Research Summary

I received the MD, PhD combined degree from Boston University and Urology residency training at UC Davis. I was recruited to join the UCSF faculty as Assistant Professor after completed the fellowship and trained as a urologic oncology surgeon under Dr. Peter Carroll. My research project has already shown incredible potential to uncover novel molecular therapeutic targets for the treatment of advanced prostate cancer. As a promising young surgeon-scientist, I was awarded the Department of Defense grant to interrogate the distinct ability of cancer cells to upregulate their stress response pathways upon oncogenic stress, chemotherapy and radiotherapy in order to evade cell death. I delineated the mechanisms underlying stress response pathways, in particular the unfolded protein response (UPR) and define their role in prostate tumorigenesis using genetic mouse models as well as in patient derived xenografts model of metastatic prostate cancer. My main research program was recently published in a high impact publication in Science Translational Medicine and resulted in a patent on the use of biomarker PTEN loss and high phospho eIF2α to identify lethal prostate cancer who may benefit from anti-eIF2α therapy. In 2016, I received the PCF young investigator award and the AUA Rising Star in Research award to develop patient derived xenograft (PDX) models to evaluate novel therapies for patients with neuroendocrine metastatic prostate cancer. In 2020, I received the 1 million-dollar PCF Challenge Grant to bring novel therapeutics for metastatic prostate cancer. I had published more than 50 journal articles and 4 book chapters. In addition to basic science, my clinical interest focuses on early detection of prostate cancer using advance imaging (PSMA PET/SPECT), novel biomarkers and MRI fusion biopsy in early diagnosis and treatment of prostate cancer. In 2019, I was appointed Benioff-Goldberg Endowed Professorship in Cancer Biology and the recipient of the William R. Smart M.D Distinguished Teaching Award.

Education

University of California, Berkeley, BA, 06/1999, Molecular Cell Biology/Cell and Developmental Biology (Graduated with Honor)
Boston University School of Medicine, MD, PhD, 06/2007
University of California, Davis, 06/2013, Residency in General Surgery, Residency in Urologic Surgery
University of California, San Francisco, 06/2015, Society of Urologic Oncology Fellowship

Honors & Awards

  • 2011
    International Volunteer in Urology (IVU) resident scholar
  • 2011
    Third Place in Clinical Research Competition at 37th annual Northern California Urology Resident Seminar
  • 2013
    First Place in Basic Science Research Competition at 39th annual Northern California Urology Resident Seminar
  • 2016
    Prostate Cancer Foundation Young Investigator Award 2016
  • 2017
    AUA Rising Stars in Urology Research Awards
  • 2018
    The Cancer League Young Investigator
  • 2019
    University of California, Davis Department of Urology Visiting Professorship
  • 2019
    Keynote Speaker Boston University School of Medicine MD-PhD program 2019 retreat
  • 2019
    Goldberg-Benioff Endowed Professorship in Cancer Biology
  • 2019
    William R. Smart M.D Distinguished Teaching Award

Selected Publications

  1. Lonergan PE, Cowan JE, Washington SL, Greenberg SA, Nguyen HG, Carroll PR. Natural history of an immediately detectable PSA following radical prostatectomy in a contemporary cohort. Prostate. 2021 Sep; 81(13):1009-1017.  View on PubMed
  2. de la Calle CM, Shee K, Chu CE, Cowan JE, Nguyen HG, Carroll PR. Association of Age With Risk of Adverse Pathological Findings in Men Undergoing Delayed Radical Prostatectomy Following Active Surveillance. Urology. 2021 Sep; 155:91-95.  View on PubMed
  3. Greenberg SA, Washington SL, Lonergan PE, Cowan JE, Baskin AS, Nguyen HG, Odisho AY, Simko JP, Carroll PR. Residual Benign Prostate Glandular Tissue after Radical Prostatectomy is Not Associated with the Development of Detectable Postoperative Serum Prostate Specific Antigen. J Urol. 2021 09; 206(3):706-714.  View on PubMed
  4. Maggi M, Cowan JE, Fasulo V, Washington SL, Lonergan PE, Sciarra A, Nguyen HG, Carroll PR. The Long-Term Risks of Metastases in Men on Active Surveillance for Early Stage Prostate Cancer. J Urol. 2020 12; 204(6):1222-1228.  View on PubMed
  5. Washington SL, Cowan JE, Herlemann A, Zuniga KB, Masic S, Nguyen HG, Carroll PR. Influence of pelvic lymph node dissection and node-positive disease on biochemical recurrence, secondary treatment, and survival after radical prostatectomy in men with prostate cancer. Prostate. 2021 02; 81(2):102-108.  View on PubMed
  6. Fasulo V, Cowan JE, Maggi M, Washington SL, Nguyen HG, Shinohara K, Lazzeri M, Casale P, Carroll PR. Characteristics of Cancer Progression on Serial Biopsy in Men on Active Surveillance for Early-stage Prostate Cancer: Implications for Focal Therapy. Eur Urol Oncol. 2020 Oct 14.  View on PubMed
  7. Lonergan PE, Washington SL, Cowan JE, Zhao S, Nguyen HG, Shinohara K, Cooperberg MR, Carroll PR. Reply by Authors. J Urol. 2020 12; 204(6):1221.  View on PubMed
  8. de la Calle CM, Fasulo V, Cowan JE, Lonergan PE, Maggi M, Gadzinski AJ, Yeung RA, Saita A, Cooperberg MR, Shinohara K, Carroll PR, Nguyen HG. Clinical Utility of 4Kscore®, ExosomeDx™ and Magnetic Resonance Imaging for the Early Detection of High Grade Prostate Cancer. J Urol. 2021 02; 205(2):452-460.  View on PubMed
  9. Herlemann A, Overland MR, Washington SL, Cowan JE, Westphalen AC, Carroll PR, Nguyen HG, Shinohara K, Cooperberg MR. How Often Does Magnetic Resonance Imaging Detect Prostate Cancer Missed by Transrectal Ultrasound? Eur Urol Focus. 2020 Aug 28.  View on PubMed
  10. Melnyk JE, Steri V, Nguyen HG, Hann B, Feng FY, Shokat KM. The splicing modulator sulfonamide indisulam reduces AR-V7 in prostate cancer cells. Bioorg Med Chem. 2020 10 15; 28(20):115712.  View on PubMed
  11. Lonergan PE, Washington SL, Cowan JE, Zhao S, Nguyen HG, Shinohara K, Cooperberg MR, Carroll PR. Risk Factors for Biopsy Reclassification over Time in Men on Active Surveillance for Early Stage Prostate Cancer. J Urol. 2020 12; 204(6):1216-1221.  View on PubMed
  12. Washington SL, Baskin AS, Ameli N, Nguyen HG, Westphalen AC, Shinohara K, Carroll PR. MRI-Based Prostate-Specific Antigen Density Predicts Gleason Score Upgrade in an Active Surveillance Cohort. AJR Am J Roentgenol. 2020 03; 214(3):574-578.  View on PubMed
  13. Baghdanian AA, Kim YJ, Baghdanian AH, Nguyen HN, Shinohara K, Westphalen AC. Differences in negative predictive value of prostate MRI based in men with suspected or known cancer. Radiol Bras. 2019 Sep-Oct; 52(5):281-286.  View on PubMed
  14. Balakrishnan AS, Cowan JE, Cooperberg MR, Shinohara K, Nguyen HG, Carroll PR. Evaluating the Safety of Active Surveillance: Outcomes of Deferred Radical Prostatectomy after an Initial Period of Surveillance. J Urol. 2019 09; 202(3):506-510.  View on PubMed
  15. Westphalen AC, Fazel F, Nguyen H, Cabarrus M, Hanley-Knutson K, Shinohara K, Carroll PR. Detection of clinically signifi cant prostate cancer with PIRADS v2 scores, PSA density, and ADC values in regions with and without mpMRI visible lesions. Int Braz J Urol. 2019 Jul-Aug; 45(4):713-723.  View on PubMed
  16. Kelley RP, Zagoria RJ, Nguyen HG, Shinohara K, Westphalen AC. The use of prostate MR for targeting prostate biopsies. BJR Open. 2019; 1(1):20180044.  View on PubMed
  17. Balakrishnan AS, Nguyen HG, Shinohara K, Au Yeung R, Carroll PR, Odisho AY. A Mobile Health Intervention for Prostate Biopsy Patients Reduces Appointment Cancellations: Cohort Study. J Med Internet Res. 2019 06 02; 21(6):e14094.  View on PubMed
  18. Fendler WP, Calais J, Eiber M, Flavell RR, Mishoe A, Feng FY, Nguyen HG, Reiter RE, Rettig MB, Okamoto S, Emmett L, Zacho HD, Ilhan H, Wetter A, Rischpler C, Schoder H, Burger IA, Gartmann J, Smith R, Small EJ, Slavik R, Carroll PR, Herrmann K, Czernin J, Hope TA. Assessment of 68Ga-PSMA-11 PET Accuracy in Localizing Recurrent Prostate Cancer: A Prospective Single-Arm Clinical Trial. JAMA Oncol. 2019 Jun 01; 5(6):856-863.  View on PubMed
  19. Bancroft Brown J, Sriram R, VanCriekinge M, Delos Santos R, Sun J, Delos Santos J, Tabatabai ZL, Shinohara K, Nguyen H, Peehl DM, Kurhanewicz J. NMR quantification of lactate production and efflux and glutamate fractional enrichment in living human prostate biopsies cultured with [1,6-13 C2 ]glucose. Magn Reson Med. 2019 08; 82(2):566-576.  View on PubMed
  20. Boreta L, Gadzinski AJ, Wu SY, Xu M, Greene K, Quanstrom K, Nguyen HG, Carroll PR, Hope TA, Feng FY. Location of Recurrence by Gallium-68 PSMA-11 PET Scan in Prostate Cancer Patients Eligible for Salvage Radiotherapy. Urology. 2019 07; 129:165-171.  View on PubMed

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