I am the Director of Basic Science in the UCSF Brain Tumor Center, the Vice-Chairman of the UCSF Department of Neurological Surgery, and a co-PI of the UCSF Brain Tumor SPORE. I am a recognized expert in the areas of cell signaling, temozolomide-based drug resistance, and gliomagenesis. As the Suzanne Marie Haderle and Robert Vincent Haderle Professor of Molecular Neuro-Oncology, I direct a lab that focuses on genetic events that drive brain tumor formation and drug resistance and that in turn may serve as targets for the development of new therapies for brain tumors.
September 20, 2002 - August 31, 2023 - Brain Tumor SPORE Grant, Co-Investigator. Sponsor: NIH/NCI, Sponsor Award ID: P50CA097257
September 15, 2017 - May 31, 2022 - Contributions of IDH1 mutation to alternative lengthening of telomeres in lower-grade glioma, Principal Investigator. Sponsor: NIH/NINDS, Sponsor Award ID: R01NS105087
September 1, 2010 - August 31, 2020 - Training Program in Translational Brain Tumor Research, Co-Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: T32CA151022
February 1, 2013 - January 31, 2018 - Understanding the role of altered metabolism in gliomagenesis, Principal Investigator. Sponsor: NIH/NCI, Sponsor Award ID: R01CA171610
University of Wisconsin, Madison, WI, B.S., 1982, Pharmacy
George Washington Univ., Washington, D.C., Ph.D., 1987, Pharmacology