Research Summary

Pratik Mukherjee, MD, PhD, is a Professor in Residence in the Department Radiology and Biomedical Imaging, Bioengineering, and he is an attending neuroradiologist at the University of California, San Francisco. He is the Director of the Center for Imaging of Neurodegenerative Disease (CIND) based at the San Francisco VA Medical Center. He also directs the Neural Connectivity Laboratory (NCL) at UCSF China Basin.

Dr. Mukherjee received his PhD in Neuroscience from Rockefeller University, New York in 1994 and his MD from Cornell University, New York, in 1995. He completed his internship in Internal Medicine at New York Hospital - Cornell Medical Center, followed by a residency in Radiology and fellowship in Neuroradiology at Washington University Medical Center in St. Louis, Missouri, completed in 2002.

Dr. Mukherjee's primary clinical research is the study of neurodevelopmental disorders and traumatic brain injury (TBI) using advanced MRI. His research has been focused on technical development, neuroscience and clinical applications of advanced imaging methods for mapping structure and function of the human brain, especially diffusion MRI, which is a popular technique for assessing the development and integrity of white matter and for mapping axonal fiber pathways.

Dr. Mukherjee has served as Principal Investigator or Co-Principal Investigator for several NIH grants. His work has also been funded by grants from the Dept. of Defense, the Simons Foundation, McDonnell Foundation, Dana Foundation, Wallace Research Foundation, GE Healthcare and the GE-NFL Head Health Initiative. He has published over 150 peer-reviewed papers.

Research Funding

  • July 8, 2019 - April 30, 2024 - Neural Mechanisms of Sensory OverResponsivity , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01MH116950
  • September 30, 2017 - July 31, 2022 - MRI CORTICOGRAPHY: DEVELOPING NEXT GENERATION MICROSCALE HUMAN CORTEX MRI SCANNER , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01EB025162
  • October 1, 2020 - September 30, 2021 - ShEEP-IC: Request to purchase MAGNETOM Skyra 3T complete concurrent field monitoring and motion correction system upgrade , Principal Investigator . Sponsor: NIH, Sponsor Award ID: IS1BX005513
  • February 1, 2017 - September 30, 2021 - Multi-level assessment and rehabilitation of combat mild traumatic brain injury , Principal Investigator . Sponsor: NIH, Sponsor Award ID: I01RX002300

Education

Yale University, New Haven, CT, B.A., 1988, Computer Science & Psychology
Rockefeller Univ., New York, NY, Ph.D., 1994, Neuroscience
Cornell University, New York, NY, M.D., 1995, Medicine

Honors & Awards

  • 1988-95
    Medical Scientist Training Program Grant, National Institutes of Health
  • 1994
    S. Koide Memorial Fellowship, Rockefeller University
  • 1999
    Roentgen Resident/Fellow Research Award, Radiological Society of North America
  • 2001
    Berlex/ASNR Award in Basic Science Research, American Society of Neuroradiology

Selected Publications

  1. Yue JK, Krishnan N, Kanter JH, Deng H, Okonkwo DO, Puccio AM, Madhok DY, Belton PJ, Lindquist BE, Satris GG, Lee YM, Umbach G, Duhaime AC, Mukherjee P, Yuh EL, Valadka AB, DiGiorgio AM, Tarapore PE, Huang MC, Manley GT, Investigators TT. Neuroworsening in the Emergency Department Is a Predictor of Traumatic Brain Injury Intervention and Outcome: A TRACK-TBI Pilot Study. J Clin Med. 2023 Mar 03; 12(5).  View on PubMed
  2. Mukherjee P, Palacios EM, Manley GT. Response to the Letter to the Editor by Dr. Michael Hutchinson re: NEU-2021-0408.R1. J Neurotrauma. 2023 Feb 28.  View on PubMed
  3. Stein MB, Jain S, Parodi L, Choi KW, Maihofer AX, Nelson LD, Mukherjee P, Sun X, He F, Okonkwo DO, Giacino JT, Korley FK, Vassar MJ, Robertson CS, McCrea MA, Temkin N, Markowitz AJ, Diaz-Arrastia R, Rosand J, Manley GT, TRACK-TBI Investigators. Polygenic risk for mental disorders as predictors of posttraumatic stress disorder after mild traumatic brain injury. Transl Psychiatry. 2023 Jan 25; 13(1):24.  View on PubMed
  4. Kulbe JR, Jain S, Nelson LD, Korley FK, Mukherjee P, Sun X, Okonkwo DO, Giacino JT, Vassar MJ, Robertson CS, McCrea MA, Wang KKW, Temkin N, Mac Donald CL, Taylor SR, Ferguson AR, Markowitz AJ, Diaz-Arrastia R, Manley GT, Stein MB, TRACK-TBI Investigators. Correction to: Association of day-of-injury plasma glial fibrillary acidic protein concentration and six-month posttraumatic stress disorder in patients with mild traumatic brain injury. Neuropsychopharmacology. 2022 Dec; 47(13):2332.  View on PubMed
  5. Gardner RC, Puccio AM, Korley FK, Wang KKW, Diaz-Arrastia R, Okonkwo DO, Puffer RC, Yuh EL, Yue JK, Sun X, Taylor SR, Mukherjee P, Jain S, Manley GT, TRACK-TBI Investigators . Effects of age and time since injury on traumatic brain injury blood biomarkers: a TRACK-TBI study. Brain Commun. 2023; 5(1):fcac316.  View on PubMed
  6. Lazerwitz MC, Rowe MA, Trimarchi KJ, Garcia RD, Chu R, Steele MC, Parekh S, Wren-Jarvis J, Bourla I, Mark I, Marco EJ, Mukherjee P. Brief Report: Characterization of Sensory Over-Responsivity in a Broad Neurodevelopmental Concern Cohort Using the Sensory Processing Three Dimensions (SP3D) Assessment. J Autism Dev Disord. 2022 Sep 30.  View on PubMed
  7. Maas AIR, Menon DK, Manley GT, Abrams M, ?kerlund C, Andelic N, Aries M, Bashford T, Bell MJ, Bodien YG, Brett BL, B?ki A, Chesnut RM, Citerio G, Clark D, Clasby B, Cooper DJ, Czeiter E, Czosnyka M, Dams-O'Connor K, De Keyser V, Diaz-Arrastia R, Ercole A, van Essen TA, Falvey ?, Ferguson AR, Figaji A, Fitzgerald M, Foreman B, Gantner D, Gao G, Giacino J, Gravesteijn B, Guiza F, Gupta D, Gurnell M, Haagsma JA, Hammond FM, Hawryluk G, Hutchinson P, van der Jagt M, Jain S, Jain S, Jiang JY, Kent H, Kolias A, Kompanje EJO, Lecky F, Lingsma HF, Maegele M, Majdan M, Markowitz A, McCrea M, Meyfroidt G, Mikolic A, Mondello S, Mukherjee P, Nelson D, Nelson LD, Newcombe V, Okonkwo D, Ore?ic M, Peul W, Pisica D, Polinder S, Ponsford J, Puybasset L, Raj R, Robba C, R?e C, Rosand J, Schueler P, Sharp DJ, Smielewski P, Stein MB, von Steinb?chel N, Stewart W, Steyerberg EW, Stocchetti N, Temkin N, Tenovuo O, Theadom A, Thomas I, Espin AT, Turgeon AF, Unterberg A, Van Praag D, van Veen E, Verheyden J, Vyvere TV, Wang KKW, Wiegers EJA, Williams WH, Wilson L, Wisniewski SR, Younsi A, Yue JK, Yuh EL, Zeiler FA, Zeldovich M, Zemek R, InTBIR Participants and Investigators. Traumatic brain injury: progress and challenges in prevention, clinical care, and research. Lancet Neurol. 2022 11; 21(11):1004-1060.  View on PubMed
  8. Cai LT, Brett BL, Palacios EM, Yuh EL, Bourla I, Wren-Jarvis J, Wang Y, Mac Donald C, Diaz-Arrastia R, Giacino JT, Okonkwo DO, Levin HS, Robertson CS, Temkin N, Markowitz AJ, Manley GT, Stein MB, McCrea MA, Zafonte RD, Nelson LD, Mukherjee P, TRACK-TBI Investigators. Emotional Resilience Predicts Preserved White Matter Microstructure Following Mild Traumatic Brain Injury. Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Sep 21.  View on PubMed
  9. Weber CF, Lake EMR, Haider SP, Mozayan A, Mukherjee P, Scheinost D, Bamford NS, Ment L, Constable T, Payabvash S. Age-dependent white matter microstructural disintegrity in autism spectrum disorder. Front Neurosci. 2022; 16:957018.  View on PubMed
  10. Korley FK, Jain S, Sun X, Puccio AM, Yue JK, Gardner RC, Wang KKW, Okonkwo DO, Yuh EL, Mukherjee P, Nelson LD, Taylor SR, Markowitz AJ, Diaz-Arrastia R, Manley GT, TRACK-TBI Study Investigators. Prognostic value of day-of-injury plasma GFAP and UCH-L1 concentrations for predicting functional recovery after traumatic brain injury in patients from the US TRACK-TBI cohort: an observational cohort study. Lancet Neurol. 2022 09; 21(9):803-813.  View on PubMed
  11. Palacios EM, Yuh EL, Mac Donald CL, Bourla I, Wren-Jarvis J, Sun X, Vassar MJ, Diaz-Arrastia R, Giacino JT, Okonkwo DO, Robertson CS, Stein MB, Temkin N, McCrea MA, Levin HS, Markowitz AJ, Jain S, Manley GT, Mukherjee P, TRACK-TBI Investigators. Diffusion Tensor Imaging Reveals Elevated Diffusivity of White Matter Microstructure that Is Independently Associated with Long-Term Outcome after Mild Traumatic Brain Injury: A TRACK-TBI Study. J Neurotrauma. 2022 Oct; 39(19-20):1318-1328.  View on PubMed
  12. Kulbe JR, Jain S, Nelson LD, Korley FK, Mukherjee P, Sun X, Okonkwo DO, Giacino JT, Vassar MJ, Robertson CS, McCrea MA, Wang KKW, Temkin N, Mac Donald CL, Taylor SR, Ferguson AR, Markowitz AJ, Diaz-Arrastia R, Manley GT, Stein MB, TRACK-TBI Investigators. Association of day-of-injury plasma glial fibrillary acidic protein concentration and six-month posttraumatic stress disorder in patients with mild traumatic brain injury. Neuropsychopharmacology. 2022 12; 47(13):2300-2308.  View on PubMed
  13. Moon JY, Mukherjee P, Madduri RK, Markowitz AJ, Cai LT, Palacios EM, Manley GT, Bremer PT. The Case for Optimized Edge-Centric Tractography at Scale. Front Neuroinform. 2022; 16:752471.  View on PubMed
  14. John K. Yue, Ryan R. L. Phelps, Debra P. Hemmerle, Pavan S. Upadhyayula, Ethan A. Winkler, Hansen Deng, Diana Chang, Mary Vassar, Sabrina Taylor, David Schnyer, Hester F. Lingsma, Ava Puccio, Esther Yuh, Pratik Mukherjee, Michael C. Huang, Laura B. Ngwenya, Alex B. Valadka, Amy Markowitz, David O. Okonkwo, Geoffrey T. Manley. 182 Predictors of Six-Month Inability to Return to Work in Previously Employed Subjects After Mild Traumatic Brain Injury: A TRACK-TBI Pilot Study. Neurosurgery. 2022 Mar 1; 68(Supplement_1):54-54.  View on PubMed
  15. Good T, Schirner M, Shen K, Ritter P, Mukherjee P, Levine B, McIntosh AR. Personalized Connectome-Based Modeling in Patients with Semi-Acute Phase TBI: Relationship to Acute Neuroimaging and 6 Month Follow-Up. eNeuro. 2022 Jan-Feb; 9(1).  View on PubMed
  16. Wickwire EM, Albrecht JS, Capaldi VF, Jain SO, Gardner RC, Werner JK, Mukherjee P, McKeon AB, Smith MT, Giacino JT, Nelson LD, Williams SG, Collen J, Sun X, Schnyer DM, Markowitz AJ, Manley GT, Krystal AD, Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators. Trajectories of Insomnia in Adults After Traumatic Brain Injury. JAMA Netw Open. 2022 01 04; 5(1):e2145310.  View on PubMed
  17. Burke J, Gugger J, Ding K, Kim JA, Foreman B, Yue JK, Puccio AM, Yuh EL, Sun X, Rabinowitz M, Vassar MJ, Taylor SR, Winkler EA, Deng H, McCrea M, Stein MB, Robertson CS, Levin HS, Dikmen S, Temkin NR, Barber J, Giacino JT, Mukherjee P, Wang KKW, Okonkwo DO, Markowitz AJ, Jain S, Lowenstein D, Manley GT, Diaz-Arrastia R, TRACK-TBI Investigators, Badjatia N, Duhaime AC, Feeser VR, Gaudette E, Gopinath S, Keene CD, Korley FK, Madden C, Merchant R, Schnyer D, Zafonte R. Association of Posttraumatic Epilepsy With 1-Year Outcomes After Traumatic Brain Injury. JAMA Netw Open. 2021 12 01; 4(12):e2140191.  View on PubMed
  18. Williams JR, Nieblas-Bedolla E, Feroze A, Young C, Temkin NR, Giacino JT, Okonkwo DO, Manley GT, Barber J, Durfy S, Markowitz AJ, Yuh EL, Mukherjee P, Mac Donald CL, Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators. Correction to: Prognostic Value of Hemorrhagic Brainstem Injury on Early Computed Tomography: A TRACK-TBI Study. Neurocrit Care. 2021 Dec; 35(3):927.  View on PubMed
  19. Rincon SP, Mukherjee P, Levin HS, Temkin NR, Mac Donald CL, Krainak DM, Sun X, Jain S, Taylor SR, Markowitz AJ, Kumar A, Manley GT, Yuh EL, TRACK-TBI Investigators. Interrater Reliability of National Institutes of Health Traumatic Brain Injury Imaging Common Data Elements for Brain Magnetic Resonance Imaging in Mild Traumatic Brain Injury. J Neurotrauma. 2021 10 15; 38(20):2831-2840.  View on PubMed
  20. Lanya T. Cai, Maria Baida, Jamie Wren-Jarvis, Ioanna Bourla, Pratik Mukherjee. Diffusion MRI Automated Region of Interest Analysis in Standard Atlas Space versus the Individual’s Native Space. . 2021 Sep 25; 13006:109-120.  View on PubMed

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