Research Funding

  • July 4, 2016 - April 30, 2020 - Structural mechanism of integrin-mediated TGF-b activation, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL134183
  • April 1, 2012 - March 31, 2016 - Role of genetic variation in TGF-beta overactivation in COPD, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL113032
  • July 1, 2002 - March 31, 2014 - Integrative Study of Brain Vascular Malformations, Co-Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: P01NS044155
  • December 1, 1999 - March 31, 2013 - Integrin alphavbeta8 Inhibits Airway Epithelial Cell Growth, Principal Investigator. Sponsor: NIH/NHLBI, Sponsor Award ID: R01HL063993


Wesleyan University, Middletown, CT, B.A., 1981, Chemistry
University of Vermont College of Medicine, M.D., 1988, Medicine
University of California, San Francisco, Resident, 1988-1991, Anatomic and Clinical Pathology
University of California, San Francisco, Fellow, 1991-1995, Molecular Biology

Honors & Awards

  • 1991
    Research Fellowship, Department of Pathology
  • 1992-93
    College of American Pathologists Foundation Scholar
  • 1993-5
    National Research Service Award (CA09335)
  • 1995-00
    Clinical Investigator Award (KO8 CA63148)
  • 1998
    ACS Institutional Award
  • 1998-00
    American Lung Association, Research Grant
  • 1998
    Edward Livingston Trudeau Scholar
  • 1998
    American Lung Association
  • 1999-01
    American Heart Association, Grant in Aid
  • 2000
    UCSF Academic Senate Award
  • 2000
    UCSF, Research Allocation Committee Award
  • 2001
    Hellman Family Award for Early-Career Faculty

Selected Publications

  1. Seed RI, Kobayashi K, Ito S, Takasaka N, Cormier A, Jespersen JM, Publicover J, Trilok S, Combes AJ, Chew NW, Chapman J, Krummel MF, Lou J, Marks J, Cheng Y, Baron JL, Nishimura SL A tumor-specific mechanism of Treg enrichment mediated by the integrin αvβ8.  View on PubMed
  2. Bibli SI, Hu J, Looso M, Weigert A, Ratiu C, Wittig J, Drekolia MK, Tombor L, Randriamboavonjy V, Leisegang MS, Goymann P, Delgado Lagos F, Fisslthaler B, Zukunft S, Kyselova A, Justo AFO, Heidler J, Tsilimigras D, Brandes RP, Dimmeler S, Papapetropoulos A, Knapp S, Offermanns S, Wittig I, Nishimura SL, Sigala F, Fleming I Mapping the Endothelial Cell S-Sulfhydrome Highlights the Crucial Role of Integrin Sulfhydration in Vascular Function.  View on PubMed
  3. Podolsky MJ, Yang CD, Valenzuela CL, Datta R, Huang SK, Nishimura SL, Dallas SL, Wolters PJ, Le Saux CJ, Atabai K Age-dependent regulation of cell-mediated collagen turnover.  View on PubMed
  4. Campbell MG, Cormier A, Ito S, Seed RI, Bondesson AJ, Lou J, Marks JD, Baron JL, Cheng Y, Nishimura SL Cryo-EM Reveals Integrin-Mediated TGF-ß Activation without Release from Latent TGF-ß.  View on PubMed
  5. Takasaka N, Seed RI, Cormier A, Bondesson AJ, Lou J, Elattma A, Ito S, Yanagisawa H, Hashimoto M, Ma R, Levine MD, Publicover J, Potts R, Jespersen JM, Campbell MG, Conrad F, Marks JD, Cheng Y, Baron JL, Nishimura SL Integrin avß8-expressing tumor cells evade host immunity by regulating TGF-ß activation in immune cells.  View on PubMed
  6. Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, Hosaka Y, Ichikawa A, Saito N, Kadota T, Yoshida M, Fujita Y, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Wakui H, Ishikawa T, Numata T, Kaneko Y, Asano H, Yamashita M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis.  View on PubMed
  7. Cormier A, Campbell MG, Ito S, Wu S, Lou J, Marks J, Baron JL, Nishimura SL, Cheng Y Cryo-EM structure of the avß8 integrin reveals a mechanism for stabilizing integrin extension.  View on PubMed
  8. Publicover J, Gaggar A, Jespersen JM, Halac U, Johnson AJ, Goodsell A, Avanesyan L, Nishimura SL, Holdorf M, Mansfield KG, Judge JB, Koshti A, Croft M, Wakil AE, Rosenthal P, Pai E, Cooper S, Baron JL An OX40/OX40L interaction directs successful immunity to hepatitis B virus.  View on PubMed
  9. Gotts JE, Chun L, Abbott J, Fang X, Takasaka N, Nishimura SL, Springer ML, Schick SF, Calfee CS, Matthay MA Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice.  View on PubMed
  10. Stockis J, Liénart S, Colau D, Collignon A, Nishimura SL, Sheppard D, Coulie PG, Lucas S Blocking immunosuppression by human Tregs in vivo with antibodies targeting integrin aVß8.  View on PubMed
  11. Gotts JE, Abbott J, Fang X, Yanagisawa H, Takasaka N, Nishimura SL, Calfee CS, Matthay MA Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.  View on PubMed
  12. Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, Ito S, Araya J, Budelsky A, Goodsell A, Baron JL, Nishimura SL Role of IL-17A in murine models of COPD airway disease.  View on PubMed
  13. Ma L, Shen F, Jun K, Bao C, Kuo R, Young WL, Nishimura SL, Su H Integrin ß8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice.  View on PubMed
  14. Publicover J, Jespersen JM, Johnson AJ, Nishimura SL, Goodsell A, Wakil AE, Rosenthal P, Pai E, Avanesyan L, Cooper S, Baron JL Liver capsule: Age-influenced hepatic immune priming determines HBV infection fate: Implications from mouse to man.  View on PubMed
  15. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL TGF-ß-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.  View on PubMed
  16. Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL Transforming Growth Factor-ß and Interleukin-1ß Signaling Pathways Converge on the Chemokine CCL20 Promoter.  View on PubMed
  17. Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Goodsell A, Ma R, Moermans C, McKnelly KJ, Baron JL, Krummel MF, Nishimura SL A critical role for dendritic cells in the evolution of IL-1ß-mediated murine airway disease.  View on PubMed
  18. Ito S, Araya J, Kurita Y, Kobayashi K, Takasaka N, Yoshida M, Hara H, Minagawa S, Wakui H, Fujii S, Kojima J, Shimizu K, Numata T, Kawaishi M, Odaka M, Morikawa T, Harada T, Nishimura SL, Kaneko Y, Nakayama K, Kuwano K PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis.  View on PubMed
  19. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL Selective targeting of TGF-ß activation to treat fibroinflammatory airway disease.  View on PubMed
  20. Wu TC, Xu K, Banchereau R, Marches F, Yu CI, Martinek J, Anguiano E, Pedroza-Gonzalez A, Snipes GJ, O'Shaughnessy J, Nishimura S, Liu YJ, Pascual V, Banchereau J, Oh S, Palucka K Reprogramming tumor-infiltrating dendritic cells for CD103+ CD8+ mucosal T-cell differentiation and breast cancer rejection.  View on PubMed

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