Research Funding

  • July 4, 2016 - May 31, 2024 - Structural mechanism of integrin-mediated TGF-b activation , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL134183
  • April 1, 2012 - March 31, 2017 - Role of genetic variation in TGF-beta overactivation in COPD , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL113032
  • July 1, 2002 - March 31, 2014 - Integrative Study of Brain Vascular Malformations , Co-Investigator . Sponsor: NIH/NINDS, Sponsor Award ID: P01NS044155
  • December 1, 1999 - March 31, 2013 - Integrin alphavbeta8 Inhibits Airway Epithelial Cell Growth , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HL063993

Education

Wesleyan University, Middletown, CT, B.A., 1981, Chemistry
University of Vermont College of Medicine, M.D., 1988, Medicine
University of California, San Francisco, Resident, 1988-1991, Anatomic and Clinical Pathology
University of California, San Francisco, Fellow, 1991-1995, Molecular Biology

Honors & Awards

  • 1991
    Research Fellowship, Department of Pathology
  • 1992-93
    College of American Pathologists Foundation Scholar
  • 1993-5
    National Research Service Award (CA09335)
  • 1995-00
    Clinical Investigator Award (KO8 CA63148)
  • 1998
    ACS Institutional Award
  • 1998-00
    American Lung Association, Research Grant
  • 1998
    Edward Livingston Trudeau Scholar
  • 1998
    American Lung Association
  • 1999-01
    American Heart Association, Grant in Aid
  • 2000
    UCSF Academic Senate Award
  • 2000
    UCSF, Research Allocation Committee Award
  • 2001
    Hellman Family Award for Early-Career Faculty

Selected Publications

  1. Bhattacharyya A, Torre P, Yadav P, Boostanpour K, Chen TY, Tsukui T, Sheppard D, Muramatsu R, Seed RI, Nishimura SL, Jung JB, Tang XZ, Allen CDC, Bhattacharya M. Macrophage Cx43 Is Necessary for Fibroblast Cytosolic Calcium and Lung Fibrosis After Injury. Front Immunol. 2022; 13:880887.  View on PubMed
  2. Seed RI, Nishimura SL. Measurement of Cell Intrinsic TGF-β Activation Mediated by the Integrin αvβ8. Bio Protoc. 2022 Apr 20; 12(8):e4385.  View on PubMed
  3. Zhang K, Yao E, Chen B, Chuang E, Wong J, Seed RI, Nishimura SL, Wolters PJ, Chuang PT. Acquisition of cellular properties during alveolar formation requires differential activity and distribution of mitochondria. Elife. 2022 Apr 06; 11.  View on PubMed
  4. Chen JV, Ohliger MA, Chung M, Sugi MD, Ye J, Nishimura SL, Choi HH. Diagnosis of acute mesenteric ischemia assisted by dual-energy CT: a case report. Emerg Radiol. 2022 Jun; 29(3):611-614.  View on PubMed
  5. Nguyen BA, Ho J, De La Cruz Diaz JS, Nishimura S, Kaplan DH. TGFβ activating integrins β6 and β8 are dysregulated in inflammatory skin disease and cutaneous melanoma. J Dermatol Sci. 2022 Apr; 106(1):2-11.  View on PubMed
  6. Ji DX, Witt KC, Kotov DI, Margolis SR, Louie A, Chevée V, Chen KJ, Gaidt MM, Dhaliwal HS, Lee AY, Nishimura SL, Zamboni DS, Kramnik I, Portnoy DA, Darwin KH, Vance RE. Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons. Elife. 2021 06 21; 10.  View on PubMed
  7. Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL. A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8. Sci Immunol. 2021 03 26; 6(57).  View on PubMed
  8. Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I. Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function. Circulation. 2021 03 02; 143(9):935-948.  View on PubMed
  9. Podolsky MJ, Yang CD, Valenzuela CL, Datta R, Huang SK, Nishimura SL, Dallas SL, Wolters PJ, Le Saux CJ, Atabai K. Age-dependent regulation of cell-mediated collagen turnover. JCI Insight. 2020 05 21; 5(10).  View on PubMed
  10. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL. Cryo-EM Reveals Integrin-Mediated TGF-β Activation without Release from Latent TGF-β. Cell. 2020 02 06; 180(3):490-501.e16.  View on PubMed
  11. Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL. Integrin αvβ8-expressing tumor cells evade host immunity by regulating TGF-β activation in immune cells. JCI Insight. 2018 10 18; 3(20).  View on PubMed
  12. Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Wakui H, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy. 2019 03; 15(3):510-526.  View on PubMed
  13. Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y. Cryo-EM structure of the αvβ8 integrin reveals a mechanism for stabilizing integrin extension. Nat Struct Mol Biol. 2018 08; 25(8):698-704.  View on PubMed
  14. Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL. An OX40/OX40L interaction directs successful immunity to hepatitis B virus. Sci Transl Med. 2018 03 21; 10(433).  View on PubMed
  15. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA. Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice. Am J Physiol Lung Cell Mol Physiol. 2018 07 01; 315(1):L25-L40.  View on PubMed
  16. Stockis J, Liénart S, Colau D, Collignon A, Nishimura SL, Sheppard D, Coulie PG, Lucas S. Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin αVβ8. Proc Natl Acad Sci U S A. 2017 11 21; 114(47):E10161-E10168.  View on PubMed
  17. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA. Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice. Nicotine Tob Res. 2017 Sep 01; 19(9):1033-1039.  View on PubMed
  18. Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, Ito S, Araya J, Budelsky A, Goodsell A, Baron JL, Nishimura SL. Role of IL-17A in murine models of COPD airway disease. Am J Physiol Lung Cell Mol Physiol. 2017 01 01; 312(1):L122-L130.  View on PubMed
  19. Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL, Su H. Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice. Transl Stroke Res. 2016 12; 7(6):488-496.  View on PubMed
  20. Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL. Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man. Hepatology. 2016 Jan; 63(1):260.  View on PubMed

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