Research Funding

  • September 1, 2022 - June 30, 2027 - Spatial multiomic mapping of gene function with CRISPRoff , Principal Investigator . Sponsor: NIH, Sponsor Award ID: UM1HG012660
  • September 10, 2021 - June 30, 2025 - Editing CG and non-CG DNA methylation to identify genomic elements that regulate gene expression , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01HG012227
  • September 30, 2018 - May 31, 2023 - A GENETIC INTERACTION MAP OF THE HUMAN NUCLEUS , Principal Investigator . Sponsor: NIH, Sponsor Award ID: DP2CA239597
  • May 1, 2020 - April 30, 2021 - Drug target identification using CRISPRi/a screening , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R41GM137625
  • April 1, 2017 - March 31, 2020 - A functional genomics approach to determine the mechanism of cellular response to new anti-cancer , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R00CA204602
  • April 1, 2016 - March 31, 2017 - A functional genomics approach to determine the mechanism of cellular response to new anti-cancer drugs , Principal Investigator . Sponsor: NIH, Sponsor Award ID: K99CA204602

Education

University of California, Los Angeles, BS, 06/2006, Microbiology, Immunology, and Molecular Genetics
Massachusetts Institute of Technology, PhD, 05/2012, Biology
University of California, San Francisco, Postdoctoral, 4/2017, Cell Biology, Synthetic Biology

Honors & Awards

  • 2010
    Virginia and Daniel K. Ludwig Graduate Research Fellow
  • 2013
    Leukemia and Lymphoma Society Postdoctoral Fellow
  • 2016
    NIH/NCI Pathway to Independence Award
  • 2018
    Gabrielle's Angel Foundation Medical Research Fellow
  • 2018
    NIH Director's New Innovator Award
  • 2019-2023
    Pew-Stewart Scholar for Cancer Research
  • 2020
    AAAS / Martin and Rose Wachtel Cancer Research Award
  • 2022-2023
    Prostate Cancer Foundation Challenge Award
  • 2022-2027
    CRUK/NCI Cancer Grand Challenge Award
  • 2022-2027
    NIH NHGRI UM1 HG012660

Selected Publications

  1. Spangenberg SH, Garaffo N, Alcindor EMC, Lusk B, Pandey V, Longhurst AD, Bolech E, Fu BXH, Gilbert LA, Wohlschlegel JA, Toczyski DP. The regulation of protein phosphatase 4 by FBXO42 is required for cancer cell survival. EMBO Rep. 2026 Jul 14. View on PubMed
  2. Raleigh D, Liu SJ, Majd N, Zou C, Congivaram H, Najem H, Youngblood M, Wang IC, Sengelmann S, Raval K, Jiang J, Foster K, Casey-Clyde T, Pak J, Pan S, Payne E, Lin K, Vasudevan H, Thompson M, Ozawa T, Mirchia K, Berger M, Weiss W, Heimberger A, de Groot J, Gilbert L. DNA-PKcs inhibition sensitizes glioblastoma to radiotherapy through reprogramming of tumor cell states and immune microenvironment cell types. Res Sq. 2026 Jun 05. View on PubMed
  3. Berquez M, Li AL, Luy MA, Venida AC, McDowall S, O'Loughlin T, Rademaker G, Barpanda A, Hu J, Yano J, Wiita AP, Gilbert LA, Bruno PM, Perera RM. A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer. Mol Cell. 2026 Jun 04; 86(11):2141-2156.e8. View on PubMed
  4. O'Loughlin TA, Stiles JS, Acharya P, Arab A, Goudy L, Dai R, Borah AA, Weiss WA, Medoh UN, Gilbert LA. mTORC1 activity suppresses ferroptosis through a SCARB1-dependent HDL-tocopherol uptake pathway. Mol Cell. 2026 Apr 16; 86(8):1546-1559.e8. View on PubMed
  5. Liu J, Moore MK, Lou K, Wassarman DR, Arab A, Ojeda S, Karakyriakou B, Koglin AS, Ott CJ, Gilbert LA, Shokat KM. A Dimeric Rocaglate Promotes Multivalent eIF4A-RNA Assembly. bioRxiv. 2026 Mar 10. View on PubMed
  6. Herken BW, Wong GT, Mäkiniemi A, Lundberg E, Norman TM, Gilbert LA. Large-scale mapping of environmental-genetic interactions illustrates the dynamic nature of cell-cycle and DNA repair regulation. Mol Cell. 2026 Feb 19; 86(4):757-773.e5. View on PubMed
  7. Yi H, Zhang S, Swinderman J, Wang Y, Kanakaveti V, Hung KL, Tsz-Lo Wong I, Srinivasan S, Curtis EJ, Bhargava-Shah A, Li R, Jones MG, Luebeck J, Bailey C, Zhao Y, Belk JA, Kraft K, Shi Q, Yan X, Pritchard SK, Mahajan KS, Liang F, Jamal-Hanjani M, Felsher DW, Gilbert LA, Bafna V, Mischel PS, Chang HY. EcDNA-borne structural variants drive oncogenic fusion transcript amplification. Cell. 2026 Feb 05; 189(3):906-921.e20. View on PubMed
  8. Umhoefer JM, Arce MM, Kasinathan S, Whalen S, Dajani R, Subramanya S, Goudy L, Belk JA, Zhou R, Pham MTN, Zhang W, Hernandez R, Tran C, Kirthivasan N, Freimer JW, Mowery CT, Nguyen V, Ota M, Gowen BG, Simeonov DR, Curie GL, Li Z, Chen AY, Corn JE, Chang HY, Tang Q, Gilbert LA, Satpathy AT, Pollard KS, Marson A. FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry. Immunity. 2026 Jan 13; 59(1):129-144.e13. View on PubMed
  9. Fanton A, Bartie LJ, Martins JQ, Tran VQ, Goudy L, Kernick C, Durrant MG, Wei J, Armour-Garb Z, Pawluk A, Konermann S, Marson A, Gilbert LA, Roth TL, Hsu PD. Site-specific DNA insertion into the human genome with engineered recombinases. Nat Biotechnol. 2025 Nov 06. View on PubMed
  10. Li H, Melnyk JE, Fu BXH, Shrestha R, Zhang M, Sjöström M, Feng S, Anderson JA, Han W, Chesner LN, Shin HJ, Farsh T, Suarez HJ, Nath S, Chou J, Das R, Egusa EA, Calvert M, Kishishita A, Barpanda A, Zhu J, Maheshwari A, Chen WS, Alshalalfa M, Winters A, Hua JT, Liu T, Davicioni E, Wiita AP, Stohr BA, Siddiqui J, Huang B, Small EJ, Shokat KM, Nelson PS, Quigley DA, Wasmuth EV, Gilbert LA, Feng FY. Genome-scale CRISPR screens identify PTGES3 as a direct modulator of androgen receptor function in advanced prostate cancer. Nat Genet. 2025 Dec; 57(12):3027-3038. View on PubMed
  11. Fu BXH, Xu A, Li H, Johnson DE, Grandis JR, Gilbert LA. Loss of Fanconi anemia proteins causes a reliance on lysosomal exocytosis. Cell Death Dis. 2025 Nov 04; 16(1):791. View on PubMed
  12. Goudy L, Ha A, Borah AA, Umhoefer JM, Chow L, Tran C, Winters A, Talbot A, Hernandez R, Li Z, Subramanya S, Arab A, Kale N, Lee JHJ, Muldoon JJ, Liu C, Schmidt R, Santangelo P, Carnevale J, Eyquem J, Shy BR, Marson A, Gilbert LA. Integrated epigenetic and genetic programming of primary human T cells. Nat Biotechnol. 2026 Sep; 44(9):1470-1481. View on PubMed
  13. Lin K, Zou C, Hubbard A, Sengelmann S, Goudy L, Wang IC, Sharma R, Pak J, Foster K, Ozawa T, de Groot JF, Phillips J, Vasudevan HN, Raleigh DR, Marson A, Murthy N, Gilbert LA, Berger MS, Liu SJ. Multiplexed epigenetic memory editing using CRISPRoff sensitizes glioblastoma to chemotherapy. Neuro Oncol. 2025 Jul 30; 27(6):1443-1457. View on PubMed
  14. Liu T, Zhang M, Farsh T, Li H, Kishishita A, Barpanda A, Leung SG, Zhu J, Jung H, Hua JT, Zhu X, Kim AB, Goo YA, Son M, Kim J, Subramanian A, Sjöström M, Fuh KC, Chapman JS, Carnevale J, Gilbert LA, Lakkaraju A, Bruno PM, Quigley D, Wiita AP, Feng FY, DeSelm CJ. Exploitable mechanisms of antibody and CAR mediated macrophage cytotoxicity. Nat Commun. 2025 Jul 01; 16(1):5616. View on PubMed
  15. Roohani YH, Hua TJ, Tung PY, Bounds LR, Yu FB, Dobin A, Teyssier N, Adduri A, Woodrow A, Plosky BS, Mehta R, Hsu B, Sullivan J, Ricci-Tam C, Li N, Kazaks J, Gilbert LA, Konermann S, Hsu PD, Goodarzi H, Burke DP. Virtual Cell Challenge: Toward a Turing test for the virtual cell. Cell. 2025 Jun 26; 188(13):3370-3374. View on PubMed
  16. Li H, Melnyk JE, Fu BXH, Shrestha R, Zhang M, Sjöström M, Feng S, Anderson JA, Han W, Chesner LN, Shin HJ, Farsh T, Suarez HJ, Nath S, Chou J, Das R, Egusa EA, Zhu J, Winters A, Maheshwari A, Hua JT, Alshalalfa M, Chen WS, Calvert M, Davicioni E, Kishishita A, Barpanda A, Liu T, Wiita AP, Stohr BA, Siddiqui J, Huang B, Small EJ, Shokat KM, Nelson P, Quigley DA, Wasmuth EV, Gilbert LA, Feng FY. Genome-wide CRISPR screens identify PTGES3 as a novel AR modulator. bioRxiv. 2025 May 31. View on PubMed
  17. Yi H, Zhang S, Swinderman J, Wang Y, Kanakaveti V, Hung KL, Wong IT, Srinivasan S, Curtis EJ, Bhargava-Shah A, Li R, Jones MG, Luebeck J, Zhao Y, Belk JA, Kraft K, Shi Q, Yan X, Pritchard SK, Liang FM, Felsher DW, Gilbert LA, Bafna V, Mischel PS, Chang HY. EcDNA-borne PVT1 fusion stabilizes oncogenic mRNAs. bioRxiv. 2025 Apr 03. View on PubMed
  18. Naara S, Cui Z, Izgutdina A, VanLandingham NK, Nazarenko A, Woerner LC, Hua Fu BX, Gilbert LA, Johnson DE, Grandis JR. Neddylation as a target in PIK3CA-mutated head and neck cancer. Biochem Biophys Res Commun. 2025 05 20; 759:151703. View on PubMed
  19. Chesner LN, Polesso F, Graff JN, Hawley JE, Smith AK, Lundberg A, Das R, Shenoy T, Sjöström M, Zhao F, Hu YM, Linder S, Chen WS, Hawkins RM, Shrestha R, Zhu X, Foye A, Li H, Kim LM, Bhalla M, O'loughlin T, Kuzuoglu-Ozturk D, Hua JT, Badura ML, Wilkinson S, Trostel SY, Bergman AM, Ruggero D, Drake CG, Sowalsky AG, Fong L, Cooperberg MR, Zwart W, Guan X, Ashworth A, Xia Z, Quigley DA, Gilbert LA, Feng FY, Moran AE. Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer. Cancer Discov. 2025 Mar 03; 15(3):481-494. View on PubMed
  20. Adli M, Przybyla L, Burdett T, Burridge PW, Cacheiro P, Chang HY, Engreitz JM, Gilbert LA, Greenleaf WJ, Hsu L, Huangfu D, Hung LH, Kundaje A, Li S, Parkinson H, Qiu X, Robson P, Schürer SC, Shojaie A, Skarnes WC, Smedley D, Studer L, Sun W, Vidovic D, Vierbuchen T, White BS, Yeung KY, Yue F, Zhou T, MorPhiC Consortium. MorPhiC Consortium: towards functional characterization of all human genes. Nature. 2025 02; 638(8050):351-359. View on PubMed

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