Research Summary

Sharmila Majumdar, PhD, is a UCSF Professor and the Vice Chair of Research in the Department of Radiology and Biomedical Imaging and Professor in the Departments of Bioengineering and Therapeutic Sciences, Orthopedic Surgery at UCSF and Bioengineering at UC Berkeley. She is Director of the Musculoskeletal Research Interest Group at UCSF, an interdisciplinary group consisting of faculty, post-doctoral scholars and students. She obtained her PhD degree in Engineering and Applied Science from Yale University in 1987, where she stayed as a post-doctoral researcher and Assistant Professor until 1989, when she joined UCSF.

Her research work on imaging, particularly magnetic resonance and micro computed tomography, and development of image processing and analysis tools, has been focused in the areas of osteoporosis, osteo-arthritis and lower back pain. Her research, which is supported by grants from the NIH and corporate entities, and is diverse ranging from technical development to clinical trials. She currently heads an NIH Center of Research Translation focused on Osteoarthritis and Imaging, a joint effort between UCSF and UC Davis.

Dr. Majumdar was selected as a fellow of the American Institute of Medical and Biological Engineers in 2004 and a fellow of the International Society of Magnetic Resonance in Medicine in 2008. In 2007 she was awarded the “Excellence in Direct Teaching and/or Excellence in Mentoring and Advising Award” by the UCSF Haile T. Debas Academy of Medical Educators.

She has published extensively in the Journal of Bone Mineral Research, Magnetic Resonance in Medicine, and other highly regarded journals. She also serves as a reviewer and is on the editorial board of scientific journals, and is a recognized expert in the area of imaging.

Research Funding

  • July 14, 2016 - June 30, 2026 - Evaluating Disease Progression in Hip Osteoarthritis , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01AR069006
  • September 26, 2019 - July 31, 2024 - Technology Research Site for Advanced, Faster Quantitative Imaging for BACPAC , Principal Investigator . Sponsor: NIH, Sponsor Award ID: UH3AR076724
  • April 1, 2018 - July 31, 2021 - Deep Learning for Characterizing Knee Joint Degeneration Predicting Progression of Osteoarthritis and Total Knee Replacement , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R33AR073552
  • September 26, 2019 - August 31, 2020 - Technology Research Site for Advanced, Faster Quantitative Imaging for BACPAC , Principal Investigator . Sponsor: NIH, Sponsor Award ID: UH2AR076724


St. Stephens College, University of Delhi, India, B.S., 1983, Physics
Yale University, Connecticut, USA, M.S., 1984, Eng. & Applied Physics
Yale University, Connecticut, USA, Ph.D., 1987, Eng. & Applied Physics
Yale University, Connecticut, USA, Postdoctoral, 1988, Radiology

Honors & Awards

  • 2002
    Celebrating Woman Faculty, Award and Recognition, Chancellor and Deans of UCSF
  • 2004
    Fellow of the American Institute of Medical and Biological Engineers (AIMBE)
  • 2008
    Fellow of the International Society of Magnetic Resonance in Medicine (ISMRM)
  • 2016
    Gold Medal of International Society of Magnetic Resonance in Medicine (ISMRM)

Selected Publications

  1. Tolpadi AA, Bharadwaj U, Gao KT, Bhattacharjee R, Gassert FG, Luitjens J, Giesler P, Morshuis JN, Fischer P, Hein M, Baumgartner CF, Razumov A, Dylov D, Lohuizen QV, Fransen SJ, Zhang X, Tibrewala R, de Moura HL, Liu K, Zibetti MVW, Regatte R, Majumdar S, Pedoia V. K2S Challenge: From Undersampled K-Space to Automatic Segmentation. Bioengineering (Basel). 2023 Feb 18; 10(2).  View on PubMed
  2. Joseph GB, McCulloch CE, Nevitt MC, Lynch J, Lane NE, Pedoia V, Majumdar S, Link TM. The effect of interactions between BMI and sustained depressive symptoms on knee osteoarthritis over 4?years: data from the osteoarthritis initiative. BMC Musculoskelet Disord. 2023 Jan 12; 24(1):27.  View on PubMed
  3. Mauck MC, Lotz J, Psioda MA, Carey TS, Clauw DJ, Majumdar S, Marras WS, Vo N, Aylward A, Hoffmeyer A, Zheng P, Ivanova A, McCumber M, Carson C, Anstrom KJ, Bowden AE, Dalton D, Derr L, Dufour J, Fields AJ, Fritz J, Hassett AL, Harte SE, Hue TF, Krug R, Loggia ML, Mageswaran P, McLean SA, Mitchell UH, O'Neill C, Pedoia V, Quirk DA, Rhon DI, Rieke V, Shah L, Sowa G, Spiegel B, Wasan AD, Wey HM, LaVange L. The Back Pain Consortium (BACPAC) Research Program: Structure, Research Priorities, and Methods. Pain Med. 2023 Jan 09.  View on PubMed
  4. Tolpadi AA, Han M, Caliv? F, Pedoia V, Majumdar S. Region of interest-specific loss functions improve T2 quantification with ultrafast T2 mapping MRI sequences in knee, hip and lumbar spine. Sci Rep. 2022 12 23; 12(1):22208.  View on PubMed
  5. Lee JJ, Namiri NK, Astuto B, Link TM, Majumdar S, Pedoia V. Personalized Risk Model and Leveraging of Magnetic Resonance Imaging-Based Structural Phenotypes and Clinical Factors to Predict Incidence of Radiographic Osteoarthritis. Arthritis Care Res (Hoboken). 2023 03; 75(3):501-508.  View on PubMed
  6. Shah R, Astuto Arouche Nunes B, Gleason T, Fletcher W, Banaga J, Sweetwood K, Ye A, Patel R, McGill K, Link T, Crane J, Pedoia V, Majumdar S. Utilizing a Digital Swarm Intelligence Platform to Improve Consensus Among Radiologists and Exploring Its Applications. J Digit Imaging. 2022 Nov 22.  View on PubMed
  7. Hess M, Allaire B, Gao KT, Tibrewala R, Inamdar G, Bharadwaj U, Chin C, Pedoia V, Bouxsein M, Anderson D, Majumdar S. Deep Learning for Multi-Tissue Segmentation and Fully Automatic Personalized Biomechanical Models from BACPAC Clinical Lumbar Spine MRI. Pain Med. 2022 Oct 31.  View on PubMed
  8. Sollmann N, Fields AJ, O'Neill C, Nardo L, Majumdar S, Chin CT, Tosun D, Han M, Vu AT, Ozhinsky E, Shah LM, Harris RE, Lobo R, Anderst W, Herzog R, Psioda MA, Standaert CJ, Price RT, Lotz JC, Link TM, Krug R. Magnetic resonance imaging of the lumbar spine-recommendations for acquisition and image evaluation from the BACPAC Spine Imaging Working Group. Pain Med. 2022 Sep 07.  View on PubMed
  9. Neumann J, Zhang AL, Bucknor M, Majumdar S, Souza R, Joseph GB, Link TM. Acetabular cartilage delamination: performance of MRI using arthroscopy as the standard of reference. Acta Radiol. 2022 Jul 28; 2841851221113966.  View on PubMed
  10. Roach KE, Souza RB, Majumdar S, Pedoia V. Local Patterns in 2-Year T1? and T2 Changes of Hip Cartilage Are Related to Sex and Functional Data: A Prospective Evaluation on Hip Osteoarthritis Participants. J Magn Reson Imaging. 2022 Jul 19.  View on PubMed
  11. Kim JS, Borges S, Clauw DJ, Conaghan PG, Felson DT, Fleming TR, Glaser R, Hart E, Hochberg M, Kim Y, Kraus VB, Lapteva L, Li X, Majumdar S, McAlindon TE, Mobasheri A, Neogi T, Roemer FW, Rothwell R, Shibuya R, Siegel J, Simon LS, Spindler KP, Nikolov NP. FDA/Arthritis Foundation osteoarthritis drug development workshop recap: Assessment of long-term benefit. Semin Arthritis Rheum. 2022 10; 56:152070.  View on PubMed
  12. Gao KT, Tibrewala R, Hess M, Bharadwaj UU, Inamdar G, Link TM, Chin CT, Pedoia V, Majumdar S. Automatic detection and voxel-wise mapping of lumbar spine Modic changes with deep learning. JOR Spine. 2022 Jun; 5(2):e1204.  View on PubMed
  13. Liao TC, Pedoia V, Link TM, Majumdar S, Souza RB. Association of patella alignment with cartilage relaxation times and self-reported symptoms in individuals with patellofemoral degeneration. J Orthop Res. 2022 May 22.  View on PubMed
  14. Scholes MJ, Kemp JL, Mentiplay BF, Heerey JJ, Agricola R, Semciw AI, Souza RB, Link TM, Majumdar S, King MG, Lawrenson PR, Crossley KM. Does Femoroacetabular Impingement Syndrome Affect Self-Reported Burden in Football Players With Hip and Groin Pain? Sports Health. 2022 Nov-Dec; 14(6):920-931.  View on PubMed
  15. Caliv? F, Kamat S, Morales Martinez A, Majumdar S, Pedoia V. Surface spherical encoding and contrastive learning for virtual bone shape aging. Med Image Anal. 2022 04; 77:102388.  View on PubMed
  16. Jacobs CA, Conley CEW, Kraus VB, Lansdown DA, Lau BC, Li X, Majumdar S, Spindler KP, Lemaster NG, Stone AV. MOntelukast as a potential CHondroprotective treatment following Anterior cruciate ligament reconstruction (MOCHA Trial): study protocol for a double-blind, randomized, placebo-controlled clinical trial. Trials. 2022 Jan 31; 23(1):98.  View on PubMed
  17. Engelke K, Fuerst T, Gl?er CC, Gl?er MG, Hans D, Majumdar S, Peterfy C, Steiger P. In memoriam - Harry K Genant, MD. Bone. 2022 04; 157:116326.  View on PubMed
  18. Heerey J, Kemp J, Agricola R, Srinivasan R, Smith A, Pizzari T, King M, Lawrenson P, Scholes M, Link T, Souza R, Majumdar S, Crossley K. Cam morphology is associated with MRI-defined cartilage defects and labral tears: a case-control study of 237 young adult football players with and without hip and groin pain. BMJ Open Sport Exerc Med. 2021; 7(4):e001199.  View on PubMed
  19. Pedoia V, Caliva F, Kazakia G, Burghardt AJ, Majumdar S. Augmenting Osteoporosis Imaging with Machine Learning. Curr Osteoporos Rep. 2021 12; 19(6):699-709.  View on PubMed
  20. Caliv? F, Namiri NK, Dubreuil M, Pedoia V, Ozhinsky E, Majumdar S. Studying osteoarthritis with artificial intelligence applied to magnetic resonance imaging. Nat Rev Rheumatol. 2022 02; 18(2):112-121.  View on PubMed

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