pritchard JK, Madhani HD. Evolutionary Persistence of DNA Methylation for Millions of Years after Ancient Loss of a De Novo Methyltransferase. Cell. 2020 01 23; 180(2):263-277.e20.  View on PubMed
  18. Burke JE, Longhurst AD, Natarajan P, Rao B, Liu J, Sales-Lee J, Mortensen Y, Moresco JJ, Diedrich JK, Yates JR, Madhani HD. A Non-Dicer RNase III and Four Other Novel Factors Required for RNAi-Mediated Transposon Suppression in the Human Pathogenic Yeast Cryptococcus neoformans. G3 (Bethesda). 2019 07 09; 9(7):2235-2244.  View on PubMed
  19. Brimacombe CA, Burke JE, Parsa JY, Catania S, O'Meara TR, Witchley JN, Burrack LS, Madhani HD, Noble SM. A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. PLoS Biol. 2019 06; 17(6):e3000331.  View on PubMed
  20. Harrigan P, Madhani HD, El-Samad H. Real-Time Genetic Compensation Defines the Dynamic Demands of Feedback Control. Cell. 2018 10 18; 175(3):877-886.e10.  View on PubMed

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