Research Summary

Dr. Michael Prados has over 35 years' experience at UCSF in treating both adults and children who have brain tumors. His current research interest is translational and clinical research in pediatric neuro-oncology. He is co-Project Leader of the Pacific Pediatric Neuro-Oncology Consortium (PNOC) and co-Scientific Chair of the Children's Brain Tumor Network (CBTN).

Dr. Prados has participated in over 120 clinical research protocols from the National Institutes of Health (NIH), UCSF, and Industry studies -- including 22 early phase trials for children with brain tumors in the last 10 years. He has published over 350 peer-reviewed articles and has been continuously funded by the NIH since 1990. He is currently Professor Emeritus and holds the Charles B. Wilson Endowed Chair of Neurosurgery. In 2014 he was awarded the Victor Levin Award for lifetime clinical research excellence from the Society of Neuro-Oncology.

Research Funding

  • September 20, 2002 - August 31, 2018 - Novel Approaches for Improving Pediatric BRAFv600e Glioma Patient Outcomes , Project Co-Leader . Sponsor: NIH/NCI, Sponsor Award ID: 2 P50 CA097257-11A1
  • September 20, 2002 - August 31, 2018 - Brain Tumor SPORE Grant , Administrative Core D co-leader . Sponsor: NIH/NCI, Sponsor Award ID: 2 P50 CA097257-11A1
  • August 5, 1999 - May 31, 2017 - The Cancer Center Support Grant , Neurological Surgery Project Leader . Sponsor: NIH/NCI, Sponsor Award ID: P30 CA 82103-15
  • December 1, 2009 - December 31, 2016 - Ivy Foundation Early Phase Clinical Trials Consortium , Principal Investigator . Sponsor: Ivy Foundation, Sponsor Award ID:
  • July 1, 2012 - October 31, 2015 - PNOC Clinical Trials Consortium , Project Leader . Sponsor: , Sponsor Award ID: Pacific Pediatric Neuro-Oncology Consortium
  • January 1, 2009 - April 30, 2014 - Adult Brain Tumor Consortium (ABTC) , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01CA137443
  • March 25, 1994 - December 31, 2009 - NABTC Member Intitution Grant (UCSF Project Leader) , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01CA062422
  • March 25, 1994 - December 31, 2009 - NABTC Central Operation Grant (UCSF Project Leader) , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01CA062399
  • December 1, 1974 - March 31, 2009 - General Clinical Research Center , Co-Investigator . Sponsor: NIH, Sponsor Award ID: M01RR000079
  • December 1, 1981 - March 31, 2007 - PEDIATRIC CLINICAL RESEARCH CENTER , Co-Investigator . Sponsor: NIH, Sponsor Award ID: M01RR001271
  • April 1, 1999 - March 31, 2004 - PEDIATRIC BRAIN TUMOR CLINICAL TRIAL CONSORTIUM , Principal Investigator . Sponsor: NIH, Sponsor Award ID: U01CA081449
  • April 1, 1979 - September 30, 2000 - CLINICAL THERAPY FOR MALIGNANT BRAIN TUMORS , Principal Investigator . Sponsor: NIH, Sponsor Award ID: P01CA013525

Education

Mississippi State University, Starkville, 1966-1969, Biology
University of New Orleans, BS, 1969-1970, Biology
LSU School of Medicine, MD, 1970-1974, Medicine
LSU Charity Hospital, New Orleans, LA, Internship, 1974-1975, Medicine
LSU Earl K Long Hospital, Baton Rouge, LA, Residency, 1975-1977, Internal Medicine

Honors & Awards

  • Victor Levin Award for Clinical Excellence, Society of Neuro-Oncology, 2014
  • President, Society of Neuro-Oncology, 2003-2005
  • Clinical Excellence Award 1997, National Brain Tumor Foundation, 1997
  • Vice-President, Society of Neuro-Oncology, 1995-1997

Selected Publications

  1. Corbett RJ, Gullickson CC, Geng Z, Brown MA, Zhang B, Zhong C, Van Kuren N, Chroni A, Blackden C, Naqvi AS, Plisiewicz A, McHugh S, Drake E, Lehmann K, Davidson TB, Prados M, Storm PB, Resnick AC, Waanders AJ, Waszak SM, Mueller S, Rokita JL, Kline C. Genetic ancestry superpopulations show distinct prevalence and outcomes across pediatric central nervous system tumors from the PBTA and PNOC. Neuro Oncol. 2025 Jan 23.  View on PubMed
  2. Roberts HJ, Ravi K, Marini BL, Schepers A, Kline C, Kilburn L, Prados M, Byron SA, Sturza J, Mueller S, Koschmann C, Franson AT. Retrospective Comparison of Targeted Anticancer Drugs Predicted by the CNS-TAP Tool Versus Those Selected by a Molecularly Driven Tumor Board in Children With DIPG. J Pediatr Hematol Oncol. 2025 01 01; 47(1):19-30.  View on PubMed
  3. Familiar AM, Fathi Kazerooni A, Vossough A, Ware JB, Bagheri S, Khalili N, Anderson H, Haldar D, Storm PB, Resnick AC, Kann BH, Aboian M, Kline C, Weller M, Huang RY, Chang SM, Fangusaro JR, Hoffman LM, Mueller S, Prados M, Nabavizadeh A. Towards consistency in pediatric brain tumor measurements: Challenges, solutions, and the role of artificial intelligence-based segmentation. Neuro Oncol. 2024 09 05; 26(9):1557-1571.  View on PubMed
  4. Yankelevich M, Zaky W, Lafay-Cousin L, Osorio D, Adamski J, Kordes U, Finlay JL, Prados M, Mueller S. Marrow-ablative consolidation chemotherapy and molecular targeted therapy delivered in a risk-adapted manner for newly diagnosed children with choroid plexus carcinoma: A work in progress. Neurooncol Adv. 2024 Jan-Dec; 6(1):vdae109.  View on PubMed
  5. Mueller S, Kline C, Franson A, van der Lugt J, Prados M, Waszak SM, Plasschaert SLA, Molinaro AM, Koschmann C, Nazarian J. Rational combination platform trial design for children and young adults with diffuse midline glioma: A report from PNOC. Neuro Oncol. 2024 May 03; 26(Supplement_2):S125-S135.  View on PubMed
  6. Mendez-Gomez HR, DeVries A, Castillo P, von Roemeling C, Qdaisat S, Stover BD, Xie C, Weidert F, Zhao C, Moor R, Liu R, Soni D, Ogando-Rivas E, Chardon-Robles J, McGuiness J, Zhang D, Chung MC, Marconi C, Michel S, Barpujari A, Jobin GW, Thomas N, Ma X, Campaneria Y, Grippin A, Karachi A, Li D, Sahay B, Elliott L, Foster TP, Coleman KE, Milner RJ, Sawyer WG, Ligon JA, Simon E, Cleaver B, Wynne K, Hodik M, Molinaro AM, Guan J, Kellish P, Doty A, Lee JH, Massini T, Kresak JL, Huang J, Hwang EI, Kline C, Carrera-Justiz S, Rahman M, Gatica S, Mueller S, Prados M, Ghiaseddin AP, Silver NL, Mitchell DA, Sayour EJ. RNA aggregates harness the danger response for potent cancer immunotherapy. Cell. 2024 May 09; 187(10):2521-2535.e21.  View on PubMed
  7. Ramakrishnan D, Brüningk SC, von Reppert M, Memon F, Maleki N, Aneja S, Kazerooni AF, Nabavizadeh A, Lin M, Bousabarah K, Molinaro A, Nicolaides T, Prados M, Mueller S, Aboian MS. Comparison of Volumetric and 2D Measurements and Longitudinal Trajectories in the Response Assessment of BRAF V600E-Mutant Pediatric Gliomas in the Pacific Pediatric Neuro-Oncology Consortium Clinical Trial. AJNR Am J Neuroradiol. 2024 04 08; 45(4):475-482.  View on PubMed
  8. Margol AS, Molinaro AM, Onar-Thomas A, Resnick A, Hanson D, Kieran M, Mishra-Kalyani P, Rivera D, Barone A, Arons D, Meehan C, Prados M. Use of External Control Cohorts in Pediatric Brain Tumor Clinical Trials. J Clin Oncol. 2024 Apr 20; 42(12):1340-1343.  View on PubMed
  9. Haas-Kogan DA, Aboian MS, Minturn JE, Leary SES, Abdelbaki MS, Goldman S, Elster JD, Kraya A, Lueder MR, Ramakrishnan D, von Reppert M, Liu KX, Rokita JL, Resnick AC, Solomon DA, Phillips JJ, Prados M, Molinaro AM, Waszak SM, Mueller S. Everolimus for Children With Recurrent or Progressive Low-Grade Glioma: Results From the Phase II PNOC001 Trial. J Clin Oncol. 2024 Feb 01; 42(4):441-451.  View on PubMed
  10. Friedman HS, Prados MD, Wen PY, Mikkelsen T, Schiff D, Abrey LE, Yung WKA, Paleologos N, Nicholas MK, Jensen R, Vredenburgh J, Huang J, Zheng M, Cloughesy T. Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma. J Clin Oncol. 2023 11 10; 41(32):4945-4952.  View on PubMed
  11. Mueller S, Kline C, Stoller S, Lundy S, Christopher L, Reddy AT, Banerjee A, Cooney TM, Raber S, Hoffman C, Luks T, Wembacher-Schroeder E, Lummel N, Zhang Y, Bonner ER, Nazarian J, Molinaro AM, Prados M, Villanueva-Meyer JE, Gupta N. PNOC015: Repeated convection-enhanced delivery of MTX110 (aqueous panobinostat) in children with newly diagnosed diffuse intrinsic pontine glioma. Neuro Oncol. 2023 11 02; 25(11):2074-2086.  View on PubMed
  12. Prados MD. Current Strategies for Management of Medulloblastoma. Diagnostics (Basel). 2023 Aug 08; 13(16).  View on PubMed
  13. Koschmann C, Prados M. Applying collaborative brain power to pull us out of the dark ages of pediatric neuro-oncology. Neoplasia. 2023 07; 41:100905.  View on PubMed
  14. Jones C, Straathof K, Fouladi M, Hargrave D, Prados M, Resnick A, Doz F, Jones DTW, Mueller S. Evaluating preclinical evidence for clinical translation in childhood brain tumours: Guidelines from the CONNECT, PNOC, and ITCC brain networks. Front Oncol. 2023; 13:1167082.  View on PubMed
  15. Mendez-Gomez HR, DeVries A, Castillo P, Stover BD, Qdaisat S, Von Roemeling C, Ogando-Rivas E, Weidert F, McGuiness J, Zhang D, Chung MC, Li D, Zhang C, Marconi C, Campaneria Y, Chardon-Robles J, Grippin A, Karachi A, Thomas N, Huang J, Milner R, Sahay B, Sawyer WG, Ligon JA, Silver N, Simon E, Cleaver B, Wynne K, Hodik M, Molinaro A, Guan J, Kellish P, Doty A, Lee JH, Carrera-Justiz S, Rahman M, Gatica S, Mueller S, Prados M, Ghiaseddin A, Mitchell DA, Sayour EJ. mRNA aggregates harness danger response for potent cancer immunotherapy. medRxiv. 2023 Mar 17.  View on PubMed
  16. Fathi Kazerooni A, Arif S, Madhogarhia R, Khalili N, Haldar D, Bagheri S, Familiar AM, Anderson H, Haldar S, Tu W, Chul Kim M, Viswanathan K, Muller S, Prados M, Kline C, Vidal L, Aboian M, Storm PB, Resnick AC, Ware JB, Vossough A, Davatzikos C, Nabavizadeh A. Automated tumor segmentation and brain tissue extraction from multiparametric MRI of pediatric brain tumors: A multi-institutional study. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad027.  View on PubMed
  17. Kazerooni AF, Arif S, Madhogarhia R, Khalili N, Haldar D, Bagheri S, Familiar AM, Anderson H, Haldar S, Tu W, Kim MC, Viswanathan K, Muller S, Prados M, Kline C, Vidal L, Aboian M, Storm PB, Resnick AC, Ware JB, Vossough A, Davatzikos C, Nabavizadeh A. Automated Tumor Segmentation and Brain Tissue Extraction from Multiparametric MRI of Pediatric Brain Tumors: A Multi-Institutional Study. medRxiv. 2023 Jan 11.  View on PubMed
  18. Budhraja KK, McDonald BR, Stephens MD, Contente-Cuomo T, Markus H, Farooq M, Favaro PF, Connor S, Byron SA, Egan JB, Ernst B, McDaniel TK, Sekulic A, Tran NL, Prados MD, Borad MJ, Berens ME, Pockaj BA, LoRusso PM, Bryce A, Trent JM, Murtaza M. Genome-wide analysis of aberrant position and sequence of plasma DNA fragment ends in patients with cancer. Sci Transl Med. 2023 01 11; 15(678):eabm6863.  View on PubMed
  19. Sloan AE, Nock CJ, Ye X, Buerki R, Chang S, Lesser G, Norden A, Cloughesy T, Olson J, Kerstetter-Fogle A, Rich J, Fisher J, Desideri S, Takebe N, Timmer W, Grossman S, Prados M. ABTC-0904: targeting glioma stem cells in GBM: a phase 0/II study of hedgehog pathway inhibitor GDC-0449. J Neurooncol. 2023 Jan; 161(1):33-43.  View on PubMed
  20. Lilly JV, Rokita JL, Mason JL, Patton T, Stefankiewiz S, Higgins D, Trooskin G, Larouci CA, Arya K, Appert E, Heath AP, Zhu Y, Brown MA, Zhang B, Farrow BK, Robins S, Morgan AM, Nguyen TQ, Frenkel E, Lehmann K, Drake E, Sullivan C, Plisiewicz A, Coleman N, Patterson L, Koptyra M, Helili Z, Van Kuren N, Young N, Kim MC, Friedman C, Lubneuski A, Blackden C, Williams M, Baubet V, Tauhid L, Galanaugh J, Boucher K, Ijaz H, Cole KA, Choudhari N, Santi M, Moulder RW, Waller J, Rife W, Diskin SJ, Mateos M, Parsons DW, Pollack IF, Goldman S, Leary S, Caporalini C, Buccoliero AM, Scagnet M, Haussler D, Hanson D, Firestein R, Cain J, Phillips JJ, Gupta N, Mueller S, Grant G, Monje-Deisseroth M, Partap S, Greenfield JP, Hashizume R, Smith A, Zhu S, Johnston JM, Fangusaro JR, Miller M, Wood MD, Gardner S, Carter CL, Prolo LM, Pisapia J, Pehlivan K, Franson A, Niazi T, Rubin J, Abdelbaki M, Ziegler DS, Lindsay HB, Stucklin AG, Gerber N, Vaske OM, Quinsey C, Rood BR, Nazarian J, Raabe E, Jackson EM, Stapleton S, Lober RM, Kram DE, Koschmann C, Storm PB, Lulla RR, Prados M, Resnick AC, Waanders AJ. The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science. Neoplasia. 2023 01; 35:100846.  View on PubMed

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