Research Summary

I am a Professor in the UCSF Departments of Neurological Surgery and Pathology, Director of the UCSF Brain Tumor Research Center Tissue Biorepository and Histology Core, Co-Director of the UCSF Neuropathology BTRC Biomarkers Laboratory, Co-Director of the UCSF Brain Tumor SPORE Biorepository, and Director of the Biospecimen and Biostatistics Core for a UCSF brain tumor-focused Program Project (P01). I received my MD and PhD in Neuroscience from the University of Pennsylvania School of Medicine in 2002, and I have over ten years of experience working in cancer and neuropathology. My research interests focus on studying how factors in the brain tumor microenvironment, including the extracellular matrix and immune cells, influence tumor development and invasion. I am the PI of an NINDS-funded R01 and an NCI-funded U01, and have published over 70 publications related to the development and therapy of brain tumors.

Research Funding

  • April 1, 2019 - March 31, 2024 - Mitigation of preanalytic factors influencing brain tumor protein phosphorylation, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA229345
  • September 30, 2012 - June 30, 2017 - Heparan sulfate proteoglycans as critical regulators of brain cancer malignancy, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R01NS081117
  • August 16, 2012 - June 30, 2017 - Extracellular Sulfatases As Novel Biomarkers For Early Detection of Cancer, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U01CA168878
  • September 26, 2011 - July 31, 2016 - Biophysical and molecular dialogue of glioma cells and the brain microenvironment, Co-Investigator. Sponsor: NIH/NCI, Sponsor Award ID: U54CA163155

Education

Cornell University, Ithaca, NY, BS, 05/1994, Biology/Biochemistry
University of Pennsylvania, Philadelphia, PA, PhD, 05/2001, Neuroscience
University of Pennsylvania, Philadelphia, PA, MD, 05/2002, Medicine
University of Washington, Seattle, WA, Residency, 2002-2004, Anatomic Pathology
University of California SF, San Francisco, CA, Fellow, 2004-2006, Neuropathology

Honors & Awards

  • 2001
    Stuart Mudd Award in Microbiology, University of Pennsylvania School of Medicine
  • 2005
    Moore Award for best paper on clinico-pathologic correlation, annual meeting of American Association of Neuropathologists
  • 2006
    Nominated UCSF School of Medicine Essential Teaching Award
  • 2006
    Young Pathologist Fellowship, American Society for Investigative Pathology, Experimental Biology annual meeting
  • 2006-08
    American Brain Tumor Association: Susan Resnick Fisher/American Brain Tumor Association Fellowship
  • 2008
    Rubinstein Award, best paper on neuro-oncology, annual meeting of American Association of Neuropathologists
  • 2010
    Aspen Cancer Conference Fellow
  • 2012
    Second place, Moore Award, Best paper on clinic-pathological correlation, annual meeting of American Association of Neuropathologists
  • 2013
    Nominated UCSF School of Medicine Essential Core Teaching Award
  • 2015
    Excellence in Teaching Award in medical education from the Haile T. Debas Academy of Medical Educators

Selected Publications

  1. Wade A, Engler JR, Tran VM, Phillips JJ. Measuring Sulfatase Expression and Invasion in Glioblastoma. Methods Mol Biol. 2022; 2303:415-425.  View on PubMed
  2. Cluceru J, Interian Y, Phillips JJ, Molinaro AM, Luks TL, Alcaide-Leon P, Olson MP, Nair D, LaFontaine M, Shai A, Chunduru P, Pedoia V, Villanueva-Meyer JE, Chang SM, Lupo JM. Improving the noninvasive classification of glioma genetic subtype with deep learning and diffusion-weighted imaging. Neuro Oncol. 2021 Oct 15.  View on PubMed
  3. Lucas CG, Mueller S, Reddy A, Taylor JW, Oberheim Bush NA, Clarke JL, Chang SM, Gupta N, Berger MS, Perry A, Phillips JJ, Solomon DA. Diffuse hemispheric glioma, H3 G34-mutant: Genomic landscape of a new tumor entity and prospects for targeted therapy. Neuro Oncol. 2021 Sep 14.  View on PubMed
  4. Wang L, Shamardani K, Babikir H, Catalan F, Nejo T, Chang S, Phillips JJ, Okada H, Diaz AA. The evolution of alternative splicing in glioblastoma under therapy. Genome Biol. 2021 01 26; 22(1):48.  View on PubMed
  5. Viswanath P, Batsios G, Mukherjee J, Gillespie AM, Larson PEZ, Luchman HA, Phillips JJ, Costello JF, Pieper RO, Ronen SM. Non-invasive assessment of telomere maintenance mechanisms in brain tumors. Nat Commun. 2021 01 04; 12(1):92.  View on PubMed
  6. Kalita M, Villanueva-Meyer J, Ohkawa Y, Kalyanaraman C, Chen K, Mohamed E, Parker MFL, Jacobson MP, Phillips JJ, Evans MJ, Wilson DM. Synthesis and Screening of α-Xylosides in Human Glioblastoma Cells. Mol Pharm. 2021 01 04; 18(1):451-460.  View on PubMed
  7. Yang YW, Phillips JJ, Jablons DM, Lemjabbar-Alaoui H. Development of novel monoclonal antibodies and immunoassays for sensitive and specific detection of SULF1 endosulfatase. Biochim Biophys Acta Gen Subj. 2021 02; 1865(2):129802.  View on PubMed
  8. Mathur R, Zhang Y, Grimmer MR, Hong C, Zhang M, Bollam S, Petrecca K, Clarke J, Berger MS, Phillips JJ, Oberheim-Bush NA, Molinaro AM, Chang SM, Costello JF. MGMT promoter methylation level in newly diagnosed low-grade glioma is a predictor of hypermutation at recurrence. Neuro Oncol. 2020 11 26; 22(11):1580-1590.  View on PubMed
  9. Schulte JD, Buerki RA, Lapointe S, Molinaro AM, Zhang Y, Villanueva-Meyer JE, Perry A, Phillips JJ, Tihan T, Bollen AW, Pekmezci M, Butowski N, Oberheim Bush NA, Taylor JW, Chang SM, Theodosopoulos P, Aghi MK, Hervey-Jumper SL, Berger MS, Solomon DA, Clarke JL. Clinical, radiologic, and genetic characteristics of histone H3 K27M-mutant diffuse midline gliomas in adults. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa142.  View on PubMed
  10. Cluceru J, Nelson SJ, Wen Q, Phillips JJ, Shai A, Molinaro AM, Alcaide-Leon P, Olson MP, Nair D, LaFontaine M, Chunduru P, Villanueva-Meyer JE, Cha S, Chang SM, Berger MS, Lupo JM. Recurrent tumor and treatment-induced effects have different MR signatures in contrast enhancing and non-enhancing lesions of high-grade gliomas. Neuro Oncol. 2020 10 14; 22(10):1516-1526.  View on PubMed
  11. Ohkawa Y, Wade A, Lindberg OR, Chen KY, Tran VM, Brown SJ, Kumar A, Kalita M, James CD, Phillips JJ. Heparan Sulfate Synthesized by Ext1 Regulates Receptor Tyrosine Kinase Signaling and Promotes Resistance to EGFR Inhibitors in GBM. Mol Cancer Res. 2021 01; 19(1):150-161.  View on PubMed
  12. Lucas CG, Gupta R, Doo P, Lee JC, Cadwell CR, Ramani B, Hofmann JW, Sloan EA, Kleinschmidt-DeMasters BK, Lee HS, Wood MD, Grafe M, Born D, Vogel H, Salamat S, Puccetti D, Scharnhorst D, Samuel D, Cooney T, Cham E, Jin LW, Khatib Z, Maher O, Chamyan G, Brathwaite C, Bannykh S, Mueller S, Kline CN, Banerjee A, Reddy A, Taylor JW, Clarke JL, Oberheim Bush NA, Butowski N, Gupta N, Auguste KI, Sun PP, Roland JL, Raffel C, Aghi MK, Theodosopoulos P, Chang E, Hervey-Jumper S, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Chang S, Berger MS, Perry A, Solomon DA. Comprehensive analysis of diverse low-grade neuroepithelial tumors with FGFR1 alterations reveals a distinct molecular signature of rosette-forming glioneuronal tumor. Acta Neuropathol Commun. 2020 08 28; 8(1):151.  View on PubMed
  13. Jones LE, Hilz S, Grimmer MR, Mazor T, Najac C, Mukherjee J, McKinney A, Chow T, Pieper RO, Ronen SM, Chang SM, Phillips JJ, Costello JF. Patient-derived cells from recurrent tumors that model the evolution of IDH-mutant glioma. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa088.  View on PubMed
  14. Mondal G, Lee JC, Ravindranathan A, Villanueva-Meyer JE, Tran QT, Allen SJ, Barreto J, Gupta R, Doo P, Van Ziffle J, Onodera C, Devine P, Grenert JP, Samuel D, Li R, Metrock LK, Jin LW, Antony R, Alashari M, Cheshier S, Whipple NS, Bruggers C, Raffel C, Gupta N, Kline CN, Reddy A, Banerjee A, Hall MD, Mehta MP, Khatib Z, Maher OM, Brathwaite C, Pekmezci M, Phillips JJ, Bollen AW, Tihan T, Lucas JT, Broniscer A, Berger MS, Perry A, Orr BA, Solomon DA. Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition. Acta Neuropathol. 2020 06; 139(6):1071-1088.  View on PubMed
  15. Molinaro AM, Hervey-Jumper S, Morshed RA, Young J, Han SJ, Chunduru P, Zhang Y, Phillips JJ, Shai A, Lafontaine M, Crane J, Chandra A, Flanigan P, Jahangiri A, Cioffi G, Ostrom Q, Anderson JE, Badve C, Barnholtz-Sloan J, Sloan AE, Erickson BJ, Decker PA, Kosel ML, LaChance D, Eckel-Passow J, Jenkins R, Villanueva-Meyer J, Rice T, Wrensch M, Wiencke JK, Oberheim Bush NA, Taylor J, Butowski N, Prados M, Clarke J, Chang S, Chang E, Aghi M, Theodosopoulos P, McDermott M, Berger MS. Association of Maximal Extent of Resection of Contrast-Enhanced and Non-Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma. JAMA Oncol. 2020 04 01; 6(4):495-503.  View on PubMed
  16. Sloan EA, Hilz S, Gupta R, Cadwell C, Ramani B, Hofmann J, Kline CN, Banerjee A, Reddy A, Oberheim Bush NA, Chang S, Braunstein S, Chang EF, Raffel C, Gupta N, Sun PP, Kim JYH, Moes G, Alva E, Li R, Bruggers CS, Alashari M, Wetmore C, Garg S, Dishop M, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Phillips JJ, Pekmezci M, Tihan T, Bollen AW, Berger MS, Costello JF, Perry A, Solomon DA. Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features. Acta Neuropathol. 2020 05; 139(5):953-957.  View on PubMed
  17. Pekmezci M, Phillips JJ, Dirilenoglu F, Atasever-Rezanko T, Tihan T, Solomon D, Bollen A, Perry A. Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker. Acta Neuropathol. 2020 03; 139(3):597-600.  View on PubMed
  18. Wong RA, Luo X, Lu M, An Z, Haas-Kogan DA, Phillips JJ, Shokat KM, Weiss WA, Fan QW. Cooperative Blockade of PKCα and JAK2 Drives Apoptosis in Glioblastoma. Cancer Res. 2020 02 15; 80(4):709-718.  View on PubMed
  19. Molinaro AM, Phillips JJ. EGFR amplification status for clinical trial inclusion: where do we draw the line? Neuro Oncol. 2019 10 09; 21(10):1215-1216.  View on PubMed
  20. Wang L, Babikir H, Müller S, Yagnik G, Shamardani K, Catalan F, Kohanbash G, Alvarado B, Di Lullo E, Kriegstein A, Shah S, Wadhwa H, Chang SM, Phillips JJ, Aghi MK, Diaz AA. The Phenotypes of Proliferating Glioblastoma Cells Reside on a Single Axis of Variation. Cancer Discov. 2019 12; 9(12):1708-1719.  View on PubMed

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