Sophie Dumont, PhD
Assistant Professor, Dept of Cell & Tissue Biology, Dept of Cellular & Molecular Pharmacology, University of California, San Francisco
Cancer Center Program Memberships
Affiliate MemberEducation
Princeton University, Princeton, NJ, USA, B.A., 08/95-06/99, Physics
University of Oxford, UK, D.Phil. candidate, 09/99-08/00, Theoretical Physics
University of California, Berkeley, CA, USA, Ph.D., 08/00-12/05, Molecular Biophysics
University of California, Berkeley, CA, USA, Postdoc, 01/06-03/06, Molecular Biophysics
Harvard Society of Fellows, Junior Fellow, 07/06-06/09, Cellular Biophysics
Harvard Medical School, Boston, MA, USA, Postdoc, 07/06-05/12, Cellular Biophysics
Professional Experience
-
1997-1999
Undergraduate Student Researcher, Princeton University, Advisor: Prof. Stanislas Leibler (Physics), Thesis: Thermal sensing network of E. coli -
1999-2000
Graduate Student Researcher, University of Oxford, Advisor: Prof. Douglas Abraham (Theoretical Physics), Topic: Statistical mechanics of neural networks -
2000-2005
Graduate Student Researcher, University of California, Berkeley, Advisor: Prof. Carlos Bustamante (Physics), Thesis: Force and helicase-catalyzed mechanical unfolding of single RNA molecules -
2006
Postdoctoral fellow, University of California, Berkeley, Advisors: Prof. Carlos Bustamante (Physics), Prof. Ignacio Tinoco Jr. (Chemistry), Topic: Helicase mechanochemistry -
2006-2009
Junior Fellow, Harvard Society of Fellows, Mentor: Prof. Timothy J. Mitchison (Systems Biology), Topic: Mechanical forces in cell division -
2006-2012
Postdoctoral Fellow, Harvard Medical School, Mentor: Prof. Timothy J. Mitchison (Systems Biology), Topic: Mechanical forces in cell division -
2012-
Assistant Professor, University of California, San Francisco, Dept of Cell & Tissue Biology, Dept of Cellular & Molecular Pharmacology
Honors & Awards
- 1999
Phi Beta Kappa; Sigma Xi - 1999
Allen G. Shenstone Prize in Physics, Princeton University - 1999-2000
Rhodes Scholarship - 1999-2001
Québec Fund for Nature and Technology Research Fellowship (masters) - 2001-2003
Natural Sciences and Engineering Council of Canada Fellowship (doctoral) - 2001-2004
Québec Fund for Nature and Technology Research Fellowship (doctoral) - 2004
Outstanding Graduate Student Instructor Award, UC Berkeley - 2004
Teaching Effectiveness Graduate Student Instructor Award, UC Berkeley - 2004-2005
Canadian Institutes of Health Research Fellowship (doctoral) - 2006
Alan Bearden Outstanding Graduate Research Award, UC Berkeley - 2006
Weintraub Graduate Student Award - 2006-2009
Junior Fellow, Harvard Society of Fellows - 2007-2009
Harvard University William F. Milton Fund Award - 2009-2011
Charles A. King Trust Postdoctoral Fellowship - 2010-2015
NIH K99/R00 Pathway to Independence Award - 2013-2015
Sloan Research Fellow - 2013-2015
Kimmel Cancer Foundation Scholar - 2013-2016
Searle Scholar - 2013-2018
Rita Allen Foundation and Milton E. Cassel Scholar - 2015-2020
NIH New Innovator Award - 2016
Margaret Oakley Dayhoff Award of the Biophysical Society
Selected Publications
- Suresh P, Long AF, Dumont S. Microneedle manipulation of the mammalian spindle reveals specialized, short-lived reinforcement near chromosomes. Elife. 2020 Mar 19; 9.
View on PubMed - Rohrberg J, Van de Mark D, Amouzgar M, Lee JV, Taileb M, Corella A, Kilinc S, Williams J, Jokisch ML, Camarda R, Balakrishnan S, Shankar R, Zhou A, Chang AN, Chen B, Rugo HS, Dumont S, Goga A. MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities. Cell Rep. 2020 Mar 10; 30(10):3368-3382.e7.
View on PubMed - Kuhn J, Dumont S. Mammalian kinetochores count attached microtubules in a sensitive and switch-like manner. J Cell Biol. 2019 Nov 04; 218(11):3583-3596.
View on PubMed - Long AF, Kuhn J, Dumont S. The mammalian kinetochore-microtubule interface: robust mechanics and computation with many microtubules. Curr Opin Cell Biol. 2019 Oct; 60:60-67.
View on PubMed - Hueschen CL, Galstyan V, Amouzgar M, Phillips R, Dumont S. Microtubule End-Clustering Maintains a Steady-State Spindle Shape. Curr Biol. 2019 02 18; 29(4):700-708.e5.
View on PubMed - Neahring L, Dumont S. Chromosome Segregation Fidelity Integrates Information across Scales. Dev Cell. 2018 12 03; 47(5):525-526.
View on PubMed - Shah KN, Bhatt R, Rotow J, Rohrberg J, Olivas V, Wang VE, Hemmati G, Martins MM, Maynard A, Kuhn J, Galeas J, Donnella HJ, Kaushik S, Ku A, Dumont S, Krings G, Haringsma HJ, Robillard L, Simmons AD, Harding TC, McCormick F, Goga A, Blakely CM, Bivona TG, Bandyopadhyay S. Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer. Nat Med. 2019 01; 25(1):111-118.
View on PubMed - Elting MW, Suresh P, Dumont S. The Spindle: Integrating Architecture and Mechanics across Scales. Trends Cell Biol. 2018 11; 28(11):896-910.
View on PubMed - Serra-Marques A, Dumont S. Shining light on spindle positioning. Elife. 2018 07 09; 7.
View on PubMed - Christina L. Hueschen, Samuel J. Kenny, Ke Xu, Sophie Dumont. NuMA Recruits Dynein Activity to Microtubule Minus-Ends at Mitosis. Biophysical Journal. 2018 Feb 1; 114(3):506a.
View on PubMed - Alexandra F. Long, Dylan B. Udy, Pooja Suresh, Sophie Dumont. Probing How the Mammalian Kinetochore Holds on to Growing versus Shrinking Microtubules. Biophysical Journal. 2018 Feb 1; 114(3):518a.
View on PubMed - Pooja Suresh, Alexandra F. Long, Sophie Dumont. Probing the Physical and Molecular Basis of the Mammalian Mitotic Spindle's Response to Force. Biophysical Journal. 2018 Feb 1; 114(3):655a.
View on PubMed - Hueschen CL, Kenny SJ, Xu K, Dumont S. NuMA recruits dynein activity to microtubule minus-ends at mitosis. Elife. 2017 11 29; 6.
View on PubMed - Elting MW, Prakash M, Udy DB, Dumont S. Mapping Load-Bearing in the Mammalian Spindle Reveals Local Kinetochore Fiber Anchorage that Provides Mechanical Isolation and Redundancy. Curr Biol. 2017 Jul 24; 27(14):2112-2122.e5.
View on PubMed - Hueschen CL, Kenny SJ, Xu K, Dumont S. NuMA Targets Dynein to Microtubule Minus-Ends at Mitosis. BioRxiv doi.org/10.1101/148692. 2017.
View on PubMed - Long AF, Udy DB, Dumont S. Hec1 Tail Phosphorylation Differentially Regulates Mammalian Kinetochore Coupling to Polymerizing and Depolymerizing Microtubules. Curr Biol. 2017 Jun 05; 27(11):1692-1699.e3.
View on PubMed - Kuhn J, Dumont S. Spindle assembly checkpoint satisfaction occurs via end-on but not lateral attachments under tension. J Cell Biol. 2017 06 05; 216(6):1533-1542.
View on PubMed - Karg T, Elting MW, Vicars H, Dumont S, Sullivan W. The chromokinesin Klp3a and microtubules facilitate acentric chromosome segregation. J Cell Biol. 2017 06 05; 216(6):1597-1608.
View on PubMed - Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S. Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Mol Biol Cell. 2017 Jul 07; 28(14):1975-1983.
View on PubMed - Mary Williard Elting, Dylan B. Udy, Manu Prakash, Sophie Dumont. Local Load-Bearing by Kinetochore-Fibers in the Mammalian Spindle Provides Mechanical Isolation and Redundancy. Biophysical Journal. 2017 Feb 1; 112(3):432a.
View on PubMed