Research Summary

Sharmila Majumdar, PhD, is a UCSF Professor and the Vice Chair of Research in the Department of Radiology and Biomedical Imaging and Professor in the Departments of Bioengineering and Therapeutic Sciences, Orthopedic Surgery at UCSF and Bioengineering at UC Berkeley. She is Director of the Musculoskeletal Research Interest Group at UCSF, an interdisciplinary group consisting of faculty, post-doctoral scholars and students. She obtained her PhD degree in Engineering and Applied Science from Yale University in 1987, where she stayed as a post-doctoral researcher and Assistant Professor until 1989, when she joined UCSF.

Her research work on imaging, particularly magnetic resonance and micro computed tomography, and development of image processing and analysis tools, has been focused in the areas of osteoporosis, osteo-arthritis and lower back pain. Her research, which is supported by grants from the NIH and corporate entities, and is diverse ranging from technical development to clinical trials. She currently heads an NIH Center of Research Translation focused on Osteoarthritis and Imaging, a joint effort between UCSF and UC Davis.

Dr. Majumdar was selected as a fellow of the American Institute of Medical and Biological Engineers in 2004 and a fellow of the International Society of Magnetic Resonance in Medicine in 2008. In 2007 she was awarded the “Excellence in Direct Teaching and/or Excellence in Mentoring and Advising Award” by the UCSF Haile T. Debas Academy of Medical Educators.

She has published extensively in the Journal of Bone Mineral Research, Magnetic Resonance in Medicine, and other highly regarded journals. She also serves as a reviewer and is on the editorial board of scientific journals, and is a recognized expert in the area of imaging.

Research Funding

  • September 26, 2019 - July 31, 2024 - Technology Research Site for Advanced, Faster Quantitative Imaging for BACPAC, Principal Investigator. Sponsor: NIH/NIAMS, Sponsor Award ID: UH3AR076724
  • April 1, 2018 - July 31, 2021 - Deep Learning for Characterizing Knee Joint Degeneration Predicting Progression of Osteoarthritis and Total Knee Replacement, Principal Investigator. Sponsor: NIH/NIAMS, Sponsor Award ID: R33AR073552
  • July 14, 2016 - April 30, 2021 - Evaluating Disease Progression in Hip Osteoarthritis, Principal Investigator. Sponsor: NIH/NIAMS, Sponsor Award ID: R01AR069006
  • September 26, 2019 - August 31, 2020 - Technology Research Site for Advanced, Faster Quantitative Imaging for BACPAC, Principal Investigator. Sponsor: NIH/NIAMS, Sponsor Award ID: UH2AR076724

Education

St. Stephens College, University of Delhi, India, B.S., 1983, Physics
Yale University, Connecticut, USA, M.S., 1984, Eng. & Applied Physics
Yale University, Connecticut, USA, Ph.D., 1987, Eng. & Applied Physics
Yale University, Connecticut, USA, Postdoctoral, 1988, Radiology

Honors & Awards

  • 2002
    Celebrating Woman Faculty, Award and Recognition, Chancellor and Deans of UCSF
  • 2004
    Fellow of the American Institute of Medical and Biological Engineers (AIMBE)
  • 2008
    Fellow of the International Society of Magnetic Resonance in Medicine (ISMRM)
  • 2016
    Gold Medal of International Society of Magnetic Resonance in Medicine (ISMRM)

Selected Publications

  1. Heerey J, Kemp J, Agricola R, Srinivasan R, Smith A, Pizzari T, King M, Lawrenson P, Scholes M, Link T, Souza R, Majumdar S, Crossley K. Cam morphology is associated with MRI-defined cartilage defects and labral tears: a case-control study of 237 young adult football players with and without hip and groin pain. BMJ Open Sport Exerc Med. 2021; 7(4):e001199.  View on PubMed
  2. Calivà F, Namiri NK, Dubreuil M, Pedoia V, Ozhinsky E, Majumdar S. Studying osteoarthritis with artificial intelligence applied to magnetic resonance imaging. Nat Rev Rheumatol. 2021 Nov 30.  View on PubMed
  3. Iriondo C, Mehany S, Shah R, Bharadwaj U, Bahroos E, Chin C, Diab M, Pedoia V, Majumdar S. Institution-wide shape analysis of 3D spinal curvature and global alignment parameters. J Orthop Res. 2021 Nov 29.  View on PubMed
  4. Bolcos PO, Mononen ME, Roach KE, Tanaka MS, Suomalainen JS, Mikkonen S, Nissi MJ, Töyräs J, Link TM, Souza RB, Majumdar S, Ma CB, Li X, Korhonen RK. Subject-specific biomechanical analysis to estimate locations susceptible to osteoarthritis-Finite element modeling and MRI follow-up of ACL reconstructed patients. J Orthop Res. 2021 Nov 24.  View on PubMed
  5. Morales AG, Lee JJ, Caliva F, Iriondo C, Liu F, Majumdar S, Pedoia V. Uncovering associations between data-driven learned qMRI biomarkers and chronic pain. Sci Rep. 2021 Nov 09; 11(1):21989.  View on PubMed
  6. Pedoia V, Caliva F, Kazakia G, Burghardt AJ, Majumdar S. Augmenting Osteoporosis Imaging with Machine Learning. Curr Osteoporos Rep. 2021 Nov 06.  View on PubMed
  7. Joseph GB, McCulloch CE, Sohn JH, Pedoia V, Majumdar S, Link TM. AI MSK clinical applications: cartilage and osteoarthritis. Skeletal Radiol. 2021 Nov 04.  View on PubMed
  8. Han M, Tibrewala R, Bahroos E, Pedoia V, Majumdar S. Magnetization-prepared spoiled gradient-echo snapshot imaging for efficient measurement of R2 -R1ρ in knee cartilage. Magn Reson Med. 2021 Sep 30.  View on PubMed
  9. Dayan I, Roth HR, Zhong A, Harouni A, Gentili A, Abidin AZ, Liu A, Costa AB, Wood BJ, Tsai CS, Wang CH, Hsu CN, Lee CK, Ruan P, Xu D, Wu D, Huang E, Kitamura FC, Lacey G, de Antônio Corradi GC, Nino G, Shin HH, Obinata H, Ren H, Crane JC, Tetreault J, Guan J, Garrett JW, Kaggie JD, Park JG, Dreyer K, Juluru K, Kersten K, Rockenbach MABC, Linguraru MG, Haider MA, AbdelMaseeh M, Rieke N, Damasceno PF, E Silva PMC, Wang P, Xu S, Kawano S, Sriswasdi S, Park SY, Grist TM, Buch V, Jantarabenjakul W, Wang W, Tak WY, Li X, Lin X, Kwon YJ, Quraini A, Feng A, Priest AN, Turkbey B, Glicksberg B, Bizzo B, Kim BS, Tor-Díez C, Lee CC, Hsu CJ, Lin C, Lai CL, Hess CP, Compas C, Bhatia D, Oermann EK, Leibovitz E, Sasaki H, Mori H, Yang I, Sohn JH, Murthy KNK, Fu LC, de Mendonça MRF, Fralick M, Kang MK, Adil M, Gangai N, Vateekul P, Elnajjar P, Hickman S, Majumdar S, McLeod SL, Reed S, Gräf S, Harmon S, Kodama T, Puthanakit T, Mazzulli T, de Lavor VL, Rakvongthai Y, Lee YR, Wen Y, Gilbert FJ, Flores MG, Li Q. Federated learning for predicting clinical outcomes in patients with COVID-19. Nat Med. 2021 Sep 15.  View on PubMed
  10. Sadre R, Sundaram B, Majumdar S, Ushizima D. Validating deep learning inference during chest X-ray classification for COVID-19 screening. Sci Rep. 2021 08 09; 11(1):16075.  View on PubMed
  11. Liao TC, Pedoia V, Majumdar S, Souza RB. Longitudinal Changes of Patellar Alignment Before and After Anterior Cruciate Ligament Reconstruction With Hamstring Autograft. Am J Sports Med. 2021 09; 49(11):2908-2915.  View on PubMed
  12. Kumar D, Link TM, Jafarzadeh SR, LaValley MP, Majumdar S, Souza RB. Association of Quadriceps Adiposity With an Increase in Knee Cartilage, Meniscus, or Bone Marrow Lesions Over Three Years. Arthritis Care Res (Hoboken). 2021 08; 73(8):1134-1139.  View on PubMed
  13. Nguyen KH, Shaw C, Link TM, Majumdar S, Souza RB, Vail TP, Zhang AL. Changes in Hip Capsule Morphology after Arthroscopic Treatment for Femoroacetabular Impingement Syndrome with Periportal Capsulotomy are Correlated With Improvements in Patient-Reported Outcomes. Arthroscopy. 2021 May 28.  View on PubMed
  14. Namiri NK, Lee J, Astuto B, Liu F, Shah R, Majumdar S, Pedoia V. Deep learning for large scale MRI-based morphological phenotyping of osteoarthritis. Sci Rep. 2021 05 25; 11(1):10915.  View on PubMed
  15. Astuto B, Flament I, Namiri NK, Shah R, Bharadwaj U, Link TM, Bucknor MD, Pedoia V, Majumdar S. Erratum: Automatic Deep Learning-assisted Detection and Grading of Abnormalities in Knee MRI Studies. Radiol Artif Intell. 2021 May; 3(3):e219001.  View on PubMed
  16. Joseph GB, Ramezanpour S, McCulloch CE, Nevitt MC, Lynch J, Lane NE, Pedoia V, Majumdar S, Link TM. Weight Cycling and Knee Joint Degeneration in Individuals with Overweight or Obesity: Four-Year Magnetic Resonance Imaging Data from the Osteoarthritis Initiative. Obesity (Silver Spring). 2021 05; 29(5):909-918.  View on PubMed
  17. Rubin EB, Mazzoli V, Black MS, Young K, Desai AD, Koff MF, Sreedhar A, Kogan F, Safran MR, Vincentini DJ, Knox KA, Yamada T, McCabe A, Majumdar S, Potter HG, Gold GE. Effects of the Competitive Season and Off-Season on Knee Articular Cartilage in Collegiate Basketball Players Using Quantitative MRI: A Multicenter Study. J Magn Reson Imaging. 2021 09; 54(3):840-851.  View on PubMed
  18. Astuto B, Flament I, K Namiri N, Shah R, Bharadwaj U, M Link T, D Bucknor M, Pedoia V, Majumdar S. Automatic Deep Learning-assisted Detection and Grading of Abnormalities in Knee MRI Studies. Radiol Artif Intell. 2021 May; 3(3):e200165.  View on PubMed
  19. Flores M, Dayan I, Roth H, Zhong A, Harouni A, Gentili A, Abidin A, Liu A, Costa A, Wood B, Tsai CS, Wang CH, Hsu CN, Lee CK, Ruan C, Xu D, Wu D, Huang E, Kitamura F, Lacey G, Corradi GCA, Shin HH, Obinata H, Ren H, Crane J, Tetreault J, Guan J, Garrett J, Park JG, Dreyer K, Juluru K, Kersten K, Rockenbach MABC, Linguraru M, Haider M, AbdelMaseeh M, Rieke N, Damasceno P, Silva PMCE, Wang P, Xu S, Kawano S, Sriswa S, Park SY, Grist T, Buch V, Jantarabenjakul W, Wang W, Tak WY, Li X, Lin X, Kwon F, Gilbert F, Kaggie J, Li Q, Quraini A, Feng A, Priest A, Turkbey B, Glicksberg B, Bizzo B, Kim BS, Tor-Diez C, Lee CC, Hsu CJ, Lin C, Lai CL, Hess C, Compas C, Bhatia D, Oermann E, Leibovitz E, Sasaki H, Mori H, Yang I, Sohn JH, Murthy KNK, Fu LC, de Mendonça MRF, Fralick M, Kang MK, Adil M, Gangai N, Vateekul P, Elnajjar P, Hickman S, Majumdar S, McLeod S, Reed S, Graf S, Harmon S, Kodama T, Puthanakit T, Mazzulli T, Lavor VL, Rakvongthai Y, Lee YR, Wen Y. Federated Learning used for predicting outcomes in SARS-COV-2 patients. Res Sq. 2021 Jan 08.  View on PubMed
  20. Tibrewala R, Pedoia V, Lee J, Kinnunen C, Popovic T, Zhang AL, Link TM, Souza RB, Majumdar S. Automatic hip abductor muscle fat fraction estimation and association with early OA cartilage degeneration biomarkers. J Orthop Res. 2020 Dec 25.  View on PubMed

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