Hao G. Nguyen, MD, PhD
Richard and Leilani Grinold Endowed Professorship in Urology, UCSF
Associate Professor, Dept. of Urology, UCSF
I received the MD, PhD combined degree from Boston University and Urology residency training at UC Davis. I was recruited to join the UCSF faculty as Assistant Professor after completed the fellowship and trained as a urologic oncology surgeon under Dr. Peter Carroll. My research project has already shown incredible potential to uncover novel molecular therapeutic targets for the treatment of advanced prostate cancer. As a promising young surgeon-scientist, I was awarded the Department of Defense grant to interrogate the distinct ability of cancer cells to upregulate their stress response pathways upon oncogenic stress, chemotherapy and radiotherapy in order to evade cell death. I delineated the mechanisms underlying stress response pathways, in particular the unfolded protein response (UPR) and define their role in prostate tumorigenesis using genetic mouse models as well as in patient derived xenografts model of metastatic prostate cancer. My main research program was recently published in a high impact publication in Science Translational Medicine and resulted in a patent on the use of biomarker PTEN loss and high phospho eIF2α to identify lethal prostate cancer who may benefit from anti-eIF2α therapy. In 2016, I received the PCF young investigator award and the AUA Rising Star in Research award to develop patient derived xenograft (PDX) models to evaluate novel therapies for patients with neuroendocrine metastatic prostate cancer. In 2020, I received the 1 million-dollar PCF Challenge Grant to bring novel therapeutics for metastatic prostate cancer. I had published more than 50 journal articles and 4 book chapters. In addition to basic science, my clinical interest focuses on early detection of prostate cancer using advance imaging (PSMA PET/SPECT), novel biomarkers and MRI fusion biopsy in early diagnosis and treatment of prostate cancer. In 2019, I was appointed Benioff-Goldberg Endowed Professorship in Cancer Biology and the recipient of the William R. Smart M.D Distinguished Teaching Award.
University of California, Berkeley, BA, 06/1999, Molecular Cell Biology/Cell and Developmental Biology (Graduated with Honor)
Boston University School of Medicine, MD, PhD, 06/2007
University of California, Davis, 06/2013, Residency in General Surgery, Residency in Urologic Surgery
University of California, San Francisco, 06/2015, Society of Urologic Oncology Fellowship